LCL-161

Catalog No.: A11928

Antagonist of IAPs inhibitor

LCL-161

LCL-161 Chemical Structure

CAS NO. 1005342-46-0

LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.

Availability: In stock

Package Price Qty
5 mg
$60.00
10 mg
$100.00
25 mg
$180.00
10mM * 1mL in DMSO
$119.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Choi SW, .et al. PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation, Mol Cell, 2018, Jun 7;70(5):920-935.e7 PMID: 29883609
  • Han-Hee Park, .et al. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis, Exp Mol Med, 2018, Sep; 50(9): 125 PMID: 30237400
  • Gi-Bang Koo, .et al. Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics, Cell Res, 2015, Jun; 25(6): 707-725 PMID: 25952668
  • Kim SK, .et al. Upregulated RIP3 Expression Potentiates MLKL Phosphorylation-Mediated Programmed Necrosis in Toxic Epidermal Necrolysis, J Invest Dermatol, 2015, Aug;135(8):2021-2030 PMID: 25748555

Biological Activity

LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.
Targets
cIAP XIAP
In vitro DMSO 100 mg/mL (199.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol 20 mg/mL heating (39.94 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.99 mL 99.96 mL 199.92 mL
0.5 mM 4 mL 19.99 mL 39.98 mL
1 mM 2 mL 10 mL 19.99 mL
5 mM 0.4 mL 2 mL 4 mL

*The above data is based on the productmolecular weight 500.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11928
Actions Antagonist
M. Wt 500.2
Formula C26H33FN4O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1005342-46-0
Synonyms LCL161, LCL 161
SMILES C[[email protected]@H](C(=O)N[[email protected]@H](C1CCCCC1)C(=O)N2CCC[[email protected]]2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC

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