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Antagonist of IAPs inhibitor

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Catalog No. A11928

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
LCL-161 5mg A11928-5

Regular Price: $60.00

Special Price: $54.00

LCL-161 10mg A11928-10

Regular Price: $100.00

Special Price: $90.00

LCL-161 25mg A11928-25

Regular Price: $180.00

Special Price: $162.00

LCL-161 10mM * 1mL in DMSO A11928-10mM-D

Regular Price: $119.00

Special Price: $107.10

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.


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Publications citing Adooq Products
LCL-161 Citations (4)
  • Choi SW, .et al. PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation, Mol Cell, 2018, Jun 7;70(5):920-935.e7 PMID: 29883609
  • Han-Hee Park, .et al. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis, Exp Mol Med, 2018, Sep; 50(9): 125 PMID: 30237400
  • Gi-Bang Koo, .et al. Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics, Cell Res, 2015, Jun; 25(6): 707-725 PMID: 25952668
  • Kim SK, .et al. Upregulated RIP3 Expression Potentiates MLKL Phosphorylation-Mediated Programmed Necrosis in Toxic Epidermal Necrolysis, J Invest Dermatol, 2015, Aug;135(8):2021-2030 PMID: 25748555

Chemical Information

Catalog Num A11928
Actions Antagonist
M. Wt 500.2
Formula C26H33FN4O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1005342-46-0
Synonyms LCL161, LCL 161
SMILES C[[email protected]@H](C(=O)N[[email protected]@H](C1CCCCC1)C(=O)N2CCC[[email protected]]2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC

Biological Activity

LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.


Solubility (25°C)* In vitro DMSO 100 mg/mL (199.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol 20 mg/mL heating (39.94 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.99 mL 99.96 mL 199.92mL
0.5 mM 4 mL 19.99 mL 39.98 mL
1 mM 2 mL 10 mL 19.99 mL
5 mM 0.4 mL 2 mL 4 mL

*The above data is based on the productmolecular weight 500.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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