LCL-161

Name: LCL-161
SKU: A11928
Price: 48 USD
Rating: 5 (9 reviews)

Catalog No.: A11928

Antagonist of IAPs inhibitor

Adooq's LCL-161 has been cited by 9 publications

LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.

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Grouped product items
Product Name	Price	Stock
LCL-161 5mg	Special Price $48.00 Regular Price $60.00	In stock
LCL-161 10mg	Special Price $80.00 Regular Price $100.00	In stock
LCL-161 25mg	Special Price $144.00 Regular Price $180.00	In stock
*LCL-161 10mM 1mL in DMSO**	Special Price $95.20 Regular Price $119.00	In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper

Adooq's LCL-161 has been cited by 9 publications

Oliver H, .et al. , J Med Chem, 2023, 66, 16, 11216-11236 PMID: 37535857

Bopei Cui, .et al. , Signal Transduct Target Ther, 2023, Sep 25;8(1):366 PMID: 37743418

Han-Hee Park, .et al. , Mol Cancer, 2021, Aug 21;20(1):107 PMID: 34419074

Se-Yeon Park, .et al. , Cell Death & Disease, 2020, 11:744 PMID: 32917855

J Chen, .et al. , JBC, 2019, June PMID: 31217278

Choi SW, .et al. , Mol Cell, 2018, Jun 7;70(5):920-935.e7 PMID: 29883609

Han-Hee Park, .et al. , Exp Mol Med, 2018, Sep; 50(9): 125 PMID: 30237400

Gi-Bang Koo, .et al. , Cell Res, 2015, Jun; 25(6): 707-725 PMID: 25952668

Kim SK, .et al. , J Invest Dermatol, 2015, Aug;135(8):2021-2030 PMID: 25748555

Biological Activity

Discription

Targets

Target	Value

Product Information

Catalog Num	A11928
Formula	C26H33FN4O3S
Molecular Weight	500.2
CAS Number	1005342-46-0
SMILES	C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC
Synonyms	LCL161, LCL 161
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro	DMSO	86 mg/mL (171.78 mM)
	Water	Insoluble
	Ethanol	Warmed: 17 mg/mL (33.95 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.99 mL	99.96 mL	199.92 mL
0.5 mM	4 mL	19.99 mL	39.98 mL
1 mM	2 mL	10 mL	19.99 mL
5 mM	0.4 mL	2 mL	4 mL

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