Imipramine-d4-1 is a deuterated derivative of Imipramine, primarily targeting autophagy induction. It exhibits significant antitumor activity through inhibition of Fascin1 and has a notable effect on serotonin transporter with an IC50 value of 32 nM. In cellular assays, Imipramine-d4-1 has been shown to stimulate autophagy in U-87MG glioma cells and induce apoptosis in HL-60 cells. Additionally, it demonstrates neuroprotective and immunomodulatory properties, making it valuable for various research applications in cancer biology and neurobiology.
Imipramine-d4-1 is a deuterated derivative of Imipramine, primarily targeting autophagy induction. It exhibits significant antitumor activity through inhibition of Fascin1 and has a notable effect on serotonin transporter with an IC50 value of 32 nM. In cellular assays, Imipramine-d4-1 has been shown to stimulate autophagy in U-87MG glioma cells and induce apoptosis in HL-60 cells. Additionally, it demonstrates neuroprotective and immunomodulatory properties, making it valuable for various research applications in cancer biology and neurobiology.
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