NCX

KB-R7943 mesylate is a cell permeable, potent, selective NCKX inhibitor of the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1.

SEA0400 is a novel and selective inhibitor of the Na+-Ca2+ exchanger with IC50 of 5-33 nM (inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia).

CGP 37157 is a benzothiazepine that acts as a selective inhibitor of the mitochondrial sodium-calcium exchanger (IC50 = 0.36 μM in isolated mitochondria).

ORM-10103 is a specific inhibitor of the Na+/Ca2+ exchanger (NCX), which decreases the NCX current with estimated IC50s of 55 and 67 nM at -80 and at 20 mV, respectively.

ORM-10962 is a potent, highly selective sodium-calcium exchanger (NCX) inhibitor, with IC50 values of 67 and 55 nM for the reverse and forward mode inhibition, respectively.

SN 6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor, and inhibits 45Ca2+ uptake by NCX1, NCX2, and NCX3, with IC50s of 2.9, 16, and 8.6 μM, respectively.

YM-244769 is a potent and selective inhibitor of the Na+/Ca2+ exchanger (NCX), primarily targeting NCX3. With IC50 values of 18 nM and 50 nM for inhibiting the unidirectional outward NCX current, it effectively reduces Ca2+ entry. This compound has demonstrated protective effects against hypoxia/reoxygenation-induced damage in SH-SY5Y neuronal cells and has been shown to increase urine volume and urinary electrolyte excretion in murine models, making it valuable for studies related to cellular stress responses and fluid regulation.

YM-244769 dihydrochloride is a selective and orally active inhibitor of the Na+/Ca2+ exchanger (NCX), particularly targeting the NCX3 isoform. With IC50 values of 18 nM for NCX3, it effectively suppresses outward NCX currents, facilitating studies on calcium signaling in neurons. This compound demonstrates protective effects against hypoxia/reoxygenation-induced damage in SH-SY5Y neuronal cells, making it a valuable reagent for research in neuroprotection and related fields. Additionally, it has been shown to influence urinary output and electrolyte excretion in mouse models, contributing to its utility in pharmacological studies.

YM-244769 hydrochloride is a selective inhibitor of the Na+/Ca2+ exchanger (NCX), primarily targeting NCX3. With IC50 values of 18 nM and 50 nM for inhibiting the outward NCX current and Ca2+ entry mode, respectively, it demonstrates significant potential in neuroprotection, effectively mitigating hypoxia/reoxygenation-induced damage in SH-SY5Y neuronal cells. Additionally, YM-244769 hydrochloride has been shown to enhance urine volume and promote urinary excretion of electrolytes in murine models.

SAR296968 is a selective inhibitor of the Na+/Ca2+ exchanger (NCX), demonstrating an IC50 value of 74 nM against human NCX1. It effectively inhibits both forward and reverse modes of NCX activity, leading to enhanced cardiac contractility and increased stroke volume. Additionally, SAR296968 exhibits antiarrhythmic properties, making it valuable for research focused on heart failure and related cardiovascular conditions.

NCX1-IN-1 is a potent inhibitor of the Na+/Ca2+ exchanger (NCX), a critical regulator of intracellular calcium levels. By specifically targeting NCX, this compound is instrumental in studying calcium homeostasis and related signaling pathways. NCX1-IN-1 is valuable for research applications focused on cardiovascular diseases, neurodegenerative disorders, and cellular stress responses.

ITH12575 is a potent and selective blocker of the mitochondrial sodium-calcium exchanger (mNCX). This compound effectively reduces calcium influx through CALHM1 channels at low micromolar concentrations. ITH12575 is valuable for research applications focused on calcium homeostasis, cell signaling, and mitochondrial function.