FFN511 is a potent fluorescent false neurotransmitter targeting the vesicular monoamine transporter 2 (VMAT2). With an IC50 of 1 µM, FFN511 effectively inhibits serotonin binding to VMAT2-containing membranes. This compound enables direct imaging of neurotransmitter release dynamics during exocytosis and is particularly useful for labeling dopamine terminals in live cortical-striatal acute slices, facilitating in-depth studies of synaptic function and neurotransmission.
FFN511 is a potent fluorescent false neurotransmitter targeting the vesicular monoamine transporter 2 (VMAT2). With an IC50 of 1 µM, FFN511 effectively inhibits serotonin binding to VMAT2-containing membranes. This compound enables direct imaging of neurotransmitter release dynamics during exocytosis and is particularly useful for labeling dopamine terminals in live cortical-striatal acute slices, facilitating in-depth studies of synaptic function and neurotransmission.
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