LCL-161

Name: LCL-161
Brand: Adooq Bioscience
SKU: A11928
Rating: 100 (7 reviews)

Catalog No.: A11928

Antagonist of IAPs inhibitor

Product Citations (7)

LCL-161 Chemical Structure

CAS NO. 1005342-46-0

LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.

Availability: In stock

Package	Price	Qty
5 mg	$60.00
10 mg	$100.00
25 mg	$180.00
10mM * 1mL in DMSO	$119.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq LCL-161

Han-Hee Park, .et al. RIPK3 activation induces TRIM28 derepression in cancer cells and enhances the anti-tumor microenvironment, Mol Cancer, 2021, Aug 21;20(1):107 PMID: 34419074
Se-Yeon Park, .et al. Reduction in MLKL-mediated endosomal trafficking enhances the TRAIL-DR4/5 signal to increase cancer cell death, Cell Death & Disease, 2020, 11:744 PMID: 32917855
J Chen, .et al. Interferon-γ induces the cell surface exposure of phosphatidylserine by activating MLKL in the absence of caspase-8 activity, JBC, 2019, June PMID: 31217278
Choi SW, .et al. PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation, Mol Cell, 2018, Jun 7;70(5):920-935.e7 PMID: 29883609
Han-Hee Park, .et al. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis, Exp Mol Med, 2018, Sep; 50(9): 125 PMID: 30237400
Gi-Bang Koo, .et al. Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics, Cell Res, 2015, Jun; 25(6): 707-725 PMID: 25952668
Kim SK, .et al. Upregulated RIP3 Expression Potentiates MLKL Phosphorylation-Mediated Programmed Necrosis in Toxic Epidermal Necrolysis, J Invest Dermatol, 2015, Aug;135(8):2021-2030 PMID: 25748555

Biological Activity

Targets

cIAP	XIAP

Solubility *

In vitro	DMSO	86 mg/mL (171.78 mM)
	Water	Insoluble
	Ethanol	Warmed: 17 mg/mL (33.95 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.99 mL	99.96 mL	199.92 mL
0.5 mM	4 mL	19.99 mL	39.98 mL
1 mM	2 mL	10 mL	19.99 mL
5 mM	0.4 mL	2 mL	4 mL

*The above data is based on the productmolecular weight 500.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11928
Actions	Antagonist
CAS No.	1005342-46-0
Formula	C26H33FN4O3S
M. Wt	500.2
Purity	>98%
Synonyms	LCL161, LCL 161
SMILES	C[[email protected]@H](C(=O)N[[email protected]@H](C1CCCCC1)C(=O)N2CCC[[email protected]]2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.