Catalog No.
Product Name
Application
Product Information
Citations
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Isomer of PB-22
PB-22 7-Hydroxyisoquinoline isomer is a structural isomer of the cannabinoid PB-22. This compound exhibits potential biological activity by interacting with cannabinoid receptors, which play a crucial role in various physiological processes. Research applications include studies on cannabinoid receptor signaling and exploration of therapeutic effects in neurological and inflammatory disorders. -
α2-Adrenergic Receptors Agonist
Methyldopa, an α2-adrenergic receptor agonist, is a potent antihypertensive compound. Acting as a proagent, it is metabolized to α-Methylepinephrine within the central nervous system, contributing to its effects on blood pressure regulation. This compound is primarily utilized in research applications focused on cardiovascular physiology and the modulation of neurogenic control of vascular tone. -
β-Adrenergic Agonist
Ritodrine hydrochloride is a potent β-adrenergic agonist that primarily targets β-adrenergic receptors. It is recognized for its ability to relax uterine smooth muscle and is utilized in the research of preterm labor management. Ritodrine hydrochloride is valuable for studying the mechanisms of uterine contractions and the pharmacological intervention of premature delivery. -
β-Adrenergic Receptor Blocker
Sotalol hydrochloride is a non-selective β-adrenergic receptor blocker that exhibits potent antiarrhythmic activity. It is utilized in research focused on pediatric arrhythmias and demonstrates efficacy by blocking β-receptors and the potassium channel KCNH2. Additionally, Sotalol hydrochloride holds potential applications as an antiepileptic agent, facilitating further studies into its diverse pharmacological effects. -
Endothelin Receptor Antagonist
Sulfisoxazole is an orally active endothelin receptor antagonist primarily targeting endothelin receptor A (IC50 = 0.60 μM) and endothelin receptor B (IC50 = 22 μM). This sulfonamide antibacterial agent boasts an oxazole substituent, enhancing its pharmacological profile. Sulfisoxazole is notably effective in inhibiting breast cancer exosome release through its action on endothelin receptor A, making it relevant for cancer research and studies focused on exosome biology. -
CXCR Agonist
VUF11207 is a potent agonist of the CXCR7 receptor, demonstrating a high affinity with a pKi of 8.1. This compound effectively induces the recruitment of β-arrestin2, with an pEC50 value of 8.8, and promotes the subsequent internalization of CXCR7, with an pEC50 of 7.9. VUF11207 is valuable for research applications focused on CXCR signaling pathways and β-arrestin-mediated processes. -
Cannabinoid Receptor Agonist
β-Caryophyllene is a potent agonist of the cannabinoid receptor type 2 (CB2). This compound is known for its anti-inflammatory and analgesic properties, making it a valuable tool in research focused on pain management and the endocannabinoid system. Additionally, β-Caryophyllene can be used to explore therapeutic applications in various disease models, including neurodegeneration and immune response studies. -
5-HT/Norepinephrine Reuptake Inhibitor
Desvenlafaxine is a selective 5-HT and norepinephrine reuptake inhibitor, primarily targeting the serotonin transporter (hSERT) and norepinephrine transporter (hNET) with IC50 values of 47.3 nM and 531.3 nM, respectively. This orally active compound effectively penetrates the blood-brain barrier, making it applicable in the treatment of major depressive disorders. Additionally, Desvenlafaxine exhibits weak binding affinity to the human dopamine transporter, with 62% inhibition observed at 100 μM, which may have implications for its overall pharmacological profile. -
Dopamine Receptor Antagonist
Droperidol is a butyrophenone compound primarily acting as a dopamine receptor antagonist. It inhibits the activation of GABA(A) and neuronal nicotinic acetylcholine receptors (nAChR), demonstrating IC50 values of 12.6 nM and 5.8 μM, respectively. This compound exhibits notable anesthetic and sedative properties, making it useful in research related to neuropharmacology and anesthesiology. -
Dopamine Receptor Inhibitor
Fluphenazine dihydrochloride is a potent dopamine receptor antagonist primarily targeting dopamine D2 receptors in the mesolimbic, nigrostriatal, and tuberoinfundibular pathways. This phenothiazine derivative also exhibits the ability to inhibit neuronal voltage-gated sodium channels. Its key biological activities include the suppression of Methylphenidate-induced stereotyped behaviors and climbing in murine models. Fluphenazine dihydrochloride is widely utilized in research related to psychosis, diabetic peripheral neuropathy, and may also have implications for the inhibition of SARS-CoV-2. -
β-Adrenergic Antagonist
Levobetaxolol hydrochloride is a selective β-adrenergic antagonist primarily used in the treatment of ocular hypertension. This compound effectively reduces intraocular pressure, making it valuable for research related to glaucoma and other eye disorders. Investigations into its pharmacological profile can advance understanding of adrenergic receptor modulation in ocular applications. -
Adrenergic Receptor Antagonist
Tolazoline hydrochloride is an α-adrenergic receptor antagonist that effectively inhibits noradrenaline-induced smooth muscle contraction. This compound modulates vascular resistance, increases arterial pressure, and serves as an intervention for bradycardia and tachypnea. Tolazoline hydrochloride is utilized in research focused on erectile dysfunction, α2-adrenergic receptor agonist-related poisoning, and skin vascular diseases, making it a valuable tool for studying vascular responses and related pathologies. -
Endogenous Metabolite
Tyramine is an endogenous metabolite primarily involved in the regulation of blood pressure through its interaction with adrenergic receptors. It plays a significant role in neurotransmission and the modulation of vascular tone. Research applications of tyramine include studies focused on cardiovascular physiology, neurochemistry, and the exploration of dietary impacts on health. -
β-Adrenergic Receptor Agonist
Methoxyphenamine hydrochloride is a selective β-adrenergic receptor agonist that acts primarily as a bronchodilator. This compound enhances airway patency by relaxing bronchial smooth muscle, making it beneficial in the management of respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). Its application in research focuses on studying β-adrenergic signaling pathways and pharmacological responses in respiratory physiology. -
β-adrenergic Receptors Agonist
Isoetharine mesylate is a selective agonist of β-adrenergic receptors, exhibiting oral bioactivity. By promoting the production of cyclic AMP (cAMP), it facilitates the relaxation of smooth muscle cells. Isoetharine mesylate is primarily utilized in research related to respiratory conditions, including emphysema and bronchitis, where it serves as a bronchodilator to aid in airway relaxation and improved airflow. -
α-Adrenergic Agonist
Metaraminol tartrate is an α-adrenergic agonist that functions primarily as a vasopressor agent. This sympathomimetic amine exerts its effects by directly and indirectly stimulating adrenergic receptors, with a predominant activity on alpha receptors. It is utilized in research applications involving cardiovascular physiology and the modulation of vascular tone. -
β1/α1-adrenergic Receptor Antagonist
Bevantolol hydrochloride is a selective β1 and α1-adrenergic receptor antagonist. With pKi values of 7.83 for the β1 receptor and 6.9 for the α1 receptor in rat cerebral cortex, it demonstrates significant antagonistic activity. Additionally, Bevantolol hydrochloride exhibits potent calcium (Ca2+) antagonism, making it a valuable tool for research applications in cardiovascular studies and related therapeutic areas. -
Cytochrome P450 Inhibitor
Olivetol is a naturally occurring phenol that functions as a competitive inhibitor of cytochrome P450 enzymes, specifically CYP2C19 and CYP2D6, with IC50 values of 15.3 μM and 7.21 μM, respectively. Additionally, olivetol has demonstrated inhibitory activity against cannabinoid receptors CB1 and CB2. This compound is useful in research related to drug metabolism, pharmacokinetics, and the modulation of cannabinoid signaling pathways. -
Adenosine A1 Receptor Agonist
Adenosine 5'-monophosphate monohydrate is an adenosine A1 receptor agonist that plays a crucial role in cellular signaling pathways. This compound exhibits significant antiviral activity against Herpes Simplex Virus types 1 and 2 (HSV-1 and HSV-2), making it valuable for studies related to viral infections. Its modulation of adenosine receptors also provides insights into various physiological and pathological processes, offering applications in pharmacological research. -
Adrenaline Antagonists
Prazosin is an α-adrenergic receptor antagonist primarily targeting adrenaline pathways. It exhibits significant biological activity in reducing inflammation, alleviating anxiety and panic, and preventing cognitive decline associated with Alzheimer's disease. Additionally, Prazosin modulates the analgesic effects of opioids, making it a valuable compound for research applications in hypertension and neurodegenerative disorders. -
D2/D3 Dopamine Receptor Antagonist
Tiapride hydrochloride is a selective antagonist of the D2 and D3 dopamine receptors, exhibiting IC50 values of 110-320 nM and 180 nM, respectively. This compound is recognized for its anti-dyskinetic and anxiolytic activities, making it valuable in neurological research. Tiapride hydrochloride is utilized as a neuroleptic agent, contributing to studies on movement disorders and anxiety-related conditions. -
Dopamine Receptor Antagonist
Clebopride malate is an orally active antagonist of dopamine D2 receptors, exhibiting significant antiemetic and prokinetic properties. This compound is useful in research focused on functional gastrointestinal disorders, providing valuable insights into dopaminergic modulation in gastrointestinal motility and emesis. Clebopride malate may serve as an important tool for understanding the underlying mechanisms of these conditions. -
Antipsychotic Agent
Dixyrazine is a phenothiazine derivative that functions as an antipsychotic agent through its antagonism of dopamine receptors. It has demonstrated efficacy in preventing brain edema induced by intracarotid injection of protamine sulfate. This compound is relevant for research applications in neuropharmacology and the investigation of psychotropic mechanisms. -
Histamine Receptor Antagonist
Famotidine is a competitive antagonist of the histamine H2-receptor, primarily involved in the inhibition of gastric acid secretion. This compound demonstrates significant biological activity in reducing gastric acidity, making it valuable in research related to acid-related gastrointestinal disorders. Famotidine can be utilized in studies investigating the pathophysiology of conditions such as peptic ulcers and gastroesophageal reflux disease (GERD). -
Catecholamine Neurotransmitter
Dopamine is a catecholamine neurotransmitter primarily produced in the substantia nigra, ventral tegmental area, and hypothalamus. It is essential for various neural processes and physiological functions. Dopamine exerts its biological effects predominantly through D2 dopamine receptors, leading to endocytosis of VEGFR2, which is vital for angiogenesis. This compound is widely utilized in research focusing on neurological disorders, cardiovascular functions, and cellular signaling pathways. -
Vasoconstrictor
(Asn1,Val5)-Angiotensin II is a potent vasoconstrictor that acts primarily through the angiotensin receptor pathway. This synthetic derivative of angiotensin II demonstrates enhanced cardiac activation properties and is utilized in various cardiovascular research applications. Its ability to modulate blood pressure and vascular tone makes it a valuable tool for studying cardiovascular physiology and related disorders. -
Dopamine Receptor Antagonist
Fluphenazine is a potent dopamine receptor antagonist primarily targeting postsynaptic dopamine D2 receptors in the mesolimbic, nigrostriatal, and tuberoinfundibular pathways. This phenothiazine derivative exhibits substantial biological activity by inhibiting dopamine signaling, making it useful for studying psychosis and diabetic peripheral neuropathy. Additionally, Fluphenazine has shown potential in inhibiting SARS-CoV-2, contributing to its relevance in current research focused on neuropharmacology and viral pathogenesis. -
Adrenergic Receptor Agonist
Norepinephrine tartrate is a potent adrenergic receptor agonist, primarily targeting α1, α2, and β1 receptors. Its key biological activity involves regulating vascular tone, heart rate, and metabolic processes. This compound is widely utilized in cardiovascular research, particularly in studies related to blood pressure modulation and the sympathetic nervous system's roles in various physiological conditions. -
Dopamine Receptor D2 Antagonist
Promazine is a dopamine receptor D2 antagonist that primarily functions by inhibiting dopaminergic neurotransmission. This compound is utilized in research related to psychotic disorders and provides insights into dopamine-mediated pathways. Its application extends to studying the neuropharmacology of antipsychotic treatments and understanding the mechanisms underlying various psychiatric conditions. -
Adrenergic Receptor
Methoxyphenamine is a β-adrenergic receptor agonist belonging to the amphetamine class, primarily utilized as a bronchodilator. This compound demonstrates significant biological activity in promoting airway smooth muscle relaxation, making it useful in the treatment of bronchial constriction. Its applications extend to research in respiratory diseases and the pharmacological modulation of adrenergic pathways. -
5-HT Receptor Agonist
Serotonin is a monoamine neurotransmitter that acts as an endogenous agonist at 5-HT receptors. It plays a critical role in various physiological processes, including mood regulation and cognitive function. Additionally, serotonin functions as a catechol O-methyltransferase (COMT) inhibitor, exhibiting a Ki value of 44 μM. This compound is essential for studies related to neuroscience, pharmacology, and the understanding of mood disorders. -
Dopamine Receptor Antagonist
Thioridazine is a dopamine receptor D2 antagonist known for its potent antipsychotic and anxiolytic properties. In addition to its neuropharmacological effects, Thioridazine significantly inhibits the PI3K-Akt-mTOR signaling pathway, exhibiting anti-angiogenic activity. It has demonstrated antiproliferative effects and the ability to induce apoptosis in various cancer cell types, with a particular efficacy in targeting cancer stem cells (CSCs). These characteristics make Thioridazine a valuable compound for research in neurobiology and cancer therapeutics. -
CCR5/CXCR4 Chemotaxis Inhibitor
Catenarin, an anthraquinone compound, serves as an inhibitor of CCR5 and CXCR4-mediated chemotaxis. It effectively reduces the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and MKK7), as well as calcium mobilization. Catenarin demonstrates anti-inflammatory properties and inhibits leukocyte migration, contributing to its potential in diabetes research. Additionally, it exhibits significant antibacterial activity against Gram-positive bacteria and has been shown to prevent type 1 diabetes in nonobese diabetic mice. -
5-HT4 Receptor Agonist
Tryptamine is a selective agonist of the 5-HT4 receptor, with an EC50 of 1-3 mM, and also functions as an endogenous ligand for the aryl hydrocarbon receptor (AHR), exhibiting a Kd of 10-50 nM. This compound enhances intestinal anion secretion and fluid transport by activating G protein-coupled receptors (GPCRs), thereby promoting gastrointestinal motility. Additionally, tryptamine plays a role in modulating Th17/Treg balance to inhibit neuroinflammation, influences central nervous system activity through competitive binding to 5-HT receptors, and participates in neuromodulation related to temperature and spinal reflexes. Tryptamine is useful for researching gastrointestinal disorders such as functional constipation and demonstrates efficacy in preclinical models of multiple sclerosis. -
Histamine Receptor Antagonist
Chlorcyclizine is a histamine H1 receptor antagonist that modulates allergic responses and reduces symptoms of histamine-mediated conditions. This compound exhibits effective anti-allergic properties, making it useful in studying the mechanisms of allergic reactions and potential therapeutic interventions. Research applications include the investigation of histamine-related pathways and the evaluation of antihistaminic effects in various biological systems. -
β-agonist
Isoetharine hydrochloride is a selective, short-acting β-agonist primarily used as a bronchodilator. Its ability to stimulate β-adrenergic receptors makes it important for research applications involving respiratory therapies and inhalation studies. This compound aids in the exploration of therapeutic strategies for bronchoconstrictive diseases such as asthma and chronic obstructive pulmonary disease (COPD). -
α1/α2 Adrenergic Receptor Antagonist
Phentolamine is a selective and orally active antagonist of α1 and α2 adrenergic receptors. This compound exhibits significant biological activity in modulating vascular tone and has been extensively utilized in research related to erectile dysfunction and adrenergic signaling. By inhibiting these receptors, Phentolamine promotes vasodilation and enhances blood flow, making it a valuable tool for studying cardiovascular and reproductive systems. -
A1AR Ligand
2-Thioadenosine is a selective ligand for the A1 adenosine receptor (A1AR), exhibiting a Ki value of 80.3 nM. This compound demonstrates minimal affinity for the A2A, A2B, and A3 adenosine receptor subtypes. Additionally, 2-Thioadenosine serves as a precursor for the synthesis of fluorescent agonists that selectively target the A3 adenosine receptor, making it valuable for research in pharmacology and receptor biology. -
CXCR4 Positive Allosteric Modulator
UCUF-965 is a positive allosteric modulator of the chemokine receptor CXCR4. This compound enhances CXCL12-induced β-arrestin recruitment and cAMP signaling, promoting lymphoblast migration and inducing calcium flux without binding to the orthosteric CXCL12 site. UCUF-965 also modulates microRNA levels in fibroblasts by reducing miR-15b and miR-29a, while increasing miR-146a. Its capabilities in enhancing angiogenesis and accelerating wound healing make UCUF-965 a valuable tool in research focused on diabetic wound healing impairment. -
CXCR5 Inhibitor
YU241279 is a selective inhibitor of CXCR5, targeting the CXCL13-mediated signaling pathways. It effectively inhibits Gαq-dependent calcium influx and Gαi2-dependent cAMP reduction in CXCR5-expressing cells, leading to reduced proliferation of lymphoma cells. In preclinical studies, YU241279 demonstrated a significant reduction in tumor burden within the peripheral blood and bone marrow of mice with lymphoma. This compound is suitable for research into angioimmunoblastic T-cell lymphoma and Burkitt B-cell lymphoma. -
Dopamine Receptor Antagonist
N-(p-Aminophenethyl)spiperone is a selective antagonist of D2-like dopamine receptors. This compound binds specifically to the ligand recognition sites of functional D2 and D3 receptors, making it a valuable tool for researchers studying dopamine signaling pathways. N-(p-Aminophenethyl)spiperone is primarily used for labeling, localizing, and identifying D2 and D3 dopamine receptors in various biological systems. -
β2-adrenergic receptor Agonist
Methoxyfenoterol is a selective β2-adrenergic receptor agonist known for its ability to stimulate intracellular cAMP accumulation. It exhibits significant anti-proliferative effects on tumor cells by inducing G1 cell cycle arrest, upregulating p27, and downregulating cyclin D1 and cyclin A levels, while also inhibiting Akt phosphorylation. Additionally, Methoxyfenoterol is capable of crossing the blood-brain barrier, demonstrating efficacy in inhibiting the growth of astrocytoma xenografts. This compound is primarily utilized in research related to astrocytoma and glioblastoma. -
Antipsychotic Agent
Clopipazan is a potent antipsychotic agent that primarily targets dopamine receptors in the brain. Its primary mechanism of action involves modulating dopaminergic activity, which contributes to its therapeutic effects in the treatment of various psychiatric disorders, including schizophrenia. Clopipazan is utilized in research to explore neural pathways and potential therapeutic interventions for mental health conditions. -
Antihistamine Agent
Buclizine is an orally active antihistamine that targets histamine receptors, reducing allergic responses. In addition to its antiallergic properties, Buclizine has demonstrated teratogenic effects in rodent models and exhibits anti-tumor activity, making it of interest in cancer research. Its diverse mechanisms of action make it valuable for studies on histamine-related pathways and potential therapeutic applications in oncology. -
Adrenergic Receptor Antagonist
Tolazoline is an α-adrenergic receptor antagonist that plays a critical role in modulating vascular responses. It inhibits noradrenaline-induced cell contraction, affects vascular resistance, increases arterial pressure, and can reverse both bradycardia and tachypnea. This compound is valuable for studying erectile dysfunction, assessing α2-adrenergic receptor agonist-related poisoning, and investigating skin vascular diseases. -
alpha-adrenoceptor Antagonist
Acepromazine is a phenothiazine tranquilizer primarily acting as an alpha-adrenoceptor antagonist. It exhibits sedative and tranquilizing effects by blocking the adrenergic receptors, which can be valuable in veterinary medicine. Acepromazine is commonly utilized in studies involving sedation, anesthesia, and behavioral research, making it an important reagent for exploring neuropharmacological pathways. -
Antipsychotic Agent
Clomacran is a potent antipsychotic agent that primarily targets dopamine receptors in the brain, particularly the D2 receptor. It exhibits significant efficacy in alleviating symptoms associated with various psychotic disorders. This compound is widely utilized in preclinical research to investigate its neuropharmacological effects and potential therapeutic applications in the treatment of schizophrenia and other related conditions. -
Anti-adrenergic Agent, Anti-anginal Agent
L 8412 is a potent anti-adrenergic agent that primarily targets adrenergic receptors, leading to decreased heart rate and myocardial oxygen demand. It exhibits significant anti-anginal activity, making it valuable in cardiovascular research. This compound is utilized for studying the effects of adrenergic modulation on heart function and in the development of therapies for angina pectoris. -
Platelet Aggregation Inhibitor
Evategrel is a potent platelet aggregation inhibitor that primarily targets ADP receptors on platelets. This compound effectively reduces thrombus formation, making it useful for research in cardiovascular diseases and the study of clotting mechanisms. Its ability to modulate platelet activity supports investigations into antiplatelet therapies and their applications in preventing thrombotic events. -
Antihypertensive Agent
Alkaloids, Rauwolfia are derived from the root of Rauwolfia serpentina and act primarily as antihypertensive agents. These bioactive compounds have been shown to effectively lower blood pressure by targeting adrenergic receptors and modulating central nervous system activity. They are widely utilized in research to investigate hypertension and related cardiovascular conditions.
