Tryptamine is a selective agonist of the 5-HT4 receptor, with an EC50 of 1-3 mM, and also functions as an endogenous ligand for the aryl hydrocarbon receptor (AHR), exhibiting a Kd of 10-50 nM. This compound enhances intestinal anion secretion and fluid transport by activating G protein-coupled receptors (GPCRs), thereby promoting gastrointestinal motility. Additionally, tryptamine plays a role in modulating Th17/Treg balance to inhibit neuroinflammation, influences central nervous system activity through competitive binding to 5-HT receptors, and participates in neuromodulation related to temperature and spinal reflexes. Tryptamine is useful for researching gastrointestinal disorders such as functional constipation and demonstrates efficacy in preclinical models of multiple sclerosis.
Tryptamine is a selective agonist of the 5-HT4 receptor, with an EC50 of 1-3 mM, and also functions as an endogenous ligand for the aryl hydrocarbon receptor (AHR), exhibiting a Kd of 10-50 nM. This compound enhances intestinal anion secretion and fluid transport by activating G protein-coupled receptors (GPCRs), thereby promoting gastrointestinal motility. Additionally, tryptamine plays a role in modulating Th17/Treg balance to inhibit neuroinflammation, influences central nervous system activity through competitive binding to 5-HT receptors, and participates in neuromodulation related to temperature and spinal reflexes. Tryptamine is useful for researching gastrointestinal disorders such as functional constipation and demonstrates efficacy in preclinical models of multiple sclerosis.
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