Azido-PEG8-NHS ester is a cleavable 8-unit polyethylene glycol (PEG) linker designed for use in antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that enables it to participate in click chemistry, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules. Its unique properties make it valuable for the efficient synthesis of ADCs and the development of novel PROTACs.
Azido-PEG8-NHS ester is a cleavable 8-unit polyethylene glycol (PEG) linker designed for use in antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that enables it to participate in click chemistry, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules. Its unique properties make it valuable for the efficient synthesis of ADCs and the development of novel PROTACs.
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