YM-244769 hydrochloride is a selective inhibitor of the Na+/Ca2+ exchanger (NCX), primarily targeting NCX3. With IC50 values of 18 nM and 50 nM for inhibiting the outward NCX current and Ca2+ entry mode, respectively, it demonstrates significant potential in neuroprotection, effectively mitigating hypoxia/reoxygenation-induced damage in SH-SY5Y neuronal cells. Additionally, YM-244769 hydrochloride has been shown to enhance urine volume and promote urinary excretion of electrolytes in murine models.
YM-244769 hydrochloride is a selective inhibitor of the Na+/Ca2+ exchanger (NCX), primarily targeting NCX3. With IC50 values of 18 nM and 50 nM for inhibiting the outward NCX current and Ca2+ entry mode, respectively, it demonstrates significant potential in neuroprotection, effectively mitigating hypoxia/reoxygenation-induced damage in SH-SY5Y neuronal cells. Additionally, YM-244769 hydrochloride has been shown to enhance urine volume and promote urinary excretion of electrolytes in murine models.
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