Fig. 1 · Structure
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Afegostat TFA
Cat. No.
A75227
CAS
1084896-50-3
Active Compound
Afegostat TFA is a pharmacological chaperone that selectively and reversibly binds to acid-β-glucosidase (GCase) within the endoplasmic reticulum. This interaction enhances the stability and activity of GCase, addressing enzyme deficiencies associated with Gaucher disease. Afegostat TFA is utilized in research exploring enzyme therapy and cellular mechanisms of lysosomal storage disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1084896-50-3 |
| Applications | Active Compound |
| Formula | C8H14F3NO5 |
| Molecular Weight | 261.20 |
| SMILES | OC(C(F)(F)F)=O.OC[C@@H]1[C@H]([C@@H](CNC1)O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.