Catalog No.
Product Name
Application
Product Information
Citations
- QW24 is a potent anti-tumor compound that exerts its effects by downregulating the expression of BMI-1, a key oncogenic regulator involved in cancer stem cell maintenance and tumor progression. It has demonstrated significant efficacy in preclinical models and is being explored as a promising therapeutic agent for clinical research in colorectal cancer.
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Anti-Insect Agent
Methyl Eugenol is an anti-insect agent primarily effective against the oriental fruit fly (Bactrocera dorsalis). In addition to its insecticidal properties, Methyl Eugenol exhibits anti-cancer and anti-inflammatory activities, making it a versatile compound for biological research. It has been shown to induce autophagy in cells and can be utilized in studies related to intestinal ischemia/reperfusion injury. -
Iron Chelator
Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19. -
Autophagy Inhibitor
Reserpine acts as an inhibitor of vesicular monoamine transporter 2 (VMAT2), thereby influencing neurotransmitter storage and release. This compound is widely utilized in research studies focusing on autophagy inhibition and its implications in various neurodegenerative disorders. Additionally, reserpine's effects on monoamine levels make it a valuable tool in the investigation of psychiatric conditions and the biochemical pathways involved in these diseases. -
Autophagy Inhibitor
Leonurine is an alkaloid derived from Leonurus artemisia, functioning predominantly as an autophagy inhibitor. This compound exhibits notable antioxidative and anti-inflammatory properties, making it valuable for research focused on cellular stress responses and neuroprotection. Its ability to modulate autophagy can be explored in studies related to aging, neurodegenerative diseases, and inflammation-related conditions. -
Apoptosis Inducer
Sanguinarine chloride is a benzophenanthridine alkaloid that functions as an apoptosis inducer primarily through the generation of reactive oxygen species (ROS). This compound is known to activate key signaling pathways, specifically JNK and NF-κB, facilitating programmed cell death. Sanguinarine chloride is widely utilized in cancer research and studies investigating apoptotic mechanisms. -
Topoisomerase I Inhibitor
Irinotecan hydrochloride is a potent inhibitor of topoisomerase I, an enzyme crucial for DNA replication and transcription. This compound exhibits significant anti-tumor activity, primarily in the treatment of colorectal cancers. Its mechanism involves the stabilization of the enzyme-DNA complex, leading to apoptosis in cancer cells. Irinotecan hydrochloride is widely utilized in cancer research to elucidate cellular response mechanisms and to develop novel therapeutic strategies. -
Apoptosis/Autophagy Inducer
Momordicine I is a cucurbitane-type triterpenoid that functions as an apoptosis and autophagy inducer. It effectively suppresses glioma growth by promoting apoptosis and disrupting mitochondrial oxidative phosphorylation. In head and neck cancer cells, Momordicine I inhibits glycolysis and lipid metabolism while stimulating autophagy. Additionally, it alleviates isoproterenol-induced cardiomyocyte hypertrophy by suppressing PLA2G6 and DGK-ζ, offering cardiovascular benefits through the upregulation of nitric oxide and inhibition of angiotensin-converting enzyme (ACE). Momordicine I also shows potential in managing type 2 diabetes by inhibiting AKT1, IL-6, and SRC. -
Autophagy/Apoptosis Inducer
Autophagy Inducer 7 is an effective modulator of autophagy and apoptosis, primarily targeting the Akt/mTOR signaling pathway. This compound promotes autophagy by inhibiting pathway activity and downregulating associated proteins, leading to a reduction in DNA synthesis and inducing G0-G1 cell cycle arrest. Additionally, Autophagy Inducer 7 has demonstrated the ability to inhibit tumor cell proliferation, making it a valuable tool for research in cancer biology and therapeutic strategies involving autophagy. -
Apoptosis/Autophagy Inducer
Formosanin C is a diosgenin saponin that functions primarily as an apoptosis and autophagy inducer. It exhibits notable anti-tumor activities through mechanisms such as blocking the cell cycle, inhibiting metastasis, and promoting ferroptosis. Additionally, Formosanin C can suppress the NF-κB signaling pathway, providing anti-inflammatory effects while enhancing immune cell activity. This compound is relevant for research in anti-inflammatory, antifungal, and anti-cancer applications, particularly concerning lung, liver, breast, and colorectal cancers. -
Autophagy Inducer
(E,E)-Bisdemethoxycurcumin is an autophagy inducer derived from curcumin, exhibiting significant anti-inflammatory and anticancer properties. This compound has been shown to enhance cellular autophagy processes, making it a valuable tool for research into cancer biology and potential therapeutic strategies. Its ability to modulate inflammatory pathways also positions it as a candidate for studies relating to chronic inflammatory diseases. -
Autophagy Inducer
Loperamide hydrochloride is an opioid receptor agonist that functions primarily as an autophagy inducer. This compound selectively inhibits human intestinal carboxylesterases (hiCE), contributing to its anti-diarrheal properties. Its unique mechanism of action makes Loperamide hydrochloride a valuable reagent for studies related to gastrointestinal motility and autophagy modulation in various biological contexts. -
Autophagy Enhancer
Corynoxine is a tetracyclic oxindole alkaloid derived from Uncaria rhynchophylla, acting primarily as an autophagy enhancer. It promotes the clearance of alpha-synuclein through the Akt/mTOR signaling pathway, making it a valuable tool for investigating neurodegenerative diseases and related cellular mechanisms. Its ability to modulate autophagy positions Corynoxine as a significant research reagent for studies focused on cellular stress responses and neuroprotection. -
Autophagy Inducer
Diazoxide is an ATP-sensitive potassium channel activator that induces autophagy through modulation of cellular ion balance. This compound demonstrates potential therapeutic effects in conditions related to hyperinsulinism. It is commonly utilized in research applications focusing on autophagy pathways and metabolic regulation. -
REV-ERB/Autophagy Inhibitor
ARN5187 trihydrochloride is a selective REV-ERBβ ligand that functions as an autophagy inhibitor. It exerts dual inhibitory effects on REV-ERB-mediated transcription and autophagy processes, demonstrating significant lysosomotropic properties. Additionally, ARN5187 trihydrochloride can induce apoptosis, making it a valuable tool for research in cellular metabolism and programmed cell death. Its biological activity positions it as a critical reagent for studies investigating the interplay between autophagy and transcriptional regulation. -
Autophagy Inducer
Physalin B is a potent autophagy inducer derived from Cape gooseberry, known for its steroidal properties. It has been shown to induce cell cycle arrest and promote apoptosis in breast cancer cells by modulating the p53-dependent apoptotic pathway. Additionally, Physalin B inhibits the ubiquitin-proteasome pathway and elicits an incomplete autophagic response in human colon cancer cells in vitro, making it a valuable tool for cancer research and the study of autophagic mechanisms. -
Autophagy Inhibitor
Autophagy-IN-1 is a selective autophagy and mitophagy inhibitor that operates by enhancing autophagic flux while obstructing the fusion of autophagosomes and lysosomes in cancer cells. This compound demonstrates significant biological activity by inducing apoptosis and facilitating cell cycle arrest. Research applications include investigating its effects on tumor growth, particularly in colorectal cancer models, as evidenced by its ability to inhibit tumor growth in an HCT116 xenograft mouse model with minimal toxicity. -
Autophagy Inducer
Sanguinarine is a benzophenanthridine alkaloid that acts as an autophagy inducer. It is derived from the root of Sanguinaria canadensis and can stimulate apoptosis through the production of reactive oxygen species (ROS). The pro-apoptotic effects of sanguinarine are linked to the activation of the JNK and NF-κB signaling pathways, making it a valuable tool for research in cancer biology and cellular stress responses. -
Autophagy Inducer
ZX-29 is a selective autophagy inducer that targets the ALK pathway, exhibiting potent inhibition with IC50 values of 2.1 nM, 1.3 nM, and 3.9 nM for wild-type ALK and its L1196M and G1202R mutations, respectively. This compound triggers apoptosis through the induction of endoplasmic reticulum stress while effectively overcoming resistance associated with ALK mutations. Additionally, ZX-29 promotes protective autophagy and demonstrates significant antitumor activity, making it a valuable tool for research into cancer therapies targeting the ALK signaling pathway. -
Autophagy Inducer
Quercetin-d5, a deuterated form of Quercetin, serves as an autophagy inducer by modulating key signaling pathways. This natural flavonoid enhances the activity of recombinant SIRT1 and exhibits inhibitory effects on phosphoinositide 3-kinases (PI3K), with IC50 values of 2.4 μM for PI3K γ, 3.0 μM for PI3K δ, and 5.4 μM for PI3K β. Quercetin-d5 is utilized in research applications exploring autophagy modulation and the consequences on cellular metabolism and longevity. -
Autophagy Inducer, NLRP3 Inhibitor
Britannin is an autophagy inducer and NLRP3 inflammasome inhibitor with an IC50 of 3.630 μM. It exhibits significant anti-inflammatory effects by disrupting the interaction between NLRP3 and NEK7, effectively preventing NLRP3 activation and assembly. Additionally, Britannin shows antitumor properties by inhibiting tumor cell proliferation through interference with the interaction of HIF-1α and Myc, leading to reduced PD-L1 expression and enhanced activity of cytotoxic T lymphocytes. This compound also promotes apoptosis and autophagy in liver cancer cells via activation of ROS-regulated AMPK, making it a valuable tool for research in anti-inflammatory and oncology studies. -
Autophagy Modulator
Tea polyphenol primarily functions as an autophagy modulator. It demonstrates significant biological activities, including antioxidant properties, anti-cancer effects, inhibition of cell proliferation, induction of apoptosis, and cell cycle arrest. Additionally, tea polyphenol plays a role in modulating carcinogen metabolism, making it a valuable reagent for research in cancer biology and cellular physiology. -
Autophagy Inducer
Soyasapogenol B is an autophagy inducer derived from soy. It enhances autophagy and promotes apoptosis, contributing to its anti-inflammatory, antioxidant, and antitumor effects. This compound is valuable for research applications focused on cancer biology and the regulation of cellular processes linked to autophagy and inflammation. -
Apoptosis Inducer/Autophagy Inhibitor
Kumatakenin is a potent apoptosis inducer and autophagy inhibitor that targets ATG5 with a Kd value of 2.94 μM. It effectively enhances the activity of caspases 3, 8, and 9, leading to caspase-dependent apoptosis in ovarian cancer cells while modulating chemokines and pro-oncogenic factors. Kumatakenin also reduces M2 macrophage polarization, inhibits tumor progression in esophageal cancer by targeting FASN, and interacts with Eno3 to mitigate ferroptosis and alleviate intestinal inflammation. This compound is valuable for studies in ovarian cancer, esophageal cancer, depression, and colitis research. -
Autophagy Inducer
Bigelovin is a sesquiterpene lactone derived from Inula hupehensis, functioning as a selective agonist of the retinoid X receptor α. It induces autophagy and apoptosis, effectively suppressing tumor growth through the inhibition of the mTOR pathway, which is modulated by reactive oxygen species (ROS) generation. This compound is valuable for research applications focused on cancer biology and the mechanisms of autophagy modulation. -
Autophagy Inducer
ZPCK is a proagent of gemcitabine that functions as an autophagy inducer. It is designed to enhance oral bioavailability, facilitating more efficient delivery in research applications. ZPCK is relevant for studies exploring cancer therapies that utilize autophagy modulation to improve treatment outcomes. -
REV-ERB/Autophagy Inhibitor
ARN5187 is a lysosomotropic ligand targeting REV-ERBβ, known for its dual inhibitory effects on REV-ERB-mediated transcriptional regulation and autophagy. This compound exhibits significant lysosomotropic potency and has cytotoxic properties, leading to the induction of apoptosis. ARN5187 serves as a valuable tool for research into the mechanisms of autophagy and the role of REV-ERBβ in cellular processes. -
Autophagy Inducer
SGI-1776 is a selective inhibitor of Pim kinases, exhibiting IC50 values of 7 nM for Pim-1, 363 nM for Pim-2, and 69 nM for Pim-3. This compound has been identified as an autophagy inducer, showcasing potential mechanisms in cellular pathways associated with cancer and metabolic disorders. SGI-1776 is employed in research applications focusing on the modulation of cell survival and proliferation, making it a valuable tool for investigating therapeutic strategies targeting the Pim kinase signaling network. -
Autophagy Inhibitor
IITZ-02 is a lysosomotropic autophagy inhibitor that disrupts lysosomal function, leading to impaired autophagosomal degradation and increased autophagosome accumulation. This compound induces apoptosis through a mitochondria-mediated pathway by abolishing mitochondrial membrane potential. IITZ-02 exhibits potent antitumor activity in MDA-MB-231 xenograft mouse models, making it a valuable tool for cancer research applications focusing on the regulation of autophagy. -
Autophagy Inhibitor
Erythrabyssin II is a potent late-stage autophagy inhibitor that selectively inhibits the fusion of autophagosomes and lysosomes. This compound promotes the accumulation of autophagic substrates without disrupting lysosomal pH or enzyme activity. Erythrabyssin II has demonstrated efficacy in suppressing ovarian cancer organoid growth and inducing apoptosis, making it a valuable tool for research in ovarian cancer studies. -
Autophagy Inhibitor
EAD1 TFA is an autophagy inhibitor that plays a critical role in the regulation of plant growth and development, particularly in maize. This compound is preferentially expressed in the xylem of immature corn ears, where it facilitates the transport of malic acid. Its function is essential for proper ear length and kernel development, with alterations in EAD1 TFA expression correlating with changes in malic acid content. EAD1 TFA represents a valuable tool for researchers investigating the genetic basis of crop yield improvement. -
Autophagy Inducer
Imipramine-d4-1 is a deuterated derivative of Imipramine, primarily targeting autophagy induction. It exhibits significant antitumor activity through inhibition of Fascin1 and has a notable effect on serotonin transporter with an IC50 value of 32 nM. In cellular assays, Imipramine-d4-1 has been shown to stimulate autophagy in U-87MG glioma cells and induce apoptosis in HL-60 cells. Additionally, it demonstrates neuroprotective and immunomodulatory properties, making it valuable for various research applications in cancer biology and neurobiology. -
Autophagy Enhancer
IR-58 is a mitochondria-targeting near-infrared fluorophore that enhances autophagy. It effectively induces apoptosis in tumor cells by promoting excessive autophagy through the activation of the reactive oxygen species (ROS)-Akt-mTOR signaling pathway. This compound is valuable for research applications focused on cancer biology, autophagy modulation, and therapeutic development. -
Autophagy Inducer
Autophagy Inducer 2 is a potent activator of autophagy, primarily targeting cellular mechanisms involved in this critical survival process. It demonstrates significant antiproliferative effects on MCF-7 breast cancer cells, with an IC50 value of 1.31 μM, and markedly reduces colony formation in these cells. By modulating cell-cycle-related proteins such as Cdk-1 and Cyclin B1, Autophagy Inducer 2 effectively induces cell cycle arrest in the G2/M phase. This compound offers valuable insights for research in breast cancer therapy and the regulation of autophagy. -
Autophagy Inhibitor
Leonurine hydrochloride is an alkaloid derived from Leonurus artemisia, acting primarily as an autophagy inhibitor. This compound exhibits notable anti-oxidative and anti-inflammatory properties, making it a valuable tool for research into cellular stress responses and inflammatory processes. It is particularly useful for studying the implications of autophagy modulation in various biological contexts, including neurodegenerative diseases and cancer. -
Autophagy Activator
Autophagy activator-1 is an autophagy enhancer that promotes the autophagic process by downregulating significant members of the HSP70 family while simultaneously activating the unfolded protein response. This compound serves as a valuable tool in research focused on cellular degradation pathways, protein homeostasis, and conditions associated with autophagy dysregulation. Its application extends to studies involving neurodegenerative diseases, cancer biology, and metabolic disorders. -
Autophagy Inducer
SR-3677 dihydrochloride is a selective inhibitor of Rho-associated coiled-coil containing protein kinase I (ROCK-I) and II (ROCK-II), exhibiting IC50 values of 56 nM and 3 nM, respectively. This compound serves as an autophagy inducer, promoting cellular degradation pathways that can enhance cell survival and homeostasis. It is particularly useful in research focused on cancer, neurodegenerative diseases, and metabolic disorders, where modulation of autophagy may offer therapeutic benefits. -
Autophagy Inducer
Dehydropachymic acid is a triterpene derived from Poria cocos, functioning primarily as an autophagy inducer. It has demonstrated enhanced efficacy in promoting the autophagy-lysosome pathway in cells with impaired autophagic processes compared to normal cells. This compound is valuable for research applications focused on autophagy modulation and cellular homeostasis. -
Autophagy Inhibitor/Purinergic Receptors Antagonist
Indophagolin is a potent autophagy inhibitor targeting purinergic receptors, demonstrating an IC50 of 140 nM. It effectively antagonizes the P2X4, P2X1, and P2X3 receptors with IC50 values of 2.71, 2.40, and 3.49 μM, respectively. Additionally, Indophagolin inhibits Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors, with IC50s ranging from 3.4 to 15.4 μM. It exhibits strong antagonistic effects on the serotonin receptor 5-HT6 (IC50=1.0 μM) and moderate effects on multiple serotonin receptors, making it a valuable tool for research into autophagy and neurological pathways. -
Autophagy Inhibitor
Autogramin-1 is a potent autophagy inhibitor that effectively suppresses autophagic processes triggered by nutrient deprivation or mTORC1 inhibition. With an IC50 of 0.17 μM against starvation-induced autophagy and 0.44 μM against Rapamycin-induced autophagy, it serves as a valuable tool for researching the role of autophagy in cellular processes and disease models. This compound provides insights into autophagic regulation and its implications in various cancer and neurodegenerative studies. -
Autophagy Inhibitor
NEO214 is an autophagy inhibitor that acts by preventing autophagy-lysosome fusion, effectively blocking autophagic flux. This compound, a covalent conjugate of the PDE4 inhibitor Rolipram and perillyl alcohol, exhibits anti-cancer activity and is capable of penetrating the blood-brain barrier. Its mechanism involves the activation of mTOR and aggregation of the transcription factor EB (TFEB), promoting the death of glioma cells. NEO214 may provide a strategy to combat chemotherapy resistance in glioblastoma. -
Autophagy Inducer
(Rac)-BL-918 is a potent autophagy inducer that activates UNC-51-like kinase 1 (ULK1). This compound facilitates cytoprotective autophagy, making it a valuable tool for research focused on neurodegenerative diseases, particularly Parkinson's disease. Its ability to modulate autophagy pathways offers insights into therapeutic strategies for enhancing neuronal survival and function. -
Autophagy Inducer
Autophagy Inducer 4 is a Mannich base derivative of Magnolol that promotes autophagy. This compound exhibits significant anticancer properties by enhancing autophagy, leading to suppression of cancer cell viability, particularly with a 76-fold increase in cytotoxicity against T47D cells compared to Magnolol. Additionally, Autophagy Inducer 4 demonstrates inhibitory effects on the migration of T47D and HeLa cancer cells, making it a valuable reagent for cancer research. -
Antioxidant/Autophagy Enhancer
Thonningianin B is an antioxidant that enhances autophagy. This compound is known for its role in mitigating oxidative stress and promoting cellular renewal processes. Its ability to modulate autophagy pathways makes it a valuable reagent for research in fields such as neuroprotection, cancer biology, and age-related diseases. Thonningianin B may facilitate studies aimed at understanding the interplay between oxidative stress and cellular homeostasis. -
Autophagy Inducer
Desethylamiodarone hydrochloride is a significant active metabolite of Amiodarone, primarily functioning as an autophagy inducer. It is produced through the action of CYP3A isoenzymes and plays a critical role in cellular processes affecting autophagy. This compound is utilized in research applications focusing on cardiovascular pharmacology and cellular stress responses, due to its influence on potassium channels and potential therapeutic implications in arrhythmias. -
Autophagy Inducer
Glaucocalyxin B is an ent kaurane diterpenoid that acts as an autophagy inducer. This compound has demonstrated significant anticancer and antitumor properties, effectively reducing the growth of HL-60 cells with an IC50 of approximately 5.86 μM after 24 hours. Its mechanism and biological activity make it a valuable tool for research in cancer biology and therapeutic development. -
Autophagy Inhibitor
CUR5g is a selective autophagy inhibitor that targets the fusion of autophagosomes and lysosomes. By inhibiting the recruitment of STX17 to autophagosomes through a UVRAG-dependent mechanism, CUR5g effectively disrupts the degradation of autophagic substrates in cancer cells. This compound enhances the anticancer efficacy of Cisplatin in both in vitro and in vivo models, making it a valuable tool for studying autophagy's role in cancer treatment and potential therapeutic synergies. -
Autophagy Inducer
Atorvastatin-d5 sodium is a deuterium-labeled analog of atorvastatin, an oral HMG-CoA reductase inhibitor. This compound effectively lowers blood lipid levels and acts as an autophagy inducer. It has been shown to inhibit human smooth muscle cell proliferation and invasion, with IC50 values of 0.39 μM and 2.39 μM, respectively. Atorvastatin-d5 sodium is valuable for research applications related to lipid metabolism and cellular growth regulation. -
Autophagy Inducer
Paeonol-d3 is a deuterium-labeled derivative of Paeonol, serving as an autophagy inducer. It enhances the autophagic process, which is crucial for cellular homeostasis and survival under stress conditions. This reagent is primarily utilized in studies investigating autophagy-related pathways and their implications in various diseases. -
Autophagy Enhancer
Valechlorine is an iridoid that functions primarily as an autophagy enhancer. It demonstrates efficacy in mitigating fatty liver conditions by promoting the breakdown of lipid droplets through autophagy. This compound is particularly useful for research involving nonalcoholic fatty liver disease (NAFLD).
