IAP

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  1. Antagonist (3)
  2. Inhibitor (3)


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Catalog No. Product Name Application Product Information
A13058

Apoptosis Inhibitor (M50054)

Apoptosis Inhibitor
Apoptosis Inhibitor is a cell-permeable inhibitor of apoptosis induction.
A11163

AT-406 (SM-406, ARRY-334543)

IAP inhibitor
AT-406 is an orally bioavailable inhibitor of IAP family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP).
A12738

Birinapant (TL32711)

XIAP/cIAP1 antagonist
Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity.
A14231

BV-6

dual cIAP and XIAP inhibitor
BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor.
A11928

LCL-161

Antagonist of IAPs inhibitor
LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.
A15800

SM-164

cIAP-2 antagonist
SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM, respectively.
A11002

YM155

Survivin Inhibitor
YM155 is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity.

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