Autophagy inducer 2

Catalog No.: A32191
Autophagy Inducer
Autophagy Inducer 2 is a potent activator of autophagy, primarily targeting cellular mechanisms involved in this critical survival process. It demonstrates significant antiproliferative effects on MCF-7 breast cancer cells, with an IC50 value of 1.31 μM, and markedly reduces colony formation in these cells. By modulating cell-cycle-related proteins such as Cdk-1 and Cyclin B1, Autophagy Inducer 2 effectively induces cell cycle arrest in the G2/M phase. This compound offers valuable insights for research in breast cancer therapy and the regulation of autophagy.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAutophagy Inducer 2 is a potent activator of autophagy, primarily targeting cellular mechanisms involved in this critical survival process. It demonstrates significant antiproliferative effects on MCF-7 breast cancer cells, with an IC50 value of 1.31 μM, and markedly reduces colony formation in these cells. By modulating cell-cycle-related proteins such as Cdk-1 and Cyclin B1, Autophagy Inducer 2 effectively induces cell cycle arrest in the G2/M phase. This compound offers valuable insights for research in breast cancer therapy and the regulation of autophagy.
Product Information
Catalog NumA32191
FormulaC41H58N6O
Molecular Weight650.94
CAS Number2684238-37-5
SMILESC[C@]12[C@@]([C@]3(C(C4=CC5=NC=CN=C5C(C)=C4C=C3)=CC1)C)(CC[C@@]6([C@@]2([H])C[C@@](C)(CC6)NC(N7CCN(C8CCN(CC8)C)CC7)=O)C)C
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