Catalog No.
Product Name
Application
Product Information
Citations
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ADC Linker
Desthiobiotin-Iodoacetamide functions primarily as an antibody-drug conjugate (ADC) linker, facilitating targeted drug delivery in therapeutic applications. It exhibits a strong affinity for biotin-binding proteins, making it useful in the labeling and detection of proteins in various biological assays. Additionally, this compound can be utilized as a probe for studying Oridonin-treated cell lysis, enhancing the understanding of cellular responses in drug treatment studies. -
Labling Agent
DOTA-NHS-ester is a labeling agent that facilitates the conjugation of affibody molecules for applications in molecular imaging. It is commonly utilized in small animal positron emission tomography (PET), single-photon emission computed tomography (SPECT), and computed tomography (CT). This reagent effectively labels radiotherapeutic agents or imaging probes, aiding in the detection and characterization of tumors. -
Azide Compound
15-Azido-pentadecanoic acid is an azide-containing compound widely utilized in click chemistry applications. This reagent is particularly effective for labeling and characterizing post-translationally palmitylated proteins through a straightforward two-step labeling process. Additionally, it can engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-functionalized molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, providing versatile approaches for conjugation in chemical biology research. -
ADC Linker
N-Hydroxysulfosuccinimide sodium serves as a non-cleavable linker for antibody-drug conjugates (ADCs). By enabling stable covalent attachment of cytotoxic drugs to antibodies, it plays a crucial role in enhancing targeted cancer therapy. This reagent is widely utilized in the development and optimization of ADC formulations for improved therapeutic efficacy. -
PROTAC Linker
Azido-PEG2-C2-amine is a PEG-based linker designed for use in PROTAC synthesis. This compound features an azide moiety that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions, facilitating conjugation with alkyne-bearing molecules. Additionally, Azido-PEG2-C2-amine serves as a non-cleavable linker for the development of antibody-drug conjugates (ADCs), making it a versatile tool in chemical biology and drug discovery applications. -
ADC Linker
N3-PEG4-C2-NHS ester is a non-cleavable 4-unit polyethylene glycol (PEG) linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN functionalities. Due to its unique properties, N3-PEG4-C2-NHS ester is a valuable tool for the development of targeted therapeutics. -
ADC Linker
Maleimide-DOTA is a non-cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). It facilitates stable attachment of therapeutic agents to antibodies, ensuring effective delivery to target cells while maintaining the drug's biological activity. This compound plays a crucial role in ADC development for targeted cancer therapies and related research applications. -
ADC Linker
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This linker facilitates the selective release of cytotoxic agents in targeted cancer therapies, enhancing therapeutic efficacy while minimizing off-target effects. Its structured design supports optimal stability and effective drug delivery, making it a valuable component in ADC research and development. -
Click Chemistry Reagent
3-Azidopropylamine is a click chemistry reagent designed for efficient bioconjugation through its azide functional group. It facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and ring strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules, including those with DBCO or BCN groups. This reagent is particularly useful in applications involving complexation and transfection of plasmid DNA, making it valuable for molecular biology and materials science research. -
ADC Linker
Fmoc-NH-PEG4-CH2CH2COOH is a cleavable linker designed for antibody-drug conjugates (ADCs), facilitating the targeted delivery of cytotoxic agents to cancer cells. This compound serves as a PEG-based PROTAC linker, enabling the construction of proteolysis-targeting chimeras (PROTACs) for efficient degradation of specific proteins in various biological contexts. It is suitable for applications in drug development and biochemical research, particularly in the fields of oncology and targeted therapeutics. -
ADC Linker
6-Azido-hexylamine is a versatile cleavable linker utilized in the development of antibody-drug conjugates (ADCs). It features an azide functional group that participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. This compound is essential for the precise attachment of cytotoxic agents to antibodies, facilitating targeted cancer therapies. -
ADC Linker
DBCO-PEG4-Maleimide is a non-cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling efficient conjugation. It is essential for applications in targeted drug delivery, enhancing the therapeutic efficacy of ADCs while minimizing off-target effects. -
ADC Linker
Mal-PEG4-NHS ester is a non-cleavable ADC linker that facilitates the conjugation of biomolecules, particularly linking Quantum dots (QDs) with PEGylated liposomes. This compound exhibits key biological activity by enhancing the stability and solubility of the assembled conjugates. It is primarily utilized in antibody-drug conjugate (ADC) development, nanomedicine, and for improving drug delivery systems in research applications. -
ADC/PROTAC Linker
DBCO-PEG5-NHS ester is a cleavable linker designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. This PEG/alkyl/ether-based reagent facilitates the formation of stable covalent bonds through strain-promoted alkyne-azide cycloaddition (SPAAC), targeting azide-functionalized molecules. Its defined structure enhances the efficacy and specificity of therapeutic compounds, making it a valuable tool for researchers in the development of targeted therapies. -
ADC Linker
Fmoc-3VVD-OH is a cleavable linker employed in the synthesis of antibody-drug conjugates (ADCs). This compound facilitates the stable attachment of cytotoxic agents to antibodies, enabling targeted delivery to cancer cells. Its hydrolyzable nature allows for efficient release of the drug in the desired cellular environment, making it a valuable tool in cancer research and therapeutic development. -
ADC Linker
Gly-Gly-Gly-PEG4-DBCO is a polyethylene glycol (PEG) linker designed for use in antibody-drug conjugates (ADCs). Featuring a dibenzocyclooctyne (DBCO) functional group, this compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-bearing compounds. Its high stability and efficiency make it an essential tool in the development of targeted therapeutics for improved delivery of cytotoxic drugs. -
ADC Linker
Fmoc-8-amino-3,6-dioxaoctanoic acid is a cleavable linker primarily utilized in the development of antibody-drug conjugates (ADCs). Its PEG-based structure also allows for incorporation in the synthesis of PROTACs (proteolysis-targeting chimeras), facilitating targeted degradation of specific proteins. This reagent provides a functional handle for the attachment of theranostic payloads, enhancing the efficacy and specificity of therapeutic agents in chemical biology research. -
Click Chemistry Reagent
Azidoacetic Acid is a versatile click chemistry reagent characterized by its azide group functionality. It serves as a valuable tool for the synthesis of protein-targeting chimeras, such as PROTACs. Azidoacetic Acid can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds, as well as ring strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN moieties, enabling the rapid assembly of bioconjugates and labeled biomolecules for various research applications. -
Click Chemistry Reagent
Kdo Azide is a click chemistry reagent that features an azide functional group, allowing it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkynyl compounds. Additionally, Kdo Azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions in the presence of DBCO or BCN moieties. This reagent is valuable for metabolic labeling applications and various bioconjugation strategies in chemical biology research. -
ADC Linker
β-D-glucuronide-pNP-carbonate is a cleavable linker specifically designed for use in antibody-drug conjugates (ADCs). It facilitates the release of cytotoxic drugs in targeted therapeutic applications, thereby enhancing the efficacy of treatment while minimizing off-target effects. This compound is valuable for researchers focusing on the development of ADCs aimed at improving precision in cancer therapies and other diseases. -
ADC Linker
Fmoc-Gly-NH-CH2-acetyloxy is a cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). This compound facilitates the stable attachment of cytotoxic drugs to antibodies while allowing for selective release in target cells. Its application is critical in developing advanced therapeutics that improve the efficacy and safety of cancer treatments through targeted drug delivery. -
ADC Linker
Maleimide is a versatile compound primarily utilized as an ADC linker in cancer research. It is instrumental in the development of antibody-drug conjugates, facilitating targeted delivery of cytotoxic agents to cancer cells. Additionally, Maleimide can be employed in the synthesis of fluorogenic probes, enabling the specific detection and quantification of thiol-containing analytes in various biological samples. -
PROTAC Linkers
Bromo-PEG2-C2-azide is a versatile PROTAC linker featuring a bromo group and an azide moiety, designed for the synthesis of antibody-drug conjugates (ADCs) and PROTACs. This compound functions effectively in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, Bromo-PEG2-C2-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups, making it a valuable tool for targeted protein degradation and bioconjugation strategies in chemical biology research. -
ADC Linker
Mal-PEG2-NHS ester is a non-cleavable antibody-drug conjugate (ADC) linker that features a maleimide group, a two-unit polyethylene glycol (PEG) spacer, and an N-hydroxysuccinimide (NHS) ester. This compound is essential for the efficient conjugation of cytotoxic agents to antibodies, facilitating targeted delivery in cancer therapy. Mal-PEG2-NHS ester enhances the stability and solubility of ADCs, making it suitable for research applications in drug development and discovery. -
ADC Linker
DBCO-Maleimide is a non-cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). As a click chemistry reagent, it features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This property enables seamless conjugation and enhances the therapeutic efficacy of ADCs, making DBCO-Maleimide an essential tool in bioconjugation and targeted drug delivery research. -
ADC Linker
Boc-NH-PEG4-CH2CH2NH2 is a cleavable five-unit polyethylene glycol (PEG) linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This linker facilitates the conjugation of therapeutic agents to antibodies, enhancing target specificity and therapeutic efficacy. Additionally, Boc-NH-PEG4-CH2CH2NH2 serves as a PEG-based linker in the development of PROTACs, contributing to the targeted degradation of proteins in various research applications. -
PROTAC Linker
Azido-PEG4-C2-acid is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) applications. It serves as a non-cleavable linker in the synthesis of antibody-drug conjugates (ADCs) and is integral to the development of compounds such as vRucaparib-TP4. This compound features an azide group that enables the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne-containing molecules, and it also facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile reagent for chemical biology research. -
ADC Linker
Fmoc-Gly-Gly-Phe-OH is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This compound facilitates the selective release of therapeutic agents in targeted cancer treatment, enhancing the efficacy of the conjugated drug while minimizing systemic exposure. Its utility in ADC formulation makes it a valuable tool for researchers developing innovative cancer therapeutics. -
ADC Linker
MAC glucuronide linker-2 is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This linker facilitates the targeted delivery of cytotoxic agents to tumor cells, allowing for enhanced efficacy while minimizing off-target effects. It is particularly valuable in research applications focused on ADC development and optimization, contributing to advancements in targeted cancer therapies. -
ADC Linkers
Azido-PEG8-NHS ester is a cleavable 8-unit polyethylene glycol (PEG) linker designed for use in antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that enables it to participate in click chemistry, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules. Its unique properties make it valuable for the efficient synthesis of ADCs and the development of novel PROTACs. -
ADC Linker
N3-PEG2-C2-NHS ester is a non-cleavable 2-unit PEG linker designed for the synthesis of antibody-drug conjugates (ADCs). Featuring an azide functional group, it serves as a click chemistry reagent capable of facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, N3-PEG2-C2-NHS ester participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool for conjugation applications in bioconjugate chemistry. -
ADC Linker
N3-C5-NHS ester is a noncleavable ADC linker designed for the synthesis of antibody-drug conjugates (ADCs). It features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified compounds. This reagent is essential for enhancing the efficacy and specificity of targeted therapeutic agents in chemical biology research. -
ADC/PROTAC Linker
Bis-PEG9-NHS ester is a polyethylene glycol (PEG)-based linker designed for use in antibody-drug conjugates (ADCs) and PROTACs (proteolysis-targeting chimeras). This cleavable linker facilitates the attachment of drugs to antibodies, enhancing selective delivery and activity. Its application in PROTAC synthesis allows for targeted protein degradation, making it a valuable tool in drug discovery and development. -
ADC Linker
Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is an ADC linker designed for the synthesis of drug-linker conjugates in antibody-drug conjugate (ADC) applications. This compound facilitates the construction of targeted therapeutics, enhancing the specificity and efficacy of drug delivery. It is particularly relevant in the development of complex conjugates such as Deruxtecan, providing researchers with a reliable tool for advancing ADC-based therapies. -
ADC Linker
Gly-Gly-Gly-PEG4-azide is an ADC linker primarily used in the synthesis of antibody-drug conjugates (ADCs). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with bicyclo[6.1.0]nonyne (DBCO) or bicyclo[4.1.0]heptene (BCN) moieties, making it a versatile tool in chemical biology research and drug development applications. -
PROTAC Linker
N3-PEG3-CH2CH2COOH is a PEG-based PROTAC linker that facilitates selective protein degradation by enabling the synthesis of specific PROTACs, including BI-3663 and BI-4216. This compound contains an azide group, allowing it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne, DBCO, or BCN-containing molecules. N3-PEG3-CH2CH2COOH is also applicable as a non-cleavable ADC linker in the development of antibody-drug conjugates, making it a versatile reagent for chemical biology research. -
ADC/PROTAC Linker
N-Boc-PEG1-bromide is a versatile cleavable linker targeting ADCs and PROTACs. This PEG/alkyl/ether-based reagent facilitates the synthesis of antibody-drug conjugates (ADCs) and enhances the design of proteolysis-targeting chimeras (PROTACs). Its unique properties allow for effective conjugation and release mechanisms, making it suitable for various applications in chemical biology and drug development research. -
ADC Linkers
Propargyl-PEG1-NHS ester is a non-cleavable PEG linker designed for antibody-drug conjugation (ADC) applications. This reagent features an alkyne group that enables its use in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, facilitating efficient conjugation to azide-containing molecules. Its unique properties make it suitable for the synthesis of stable ADCs in research focused on targeted therapies and drug delivery systems. -
Click Chemical Agent
DBCO-PEG24-NHS ester is a click chemistry reagent designed for selective conjugation through the reaction with primary amines, such as lysine side chains or aminosilane-coated surfaces, under neutral to slightly basic conditions. The NHS ester facilitates the formation of a stable covalent bond, while the hydrophilic PEG spacer enhances water solubility and offers a flexible linkage that reduces steric hindrance during ligation. This compound is particularly suited for applications in bioconjugation and the development of targeted delivery systems. -
ADC linker
Fmoc-Val-Ala-PAB-PNP is a cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). This compound facilitates the effective attachment and release of cytotoxic agents upon internalization, enhancing targeted delivery to tumor cells. It is invaluable for research in ADC development, enabling studies focused on improving therapeutic efficacy and reducing off-target effects. -
ADC/PROTAC Linker
Bis-PEG5-NHS ester is a polyethylene glycol (PEG) based linker that targets protein degradation for the development of PROTACs (proteolysis targeting chimeras) and serves as a cleavable linker in antibody-drug conjugates (ADCs). This compound facilitates the conjugation of bioactive molecules with antibodies, enhancing the targeted delivery of therapeutic agents. Its versatile application in synthesizing both PROTACs and ADCs makes it valuable for advancing research in targeted therapies and drug delivery systems. -
PROTAC Linker
Amino-PEG4-alcohol is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This linker facilitates the assembly of heterobifunctional molecules and enables targeted degradation of proteins within cellular systems. Additionally, Amino-PEG4-alcohol serves as a non-cleavable 4-unit PEG linker for the development of antibody-drug conjugates (ADCs), enhancing the delivery of therapeutic agents. It is suitable for applications in chemical biology and drug development research. -
ADC Linker
Methyl azetidine-3-carboxylate hydrochloride is a non-cleavable linker for antibody-drug conjugates (ADCs) that facilitates the stable attachment of cytotoxic agents to antibodies. This compound also serves as an alkyl chain-based linker in the development of PROTACs (proteolysis-targeting chimeras), enabling targeted protein degradation. Its robust chemical properties make it essential for advancing research in targeted therapeutics and drug delivery systems. -
ADC Linker
Boc-Val-Cit-PAB-PNP is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This compound facilitates the selective release of therapeutic agents upon internalization, enhancing the efficacy of targeted cancer therapies. Its application extends to various research endeavors focused on developing and optimizing ADC formulations. -
ADC Linker
MAC glucuronide linker-1 is a cleavable linker specifically designed for antibody-drug conjugate (ADC) applications. It facilitates the targeted delivery of cytotoxic agents to cancer cells, enhancing therapeutic efficacy while minimizing off-target effects. This linker is suitable for various research applications, including the development and optimization of ADCs for cancer treatment. -
ADC Linker
DBCO-Sulfo-NHS ester sodium is an efficient ADC linker designed for the synthesis of antibody-drug conjugates (ADCs), facilitating targeted drug delivery. This reagent features a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its versatile coupling capabilities make it an essential tool for researchers developing novel therapeutics in cancer and other diseases. -
ADC Linker
Val-Cit-PAB-OSBT is a degradable ADC linker designed for antibody-drug conjugate applications. It consists of the polypeptide Val-Cit-PAB linked to OSBT moieties, enabling selective release of cytotoxic agents in targeted therapies. This compound facilitates precise drug delivery, enhancing the therapeutic index while minimizing off-target effects. Its applications include cancer research and the development of more effective targeted treatments. -
ADC Linker
Fmoc-NH-PEG8-CH2CH2COOH is a cleavable linker designed for antibody-drug conjugate (ADC) synthesis. This compound facilitates the conjugation of antibodies with therapeutic agents, enabling targeted drug delivery. Its unique structure supports efficient hydrolysis in the cellular environment, promoting the release of the drug at the site of action. Fmoc-NH-PEG8-CH2CH2COOH is essential for enhancing the efficacy and specificity of ADCs in cancer research and therapeutic development. -
ADC Linker
Boc-C16-COOH is a non-cleavable linker for the development of antibody-drug conjugates (ADCs), facilitating the stable attachment of cytotoxic agents to antibodies. Additionally, this alkyl chain-based compound serves as a versatile linker for the synthesis of PROTACs, enhancing targeted protein degradation applications. Its structural properties make it an essential component in advanced drug delivery and therapeutic strategies in chemical research. -
ADC Linker
Mal-PEG6-NHS ester is an ADC linker characterized by its Maleimide moiety, a six-unit polyethylene glycol (PEG) segment, and a N-hydroxysuccinimide (NHS) ester. This compound facilitates the conjugation of biomolecules by forming stable thioether bonds with cysteine residues, enhancing the delivery and efficacy of antibody-drug conjugates (ADCs). It is applicable in bioconjugation experiments and research aimed at developing targeted therapies.
