Catalog No.
Product Name
Application
Product Information
Citations
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α-Glucosidase Product
Alglucosidase alfa is a recombinant human α-glucosidase that acts as a hydrolytic enzyme, targeting lysosomal glycogen metabolism. This reagent is primarily utilized in research related to Pompe disease, a glycogen storage disorder. It aids in elucidating the pathogenic mechanisms of the disease and evaluates potential therapeutic strategies aimed at restoring α-glucosidase activity and improving glycogen clearance. -
Antioxidant
Ferruginoside C is a phenylethanoid that exhibits potent antioxidant activity. Isolated from V. leiocarpum, it demonstrates significant alpha-glucosidase inhibitory properties with an IC50 of 19.93 μM. This compound is of interest in cancer research, particularly in studies related to cervical, ovarian, and colon cancers. Ferruginoside C serves as a valuable tool for exploring therapeutic strategies and understanding the mechanisms of oxidative stress in these cancer types. -
α-Glucosidase Inhibitor
Kouitchenside G is a natural inhibitor of α-Glucosidase, isolated from the plant Swertia kouitchensis. It demonstrates inhibitory activity with an IC50 value of 956 μM, making it a valuable tool for studying carbohydrate metabolism and enzyme modulation. This compound is pertinent for research applications focused on diabetes and metabolic disorders. -
α-Glucosidase Inhibitor
Resinacein L is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 0.635 mM. By impeding the digestion and absorption of carbohydrates in the gastrointestinal tract, Resinacein L effectively reduces postprandial blood glucose levels. This compound is valuable in research applications focused on diabetes management and the study of carbohydrate metabolism. -
Fusion Protein
Clervonafusp alfa is a fusion protein designed to target both cytosolic and lysosomal glycogen. It consists of the Fab portion of a cell-penetrating antibody that utilizes the nucleoside transporter ENT-2 for cytosolic access, along with recombinant human acid alpha-glucosidase (rhGAA) that enters lysosomes via mannose-6-phosphate receptors. This reagent is primarily used in research related to late-onset Pompe disease, facilitating studies on glycogen storage disorders and potential therapeutic approaches. -
β-Glucosidase Substrate
2-Nitrophenyl a-D-glucopyranoside serves as a substrate for the enzyme β-glucosidase. Its hydrolysis by β-glucosidase produces a yellow chromogenic product, allowing for the quantification of enzyme activity. This reagent is widely used in biochemical assays to study glycoside hydrolase activity and in research focused on carbohydrate metabolism. -
Glycosidase Inhibitor
Glycosidase-IN-1 is a glycosidase inhibitor derived from D-mannose. This compound exhibits hypoglycemic activity and holds potential for the synthesis of immunosuppressive agents and β-glucosidase inhibitors. Its ability to modulate glycosidase activity makes it a valuable tool in biochemical research focused on carbohydrate metabolism and related diseases. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-10 is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 92.7 μM. This compound serves as a valuable tool for investigating the modulation of carbohydrate metabolism and is particularly relevant for research in type II diabetes. Its ability to effectively inhibit α-glucosidase makes it suitable for studies focused on glucose absorption regulation and diabetes management strategies. -
α-glucosidase Inhibitor
Bisabolone oxide A is an α-glucosidase inhibitor that modulates carbohydrate metabolism by delaying the absorption of glucose in the intestine. This compound demonstrates significant potential in research applications related to diabetes management and glycemic control. Its ability to influence α-glucosidase activity makes it a valuable tool for studies focused on metabolic disorders and enzymatic regulation. -
Alpha-glucosidase Inhibitor
α-Glucosidase-IN-17 is a potent inhibitor of α-glucosidase, displaying an IC50 value of 3.79 μM. This compound demonstrates significant antidiabetic activity, making it a valuable research tool for studying the regulation of carbohydrate metabolism and the management of diabetes. It can be utilized in pharmacological studies aimed at exploring the modulation of blood glucose levels. -
α-glucosidase Inhibitor
α-Glucosidase-IN-21 is a potent inhibitor of α-glucosidase, demonstrating an IC50 of 2.62 μM. This compound exhibits significant anti-diabetic activity, making it valuable for research into glycemic control and obesity-related metabolic disorders. Its efficacy as an α-glucosidase inhibitor supports its use in studies targeting carbohydrate metabolism and related therapeutic applications. -
α-glucosidase Inhibitor
α-Glucosidase-IN-20 is a potent orally active inhibitor of α-glucosidase, with an IC50 value of 3.01 μM. This compound demonstrates significant anti-diabetic activity by modulating carbohydrate metabolism and reducing postprandial glucose levels. It is suitable for research applications aimed at exploring therapeutic strategies for managing type 2 diabetes and related metabolic disorders. -
α-glucosidase Inhibitor
(+)-Cembrene A is an α-glucosidase inhibitor, exhibiting an IC50 of 30.31 μM. This compound demonstrates nontoxicity towards human normal hepatocyte (LO2) cells, making it a suitable candidate for research in metabolic disorders and carbohydrate metabolism regulation. Its ability to modulate α-glucosidase activity suggests potential applications in studies focused on diabetes and related pathophysiological conditions. -
Glucosidase Inhibitor
Afegostat tartrate is a potent glucosidase inhibitor that selectively binds to acid-β-glucosidase (GCase) within the endoplasmic reticulum, functioning as a pharmacological chaperone. This compound enhances enzyme stability and promotes proper folding, making it valuable for research related to Gaucher disease and other lysosomal storage disorders. Its ability to influence GCase activity makes it an important tool for studies aimed at understanding enzyme deficiencies and developing therapeutic strategies. -
Natural Products
α-Glucosidase-IN-35 is a chromene that functions as a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 0.169 mg/mL. Isolated from the aqueous extract of the aerial parts of Brickellia cavanillesii, this compound is valuable in studies targeting carbohydrate metabolism and diabetes research. Its application may facilitate the exploration of α-glucosidase inhibition as a therapeutic strategy in metabolic disorders. -
α-Glucosidase Inhibitor
Saponin QS-L1 is a triterpenoid saponin that acts as an α-glucosidase inhibitor, exhibiting an IC50 value of 23.1 μM. This compound is valuable for research into diabetes management and glucose regulation. Its inhibition of α-glucosidase may provide insights into therapeutic strategies for glycemic control in diabetic patients. -
alpha-Glucosidase Inhibitor
9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one is a mixed competitive inhibitor of alpha-glucosidase, primarily targeting the enzyme from Bacillus stearothermophilus, with an IC50 value of 3.86 mg/L. This compound exhibits potential as a phytoalexin, demonstrating biological activity relevant for research in glycemic control and carbohydrate metabolism. Its inhibitory properties make it suitable for studies investigating the modulation of glucose absorption and related metabolic disorders. -
Glycosidase Inhibitor
Panosialin wA is a potent glycosidase inhibitor that selectively targets α,β-glucosidase and mannose glycosidase. Its ability to modulate these enzymes may have applications in research related to carbohydrate metabolism and pathogen interaction. While Panosialin wA does not inhibit the influenza virus, it exhibits a weak anti-microbial effect, making it a useful tool in studies of microbial activity. -
α-Glucosidase Inhibitor
N-Methyltetrachlorophthalimide is a potent inhibitor of α-glucosidase, exhibiting an IC50 of 22.1 μM. This compound is valuable for research focused on anti-diabetic mechanisms as well as antiviral applications, enabling the exploration of therapeutic strategies against conditions related to glycemic control and viral infections. -
Active Compound
Afegostat TFA is a pharmacological chaperone that selectively and reversibly binds to acid-β-glucosidase (GCase) within the endoplasmic reticulum. This interaction enhances the stability and activity of GCase, addressing enzyme deficiencies associated with Gaucher disease. Afegostat TFA is utilized in research exploring enzyme therapy and cellular mechanisms of lysosomal storage disorders. -
Natural product
Sumaresinolic acid is a natural product extracted from the root of Heterophyllum species. Its primary mechanism involves the inhibition of alpha-glucosidase, an enzyme implicated in carbohydrate metabolism. This compound exhibits significant biological activity in regulating blood glucose levels, making it valuable for research in diabetes and metabolic disorders. Its potential applications extend to studies on glycemic control and the development of therapeutic agents targeting carbohydrate metabolism. -
α-Glucosidase inhibitor
α-Glucosidase-IN-45 is an inhibitor targeting α-glucosidase, a key enzyme involved in carbohydrate metabolism. This novel indol-fused pyrano[2,3-D]pyrimidine compound exhibits significant biological activity by obstructing the enzyme's function, thereby influencing glucose absorption and metabolism. It is suitable for research applications related to diabetes, metabolic disorders, and carbohydrate enzyme modulation. -
α-glucosidase Inhibitor
1'-O-Methyl neochebulinate is a hydrolyzable tannin that functions as an α-glucosidase inhibitor, exhibiting an IC50 value of 59.5 μM. Isolated from the fruits of Terminalia chebula Retz, this compound significantly impedes the activity of α-glucosidase, making it relevant for studies in diabetes management and carbohydrate metabolism. Its inhibitory properties provide a useful tool for investigating potential therapeutic strategies for controlling postprandial glucose levels. -
Stable Isotope
Acarbose-d4 is a deuterium-labeled derivative of Acarbose, targeting alpha-glucosidases. This stable isotope maintains the biological activity of its parent compound, functioning as an antihyperglycemic agent with an IC50 of 11 nM. Acarbose-d4 is utilized in research to study glucose metabolism and the enhancement of hypoglycemic effects in combination therapies involving sulfonylureas or insulin. -
Glucosidase Inhibitor
N-5-Carboxypentyl-1-deoxynojirimycin is an alpha-glucosidase inhibitor with significant potential in glycosidase research. This compound is utilized for its ability to selectively inhibit glucosidase enzymes, making it valuable in studies exploring carbohydrate metabolism and related pathways. Additionally, it serves as a precursor for the preparation of affinity matrices, facilitating the binding of target proteins to resins for purification and analysis. -
α-Glucosidase Inhibitor
Sativanone is a potent α-glucosidase inhibitor, exhibiting an EC50 value of 0.357 mg/mL for rat α-glucosidase. Isolated from Dalbergia tonkinensis, this compound demonstrates antibacterial activity against Ralstonia solanacearum. Additionally, Sativanone exhibits anti-senescent and antioxidant properties, making it a valuable reagent for research in metabolic disorders, bacterial infections, and oxidative stress-related studies. -
Glycosidase Inhibitor
Panosialin D is a glycosidase inhibitor that selectively targets α,β-glucosidase and mannose glycosidase. This compound does not exhibit activity against the influenza virus; however, it demonstrates weak antimicrobial properties. It serves as a valuable reagent for research focused on glycosidase-related pathways and antimicrobial studies. -
α-glucosidase Inhibitor
Enhydrin is a naturally occurring α-glucosidase inhibitor derived from the leaves of Smallanthus sonchifolius. It demonstrates potent inhibitory activity with an IC50 value of 34.17 μg/mL, making it relevant for the management of postprandial hyperglycemia. Research indicates that Enhydrin can effectively reduce blood glucose levels in diabetic rat models, supporting its potential application in diabetes research and therapy development. -
α-Glucosidase Inhibitor
Cembrene A is an α-glucosidase inhibitor derived from the soft coral S. crassa, demonstrating an IC50 value of 30.31 μM. This compound exhibits minimal cytotoxicity in human normal hepatocyte (LO2) cells, with an IC50 greater than 100 μM. Cembrene A is a valuable reagent for research focused on diabetes and the modulation of carbohydrate metabolism. -
Alpha-Glucosidase Inhibitor
Acarbose sulfate is a potent alpha-glucosidase inhibitor, exhibiting an IC50 of 11 nM. This antihyperglycemic agent is utilized in research to investigate its potential to enhance the hypoglycemic effects of sulfonylureas or insulin. Its mechanism of action involves the modulation of carbohydrate absorption, making it valuable in studies related to diabetes and blood glucose regulation. -
α-Glucosidase Inhibitor
Arisanschinin D is an inhibitor of α-Glucosidase, a critical enzyme involved in carbohydrate metabolism. This compound can be isolated from Schisandra arisanensis and is of particular interest for research in diabetes management and metabolic disorders. Its ability to modulate enzyme activity makes it a valuable tool for studying the effects of carbohydrate absorption and glucose homeostasis. -
Glycosidase Inhibitor
Cefetrizole is an α-Glucosidase inhibitor that exhibits potent enzymatic activity, with an IC50 of 2.1 μM and a Ki value of 0.578 μM. This compound is primarily utilized in research applications focused on carbohydrate metabolism and associated disorders. Its ability to inhibit glycosidase activity makes it a valuable tool for investigating enzymatic pathways and developing therapeutic strategies. -
α-Amylase/α-Glucosidase Inhibitor
α-Amylase/α-Glucosidase-IN-23 is a potent inhibitor of α-amylase and α-glucosidase, demonstrating IC50 values of 73.68 nM and 146.18 nM, respectively. This compound is valuable for research focused on glucose metabolism and the management of hypoglycemia. Its ability to inhibit carbohydrate-hydrolyzing enzymes makes it a useful tool for studies investigating glycemic control and related metabolic disorders. -
α-Amylase Substrate
Ethylidene-4-nitrophenyl-α-D-maltoheptaoside serves as a substrate for α-amylase, facilitating the assessment of enzyme activity. Upon degradation by α-amylase, along with auxiliary enzymes like α-glucosidase, it releases a chromophore that enables quantification of amylase activity. This reagent is particularly valuable in the diagnosis of pancreatitis and other related disorders. -
α-Glucosidase Inhibitor
Quinoline-2-carboxylic acid functions as an α-glucosidase inhibitor, demonstrating significant potential in the modulation of glucose metabolism. This compound is of interest for its antidiabetic properties and serves as a valuable intermediate for the synthesis of various biologically active compounds in chemical research. Its role in enzyme inhibition makes it a relevant agent for studies aimed at understanding carbohydrate metabolism and diabetes management. -
Flavonoid
Chrysin-7-O-glucuronide is a flavonoid that targets α-glucosidase and α-amylase, exhibiting inhibitory activity with IC50 values of 612.13 and 980.73 μg/mL, respectively. This compound is known to suppress NF-κB signaling and possesses free radical scavenging abilities, functioning as a protectant for tight junctions and alleviating intestinal mucosal barrier injury. Chrysin-7-O-glucuronide is relevant for research focused on type 2 diabetes and the impacts of severe acute pancreatitis on intestinal health. -
Alkaloid
Lotusine hydroxide is an alkaloid that functions as a signaling pathway modulator and enzyme inhibitor. It exhibits notable inhibitory activity against α-amylase and α-glucosidase, with IC50 values of 30.60 μg/mL and 36.15 μg/mL, respectively. Lotusine hydroxide effectively inhibits the EGFR-Akt-ERK signaling pathway by decreasing phosphorylated levels of EGFR, Akt, and ERK, leading to apoptosis, G0/G1 cell cycle arrest, and reduced cancer cell proliferation. Additionally, it enhances antioxidant enzyme activities and is relevant for research on non-small cell lung cancer, type 2 diabetes, and autism spectrum disorder. -
α-Glucosidase Inhibitors
2,4,6-Triphenylaniline serves as an α-glucosidase inhibitor, demonstrating significant anti-diabetic properties. Its formulation in nano-emulsions enhances stability and bioavailability, enabling more efficient inhibition of both α-glucosidase and α-amylase enzymes. This compound is valuable for research focused on glycemic control and potential therapeutic strategies for diabetes management. -
α-amylase Inhibitor, α-glucosidase Inhibitor
Lotusine is an α-amylase and α-glucosidase inhibitor, demonstrating IC50 values of 30.60 μg/mL and 36.15 μg/mL, respectively. This compound modulates the EGFR-Akt-ERK signaling pathway by lowering the levels of phosphorylated EGFR, Akt, and ERK, leading to apoptosis, G0/G1 cell cycle arrest, and reduced cancer cell proliferation. Additionally, Lotusine decreases lipid peroxidation and enhances the activities of antioxidant enzymes such as SOD, CAT, and GPx. Its potential applications include research in non-small cell lung cancer, type 2 diabetes, and autism spectrum disorder. -
α-Amylase/α-Glucosidase Inhibitor
α-Amylase/α-Glucosidase-IN-19 is a dual inhibitor targeting α-amylase and α-glucosidase, exhibiting IC50 values of 170.7 μM and 60.37 μM, respectively. This compound demonstrates significant inhibitory activity that may be beneficial in the study of carbohydrate metabolism and the management of diabetes. Its applications include examining mechanisms of enzyme inhibition and exploring potential therapeutic strategies for controlling postprandial glucose levels. -
α-amylase/α-glucosidase Inhibitor
ABCB1-IN-4 is a potent dual inhibitor of α-amylase and α-glucosidase, exhibiting IC50 values of 1.63 μM and 0.14 μM, respectively. This compound demonstrates significant potential in the study of diabetes by modulating carbohydrate metabolism. Its orally active nature makes it a valuable tool for research applications focused on glycemic control and related metabolic pathways. -
HPA Inhibitor
HPA-IN-2 is a potent and selective inhibitor of human pancreatic α-amylase (HPA) with an IC50 value of 8.2 μM, demonstrating its efficacy in modulating carbohydrate digestion. In contrast, it shows significantly weaker inhibition of α-glucosidase with an IC50 of 450.7 μM. This compound is utilized in research focused on diabetes and metabolic disorders, particularly in understanding the regulation of carbohydrate metabolism. -
α-glucosidase/α-amylase Inhibitor
Sekikaic acid is a potent inhibitor of α-glucosidase and α-amylase, playing a significant role in the management of carbohydrate metabolism. Its biological activities include hypolipidemic and antioxidant effects, as well as antidiabetic properties, making it a valuable compound for research into metabolic disorders. Sekikaic acid has been shown to significantly reduce LDL cholesterol, total cholesterol, and triglyceride levels, while also promoting the regeneration of pancreatic beta cells. This compound is an essential tool for studies focused on diabetes and lipid metabolism. -
α-amylase Inhibitor
α-Amylase-IN-12 is a selective inhibitor of α-amylase, exhibiting a mixed inhibition mechanism with an IC50 value of 0.15 mM. It also demonstrates an IC50 of 9.40 mM against α-glucosidase. This compound promotes glucose uptake in yeast cells and shows notable antiglycation activity at elevated concentrations. α-Amylase-IN-12 is applicable in diabetes research, providing insights into carbohydrate metabolism and potential therapeutic strategies. -
α-glucosidase/α-amylase Dual Inhibitor
2,7"-Phloroglucinol-6,6'-bieckol functions as a dual inhibitor of α-glucosidase and α-amylase, exhibiting IC50 values of 6.94 μM and 23.35 μM, respectively. This compound has demonstrated the ability to mitigate postprandial hyperglycemia in diabetic mouse models. 2,7"-Phloroglucinol-6,6'-bieckol is valuable for research focused on diabetes and glucose metabolism. -
α-glucosidase/α-amylase enzyme Dual Inhibitor
α-Amylase/α-Glucosidase-IN-7 is a competitive dual inhibitor targeting α-glucosidase and α-amylase, demonstrating IC50 values of 18.52 µM and 20.25 µM, respectively. Additionally, this compound effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 9.25 µM and 10.06 µM. α-Amylase/α-Glucosidase-IN-7 is valuable for research applications related to diabetes and Alzheimer’s disease. -
α-Amylase/α-Glucosidase Inhibitor
3,4,6-Tri-O-galloyl-D-glucose is a mixed-type inhibitor of α-amylase and α-glucosidase, with an IC50 of 334.6 μM against porcine α-amylase and 46.5 μM against yeast α-glucosidase. This compound demonstrates free radical scavenging capabilities, ferric-reducing power, and significant antioxidant activity. Its properties make it a valuable tool for research focused on diabetes and related metabolic disorders. -
Antidiabetic Agent
Antidiabetic Agent 5 is an inhibitor of α-glucosidase and α-amylase, demonstrating IC50 values of 3.91 μM and 8.89 μM, respectively. This compound effectively reduces sugar levels in biological systems, making it a valuable tool for the study of type II diabetes. Antidiabetic Agent 5 offers potential insights into therapeutic strategies for managing glycemic control and advancing diabetes research. -
Triterpenoid Saponin
Ladyginoside A is a triterpenoid saponin derived from the leaves of Polyscias fruticosa. It exhibits inhibitory activity against α-amylase and α-glucosidase, making it relevant for the regulation of carbohydrate metabolism. Additionally, Ladyginoside A shows potential anti-inflammatory properties and may stabilize mast cells. This compound is suitable for investigations into inflammation and metabolic disorders, including diabetes. -
Component Of Phospholipids
Docosapentaenoic acid (22n-3) sodium is a key component of phospholipids, influencing cell membrane integrity and function. It exhibits inhibitory activity against α-amylase and α-glucosidase with IC50 values of 17 μg/mL and 22 μg/mL, respectively, contributing to its potential applications in metabolic research. Additionally, Docosapentaenoic acid (22n-3) sodium has been shown to enhance cell viability and demonstrates mild anti-inflammatory properties, making it useful for various biological studies.
