Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Reserpine-d9 is a deuterated form of Reserpine that serves as an inhibitor of the vesicular monoamine transporter 2 (VMAT2). This stable isotope-labeled compound is valuable for studies in neuropharmacology and metabolism, allowing for precise tracking and quantification of Reserpine interactions in various biological systems. It enables researchers to explore its effects on neurotransmitter release and potential applications in psychiatric and neurological disorders. -
Protein kinase inhibitor
Apigenin, found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally-occurring glycosides. Apigenin acts as a monoamine transporter activator, one of the few chemicals demonstrated to possess this property. Apigenin is a ligand for central benzodiazepine receptors that competitively inhibited the binding of flunitrazepam with a Ki of 4μM, exerting anxiolytic and slight sedative effects.
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PDE4 inhibitor
Luteolin is a PDE4 inhibitor, phosphodiesterase inhibitor, and an interleukin 6 inhibitor, affecting xylazine/ketamine-induced anesthesia in mice. Luteolin acts as a monoamine transporter activator, and is one of the few chemicals demonstrated to possess this property. -
VMAT-2 inhibitor
Tetrabenazine Racemate (Ro 1-9569 Racemate) is a selective and reversible inhibitor of vesicular monoamine transporter-2 (VMAT-2). -
Autophagy Inhibitor
Reserpine acts as an inhibitor of vesicular monoamine transporter 2 (VMAT2), thereby influencing neurotransmitter storage and release. This compound is widely utilized in research studies focusing on autophagy inhibition and its implications in various neurodegenerative disorders. Additionally, reserpine's effects on monoamine levels make it a valuable tool in the investigation of psychiatric conditions and the biochemical pathways involved in these diseases. -
VMAT2 Inhibitor
Reserpine hydrochloride is a potent inhibitor of the vesicular monoamine transporter 2 (VMAT2). It is primarily utilized in research to study neurotransmitter release and its implications in neurodegenerative diseases and mental health disorders. By inhibiting VMAT2, Reserpine hydrochloride disrupts the storage of monoamines, allowing for investigation into their effects on various physiological and pathological processes. -
Monoamine Transporter Modulator
6-APDB is a monoamine transporter modulator that selectively influences human monoamine transporters while acting as a partial agonist at 5-HT2 family receptors. It demonstrates potent inhibition of norepinephrine and serotonin reuptake, with IC50 values of 0.56 μM for norepinephrine transporters (NET) and 2.3 μM for serotonin transporters (SERT). Additionally, 6-APDB mediates the release of multiple monoamine neurotransmitters, exhibiting a dose-dependent, biphasic locomotor effect in mice. This compound also has potential empathogenic properties along with behavioral effects relevant to research on monoamine signaling and neuropsychopharmacology, with no significant cytotoxicity observed at high concentrations. -
Histone Methyltransferase
Lobelane hydrochloride selectively inhibits the vesicular monoamine transporter-2 (VMAT2). This compound demonstrates an affinity for VMAT2 with a K(i) value of 630 nM, while exhibiting low interaction with nicotinic acetylcholine receptors (nAChR). The unique mechanism of action of lobelane hydrochloride makes it a valuable tool for studying neurotransmitter dynamics and offers potential in the development of therapeutic agents aimed at addressing methamphetamine abuse. Its structural analogs may further expand its applications in neuropharmacological research. -
SERT/VMAT2 probe
FFN246 is a fluorescent probe that selectively targets the serotonin transporter (SERT) and vesicular monoamine transporter 2 (VMAT2), exhibiting excitation and emission spectra of 392 nm and 427 nm, respectively. This compound is ideal for labeling serotonergic neurons in mouse brain tissue, facilitating the study of serotonergic signaling and neuronal activity. Its dual substrate properties make FFN246 a valuable tool in neurobiological research and the exploration of neurotransmitter dynamics. -
Noradrenalin Reuptake Inhibitor
Beloxepin is a synaptosomal noradrenalin reuptake inhibitor and a 5-HT2 receptor antagonist. It demonstrates selective inhibition with approximately 100-fold lower affinity for other monoamine transporters. Beloxepin exhibits significant antidepressant and analgesic properties, making it useful for research centered on mood disorders and pain management. -
Dopamine Receptor Inhibitor
Valbenazine dihydrochloride is a selective inhibitor of the vesicular monoamine transporter 2 (VMAT2) and primarily targets dopamine receptors. It is utilized in the treatment of tardive dyskinesia, offering therapeutic benefits for alleviating movement disorder symptoms linked to chronic dopamine receptor antagonism. Extensive preclinical studies support its efficacy, particularly in relation to the genetic factors contributing to tardive dyskinesia. -
Serotonin And Norepinephrine Reuptake Inhibitor
Milnacipran is an orally active serotonin and norepinephrine reuptake inhibitor that primarily targets the monoamine transporters responsible for neurotransmitter reuptake. It demonstrates high affinity for the norepinephrine transporter and serotonin transporter, with Ki values of 31 nM and 8.5 nM, respectively. Milnacipran exhibits antidepressant, anxiolytic, and analgesic properties, and has been shown to inhibit pERK1/2 activation. This compound is applicable in the study of major depressive disorder, anxiety disorders, and neuropathic pain conditions such as fibromyalgia. -
Stable Isotope
Milnacipran-d5 hydrochloride is a deuterated form of Milnacipran hydrochloride, a potent serotonin and norepinephrine reuptake inhibitor. It targets monoamine transporters, exhibiting Ki values of 31 nM for the norepinephrine transporter and 8.5 nM for the serotonin transporter. With notable antidepressant, anxiolytic, and analgesic properties, Milnacipran-d5 hydrochloride is valuable for research on major depressive disorder, anxiety disorders, and neuropathic pain conditions such as fibromyalgia. Additionally, it has been shown to affect behavior in preclinical models, providing insights into its pharmacological mechanisms. -
Stable Isotope
Milnacipran-d10 hydrochloride is a deuterium-labeled form of the serotonin and norepinephrine reuptake inhibitor, Milnacipran hydrochloride. It effectively inhibits monoamine transporters, targeting the norepinephrine and serotonin transporters with reported Ki values of 31 nM and 8.5 nM, respectively. This compound exhibits antidepressant, anxiolytic, and analgesic properties, and has demonstrated efficacy in reducing biting behavior in murine models. Milnacipran-d10 hydrochloride is valuable for research applications focused on major depressive disorder, anxiety disorders, and neuropathic pain syndromes, such as fibromyalgia. -
Adrenergic Receptor
FFN270 hydrochloride is a fluorescent tracer that specifically targets adrenergic receptors, functioning as a substrate for norepinephrine and vesicular monoamine transporters. This compound displays distinct absorption and excitation maxima at either 320 nm or 365 nm depending on the solvent pH, with an emission wavelength of 475 nm. FFN270 hydrochloride is valuable in research applications that involve monitoring norepinephrine dynamics and can also serve as a ratiometric pH sensor for various biological studies. -
Tricyclic Antidepressant Trimipramine Active Metabolite
Trimipramine N-oxide is the active metabolite of the tricyclic antidepressant trimipramine, primarily targeting human monoamine transporters. It effectively inhibits noradrenaline (hNAT), serotonin (hSERT), and dopamine (hDAT) transporters, along with human organic cation transporters (hOCT1 and hOCT2), with IC50 values of 11.7, 3.59, 9.4, 9.35, and 27.4 nM, respectively. This compound is valuable for research focused on depression and anxiety, contributing to the understanding of mood disorders and the pharmacological mechanisms of antidepressants. -
Stable Isotope
cis-Dihydro Tetrabenazine-d7 is a deuterium-labeled analog of cis-Dihydro Tetrabenazine, primarily utilized as a stable isotope in research applications. Its incorporation of deuterium enhances the precision of metabolic studies and pharmacokinetic analyses. This reagent is valuable in the investigation of vesicular monoamine transporters and can aid in the understanding of neurological disorders where dopaminergic signaling is implicated. -
Reserpine Analog
Bishomoreserpine is a reserpine analog that acts primarily as a monoamine transporter inhibitor. It exhibits significant inhibitory activity, impacting neurotransmitter uptake and revealing potential roles in studying neuropharmacology. This compound is useful in research aimed at understanding the mechanisms of neurotransmitter regulation and developing therapeutic strategies for related disorders. -
Amphetamine Derivative
N-Ethyl-3,4-DMA hydrochloride is an amphetamine derivative that primarily targets the monoamine transporters, particularly the serotonin and dopamine transporters. This compound exhibits psychoactive properties and is explored for its potential effects on mood and cognition. Its unique profile makes it a valuable reagent for studies in neuropharmacology and the investigation of amphetamine-like substances. -
Drug Derivative
1-(4-Methylphenyl)-2-(propylamino)propan-1-one hydrochloride is a drug derivative that primarily targets monoamine transporters. This compound exhibits significant biological activity as a stimulant and may influence neurotransmitter release. Its applications in research include investigating the mechanisms of action of psychoactive substances and studying mood disorders. -
Drug Derivative
N-Demethyl methylone hydrochloride is a drug derivative that primarily targets monoamine transporters, including the serotonin and dopamine transporters. This compound exhibits stimulatory effects and is often utilized in research focused on psychoactive substances and their metabolic pathways. Its biological activity is relevant for studies exploring the pharmacological properties of substituted cathinones and their effects on neurotransmitter systems. -
α-Pyrrolidinopropiophenone Derivative
4'-Fluoro-α-pyrrolidinopropiophenone hydrochloride is a derivative of α-Pyrrolidinopropiophenone, primarily acting on the monoamine transporters. This compound exhibits stimulant properties, making it relevant for research in neuropharmacology and the study of addiction mechanisms. Its applications also extend to the exploration of dopamine and norepinephrine reuptake inhibition, aiding in the development of potential therapeutic agents targeting these neurotransmitter systems. -
Amphetamine Derivative
N-Benzyl-3,4-DMA hydrochloride is an amphetamine derivative that primarily targets monoamine transporters. This compound exhibits stimulant properties, making it valuable for research into neurotransmitter regulation and potential therapeutic applications in neuropharmacology. Its structural similarities to other amphetamines enable exploration into their effects on behavior and cognitive function. -
Amphetamine compound
MMDPPO is an amphetamine compound that primarily acts as a monoamine transporter inhibitor. This reagent displays key biological activity by enhancing dopamine and norepinephrine levels in the synaptic cleft, which can influence neurotransmitter release and receptor activation. MMDPPO is useful in research applications related to neuropharmacology, behavioral studies, and the mechanisms underlying stimulant effects. -
Amphetamine
Tosyl-methamphetamine is a potent amphetamine analogue that primarily targets monoamine transporters. It exhibits stimulant properties and is commonly used in research to investigate the effects of amphetamines on neurotransmitter release and behavior. This compound plays a significant role in the study of addiction mechanisms and pharmacological profiling of stimulant drugs. -
Amphetamine
4-Chloroethamphetamine hydrochloride is a potent amphetamine analog that primarily targets the monoamine transporters, particularly the norepinephrine and serotonin transporters. This compound exhibits significant stimulant properties, making it relevant for research into neuropharmacology and the mechanisms of substance use disorders. Its structural modifications provide insights into the development of new therapeutic strategies for various neurological and psychiatric conditions. -
Drug Derivative Control
3-Methylbuphedrone hydrochloride is a methylated derivative of Buphedrone, primarily targeting monoamine transporters. This compound exhibits stimulant properties and has been studied for its effects on dopaminergic and serotonergic systems. It is relevant in research related to drug control, psychoactive substances, and their pharmacological profiles. -
Drug Derivative
3,4-DMMC hydrochloride is a derivative of Mephedrone, primarily targeting monoamine transporters including the serotonin and dopamine transporters. It has demonstrated psychostimulant properties, which makes it a valuable compound for studying drug-related behavior and neuropharmacology. Its application in research includes investigations into the mechanisms of addiction and mood regulation. -
Amphetamine
3-Methoxymethamphetamine hydrochloride is an analog of amphetamine, primarily targeting monoamine transporters. This compound exhibits stimulant properties and is utilized in the study of neuropharmacology, particularly in understanding the mechanisms of action associated with amphetamines. Its application in research can provide insights into drug addiction, behavioral studies, and the effects of stimulant drugs on the central nervous system. -
Methylenedioxy Pyrovalerone Analog
3,4-Dimethoxy-α-Pyrrolidinopentiophenone hydrochloride is a structural analog of Methylenedioxy Pyrovalerone primarily targeting monoamine transporters. This compound exhibits stimulant properties and is utilized in research for studying the effects on neurotransmitter uptake and release. Its unique properties make it a valuable reagent for investigating mechanisms of action in the fields of neuropharmacology and psychopharmacological studies. -
α-PVP Analog
α-Dimethylaminopentiophenone hydrochloride is an analog of α-Pyrrolidinopentiophenone (α-PVP), characterized by the substitution of a dimethylamino group in place of the pyrrolidine moiety. This compound exhibits stimulant properties and has been used in research to investigate its effects on monoamine transporters, contributing to the understanding of its neuropharmacological profile. Its utility in exploring mechanisms underlying addiction and substance use disorders makes it a valuable tool for scientific studies in pharmacology and toxicology. -
Drug Derivative
N-Methoxy mephedrone hydrochloride is a derivative of mephedrone, primarily targeting monoamine transporters. This compound exhibits stimulant properties and can influence serotonin and dopamine release, making it valuable for research in neuropharmacology. Its applications extend to studies investigating psychostimulant effects and the development of new therapeutic strategies for mood disorders. -
Drug Derivative
4-Methyl-α-pyrrolidinoisohexanophenone hydrochloride is a drug derivative that primarily targets the monoamine transporter system. It exhibits stimulant and psychoactive properties, making it a valuable tool in neuropharmacological research. This compound may be utilized in studies investigating the mechanisms of drug action and the effects of novel psychoactive substances on neurotransmitter dynamics. -
Drug Derivative
N-Acetyl-3,4-MDMC is a drug derivative structurally related to 3,4-methylenedioxymethcathinone. This compound has been investigated for its psychoactive properties and potential interactions with monoamine transporters, particularly serotonin and dopamine receptors. Research applications include studies on its effects on neural activity and behavioral responses in various models of neurotransmission. -
Drug Derivative
3-Bromomethcathinone hydrochloride is a drug derivative targeting monoamine transporters. It exhibits stimulant properties and has been studied for its effects on catecholamine and serotonin release. This compound is utilized in research related to neuropharmacology and the exploration of synthetic cathinones. -
Neuroactive Compound
Para-fluoro methylaminorex is a neuroactive compound that primarily interacts with monoamine transporters. This compound exhibits stimulant properties and has been utilized in research to explore mechanisms underlying neuropharmacology and psychoactive effects. Its unique structure allows for the investigation of its impact on neurotransmitter systems, contributing to the understanding of CNS function and disorder. -
Benzylamine
N-Methyl-1-phenylpropan-1-amine hydrochloride is a benzylamine derivative that primarily acts as a monoamine transporter inhibitor. This compound exhibits significant biological activity by modulating neurotransmitter levels, making it useful in studies related to neuropharmacology and behavioral research. It serves as a valuable tool for investigating the mechanisms of action in various neurological disorders. -
3,4-MDMA Metabolite
3,4-DHMA TFA (3,4-Dihydroxymethamphetamine) is an active metabolite of 3,4-MDMA, primarily targeting monoamine transporters. This compound exhibits potential biological activity in modulating neurotransmitter levels, contributing to the understanding of its psychoactive effects. It is commonly used in research to study the metabolic pathways and neuropharmacology associated with MDMA. -
Drug Derivative
N-Isopropyl hexylone hydrochloride is a novel drug derivative with potential stimulant properties. It primarily acts on the monoamine transporters, leading to increased levels of neurotransmitters such as dopamine and serotonin. This compound is often utilized in research related to psychostimulant effects and the exploration of new therapeutic avenues for mood disorders and attention-related conditions. -
Benzofuran
4-APB hydrochloride is a benzofuran derivative that acts as a selective serotonin and dopamine reuptake inhibitor. It exhibits significant biological activity, influencing neurotransmitter release and modulating synaptic signaling. 4-APB hydrochloride is commonly utilized in neuropharmacological research to study the effects of monoamine transporters and their role in various neurological disorders. Its properties make it a valuable tool for investigating serotonin and dopamine-related pathways in both in vitro and in vivo studies. -
Drug Derivative
Metfendrazine is a drug derivative that acts primarily as a monoamine transporter inhibitor. It exhibits significant activity in modulating neurotransmitter levels, making it valuable for research in neuropharmacology and behavioral studies. This compound is particularly relevant for investigations into mood disorders and the mechanisms underlying addiction. -
Drug Derivative
MDPT (tBuONE) is a derivative of 3',4'-Methylenedioxy-N-tert-butylcathinone, primarily targeting monoamine transporters. This compound exhibits stimulant properties, making it relevant for research focusing on neuropharmacology and the mechanisms of drug addiction. Its structural similarity to known psychoactive substances enables investigations into their pharmacodynamic profiles and potential therapeutic applications. -
NMDAR Antagonist
NMDAR antagonist 5 (Compound A17) is a selective antagonist targeting the N-methyl-D-aspartate receptor (NMDAR) with an IC50 of 0.3 µM. This compound also inhibits monoamine transporters, including the serotonin transporter (SERT, IC50 = 1.1 µM), dopamine transporter (DAT, IC50 = 0.7 µM), and norepinephrine transporter (NET, IC50 = 2.7 µM). With a favorable safety profile and low toxicity across multiple organ systems, NMDAR antagonist 5 demonstrates potential antidepressant effects, making it a valuable tool for research into depression and related neurological disorders. -
Transporter Inhibitor
Pseudoisocyanine iodide, also known as 1,1'-Diethyl-2,2'-cyanine iodide, functions as an inhibitor of organic cation transporters (OCT1, OCT2, OCT3) and the plasma membrane monoamine transporter (PMAT). This compound exhibits antidepressant activity, making it valuable for research in mental health and neuropharmacology. Its ability to modulate transporter function positions it as a useful tool for studying mechanisms of neurotransmitter regulation and potential therapeutic interventions in mood disorders. -
Deuterium Substitute
Tetrabenazine-d6 is a deuterium-labeled analogue of Tetrabenazine, designed for improved stability and pharmacokinetic profiles in research. This compound primarily targets the vesicular monoamine transporter 2 (VMAT2), leading to decreased monoamine release and significant reduction in hyperkinetic movements. Tetrabenazine-d6 is instrumental in the study of Huntington's disease and various other hyperkinetic movement disorders, providing a valuable tool for understanding disease mechanisms and therapeutic interventions. -
FFNs
FFN511 is a potent fluorescent false neurotransmitter targeting the vesicular monoamine transporter 2 (VMAT2). With an IC50 of 1 µM, FFN511 effectively inhibits serotonin binding to VMAT2-containing membranes. This compound enables direct imaging of neurotransmitter release dynamics during exocytosis and is particularly useful for labeling dopamine terminals in live cortical-striatal acute slices, facilitating in-depth studies of synaptic function and neurotransmission. -
Monoamine Transporter Inhibitor
(+)-Tetrabenazine is a reversible inhibitor of the vesicular monoamine transporter 2 (VMAT-2). It exhibits a potency that is 10-fold greater for VMAT-2 than for VMAT-1, effectively restricting monoamine transport. This compound is primarily utilized in research focused on neurochemical pathways and the treatment of movement disorders, such as Huntington's disease and tardive dyskinesia, by regulating dopamine levels in the synaptic cleft.
