Fig. 1 · Structure
Documents & Downloads
TIP48/49-IN-1
RUVBL1/2 ATPase Inhibitor
TIP48/49-IN-1 is a selective inhibitor of the RUVBL1/2 ATPase, demonstrating an IC50 of 59 nM against purified RUVBL1/2. By disrupting the DNA replication process, TIP48/49-IN-1 induces S-phase arrest and apoptosis in cancer cells. This compound has been shown to inhibit tumor growth and enhance radiosensitivity in non-small cell lung cancer (NSCLC) models, making it a valuable tool for cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1807337-58-1 |
| Applications | RUVBL1/2 ATPase Inhibitor |
| Formula | C28H30ClN5O4 |
| Molecular Weight | 536.02 |
| SMILES | CCOC(C=CC(Cl)=C1)=C1C2=NN=C([C@@H](CCC3)C[C@@H]3C(NC(C(N(C4=CC=CC=C4)N5C)=O)=C5C)=O)O2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.