Catalog No.
Product Name
Application
Product Information
Citations
-
Torvoside H Derivative
26-Degluco-torvoside H is a furostanol glycoside derivative that serves as a modified form of Torvoside H. This compound is produced through the hydrolysis of Torvoside H by β-glucosidase derived from Solanum torvum leaves. It exhibits potential biological activities related to glycoside metabolism and can be utilized in various research applications, including the study of plant metabolites and their effects on biological systems. -
α-Glucosidase Inhibitor
Mortatarin G is a prenylated flavonoid that functions as an α-glucosidase inhibitor. It demonstrates significant inhibitory activity against α-glucosidase, with an IC50 value of 20.4±1.4 μM. This compound is useful for research applications focused on carbohydrate metabolism and potential therapeutic strategies for managing diabetes and related metabolic disorders. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-3 is an oleanolic acid oxime ester derivative that acts as an inhibitor of α-glucosidase, exhibiting an IC50 value of 0.35 µM. This compound also demonstrates inhibitory activity against α-amylase, making it a valuable tool for studies focused on carbohydrate metabolism. Its potential applications include investigating the mechanisms of diabetes management and exploring the therapeutic effects of glycosidase inhibition in metabolic disorders. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-28 is a potent α-glucosidase inhibitor, exhibiting an IC50 of 0.62 μM and a Ki of 3.93 μM. This compound selectively binds to the original binding site of α-glucosidase, engaging in multiple hydrophobic interactions with adjacent amino acids. α-Glucosidase-IN-28 is primarily utilized in research related to diabetes and its associated metabolic disorders, providing valuable insights into glucose regulation and enzyme modulation. -
Alpha-glucosidase Inhibitor
α-Glucosidase-IN-15 is a potent inhibitor of α-glucosidase, demonstrating an IC50 value of 3.34 μM. This compound exhibits significant antidiabetic activity by preventing the hydrolysis of carbohydrates, thereby reducing postprandial blood glucose levels. It is suitable for research applications focused on diabetes management and metabolic disorders. -
α-Glucosidase Product
Alglucosidase alfa is a recombinant human α-glucosidase that acts as a hydrolytic enzyme, targeting lysosomal glycogen metabolism. This reagent is primarily utilized in research related to Pompe disease, a glycogen storage disorder. It aids in elucidating the pathogenic mechanisms of the disease and evaluates potential therapeutic strategies aimed at restoring α-glucosidase activity and improving glycogen clearance. -
Antioxidant
Ferruginoside C is a phenylethanoid that exhibits potent antioxidant activity. Isolated from V. leiocarpum, it demonstrates significant alpha-glucosidase inhibitory properties with an IC50 of 19.93 μM. This compound is of interest in cancer research, particularly in studies related to cervical, ovarian, and colon cancers. Ferruginoside C serves as a valuable tool for exploring therapeutic strategies and understanding the mechanisms of oxidative stress in these cancer types. -
α-Glucosidase Inhibitor
Kouitchenside G is a natural inhibitor of α-Glucosidase, isolated from the plant Swertia kouitchensis. It demonstrates inhibitory activity with an IC50 value of 956 μM, making it a valuable tool for studying carbohydrate metabolism and enzyme modulation. This compound is pertinent for research applications focused on diabetes and metabolic disorders. -
α-Glucosidase Inhibitor
Resinacein L is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 0.635 mM. By impeding the digestion and absorption of carbohydrates in the gastrointestinal tract, Resinacein L effectively reduces postprandial blood glucose levels. This compound is valuable in research applications focused on diabetes management and the study of carbohydrate metabolism. -
Fusion Protein
Clervonafusp alfa is a fusion protein designed to target both cytosolic and lysosomal glycogen. It consists of the Fab portion of a cell-penetrating antibody that utilizes the nucleoside transporter ENT-2 for cytosolic access, along with recombinant human acid alpha-glucosidase (rhGAA) that enters lysosomes via mannose-6-phosphate receptors. This reagent is primarily used in research related to late-onset Pompe disease, facilitating studies on glycogen storage disorders and potential therapeutic approaches. -
β-Glucosidase Substrate
2-Nitrophenyl a-D-glucopyranoside serves as a substrate for the enzyme β-glucosidase. Its hydrolysis by β-glucosidase produces a yellow chromogenic product, allowing for the quantification of enzyme activity. This reagent is widely used in biochemical assays to study glycoside hydrolase activity and in research focused on carbohydrate metabolism. -
Glycosidase Inhibitor
Glycosidase-IN-1 is a glycosidase inhibitor derived from D-mannose. This compound exhibits hypoglycemic activity and holds potential for the synthesis of immunosuppressive agents and β-glucosidase inhibitors. Its ability to modulate glycosidase activity makes it a valuable tool in biochemical research focused on carbohydrate metabolism and related diseases. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-10 is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 92.7 μM. This compound serves as a valuable tool for investigating the modulation of carbohydrate metabolism and is particularly relevant for research in type II diabetes. Its ability to effectively inhibit α-glucosidase makes it suitable for studies focused on glucose absorption regulation and diabetes management strategies. -
α-glucosidase Inhibitor
Bisabolone oxide A is an α-glucosidase inhibitor that modulates carbohydrate metabolism by delaying the absorption of glucose in the intestine. This compound demonstrates significant potential in research applications related to diabetes management and glycemic control. Its ability to influence α-glucosidase activity makes it a valuable tool for studies focused on metabolic disorders and enzymatic regulation. -
Alpha-glucosidase Inhibitor
α-Glucosidase-IN-17 is a potent inhibitor of α-glucosidase, displaying an IC50 value of 3.79 μM. This compound demonstrates significant antidiabetic activity, making it a valuable research tool for studying the regulation of carbohydrate metabolism and the management of diabetes. It can be utilized in pharmacological studies aimed at exploring the modulation of blood glucose levels. -
α-glucosidase Inhibitor
α-Glucosidase-IN-21 is a potent inhibitor of α-glucosidase, demonstrating an IC50 of 2.62 μM. This compound exhibits significant anti-diabetic activity, making it valuable for research into glycemic control and obesity-related metabolic disorders. Its efficacy as an α-glucosidase inhibitor supports its use in studies targeting carbohydrate metabolism and related therapeutic applications. -
α-glucosidase Inhibitor
α-Glucosidase-IN-20 is a potent orally active inhibitor of α-glucosidase, with an IC50 value of 3.01 μM. This compound demonstrates significant anti-diabetic activity by modulating carbohydrate metabolism and reducing postprandial glucose levels. It is suitable for research applications aimed at exploring therapeutic strategies for managing type 2 diabetes and related metabolic disorders. -
α-glucosidase Inhibitor
(+)-Cembrene A is an α-glucosidase inhibitor, exhibiting an IC50 of 30.31 μM. This compound demonstrates nontoxicity towards human normal hepatocyte (LO2) cells, making it a suitable candidate for research in metabolic disorders and carbohydrate metabolism regulation. Its ability to modulate α-glucosidase activity suggests potential applications in studies focused on diabetes and related pathophysiological conditions. -
Glucosidase Inhibitor
Afegostat tartrate is a potent glucosidase inhibitor that selectively binds to acid-β-glucosidase (GCase) within the endoplasmic reticulum, functioning as a pharmacological chaperone. This compound enhances enzyme stability and promotes proper folding, making it valuable for research related to Gaucher disease and other lysosomal storage disorders. Its ability to influence GCase activity makes it an important tool for studies aimed at understanding enzyme deficiencies and developing therapeutic strategies. -
Natural Products
α-Glucosidase-IN-35 is a chromene that functions as a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 0.169 mg/mL. Isolated from the aqueous extract of the aerial parts of Brickellia cavanillesii, this compound is valuable in studies targeting carbohydrate metabolism and diabetes research. Its application may facilitate the exploration of α-glucosidase inhibition as a therapeutic strategy in metabolic disorders. -
α-Glucosidase Inhibitor
Saponin QS-L1 is a triterpenoid saponin that acts as an α-glucosidase inhibitor, exhibiting an IC50 value of 23.1 μM. This compound is valuable for research into diabetes management and glucose regulation. Its inhibition of α-glucosidase may provide insights into therapeutic strategies for glycemic control in diabetic patients. -
alpha-Glucosidase Inhibitor
9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one is a mixed competitive inhibitor of alpha-glucosidase, primarily targeting the enzyme from Bacillus stearothermophilus, with an IC50 value of 3.86 mg/L. This compound exhibits potential as a phytoalexin, demonstrating biological activity relevant for research in glycemic control and carbohydrate metabolism. Its inhibitory properties make it suitable for studies investigating the modulation of glucose absorption and related metabolic disorders. -
Glycosidase Inhibitor
Panosialin wA is a potent glycosidase inhibitor that selectively targets α,β-glucosidase and mannose glycosidase. Its ability to modulate these enzymes may have applications in research related to carbohydrate metabolism and pathogen interaction. While Panosialin wA does not inhibit the influenza virus, it exhibits a weak anti-microbial effect, making it a useful tool in studies of microbial activity. -
α-Glucosidase Inhibitor
N-Methyltetrachlorophthalimide is a potent inhibitor of α-glucosidase, exhibiting an IC50 of 22.1 μM. This compound is valuable for research focused on anti-diabetic mechanisms as well as antiviral applications, enabling the exploration of therapeutic strategies against conditions related to glycemic control and viral infections. -
Active Compound
Afegostat TFA is a pharmacological chaperone that selectively and reversibly binds to acid-β-glucosidase (GCase) within the endoplasmic reticulum. This interaction enhances the stability and activity of GCase, addressing enzyme deficiencies associated with Gaucher disease. Afegostat TFA is utilized in research exploring enzyme therapy and cellular mechanisms of lysosomal storage disorders. -
Natural product
Sumaresinolic acid is a natural product extracted from the root of Heterophyllum species. Its primary mechanism involves the inhibition of alpha-glucosidase, an enzyme implicated in carbohydrate metabolism. This compound exhibits significant biological activity in regulating blood glucose levels, making it valuable for research in diabetes and metabolic disorders. Its potential applications extend to studies on glycemic control and the development of therapeutic agents targeting carbohydrate metabolism. -
α-Glucosidase inhibitor
α-Glucosidase-IN-45 is an inhibitor targeting α-glucosidase, a key enzyme involved in carbohydrate metabolism. This novel indol-fused pyrano[2,3-D]pyrimidine compound exhibits significant biological activity by obstructing the enzyme's function, thereby influencing glucose absorption and metabolism. It is suitable for research applications related to diabetes, metabolic disorders, and carbohydrate enzyme modulation. -
α-glucosidase Inhibitor
1'-O-Methyl neochebulinate is a hydrolyzable tannin that functions as an α-glucosidase inhibitor, exhibiting an IC50 value of 59.5 μM. Isolated from the fruits of Terminalia chebula Retz, this compound significantly impedes the activity of α-glucosidase, making it relevant for studies in diabetes management and carbohydrate metabolism. Its inhibitory properties provide a useful tool for investigating potential therapeutic strategies for controlling postprandial glucose levels. -
Stable Isotope
Acarbose-d4 is a deuterium-labeled derivative of Acarbose, targeting alpha-glucosidases. This stable isotope maintains the biological activity of its parent compound, functioning as an antihyperglycemic agent with an IC50 of 11 nM. Acarbose-d4 is utilized in research to study glucose metabolism and the enhancement of hypoglycemic effects in combination therapies involving sulfonylureas or insulin. -
Glucosidase Inhibitor
N-5-Carboxypentyl-1-deoxynojirimycin is an alpha-glucosidase inhibitor with significant potential in glycosidase research. This compound is utilized for its ability to selectively inhibit glucosidase enzymes, making it valuable in studies exploring carbohydrate metabolism and related pathways. Additionally, it serves as a precursor for the preparation of affinity matrices, facilitating the binding of target proteins to resins for purification and analysis. -
α-Glucosidase Inhibitor
Sativanone is a potent α-glucosidase inhibitor, exhibiting an EC50 value of 0.357 mg/mL for rat α-glucosidase. Isolated from Dalbergia tonkinensis, this compound demonstrates antibacterial activity against Ralstonia solanacearum. Additionally, Sativanone exhibits anti-senescent and antioxidant properties, making it a valuable reagent for research in metabolic disorders, bacterial infections, and oxidative stress-related studies. -
Glycosidase Inhibitor
Panosialin D is a glycosidase inhibitor that selectively targets α,β-glucosidase and mannose glycosidase. This compound does not exhibit activity against the influenza virus; however, it demonstrates weak antimicrobial properties. It serves as a valuable reagent for research focused on glycosidase-related pathways and antimicrobial studies. -
α-glucosidase Inhibitor
Enhydrin is a naturally occurring α-glucosidase inhibitor derived from the leaves of Smallanthus sonchifolius. It demonstrates potent inhibitory activity with an IC50 value of 34.17 μg/mL, making it relevant for the management of postprandial hyperglycemia. Research indicates that Enhydrin can effectively reduce blood glucose levels in diabetic rat models, supporting its potential application in diabetes research and therapy development. -
α-Glucosidase Inhibitor
Cembrene A is an α-glucosidase inhibitor derived from the soft coral S. crassa, demonstrating an IC50 value of 30.31 μM. This compound exhibits minimal cytotoxicity in human normal hepatocyte (LO2) cells, with an IC50 greater than 100 μM. Cembrene A is a valuable reagent for research focused on diabetes and the modulation of carbohydrate metabolism. -
Alpha-Glucosidase Inhibitor
Acarbose sulfate is a potent alpha-glucosidase inhibitor, exhibiting an IC50 of 11 nM. This antihyperglycemic agent is utilized in research to investigate its potential to enhance the hypoglycemic effects of sulfonylureas or insulin. Its mechanism of action involves the modulation of carbohydrate absorption, making it valuable in studies related to diabetes and blood glucose regulation. -
α-Glucosidase Inhibitor
Arisanschinin D is an inhibitor of α-Glucosidase, a critical enzyme involved in carbohydrate metabolism. This compound can be isolated from Schisandra arisanensis and is of particular interest for research in diabetes management and metabolic disorders. Its ability to modulate enzyme activity makes it a valuable tool for studying the effects of carbohydrate absorption and glucose homeostasis. -
Glycosidase Inhibitor
Cefetrizole is an α-Glucosidase inhibitor that exhibits potent enzymatic activity, with an IC50 of 2.1 μM and a Ki value of 0.578 μM. This compound is primarily utilized in research applications focused on carbohydrate metabolism and associated disorders. Its ability to inhibit glycosidase activity makes it a valuable tool for investigating enzymatic pathways and developing therapeutic strategies. -
α-Glucosidase Inhibitor
Glyurallin A is a potent α-glucosidase inhibitor, effectively isolated from Glycyrrhiza uralensis. With an IC50 value of 0.3 μM, it demonstrates significant inhibitory activity against α-glucosidase, making it a valuable compound for research on anti-diabetic mechanisms. Glyurallin A is suitable for studies focusing on glucose metabolism and potential therapeutic applications in diabetes management. -
α-Glucosidase Inhibitor
(6-O-p-Coumaroyl)-β-D-glucopyranosyl-2-O-(4-hydroxybenzoyl)-4-O-β-D-glucopyranosyl-6-hydroxyphenylacetate functions as a selective α-glucosidase inhibitor, exhibiting an IC50 of 10.53 μg/mL. This compound demonstrates significant anti-hepatic fibrosis and anti-diabetic activities, while also inhibiting the proliferation of mouse hepatic stellate cells (t-HSC/Cl-6) with an IC50 of 109.2 μg/mL. Isolated from the ester derivatives of Impatiens balsamina L. flowers, it serves as a valuable reagent for research focusing on hepatic fibrosis and type 2 diabetes. -
α-glucosidase
2,3-Indolobetulin is a pentacyclic triterpene and a derivative of betulin that acts as an α-glucosidase inhibitor. This compound demonstrates significant biological activity in modulating carbohydrate metabolism and is applicable in research focused on diabetes management and glycemic control. Its potential as a therapeutic agent in glucose regulation makes it valuable for studies on metabolic disorders. -
Endogenous Metabolite
Cedefingol is an endogenous metabolite that acts as an α-glucosidase inhibitor. This compound demonstrates antitumor properties and exhibits diverse bioactivities influenced by the fermentation time of dark tea samples. Additionally, cedefingol displays antioxidant activity, as evidenced by its effectiveness in the DPPH assay. Research applications include studies on metabolic pathways, enzymatic processes, and potential therapeutic effects in cancer research. -
Transglucosidase
Sucrose phosphorylase is a bacterial transglucosidase that facilitates the conversion of sucrose and phosphate into α-D-glucose-1-phosphate and D-fructose. This enzyme can also hydrolyze the glucosylated product into α-D-glucose or transfer the glucosyl moiety to hydroxyl groups of acceptors, leading to the formation of novel α-D-glucoside compounds. Sucrose phosphorylase exhibits specific enzymatic activity, making it valuable for applications in carbohydrate synthesis and bioconversion research. -
β-glycosidic linkage (between glucose and ceramide) Cleaver\nGlycosphingolipid Glycan Releaser\nEGCase II Conformational Stabilizer
Endoglycoceramidase II (EGCase II) is an endo-β-glucosidase that specifically cleaves β-glycosidic linkages between glucose and ceramide in glycosphingolipids. This enzyme catalyzes the hydrolysis of these linkages, thereby releasing intact glycans from ceramides. EGCase II is instrumental in glycosphingolipid research, facilitating the structural analysis and functional studies of glycoconjugates in various biological contexts. It serves as a valuable tool in understanding glycan-mediated cellular processes and their implications in health and disease. -
Degradative Product of Starch
Maltose monohydrate is a degradative product of starch and serves as a substrate for α-glucosidase, which hydrolyzes maltose into glucose. This compound plays a significant role in various biological processes, including carbohydrate metabolism. Additionally, maltose monohydrate demonstrates protective effects on proteins, membranes, and the photosynthetic electron transport chain under conditions of heat stress and freezing stress, making it valuable for research into stress responses in biological systems. -
Endogenous Metabolite
1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride is an endogenous metabolite that functions as an inhibitor of glycogen phosphorylase and α-glucosidases. This naturally occurring pyrrolidine alkaloid, isolated from Arachniodes standishii and Angylocalyx boutiqueanus, plays a critical role in carbohydrate metabolism. Its unique inhibitory properties make it valuable for research applications in studying metabolic disorders and enzyme regulation. -
Tyrosinase/α-glucosidase Inhibitor
Pedalitin is a dual inhibitor of tyrosinase (IC50 = 0.28 mM) and α-glucosidase (IC50 = 0.29 mM). This compound demonstrates significant biological activity in the regulation of melanin production and glucose metabolism. Pedalitin is suitable for research applications exploring skin pigmentation disorders and metabolic diseases. -
Metabolic Enzyme
Amyloglucosidase, derived from Aspergillus niger, is a metabolic enzyme that catalyzes the hydrolysis of starch into glucose. Its primary application lies in the saccharification of starch, making it essential for various industrial processes such as brewing and distilling. This enzyme enhances the efficiency of carbohydrate conversion and is valuable for researchers studying enzymatic activity and carbohydrate metabolism. -
Carbohydrate Hydrolyzing Enzyme
α-Glucosidase, Yeast is a carbohydrate hydrolyzing enzyme that catalyzes the release of α-glucose from the non-reducing end of carbohydrate substrates. This enzyme plays a crucial role in glucose absorption in the small intestine. Inhibition of α-glucosidase is a well-established strategy for the management of non-insulin-dependent diabetes mellitus (NIDDM), making it a valuable tool for biochemical research and therapeutic development targeting glycemic control. -
Anti-inflammatory Compound
Cuminaldehyde, a primary component of Cuminum cyminum, is recognized for its anti-inflammatory properties. This compound exhibits various biological activities, including inhibition of aldose reductase (IC50 = 0.00085 mg/mL), α-glucosidase (IC50 = 0.5 mg/mL), and lipoxygenase (IC50 = 1370 μM). Additionally, cuminaldehyde inhibits the fibrillation and aggregation of α-synuclein, indicating its potential application in the study of neurodegenerative diseases, cancer, diabetes, and neuropathic pain disorders. -
AChE Inhibitor
AChE-IN-20 is a potent acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 value of 397.32 nM and a Ki value of 335.76 nM. In addition to its primary target, AChE-IN-20 exhibits significant inhibitory activity against human carbonic anhydrases I and II, and α-glucosidase, with IC50 values of 84.14 nM, 69.24 nM, and 52.08 nM, respectively. This compound is valuable for research into neurodegenerative diseases and enzymatic regulation, providing insights into potential therapeutic strategies.
