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Apigenin, found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally-occurring glycosides. Apigenin acts as a monoamine transporter activator, one of the few chemicals demonstrated to possess this property. Apigenin is a ligand for central benzodiazepine receptors that competitively inhibited the binding of flunitrazepam with a Ki of 4μM, exerting anxiolytic and slight sedative effects.
Targets
| CYP2C9 | ||||
| 2 μM(Ki) |
| In vitro | DMSO | 46 mg/mL (170.22 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37.01 mL | 185.05 mL | 370.1 mL |
| 0.5 mM | 7.4 mL | 37.01 mL | 74.02 mL |
| 1 mM | 3.7 mL | 18.5 mL | 37.01 mL |
| 5 mM | 0.74 mL | 3.7 mL | 7.4 mL |
*The above data is based on the productmolecular weight 270.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10081 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 520-36-5 |
| Formula | C15H10O5 |
| M. Wt | 270.2 |
| Purity | >98% |
| Synonyms | 4’,5,7-trihydroxyflavone |
| SMILES | C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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