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Fig. 1 · Structure
Cat. No.
A70509
CAS No.
14171-70-1
Formula
C20H26N2O
Mol. Weight
310.43

Documents & Downloads

Trimipramine N-oxide

Cat. No. A70509 CAS 14171-70-1

Tricyclic Antidepressant Trimipramine Active Metabolite

Trimipramine N-oxide is the active metabolite of the tricyclic antidepressant trimipramine, primarily targeting human monoamine transporters. It effectively inhibits noradrenaline (hNAT), serotonin (hSERT), and dopamine (hDAT) transporters, along with human organic cation transporters (hOCT1 and hOCT2), with IC50 values of 11.7, 3.59, 9.4, 9.35, and 27.4 nM, respectively. This compound is valuable for research focused on depression and anxiety, contributing to the understanding of mood disorders and the pharmacological mechanisms of antidepressants.

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Specifications

Manufacturer Adooq Bioscience
CAS Number 14171-70-1
Applications Tricyclic Antidepressant Trimipramine Active Metabolite
Formula C20H26N2O
Molecular Weight 310.43
SMILES
[O-][N+](C)(CC(CN1C2=C(CCC3=C1C=CC=C3)C=CC=C2)C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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