SGI-1776 is a selective inhibitor of Pim kinases, exhibiting IC50 values of 7 nM for Pim-1, 363 nM for Pim-2, and 69 nM for Pim-3. This compound has been identified as an autophagy inducer, showcasing potential mechanisms in cellular pathways associated with cancer and metabolic disorders. SGI-1776 is employed in research applications focusing on the modulation of cell survival and proliferation, making it a valuable tool for investigating therapeutic strategies targeting the Pim kinase signaling network.
SGI-1776 is a selective inhibitor of Pim kinases, exhibiting IC50 values of 7 nM for Pim-1, 363 nM for Pim-2, and 69 nM for Pim-3. This compound has been identified as an autophagy inducer, showcasing potential mechanisms in cellular pathways associated with cancer and metabolic disorders. SGI-1776 is employed in research applications focusing on the modulation of cell survival and proliferation, making it a valuable tool for investigating therapeutic strategies targeting the Pim kinase signaling network.
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