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SAR296968

Catalog No.: A67497
Na+/Ca2+ exchanger (NCX) Inhibitor
SAR296968 is a selective inhibitor of the Na+/Ca2+ exchanger (NCX), demonstrating an IC50 value of 74 nM against human NCX1. It effectively inhibits both forward and reverse modes of NCX activity, leading to enhanced cardiac contractility and increased stroke volume. Additionally, SAR296968 exhibits antiarrhythmic properties, making it valuable for research focused on heart failure and related cardiovascular conditions.
SAR296968 1426899-28-6 Na+/Ca2+ exchanger (NCX) Inhibitor
Grouped product items
Size Price Stock Qty
25mg
$1,405.00
In stock
50mg
$1,790.00
In stock
100mg
$2,240.00
In stock
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Research use only. We do not sell to patients.
Data Sheet SDS

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSAR296968 is a selective inhibitor of the Na+/Ca2+ exchanger (NCX), demonstrating an IC50 value of 74 nM against human NCX1. It effectively inhibits both forward and reverse modes of NCX activity, leading to enhanced cardiac contractility and increased stroke volume. Additionally, SAR296968 exhibits antiarrhythmic properties, making it valuable for research focused on heart failure and related cardiovascular conditions.
Product Information
Catalog NumA67497
FormulaC22H22N2O4S
Molecular Weight410.49
CAS Number1426899-28-6
SMILESCC(C=CC=C1)=C1[C@H]2OC3=CC=C(C=C3CC2)OC4=NC=C(C(NCCO)=O)S4
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Membrane Transporters-Ion Channels > NCX