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IAP

IAP

Catalog No.	Product Name	Application	Product Information
A13058	Apoptosis Inhibitor (M50054)	Apoptosis Inhibitor	Apoptosis Inhibitor is a cell-permeable inhibitor of apoptosis induction.
A11163 SALE	AT-406 (SM-406, ARRY-334543)	IAP inhibitor	AT-406 is an orally bioavailable inhibitor of IAP family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP). cIAP XIAP cIAP1 IAP cIAP2
A12738 SALE	Birinapant (TL32711)	XIAP/cIAP1 antagonist	Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. XIAP cIAP1
A14231	BV-6	dual cIAP and XIAP inhibitor	BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor. cIAP XIAP
A14135 SALE	GDC-0152	IAP antagonist	GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. cIAP XIAP cIAP1 IAP cIAP2
A11928 SALE	LCL-161 Product Citations (2) GB Koo ,etc. Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics. Cell research, 2015, 25(6), 707-725. SK Kim ,etc. Upregulated RIP3 Expression Potentiates MLKL Phosphorylation–Mediated Programmed Necrosis in Toxic Epidermal Necrolysis. Journal of Investigative Dermatology, 2015, 135(8), 2021-2030.	Antagonist of IAPs inhibitor	LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity. cIAP XIAP
A15800	SM-164	cIAP-2 antagonist	SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM, respectively. cIAP XIAP cIAP1 IAP cIAP2
A11002 SALE	YM155 (Sepantronium Bromide) Product Citations (1) M Minoda ,etc. Antitumor effect of YM155, a novel small-molecule survivin suppressant, via mitochondrial apoptosis in human MFH/UPS. International journal of oncology, 2015, 47(3), 891-899.	Survivin Inhibitor	YM155 is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity. Survivin