YM-244769 is a potent and selective inhibitor of the Na+/Ca2+ exchanger (NCX), primarily targeting NCX3. With IC50 values of 18 nM and 50 nM for inhibiting the unidirectional outward NCX current, it effectively reduces Ca2+ entry. This compound has demonstrated protective effects against hypoxia/reoxygenation-induced damage in SH-SY5Y neuronal cells and has been shown to increase urine volume and urinary electrolyte excretion in murine models, making it valuable for studies related to cellular stress responses and fluid regulation.
YM-244769 is a potent and selective inhibitor of the Na+/Ca2+ exchanger (NCX), primarily targeting NCX3. With IC50 values of 18 nM and 50 nM for inhibiting the unidirectional outward NCX current, it effectively reduces Ca2+ entry. This compound has demonstrated protective effects against hypoxia/reoxygenation-induced damage in SH-SY5Y neuronal cells and has been shown to increase urine volume and urinary electrolyte excretion in murine models, making it valuable for studies related to cellular stress responses and fluid regulation.
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