Catalog No.
Product Name
Application
Product Information
Citations
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LTB4 Receptor Antagonist
Leukotriene B4 ethanolamide is a selective antagonist and partial agonist of the Leukotriene B4 receptor 1 (BLTR1). This compound exhibits significant anti-inflammatory activity and is shown to inhibit tumor progression associated with inflammatory processes. It serves as a valuable tool for research into the mechanisms underlying inflammation and its role in cancer biology. -
LTD4 antagonist
Triptinin B is a leukotriene D4 (LTD4) antagonist isolated from the plant Tripterygium wilfordii. This compound demonstrates significant biological activity by inhibiting LTD4-mediated signaling pathways, which are implicated in various inflammatory responses. Triptinin B is useful for researching therapeutic interventions in conditions associated with leukotriene receptor activity, such as asthma and allergic responses. -
Leukotriene Inhibitor
SCH 40120 is a potent leukotriene inhibitor that exhibits significant anti-inflammatory properties. This compound effectively suppresses T cell proliferation as well as both antigen-specific and polyclonal antibody responses in vitro. SCH 40120 also diminishes edematous responses and inhibits the recruitment of circulating neutrophils to inflamed tissues, making it a valuable tool in research related to anti-psoriatic agents. -
LTA4H Inhibitor
JNJ-40929837 succinate is a selective and orally active inhibitor of leukotriene A4 hydrolase (LTA4H). This compound effectively inhibits aminopeptidase activity, leading to the accumulation of Pro-Gly-Pro in serum. JNJ-40929837 succinate is particularly relevant for asthma research, providing a valuable tool for investigating inflammatory pathways and potential therapeutic interventions in respiratory conditions. -
LTD4 Receptor Antagonist
SC-39070 is a potent LTD4 receptor antagonist. It effectively inhibits the contractile response of leukotriene D4 (LTD4) in guinea pig trachea, making it a valuable tool for studying pathways related to allergic responses and asthma. This compound is applicable in research aimed at elucidating the roles of leukotrienes in respiratory physiology and pathology. -
LTB4 Analog
SC-45694 lithium is an LTB4 analog that acts primarily as an agonist, enhancing neutrophil chemotaxis, while also functioning as an antagonist by inhibiting LTB4-induced degranulation. This dual activity makes SC-45694 lithium a valuable tool for studying inflammatory responses and the role of leukotrienes in immune regulation. Its applications in research include investigations into chemotactic mechanisms and the modulation of immune cell functions. -
Mast Cell Activator
ST026567 is a potent mast cell activator that functions by inducing the secretion of prostaglandin D2 (PGD2) and leukotriene C4 (LTC4) from mast cells. This compound exhibits strong degranulation activity, making it a valuable tool for studies focused on mast cell biology and allergic responses. Research applications include investigations into inflammatory processes and the development of potential therapeutic strategies targeting mast cell-related disorders. -
Leukotriene Receptor Inhibitor
(R)-Ontazolast is a potent leukotriene receptor inhibitor that effectively blocks leukotriene biosynthesis. It demonstrates a remarkable IC50 value of 0.001 µM in human polymorphonuclear leukocytes, inhibiting the release of arachidonic acid. This compound is valuable for research applications related to inflammation and immune response modulation. -
BLT1 Antagonist
Moxilubant hydrochloride is a potent BLT1 antagonist that inhibits leukotriene B4 (LTB4) signaling with an IC50 of 2-4 nM. This compound demonstrates significant potential in cancer research, particularly in exploring the role of inflammatory pathways in tumor progression. Its oral activity makes it a valuable tool for studying BLT1-related mechanisms in various biological contexts. -
Antiasthmatic
Zafirlukast metabolite M1 is a potent leukotriene receptor antagonist. It plays a crucial role in the management of allergic lung diseases, particularly asthma, by inhibiting the actions of leukotrienes that contribute to airway inflammation and hyperresponsiveness. This compound is useful for researching the mechanisms of asthma and evaluating therapeutic options for allergic respiratory conditions. -
Leukotriene B4 Inhibitor
Chamazulene is a natural compound that acts as an inhibitor of leukotriene B4 formation. Its antioxidant properties contribute to modulating inflammatory responses, making it relevant for research in inflammation and immune response studies. Chamazulene is particularly useful in exploring pathways related to leukotriene signaling and its role in various pathologies. -
LTB4 Antagonist
LTB4 antagonist 2 is a carboxamide-acid compound that functions as a selective antagonist of leukotriene B4 (LTB4), demonstrating anti-inflammatory potential. This compound exhibits a notable affinity for the LTB4 receptor, with an IC50 value of 439 nM. Its application is particularly relevant in studies exploring inflammation and related pathways in various biological systems. -
LTD4 Receptor Antagonist
CP-85958 is a specific antagonist of the leukotriene D4 (LTD4) receptor. This compound exhibits significant biological activity by blocking LTD4 signaling, which is implicated in the pathophysiology of inflammatory diseases. CP-85958 is valuable in research focused on asthma and other conditions associated with leukotriene-mediated inflammation. -
Leukotrienes C4/D4 Antagonist
ONO-RS-347 is a potent oral antagonist of leukotrienes C4 and D4. It effectively inhibits LTD4-induced bronchoconstriction in guinea pig models, making it a valuable tool for studying respiratory conditions. This compound holds promise for research into allergic asthma and other immediate hypersensitivity diseases, aiding in the exploration of potential therapeutic interventions. -
LTB4 Antagonist
LTB4 antagonist 3 is a potent leukotriene B4 (LTB4) antagonist, exhibiting an IC50 value of 477 nM. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research into inflammatory pathways and the modulation of immune responses. It is suitable for studies focused on conditions where LTB4 plays a detrimental role, providing insights into therapeutic interventions. -
(5S,6R)-DiHETE Isomer
(5S,6R)-DiHETEs is the isomer of (5S,6R)-DiHETE, targeting leukotriene receptors, particularly LTD4 receptors. It demonstrates significant biological activity by inducing contraction in guinea pig isolated ileum, with an EC50 value of 1.3 μM. This action can be effectively inhibited by LTD4 receptor antagonists, making (5S,6R)-DiHETEs valuable for research in inflammatory response and receptor signaling pathways. -
LTD4 Agonist
YM-17690 is a potent agonist of leukotriene D4 (LTD4) and leukotriene E4 (LTE4), exhibiting a pKi value of 9.28 for [3H]LTD4 binding. It induces dose-dependent contractions in guinea pig ileum, lung parenchyma, and trachea, with EC50 values of 16 nM, 3.9 nM, and 22 nM, respectively. This compound is valuable for research focused on asthma, inflammation, and related respiratory conditions. -
Leukotriene Inhibitor
FK-664 is a potent leukotriene inhibitor that enhances ventricular contractility and reduces the time to peak tension in cardiac cells. In canine models of heart failure, FK-664 has been shown to decrease mean circulating pressure (MCP), indicating its potential therapeutic effects. This compound is valuable for research focused on cardiovascular diseases, particularly heart failure, and its underlying mechanisms. -
Leukotriene B4 Receptor Antagonist
RG 14893 is a highly potent and selective antagonist of the leukotriene B4 receptor. This compound exhibits competitive binding, demonstrating its potential to inhibit leukotriene-induced pathways. RG 14893 is valuable for research applications investigating inflammatory responses and therapeutic interventions in conditions such as asthma and other allergic reactions. -
LTD4 Receptor Antagonist
Ablukast is a selective leukotriene D4 (LTD4) receptor antagonist that demonstrates significant efficacy in reducing bronchoconstriction induced by leukotriene C4 (LTC4) and antigens. This compound is valuable for research focused on allergic responses and asthma mechanisms, as it modulates the bronchial response to inflammatory mediators. It serves as an important tool in studies aiming to better understand leukotriene signaling and its impact on respiratory conditions. -
CYS LT1 Antagonist
Bay-X-7195 is an antagonist of the CYS leukotriene 1 receptor (CYS LT1). It effectively mitigates bronchoconstriction induced by LTD4, demonstrating both in vitro and in vivo biological activity. This compound is valuable for research focused on allergic responses and asthma pathophysiology. -
LTB4 Receptor Antagonist
SM-15178 is a selective leukotriene B4 (LTB4) receptor antagonist with an IC50 of 0.30 μM, exhibiting potent oral bioactivity. This compound effectively reduces LTB4-induced neutrophil accumulation in murine models and alleviates bronchoconstriction in guinea pig studies. SM-15178 shows significant anti-inflammatory properties and is valuable for investigating chronic inflammatory conditions, including inflammatory bowel disease, psoriasis, and asthma. -
Leukotriene Receptor/FLAP Inhibitor
(S)-Veliflapon is a potent inhibitor of leukotriene biosynthesis targeting the 5-lipoxygenase activating protein (FLAP). It effectively inhibits the formation of leukotriene B4 (LTB4) in rat, mouse, and human leukocytes with IC50 values of 0.026 µM, 0.039 µM, and 0.22 µM, respectively. Additionally, (S)-Veliflapon demonstrates enantioselectivity in human whole blood, making it a valuable reagent for research in inflammation and related biological processes. -
LTB4 Receptor Antagonist
SC-53228 is an orally active antagonist of the human leukotriene B4 receptor (LTB4 receptor). By specifically inhibiting this receptor, SC-53228 exerts anti-inflammatory effects primarily by reducing neutrophil infiltration. Its demonstrated efficacy and safety in various inflammatory models make SC-53228 suitable for research applications related to inflammatory diseases, including psoriasis and ulcerative colitis. -
Leukotriene Biosynthesis Inhibitor
L-691678 is an inhibitor of leukotriene biosynthesis that selectively binds to the 5-lipoxygenase-activating protein (FLAP). This compound disrupts leukotriene production, making it a valuable tool for investigating leukotriene-associated pathologies, including allergic responses, asthma, and inflammatory conditions. Its ability to modulate leukotriene levels provides insights into their role in various biological processes and disease mechanisms. -
Leukotriene Receptor Antagonist
SB 201146 is a potent leukotriene B4 (LTB4) receptor antagonist, exhibiting activity in the range of 10 pM to 1 μM. Its primary mechanism involves the modulation of eosinophil survival, which is a critical factor in asthma-related airway inflammation. Research indicates that SB 201146 can effectively reverse the eosinophil survival promoted by mast cells and lymphocytes, suggesting its therapeutic potential in disrupting the autocrine cysteinyl leukotriene pathway. Furthermore, this compound underscores the role of LTB4 as a paracrine mediator, influencing eosinophil dynamics in various inflammatory conditions, particularly asthma. -
Leukotriene Receptor Antagonist
LY203647 is an orally active antagonist targeting the leukotriene receptors LTD4 and LTE4. This compound exhibits significant biological activity by inhibiting leukotriene-mediated signaling pathways, making it a valuable tool for research on asthma and other inflammatory diseases. LY203647 aids in the exploration of therapeutic strategies for managing conditions associated with leukotriene dysregulation. -
Leukotriene Receptor Antagonist
RG-7152 is a tetrazolyl-substituted leukotriene D4 receptor antagonist that enhances peroxisomal β-oxidation and promotes peroxisome bifunctional enzymes (PBEs) in hepatocytes across various animal models. Research indicates that RG-7152 significantly elevates PBE levels and β-oxidation activity in rat and mouse liver homogenates. Furthermore, comparative in vitro studies demonstrate its ability to induce PBEs similarly to clofibric acid, highlighting its potential utility in studying peroxisome proliferation and related metabolic pathways. -
Leukotriene B4 Receptor Antagonist
Ricinelaidic acid is a potent leukotriene B4 (LTB4) receptor antagonist, exhibiting a Ki of 2 μM in porcine neutrophil membranes. This compound effectively inhibits LTB4-induced chemotaxis and calcium flux in isolated human neutrophils, with IC50 values of 10 μM and 7 μM, respectively. Additionally, ricinelaidic acid demonstrates the ability to mitigate bronchoconstriction induced by LTB4 in rat models, making it a valuable reagent for studying inflammatory processes and potential therapeutic interventions in respiratory conditions. -
LTD4 Antagonist
CGP-35949 sodium is a leukotriene D4 (LTD4) antagonist that exerts its effects through phospholipase inhibitory activity. It is primarily utilized in research related to asthma and other respiratory conditions, where it helps to elucidate the role of leukotrienes in inflammation and bronchoconstriction. -
LTD4 Antagonist
LY290324 is a potent leukotriene D4 (LTD4) antagonist, which functions by inhibiting the action of LTD4 on its receptors. This compound effectively reduces bronchospasm induced by leukotriene C4 (LTC4), LTD4, and leukotriene E4 (LTE4). LY290324 is valuable for research exploring antigen-induced bronchospasm and related respiratory conditions. -
BLT2 Antagonist
ZK-158252 is a selective antagonist of the leukotriene B4 type-2 receptor (BLT2). It exhibits inhibitory activity on leukotriene-mediated signaling pathways, making it valuable for investigating inflammatory responses. This compound is relevant for research into the modulation of immune responses and the role of BLT2 in various pathological conditions. -
cytokine
Maresin conjugates in tissue regeneration 1 (MCTR1) is a potent pro-resolving cytokine that plays a critical role in reducing inflammation and promoting tissue regeneration. MCTR1 effectively antagonizes LTD4-stimulated vascular responses, making it a valuable tool for research in inflammatory diseases and tissue repair mechanisms. Its unique properties make it suitable for investigations into pro-resolving pathways and their therapeutic potential in regenerative medicine. -
LTD4 antagonist
L-648051 is a leukotriene D4 receptor (LTD4) antagonist that demonstrates significant potential in modulating inflammatory responses associated with various pathological conditions. Its primary biological activity includes the inhibition of LTD4-mediated signaling pathways, which are implicated in the development of arrhythmias. This compound is valuable for research focused on cardiovascular diseases and the exploration of new therapeutic avenues for managing inflammation-related disorders. -
LTB4 Receptor Antagonist
LY 292728 is a potent leukotriene B4 (LTB4) receptor antagonist. It demonstrates high affinity binding to human neutrophils with a Ki of 0.47 nM and binds even more tightly to guinea pig lung membranes with a Ki of 0.04 nM. This compound is valuable for research involving inflammation and immune response modulation, making it an important tool for studies on leukotriene signaling pathways. -
LTB4 Receptor Antagonist
LY306669 is a selective antagonist of the leukotriene B4 (LTB4) receptor, demonstrating significant potency in modulating LTB4-mediated signaling. This compound is primarily utilized in research focusing on inflammatory responses and lung injury mechanisms. Its ability to inhibit LTB4 activity makes it a valuable tool for studying various pulmonary conditions and therapeutic interventions aimed at mitigating lung damage. -
Leukotriene A4 Hydrolase Substrate
H-Ala-pNA is a specific substrate for leukotriene A4 hydrolase, consisting of an L-amino acid p-nitroaniline derivative. Upon catalytic hydrolysis by leukotriene A4 hydrolase, H-Ala-pNA generates p-nitroaniline, which can be quantitatively monitored at 405 nm, facilitating the assessment of enzyme activity. This compound is essential for evaluating the effectiveness of inhibitors that target the amidase function of leukotriene A4 hydrolase, contributing to research on inflammatory processes and related diseases. -
Leukotriene Biosynthesis Inhibitor
ABT-080 is an orally active inhibitor of leukotriene biosynthesis, specifically targeting the pathways responsible for the production of LTB4 and LTC4. This compound effectively prevents bronchoconstriction, making it valuable for research into asthma and related inflammatory conditions. By selectively inhibiting leukotriene synthesis without affecting PGH2 biosynthesis, ABT-080 provides a critical tool for studying the role of leukotrienes in respiratory diseases. -
CysLT1R/CysLT2R Antagonist
BRI-12349 is a dual antagonist of the CysLT1R and CysLT2R receptors, exhibiting Ki values of 1.03 μM and 6.46 μM, respectively. This compound effectively inhibits the production of inositol monophosphate (IP1) induced by leukotriene D4 (LTD4), the primary ligand for cysteinyl leukotrienes. BRI-12349 is a valuable tool for research in immunology and inflammation, particularly in studies related to asthma and other allergic responses. -
Cysteinyl LT1 Receptor Antagonist
CP-199330 is a potent antagonist of the cysteinyl leukotriene 1 (CysLT1) receptor. By blocking this receptor, CP-199330 exhibits significant anti-inflammatory properties, making it applicable in research focused on asthma, allergic rhinitis, and other inflammatory disorders. Its oral bioactivity enhances its utility in preclinical studies and therapeutic investigations. -
Leukotriene Receptor Antagonist
RS-601 is a dual antagonist of leukotriene D4 (LTD4) and thromboxane A2 (TxA2) receptors, primarily targeting inflammatory pathways associated with asthma. This compound exhibits significant antiasthmatic properties, making it a valuable tool in the study of respiratory diseases. Researchers can utilize RS-601 for investigating the mechanisms of leukotriene signaling and its implications in inflammatory responses. -
CysLT1R Antagonist
CysLT1 receptor antagonist-1 is a selective antagonist of the cysteinyl leukotriene receptor 1 (CysLT1R), exhibiting an IC50 value of 3.9 µM. This compound demonstrates weak agonistic activity against the G-protein-coupled bile acid receptor 1 (GPBAR1) with an efficacy of 23% at 10 µM. CysLT1 receptor antagonist-1 is primarily utilized in research related to asthma and allergic diseases, aiding in the exploration of therapeutic interventions targeting these conditions. -
LTD4 Antagonist
LTD4 antagonist 2 is a selective antagonist of leukotriene D4 (LTD4) that exhibits an IC50 of 2.8 μM for the cysteinyl leukotriene 1 receptor (CysLT1R). Additionally, this compound acts as an agonist of G protein-coupled bile acid receptor 1 (GPBAR1). It is valuable for research applications related to inflammatory conditions such as colitis, as well as metabolic syndromes and diseases associated with GPBAR1 and CysLT1R pathways. -
LTB4 Inhibitor
Ontazolast is a potent inhibitor of leukotriene B4 (LTB4) biosynthesis, making it a valuable tool for studying inflammatory pathways. Its primary mechanism targets the LTB4 synthesis pathway, which is associated with various inflammatory conditions. Ontazolast is particularly relevant in research applications focused on asthma and related respiratory disorders. -
Leukotriene Receptor Antagonist
Verlukast-d6 is a deuterium-labeled variant of Verlukast, a selective and potent antagonist of leukotriene receptors. This compound demonstrates significant activity in inhibiting leukotriene-mediated pathways, which are involved in the pathophysiology of asthma. Verlukast-d6 is utilized in pharmacological research to better understand the mechanisms of leukotriene signaling and its role in respiratory diseases. -
Leukotriene Receptor Antagonist
LTD4 antagonist 1 is a selective inhibitor of the leukotriene D4 receptor, exhibiting a binding affinity with a Ki value of 0.57 nM. This compound demonstrates significant potential for modulating inflammatory responses associated with allergic conditions and asthma. It serves as an important tool in research aimed at exploring leukotriene-mediated pathways and therapeutic interventions in related diseases. -
Leukotriene Receptor Antagonist
LY210073 is a potent leukotriene B4 (LTB4) receptor antagonist, exhibiting an IC50 of 6.2 nM. It effectively inhibits LTB4-mediated signaling pathways, which are implicated in inflammatory responses. This compound is valuable for research applications focused on studying inflammation, immune response modulation, and related therapeutic interventions. -
Leukotriene Receptor Antagonist
YM158 free base is a potent and selective antagonist of the leukotriene D4 (LTD4) and thromboxane A2 (TXA2) receptors, exhibiting pA2 values around 8.87 and 8.81, respectively. This compound effectively modulates inflammatory responses and is valuable for research applications related to respiratory diseases, cardiovascular conditions, and allergy-related studies. Its specificity makes it an important tool for examining the roles of leukotriene and thromboxane signaling in various biological processes. -
Leukotriene Receptor Inhibitor
Bunaprolast is a potent leukotriene receptor inhibitor that effectively reduces LTB4 production in human whole blood. Additionally, it demonstrates significant inhibition of lipoxygenase activity and TXB2 release. This compound is valuable for research applications related to inflammatory diseases and respiratory conditions. -
Leukotriene Receptor Inhibitor
LTB4-IN-1 is a selective leukotriene receptor inhibitor, effectively blocking leukotriene B4 synthesis with an IC50 of 70 nM. This compound serves as a valuable tool for research in inflammation and immune response, potentially aiding in the investigation of leukotriene-mediated pathophysiological conditions. Its application can extend to studies focused on cellular signaling and therapeutic interventions targeting leukotriene pathways.
