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Publications citing Adooq Products
LCL-161 Citations (4)
- Choi SW, .et al. PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation, Mol Cell, 2018, Jun 7;70(5):920-935.e7 PMID: 29883609
- Han-Hee Park, .et al. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis, Exp Mol Med, 2018, Sep; 50(9): 125 PMID: 30237400
- Gi-Bang Koo, .et al. Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics, Cell Res, 2015, Jun; 25(6): 707每725 PMID: 25952668
- Kim SK, .et al. Upregulated RIP3 Expression Potentiates MLKL Phosphorylation-Mediated Programmed Necrosis in Toxic Epidermal Necrolysis, J Invest Dermatol, 2015, Aug;135(8):2021-2030 PMID: 25748555
Chemical Information
| Catalog Num | A11928 |
|---|---|
| Actions | Antagonist |
| M. Wt | 500.2 |
| Formula | C26H33FN4O3S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1005342-46-0 |
| Synonyms | LCL161, LCL 161 |
| SMILES code | C[[email protected]@H](C(=O)N[[email protected]@H](C1CCCCC1)C(=O)N2CCC[[email protected]]2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC |
| Chemical Name | (S)-N-((S)-1-cyclohexyl-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide |
Description |
LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity. | ||||||||||
Targets |
|
||||||||||
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (199.74 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 20 mg/mL heating (39.94 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.99 mL | 99.96 mL | 199.92mL |
| 0.5 mM | 4 mL | 19.99 mL | 39.98 mL |
| 1 mM | 2 mL | 10 mL | 19.99 mL |
| 5 mM | 0.4 mL | 2 mL | 4 mL |
*The above data is based on the productmolecular weight 500.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|
Cat. No. | Product Name | Solubility(mg/mL) | ||
|---|---|---|---|---|
| Water | DMSO | Ethanol | ||
| A10255 | ABT-737 | <1 mg/mL | 163 mg/mL | <1 mg/mL |
| A10022 | ABT-263 (Navitoclax) | <1 mg/mL | 195 mg/mL | <1 mg/mL |
| A10665 | Obatoclax mesylate (GX15-070) | <1 mg/mL | 83 mg/mL | <1 mg/mL |
| A10955 | TW-37 | <1 mg/mL | 115 mg/mL | 4 mg/mL |
| A10984 | VX-765 | <1 mg/mL | 102 mg/mL | 102 mg/mL |
| A11090 | PAC-1 | <1 mg/mL | 78 mg/mL | 16 mg/mL |
| A10491 | JNJ 26854165 | <1 mg/mL | 66 mg/mL | 2 mg/mL |
| A11931 | RITA (NSC 652287) | <1 mg/mL | 115 mg/mL | 4 mg/mL |
| A10522 | Lenalidomide (CC-5013) | <1 mg/mL | 52 mg/mL | <1 mg/mL |
| A10743 | Pomalidomide (CC-4047) | <1 mg/mL | 55 mg/mL | <1 mg/mL |
| A11163 | AT-406 | <1 mg/mL | 112 mg/mL | 112 mg/mL |
| A11002 | YM155 | 89 mg/mL | 55 mg/mL | 6 mg/mL |
| A10935 | Tipifarnib (Zarnestra) | <1 mg/mL | 83 mg/mL | <1 mg/mL |
| A10657 | Nutlin-3 | <1 mg/mL | 116 mg/mL | 116 mg/mL |
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