Fig. 1 · Structure
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Tryptamine
5-HT4 Receptor Agonist
Tryptamine is a selective agonist of the 5-HT4 receptor, with an EC50 of 1-3 mM, and also functions as an endogenous ligand for the aryl hydrocarbon receptor (AHR), exhibiting a Kd of 10-50 nM. This compound enhances intestinal anion secretion and fluid transport by activating G protein-coupled receptors (GPCRs), thereby promoting gastrointestinal motility. Additionally, tryptamine plays a role in modulating Th17/Treg balance to inhibit neuroinflammation, influences central nervous system activity through competitive binding to 5-HT receptors, and participates in neuromodulation related to temperature and spinal reflexes. Tryptamine is useful for researching gastrointestinal disorders such as functional constipation and demonstrates efficacy in preclinical models of multiple sclerosis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 61-54-1 |
| Applications | 5-HT4 Receptor Agonist |
| Formula | C10H12N2 |
| Molecular Weight | 160.22 |
| Synonyms | 3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine |
| SMILES | NCCC1=CNC2=C1C=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.