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IAP
Inhibitory Selectivity
| Catalog No. | Inhibitor Name | cIAP | XIAP | Other |
|---|---|---|---|---|
| A12738 | Birinapant | **** | ** | |
| A14135 | GDC-0152 | *** | *** | MLXBIR3SG |
| A13055 | Embelin | * | 5-LO,mPGES-1 | |
| A14231 | BV-6 | |||
| A11928 | LCL161 | |||
| A15800 | SM-164 | **** | **** | |
| A11163 | AT406 (SM-406) | **** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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| Catalog No. | Product Name | Application | Product Information |
|---|---|---|---|
A11163 SALE |
AT-406 (SM-406, ARRY-334543) |
IAP inhibitor |
AT-406 is an orally bioavailable inhibitor of IAP family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP).
|
A11928 SALE |
LCL-161 |
Antagonist of IAPs inhibitor |
LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.
|
A12738 SALE |
Birinapant (TL32711) |
XIAP/cIAP1 antagonist |
Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity.
|
A14135 SALE |
GDC-0152 |
IAP antagonist |
GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity.
|
A14231 |
BV-6 |
dual cIAP and XIAP inhibitor |
BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor.
|
A15800 |
SM-164
|
cIAP-2 antagonist |
SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM, respectively.
|
A13055 |
Embelin |
XIAP inhibitor |
Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties.
|
A13058 |
Apoptosis Inhibitor (M50054) |
Apoptosis Inhibitor |
Apoptosis Inhibitor is a cell-permeable inhibitor of apoptosis induction.
|
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