Catalog No.
Product Name
Application
Product Information
Citations
- Chlorpromazine is a dopamine antagonist of the typical antipsychotic class of medications possessing additional antiadrenergic, antiserotonergic, anticholinergic and antihistaminergic properties used to treat schizophrenia.
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HnsPLA inhibitor
LY315920 (Varespladib) is an inhibitor of the IIa, V, and X isoforms of secretory phospholipase A2 (sPLA2).- Yap WH, .et al. , Mol Cell Biochem, 2018, Oct;447(1-2):93-101 PMID: 29374817
- Yamato Okita, .et al. , Infect Immun, 2016, Feb; 84(2): 573-579 PMID: 26644377
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PLA inhibitor
Polydatin protects cerebral cells from ischemic damages via improvement of microcirculation and inhibition of platelet aggregation. In addition, polydatin inhibits ICAM-1 expression in endothelial cells stimulated by lipopolysaccharide; it also attenuates adhesion between white blood cells and endothelial cells.- Darshika Pathiraja, .et al. , Food Chem, 2023, May 1;407:135145 PMID: 36521391
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MAO-B inhibitor
Quercetin inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. -
MAO-B inhibitor
Quercetin inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C.- Sumayyah Saeed, .et al. , Int J Mol Sci, 2025, Jan 14;26(2):654 PMID: 39859369
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Phospholipase inhibitor
Tanshinones are the major bioactive compounds of Salvia miltiorrhiza Bunge (Danshen) roots, which are used in many therapeutic remedies in Chinese traditional medicine.- Kumar R, .et al. , Mol Biol Rep, 2018, Oct 11 PMID: 30311125
- Lp-PLA2 -IN-1 inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.
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Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) inhibitor
Rilapladib is a selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) inhibitor with an IC50 of 230 pM. - Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2 but not PLC or PLD.
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PLD inhibitor
Isoforms of phospholipase D (PLD) cleave the head group from phospholipids, releasing the second messenger phosphatidic acid (PA), which can produce changes in Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. FIPI is a derivative of halopemide which potently inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC50 = 20 nM). -
Lp-PLA2 Inhibitor
Darapladib is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor . -
Phospholipase C inhibitor
U 73122 is a phospholipase C inhibitor. It inhibits agonist-induced platelet aggregation with IC50 values of 1-5 uM.- Ke Qian, .et al. , EBioMedicine, 2023, Dec:98:104863 PMID: 37950995
- Clofazimine is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2.
- Nabila Ismail, .et al. , bioRxiv, 2025, March 11
- Difluprednate(Durezol) is a corticosteroid, approved difluprednate for the treatment of post-operative ocular inflammation and pain.
- 1-Linoleoyl glycerol (1-LG) is a fatty acid glycerol that has been isolated from S. chinensis roots. It inhibits PAF-AH with an IC50 of 45 μM.
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PLC-γ inhibitor
3-Nitrocoumarin (3-NC) is a potent and selective Phospholipase C-γ (PLC-γ) inhibitor. -
sPLA2-X inhibitor
sPLA2-X Inhibitor 31 is a selective secreted phospholipase A2 type X (sPLA2-X) inhibitor with IC50s of 26 nM, 310 nM, and 2230 nM for sPLA2-X, sPLA2-IIa, and sPLA2-V, respectively. -
phospholipase A2 inhibitor
Varespladib methyl (A-002; LY333013) is a selective inhibitor of group II secretory phospholipase A2 (PLA2). -
phospholipase A2/HDAC2 inhibitor
Rhamnetin is a naturally occurring flavonoid and quercetin derivative found in *Coriandrum sativum*. It functions as an inhibitor of secretory phospholipase A₂ and histone deacetylase 2 (HDAC2), contributing to its broad pharmacological profile. Rhamnetin exhibits notable antitumor, antioxidant, and anti-inflammatory activities, making it a promising compound for research in cancer, oxidative stress-related conditions, and inflammatory diseases. -
Phospholipase C Inhibitor, Angiogenesis Modulator
Neomycin sulfate is a phospholipase C inhibitor that modulates angiogenesis through its influence on calcium signaling pathways. This aminoglycoside antibiotic disrupts bacterial protein synthesis by binding irreversibly to the 30S ribosomal subunit. In addition to its antibacterial properties, neomycin sulfate effectively inhibits angiogenin-mediated nuclear translocation, cell proliferation, and angiogenesis. It also disrupts inositol trisphosphate (IP3)-mediated calcium release and electrical excitation-evoked calcium transients in skeletal muscle. Neomycin sulfate is utilized in cancer research and studies related to calcium signaling and angiogenesis. -
Phospholipase A2 Inhibitor
(2E)-OBAA is a selective inhibitor of phospholipase A2 (PLA2) with an IC50 value of 70 nM. This compound effectively induces apoptosis in human umbilical vein endothelial cells (HUVECs) and demonstrates its capacity to inhibit melittin-induced Ca2+ influx in Trypanosoma brucei, exhibiting an IC50 of 0.4 μM. (2E)-OBAA is valuable for research focused on cell signaling, apoptosis, and parasitology. -
Phospholipase D Inhibitor
PLD-IN-1 is a selective inhibitor of phospholipase D, exhibiting an IC50 of 1.97 μM. This compound reduces the expression of immune evasion markers such as CD24, CD47, and PD-L1 while promoting calreticulin, thereby enhancing phagocytosis of lung cancer cells by macrophages. PLD-IN-1 demonstrates significant cytotoxic effects on various lung cancer cell lines, including A549, HCC44, H460, and HCC15, with IC50 values ranging from 18.44 to 24.85 μM. Additionally, it induces apoptosis, inhibits cell migration, enhances M1 macrophage polarization, and exhibits antitumor efficacy in mouse models, making it a valuable tool for cancer research. -
Phospholipase C Activator
m-3M3FBS is a potent activator of phospholipase C (PLC). It effectively stimulates superoxide generation in human neutrophils and enhances intracellular calcium concentrations, leading to inositol phosphate production in diverse cell lines. Additionally, m-3M3FBS has been shown to induce apoptosis in monocytic leukemia cells, making it valuable for studying cellular signaling pathways and apoptosis mechanisms in research applications. -
Phospholipase A2 Inhibitor
OBAA is a potent inhibitor of phospholipase A2 (PLA2), exhibiting an IC50 of 70 nM. This compound effectively blocks Melittin-induced calcium influx in Trypanosoma brucei, demonstrating an IC50 of 0.4 μM. OBAA is valuable for research applications aimed at understanding the role of PLA2 in various biological processes and cellular responses. -
Phospholipase A Metabolite
Glycerophosphoinositol 4-phosphate (GroPIns-4-P) is a metabolite of phospholipase A that functions as an inhibitor of adenylyl cyclase. This compound plays a crucial role in regulating cAMP-dependent cellular activities and can stimulate the formation of membrane ruffles and stress fibers in serum-starved Swiss 3T3 cells by activating small GTPases Rac and Rho. Glycerophosphoinositol 4-phosphate is valuable for research involving cancer cell motility and invasiveness. -
Semaphorin3A/Phospholipase C/FabI Inhibitor
Vinaxanthone is a selective inhibitor of semaphorin3A, phospholipase C (PLC), and FabI, exhibiting IC50 values of 0.1-0.2 μM for semaphorin3A and 0.9 mM for FabI. This compound also inhibits the substrate t-o-NAC thioester and the cofactor NADPH, with inhibition constants (Kis) of 3.1 μM and 1.0 μM, respectively. Vinaxanthone shows potential for combating infections caused by multidrug-resistant pathogens, making it a valuable tool for research in infectious diseases and drug resistance mechanisms. -
Phospholipase C Inhibitor, Angiogenesis Modulator
Neomycin is an aminoglycoside antibiotic known for its role as a phospholipase C (PLC) inhibitor and angiogenesis modulator. It effectively inhibits the nuclear translocation of angiogenin, resulting in reduced cell proliferation and angiogenesis. Additionally, Neomycin interferes with IP3-mediated calcium release and MgATP-dependent calcium uptake, influencing skeletal muscle calcium transients. Its ability to modulate crucial biological pathways makes Neomycin a valuable tool for cancer research and understanding microbial impact on health. Prolonged exposure may lead to adverse effects such as hearing impairment and kidney damage. -
Phospholipase D Inhibitor
Halopemide is a potent inhibitor of phospholipase D (PLD), exhibiting IC50 values of 220 nM for human PLD1 and 310 nM for PLD2. In addition to its enzymatic inhibition, Halopemide functions as a dopamine receptor antagonist and exhibits psychotropic properties. This reagent is valuable for research applications exploring PLD-mediated signaling pathways and dopamine receptor interactions in various biological contexts. -
Phospholipase Activator
9-Oxononanoic acid is a potent phospholipase A2 (PLA2) activator that arises as a secondary product of lipid peroxidation. It stimulates the production of thromboxane A2 (TXA2) and promotes platelet aggregation in human blood, making it a valuable tool for studying platelet function and related cardiovascular processes. Its oral bioavailability enhances its utility in various in vivo research applications. -
Muscarinic Receptor/Phospholipase C Activator
(S)-Albuterol is a selective muscarinic receptor agonist that acts as a phospholipase C activator. It is known to elevate intracellular free calcium levels in airway smooth muscle, enhancing muscle contraction. This compound is widely utilized in research applications focusing on airway physiology and the mechanisms underlying bronchoconstriction. -
Muscarinic Receptor/Phospholipase C Activator
(S)-Albuterol hydrochloride is a selective muscarinic receptor activator that enhances phospholipase C activity. This compound increases intracellular free calcium levels in airway smooth muscle, making it valuable for research on respiratory physiology and pharmacology. Its ability to modulate calcium signaling pathways makes it useful for studying smooth muscle contraction and respiratory function. -
Phospholipase Inhibitor
ML-211 is a carbamate-based inhibitor targeting acyl-protein thioesterase 1 (APT1) and lysophospholipase 1 (LYPLA1), with an IC50 of 17 nM, as well as lysophospholipase 2 (LYPLA2) with an IC50 of 30 nM. Additionally, it inhibits the serine hydrolase ABHD11 at an IC50 of 10 nM while demonstrating greater than 50-fold selectivity for LYPLA in a diverse panel of 20 serine hydrolases. ML-211 is valuable for research involving lipid metabolism and signaling pathways, particularly those associated with phospholipase activity. -
Phospholipase D
Phospholipase D from Streptomyces chromofuscus is an enzyme that hydrolyzes phosphodiester bonds in glycerophospholipids, producing phosphatidic acid and free choline. This enzyme plays a crucial role in various biological processes, including lipid metabolism, signal transduction, and membrane dynamics. Its activity is relevant in the study of several disease states, such as diabetes, obesity, tumorigenesis, and immune responses. Phospholipase D is widely utilized in biochemical research to investigate cellular signaling pathways and lipid-related disorders. -
Phospholipase C Substrate
Phosphatidylinositol 4,5-bisphosphate serves as a critical substrate for phospholipase C, facilitating the production of diacylglycerol and inositol (1,4,5)-trisphosphate. This phospholipid is predominantly located in the cytoplasmic leaflet of the plasma membrane and plays a pivotal role in cellular processes such as lamellipodial protrusion, directional cell migration, and focal adhesion formation. Additionally, it is involved in the trafficking of GABAA receptors. Phosphatidylinositol 4,5-bisphosphate is relevant for research focusing on acute lung injury and pulmonary edema. -
PLA2 Inhibitor
Cinatrin C2 is a potent inhibitor of phospholipase A2 (PLA2) with an IC50 of 800 μM. This compound, sourced from Circinotrichum falcatisporum RF-641, is valuable for studying PLA2's role in various biological processes. It is applicable in research areas related to inflammation, pain mechanisms, and cellular signaling pathways. -
ASM Inhibitor
ASM-IN-3 is a selective inhibitor of acid sphingomyelinase (ASM) with a reported IC50 of 3.37 μM for human ASM. This compound demonstrates the ability to penetrate the blood-brain barrier and has been shown to enhance neurogenesis in the hippocampus, alleviating depression-like behaviors in Reserpine-induced rat models. ASM-IN-3 serves as a valuable tool for research in neurobiology and the treatment of mood disorders. -
PLA2 Inhibitor
Cinatrin C3 is a selective phospholipase A2 (PLA2) inhibitor, exhibiting an IC50 value of 70 μM. This compound is derived from the marine fungus Circinotrichum falcatisporum RF-641. Cinatrin C3 is utilized in research to explore the functional roles of PLA2 in various biological processes, including inflammation and cellular signaling pathways. Its inhibitory properties make it a valuable tool for studying the mechanistic functions of PLA2 in pathophysiological contexts.
