Catalog No.
Product Name
Application
Product Information
Citations
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Adenosine Analog
8-Bromo-5’-O-(4-cyanobenzyl)-2’,3’-di-O-isopropylidene adenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits smooth muscle vasodilatory activity and has potential applications in cancer research due to its ability to inhibit cancer progression. Its structural modifications make it a valuable tool for studying adenosine signaling pathways in various biological systems. -
Adenosine Analog
2'-O-t-Butyldimethylsilyladenosine is an adenosine analog that primarily targets adenosine receptors. This compound functions as a smooth muscle vasodilator and has demonstrated potential in inhibiting cancer progression. It is valuable for research applications in vascular biology and oncology, contributing to studies on therapeutic pathways involving adenosine signaling. -
Adenosine Analog
2-Benzylthioadenosine is an adenosine analog that primarily acts on adenosine receptors. It is known for its vasodilatory effects on smooth muscle and has been investigated for its potential to inhibit cancer progression. This compound is valuable in research applications related to cardiovascular health and oncology, contributing to the understanding of adenosine signaling pathways. -
Biochemical Assay Reagent
Adenosine 2'-PEG-Biotin is a biochemical assay reagent that acts as a bioisostere of endogenous adenosine, allowing it to engage adenosine receptors effectively. This compound plays a crucial role in regulating various cell signaling pathways, facilitating research into its applications as a bioprobe, biosensor, or diagnostic reagent. Its incorporation of biotin also enhances its utility in various biochemical assays and detection methodologies. -
Adenosine Analog
N6-Benzoyl-2',3'-isopropylidene adenosine is an adenosine analog targeting adenosine receptors. This compound exhibits significant smooth muscle vasodilatory activity and has demonstrated potential in inhibiting cancer progression. Its applications in research include studying vascular physiology and cancer biology, making it a valuable tool in the investigation of therapeutic strategies involving adenosine modulation. -
Adenosine Analog
2'-O-Acetyl-3,5-bis-O-(2,4-dichlorobenzyl)adenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits significant smooth muscle vasodilatory activity and has potential applications in inhibiting cancer progression. Its mechanism of action makes it a valuable tool for researchers studying cardiovascular function and cancer therapeutics. -
Adenosine Analog
5′-O-[(4-Cyanophenyl)methyl]-2′,3′-O-(1-methylethylidene)adenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits vasodilatory properties and demonstrates potential in inhibiting cancer cell proliferation. It is a valuable tool in research exploring the effects of adenosine signaling in cardiovascular diseases and cancer therapy. -
Adenosine Analog
N4-Benzoyl-5'-O-DMT-2'-O-propargyl adenosine is an adenosine analog that acts primarily as a smooth muscle vasodilator. This compound has demonstrated potential in inhibiting cancer progression, making it valuable for various biological research applications. Its distinctive structural properties facilitate the study of adenosine receptor interactions and signaling pathways, contributing to the understanding of cardiovascular physiology and tumor biology. -
Adenosine Analog
N6-Benzyl-2’-C-methyladenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits vasodilatory effects in smooth muscle and demonstrates potential in inhibiting cancer progression. It serves as a valuable tool in studies focusing on cardiovascular function and cancer biology, facilitating research into therapeutic strategies for related conditions. -
Adenosine Analog
N-[(3-Methoxyphenyl)methyl]adenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits significant biological activity as a smooth muscle vasodilator and has demonstrated potential in inhibiting cancer progression. It is a valuable tool for researchers investigating vascular biology and cancer therapeutics. -
Uridine Analog
5-Iodo-2’-β-C-methyl uridine is a uridine analog that primarily targets adenosine receptors. This compound exhibits potential antiepileptic properties and serves as a valuable tool in the investigation of anticonvulsant and anxiolytic activities. Additionally, it may contribute to the development of innovative antihypertensive agents in chemical research. -
Adenosine Analog
5’-O-(4,4’-Dimethoxytrityl)-2’-O-(2-methoxyethyl) adenosine is an adenosine analog that primarily targets adenosine receptors. This compound demonstrates biological activities such as smooth muscle vasodilation and potential inhibition of cancer progression. It is valuable for research in cardiovascular studies and cancer biology, facilitating investigations into adenosine signaling and therapeutic applications. -
Adenosine Analog
N6-Methyl-xylo-adenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits smooth muscle vasodilatory effects and has demonstrated potential in inhibiting cancer progression. Its unique properties make it a valuable tool for researchers investigating vascular biology and cancer therapies. -
5'-AMP Analogue
2-Cl-5'-AMP is a 5'-AMP analogue that functions primarily by interacting with adenosine receptors. This compound exhibits key biological activity in receptor mapping research, facilitating the study of adenosine receptor signaling pathways and their physiological roles. Its use in biochemical assays enables a deeper understanding of receptor-ligand interactions and their implications in various biological systems. -
Adenosine Analog
N-Benzoyl-5'-O-dmtr-2'-O-(2-methoxyethyl)-adenosine is an adenosine analog that primarily targets adenosine receptors. It exhibits significant vasodilatory effects by relaxing smooth muscle and has demonstrated potential in inhibiting cancer progression. This compound is valuable in biomedical research, particularly in studies focused on cardiovascular health and cancer therapy. -
Adenosine Analog
9-(β-D-Xylofuranosyl)adenine is an adenosine analog that primarily acts as a vasodilator by targeting adenosine receptors. This compound has demonstrated significant biological activity, including the inhibition of cancer progression. It is particularly useful for researchers exploring the mechanisms of vasodilation and the therapeutic potential of adenosine-related pathways in cancer biology. -
Adenosine Analog
2'-O-Methyladenosine 5'-monophosphate triethylammonium is an adenosine analog that primarily targets adenosine receptors. It exhibits significant biological activity, functioning as a smooth muscle vasodilator while also demonstrating potential for inhibiting cancer progression. This compound is valuable for research applications focusing on cardiovascular studies and cancer biology. -
Adenosine Analog
8-Chloro-2'-deoxyadenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits significant biological activity as a potential vasodilator and has demonstrated inhibitory effects on cancer progression. It is useful in various research applications, particularly in studying the pharmacological effects of adenosine and its derivatives in cardiovascular and oncology research. -
Adenosine Analog
2-Methoxy-2'-deoxyadenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits vasodilatory effects on smooth muscle and has demonstrated potential in inhibiting cancer progression, making it relevant for various research applications, including cardiovascular studies and oncology. Its structural similarity to adenosine allows for exploration in drug development targeting related pathways. -
Adenosine Analog
N-(2-Phenoxyacetyl)adenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits smooth muscle vasodilatory effects and has demonstrated potential in inhibiting cancer progression. It serves as a valuable tool in cancer research and studies related to vascular biology. -
Adenosine Analog
N6-Benzoyl-9-β-D-arabinofuranosyladenine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits smooth muscle vasodilatory effects and demonstrates potential in inhibiting cancer progression. It serves as a valuable tool in studies focused on cardiovascular research and oncology, enabling researchers to explore the therapeutic implications of adenosine signaling pathways. -
Adenosine Analog
8-Allylthioadenosine is an adenosine analog that primarily targets adenosine receptors. It demonstrates smooth muscle vasodilatory effects and has been implicated in inhibiting cancer progression, making it a valuable compound for oncology research. Its utility extends to studies involving vascular biology and the modulation of cellular signaling pathways. -
Adenosine Analog
3’-O-(2-Methoxyethyl)-2-aminoadenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits significant smooth muscle vasodilatory properties and has demonstrated potential in inhibiting cancer progression. Research applications include studying vascular biology, exploring therapeutic avenues in oncology, and investigating the signaling pathways mediated by adenosine receptors. -
Adenosine Analog
3',5'-TIPS-N-Ac-Adenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits significant smooth muscle vasodilatory activity and has potential applications in inhibiting cancer progression. It is valuable for research related to vascular biology and oncology, facilitating the study of adenosine receptor signaling pathways and their therapeutic implications. -
Adenosine Analog
8-(Methylamino)adenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits significant vasodilatory effects on smooth muscle and has been demonstrated to possess anti-cancer properties by inhibiting tumor progression. It is utilized in various research applications related to vascular biology and oncology. -
Adenosine Analog
N6-(3-Trifluoromethylbenzyl)-2’-C-methyl adenosine is an adenosine analog that primarily acts on adenosine receptors. This compound demonstrates smooth muscle vasodilatory properties and has potential applications in inhibiting cancer progression. Its structural modifications enhance its affinity and selectivity, making it a valuable reagent for research in vascular biology and oncology. -
Adenosine Analog
N6,N6-Dimethyl-xylo-adenosine is an adenosine analog with a primary mechanism of action involving modulation of adenosine receptors. This compound has demonstrated significant smooth muscle vasodilator activity and holds potential in inhibiting cancer progression. It is widely utilized in research applications focusing on vascular biology and oncology. -
Adrenergic Receptor
Bremazocine is a potent agonist of the kappa opioid receptor, demonstrating significant analgesic activity. It exerts its effects by enhancing the release of endogenous norepinephrine, leading to peripheral analgesia. Additionally, Bremazocine interacts with adenosine receptors, further contributing to its analgesic properties. Its peripheral analgesic effects are dose-dependent and may be influenced by nonselective α(2) adrenergic receptor antagonists, indicating a mechanism involving norepinephrine pathways. This compound is suitable for research applications focused on pain modulation and neuropharmacology. -
ADRA2A Antagonist
Yohimbic acid ethyl ester is a selective antagonist of the alpha-2 adrenergic receptor subtype ADRA2A, exhibiting an IC50 of 31 nM. This compound is significant for studies investigating the modulation of adrenergic signaling pathways and has potential applications in researching cardiovascular function and neuropharmacology. Its specificity for ADRA2A makes it a valuable tool for exploring therapeutic strategies targeting adrenergic receptor-related disorders. -
A3AR Agonist
MRS5698 is a selective agonist of the A3 adenosine receptor (A3AR), effectively activating Gi protein signaling pathways. With Kis of approximately 3 nM for both human and mouse A3AR, this compound is valuable for investigating mechanisms related to pain and psoriasis. Its specificity may facilitate research into therapeutic applications targeting inflammatory and pain-related disorders. -
Adenosine A3 Receptor Modulator
VUF8507 is an allosteric modulator of the adenosine A3 receptor, demonstrating a binding affinity with a Ki of 204 nM. This compound enhances A3 receptor activity and has potential applications in the study of inflammatory diseases and neuroprotection. Researchers may utilize VUF8507 to gain insights into the modulation of adenosine signaling pathways and their implications in various biological processes. -
Adenosine Receptor Agonist
2-Chloro-3-deazaadenosine is an adenosine receptor agonist that demonstrates specific interactions with A1, A2A, A2B, and A3 receptors, exhibiting inhibitory constants (Kis) of 0.3, 0.08, 25.5, and 1.9 μM, respectively. This compound is valuable in the study of adenosine signaling pathways and its diverse biological effects, making it suitable for research applications involving receptor pharmacology and cell signaling. -
A2A Adenosine Receptor Antagonist
MSX-2 is a potent antagonist of the A2A adenosine receptor, exhibiting a Ki of 5 nM in human tissues. This compound plays a significant role in the modulation of physiological processes associated with Parkinson's disease. MSX-2 can be utilized in research aimed at understanding the therapeutic effects of A2A receptor inhibition in neurological disorders. -
Adenosine Receptor Inhibitor
CVT-2759 is a potent inhibitor of the A1 adenosine receptor, exhibiting IC50 values of 0.18 μM and 9.5 μM to antagonize [3H]CPX binding in the absence and presence of 1 mM GTP, respectively. This compound is essential for assessing the modulation of AV nodal conduction, facilitating a reduction in ventricular rate without inducing AV block, bradycardia, atrial arrhythmias, or vasodilation. It serves as a valuable reagent for research on cardiovascular physiology and pharmacological modulation of adenosine receptor pathways. -
A1 Adenosine Receptor Antagonist
(Rac)-WRC-0571 is a potent and selective antagonist of A1 adenosine receptors, characterized by its non-xanthine structure and oral bioavailability. It effectively inhibits the binding of [3H]-N6-cyclohexyladenosine (CHA) to guinea pig A1 receptors, demonstrating a Ki value of 1.1 nM. This compound is valuable for research into adenosine receptor signaling and its implications in various physiological and pathological processes. -
Adenosine A3 Receptor Antagonist
KF26777 (free base) is a highly selective antagonist of the adenosine A3 receptor, exhibiting a Ki value of 0.2 nM. It demonstrates significant selectivity over adenosine A1, A2A, and A2B receptors, with factors of 9000-fold, 2350-fold, and 3100-fold, respectively. This compound effectively inhibits [125I]AB-MECA binding to adenosine A3 receptors and holds potential for research into brain ischemia and inflammatory diseases, such as asthma. -
A3AR Ligand
I-AB-MECA is a selective ligand for the A3 adenosine receptor (A3AR), functioning as an important tool in receptor binding studies. This radioligand is utilized in various biological research applications, including pharmacological profiling and understanding adenosine receptor signaling pathways. It aids in elucidating the role of A3AR in various physiological and pathological processes. -
A1AR Agonist
(±)-5'-Chloro-5'-deoxy-ENBA is an A1 adenosine receptor (A1AR) agonist that induces hypothermia in murine models. This compound is instrumental in studying the physiological effects and therapeutic potential of A1AR modulation. It serves as a valuable tool for researchers investigating adenosine signaling pathways and their implications in various biological processes. -
Adenosine Receptor Antagonist
Xanthine amine congener trihydrochloride is a potent antagonist of adenosine A1 and A2 receptors, exhibiting IC50 values of 1.8 nM and 114 nM, respectively. This compound is utilized in research applications focusing on the modulation of adenosine receptors and elucidating their roles in various physiological and pathological processes. Additionally, Xanthine amine congener has been characterized as a convulsant agent in murine models, aiding in the study of seizure mechanisms. -
A1AR Antagonist
L-97-1 is a selective antagonist of the A1 adenosine receptor (A1AR). This water-soluble small molecule exhibits high affinity for human A1AR, effectively blocking receptor activation. By competitively inhibiting A1AR, L-97-1 alleviates adenosine-induced bronchoconstriction and inflammation, making it a valuable tool in asthma research and the study of airway hyperreactivity. Its action can contribute to a better understanding of therapeutic approaches for respiratory conditions associated with adenosine signaling. -
Adenosine Receptor Agonist
LUF5831 is a selective adenosine A1 receptor agonist with a binding affinity of Ki = 18 nM. It exhibits pharmacological activity by modulating adenosine signaling pathways, making it valuable for research applications investigating neurological processes and cardiovascular functions. Its unique properties facilitate studies on adenosine receptor-mediated effects in various biological systems. -
Adenosine Receptor Antagonist
Dansyl-NECA is a dansyl-labeled antagonist of adenosine receptors, functioning primarily through the inhibition of adenosine signaling pathways. This compound serves as a valuable tool in studying the biological effects of adenosine receptor modulation, providing insights into cellular mechanisms involved in neuroprotection, inflammation, and cancer research. Its fluorescence properties enhance detection and visualization in biochemical assays. -
A2AAR Antagonist
A2AAR antagonist 1 is a selective antagonist of the adenosine A2A receptor (A2AAR) with a Ki value of 20 nM. This compound exhibits high ligand efficiency and is suitable for research into neurodegenerative diseases, offering potential insights into therapeutic strategies targeting A2AAR-related pathways. Its pharmacological properties make it a valuable tool for elucidating receptor functions and investigating the role of adenosine signaling in various biological contexts. -
A1 AdoR Partial Agonist
CVT-2759 analog is a partial agonist of the A1 adenosine receptor, exhibiting a Ki value of 167 nM. This compound is valuable for research into cardiac arrhythmias, providing insights into the modulation of adenosine receptor signaling and its implications in cardiac health. Its specificity for the A1 receptor makes it a suitable tool for studying the physiological effects of adenosine in cardiac tissue. -
A2A Antagonist
LUF5981 is a potent antagonist of the adenosine A2A receptor, exhibiting a pIC50 value of 6.7. This compound has shown efficacy in modulating adenosine receptor activity, making it a valuable tool for research in areas such as neuroprotection, immunology, and cancer therapy. Its application in preclinical studies can aid in the exploration of A2A-mediated pathways and their role in various biological processes. -
A2B AdoR Antagonist
CVT-5440 is a selective antagonist of the A2B adenosine receptor, exhibiting high affinity with a Ki value of 50 nM. It demonstrates significant selectivity over other adenosine receptor subtypes, including A1, A2A, and A3, with selectivity ratios greater than 200. This compound is suitable for research applications focusing on asthma and related respiratory conditions, where modulation of adenosine signaling is of interest. -
Adenosine A3 Receptor Antagonist
MRS1067 is a competitive antagonist of the adenosine A3 receptor, effectively inhibiting the suppression of adenylate cyclase induced by adenosine A3 receptor agonists and influencing G protein activation. This compound is valuable in research applications focused on inflammation and cancer, providing insights into the role of adenosine A3 receptor signaling in various physiological and pathological processes. -
A2B Adenosine Receptor Antagonist
PSB-1115 potassium salt is a selective antagonist of the A2B adenosine receptor, demonstrating significant inhibitory effects on the receptor's activity. This compound is particularly notable for its ability to block the contraction inhibition of acetylcholine induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS). It serves as a valuable tool for research into adenosine signaling pathways and the modulation of inflammation-related responses. -
Adenosine Receptor Binding Enhancer
PD81723 is an adenosine receptor binding enhancer that significantly boosts the inhibition of exogenous adenosine in a dose-dependent manner within hippocampal brain sections. This compound is vital for research exploring adenosine receptor modulation and its implications in neurological processes. Its ability to facilitate adenosine receptor interactions makes it an invaluable tool for studies focusing on cognitive function and related disorders. -
ADORA1 Modulator
ADORA1 modulator-1 is a selective modulator of the adenosine A1 receptor (ADORA1), known for its role in cellular signaling pathways. It demonstrates significant influence on neuroprotective and cardioprotective activities, making it valuable for the exploration of metabolic disorders and neurological diseases. This compound serves as a critical tool for researchers investigating the manipulation of adenosine receptor signaling in various biological contexts.
