LCL-161

Catalog No.: A11928
Antagonist of IAPs inhibitor
LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.
Grouped product items
Product Name Price Stock Qty
LCL-161 5mg
$60.00
In stock
LCL-161 10mg
$100.00
In stock
LCL-161 25mg
$180.00
In stock
LCL-161 10mM * 1mL in DMSO
$119.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's LCL-161 has been cited by 7 publications
  • Han-Hee Park, .et al. , Mol Cancer, 2021, Aug 21;20(1):107 PMID: 34419074
  • Se-Yeon Park, .et al. , Cell Death & Disease, 2020, 11:744 PMID: 32917855
  • J Chen, .et al. , JBC, 2019, June PMID: 31217278
  • Choi SW, .et al. , Mol Cell, 2018, Jun 7;70(5):920-935.e7 PMID: 29883609
  • Han-Hee Park, .et al. , Exp Mol Med, 2018, Sep; 50(9): 125 PMID: 30237400
  • Gi-Bang Koo, .et al. , Cell Res, 2015, Jun; 25(6): 707-725 PMID: 25952668
  • Kim SK, .et al. , J Invest Dermatol, 2015, Aug;135(8):2021-2030 PMID: 25748555
  • Biological Activity
    Discription LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.
    Targets
    Target Value
    Product Information
    Catalog Num A11928
    Formula C26H33FN4O3S
    Molecular Weight 500.2
    CAS Number 1005342-46-0
    SMILES C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC
    Synonyms LCL161, LCL 161
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 86 mg/mL (171.78 mM)
    Water Insoluble
    Ethanol Warmed: 17 mg/mL (33.95 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 19.99 mL 99.96 mL 199.92 mL
    0.5 mM 4 mL 19.99 mL 39.98 mL
    1 mM 2 mL 10 mL 19.99 mL
    5 mM 0.4 mL 2 mL 4 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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