Catalog No.
Product Name
Application
Product Information
Citations
-
Glycosidase Inhibitor
Glycyrrhisoflavone is a potent α-glucosidase inhibitor that acts primarily by blocking the enzyme's activity, thereby modulating carbohydrate metabolism. This natural prenylflavonoid exhibits significant biological activity, making it useful in research related to diabetes management and metabolic disorders. Its ability to influence glycemic control highlights its potential applications in pharmacological studies and nutraceutical development. -
Sweetener
Erlose is a trisaccharide sucrose derivative and low-calorie sweetener, synthesized through an α-glucosidase-mediated transglycosylation of glucose and sucrose. It possesses approximately half the sweetness of sucrose while maintaining a comparable taste profile. Erlose is primarily employed as a marker for detecting artificial sucrose adulteration in honey and demonstrates efficacy in inhibiting crystal formation and browning reactions during food heat treatment. This compound is valuable in research applications focused on food science and sweetener development. -
Cyclophenyl Alcohol
Cyclophellitol aziridine is a cyclophenol analogue that acts as a potent inhibitor of β-glucosidase. This compound demonstrates significant potential in studying carbohydrate metabolism and related enzymatic pathways. Its inhibitory activity makes it a valuable tool for investigating β-glucosidase-related diseases and for screening potential therapeutic agents. -
Alpha-glucosidase Inhibitor
Valiolamine is an aminocyclitol that functions as an alpha-glucosidase inhibitor. It exhibits significant inhibitory activity against porcine intestinal sucrase and maltase, with Ki values of 30 nM and 350 nM, respectively. This compound is valuable for research applications focused on carbohydrate metabolism, specifically in studying the modulation of glucose absorption and the potential therapeutic approaches to disorders such as diabetes. -
UV Filter
Benzophenone-2 is an organic ultraviolet absorber that serves as a UV filter in various personal care and industrial products, including plastics and coatings. It functions as an endocrine disruptor, impacting estrogen receptor (ERα) and pregnane X receptor (PXR) activity, which may contribute to reproductive toxicity, immune disorders, and metabolic abnormalities. Additionally, Benzophenone-2 exhibits inhibitory activity against α-glucosidase (IC50 = 49.72 μM), making it relevant for research in diabetes mellitus and related metabolic studies. -
α-Glucosidase Inhibitor
Panasenoside is a flavonoid that acts as an α-glucosidase inhibitor. Derived from Lilium pumilum DC, it has demonstrated significant inhibitory activity against α-glucosidase, making it a valuable tool for research on carbohydrate metabolism and related disorders. This compound is relevant for studies investigating diabetes management and the modulation of postprandial blood glucose levels. -
Anti-Viral Agent
IHVR-17028 is a broad-spectrum antiviral agent that primarily targets endoplasmic reticulum α-glucosidase I. It demonstrates significant antiviral activity against various viruses, including Bovine viral diarrhea virus (BVDV), Tick-borne choriomeningitis virus (TCRV), and Dengue virus (DENV), with EC50 values of 0.4 μM, 0.26 μM, and 0.3 μM, respectively. With an IC50 of 0.24 μM, it effectively inhibits ER α-glucosidase I, making it a valuable tool for research into infectious diseases. -
Alkaloid
N-Caffeoyl O-methyltyramine is an alkaloid with demonstrated inhibitory activity against α-glucosidase, exhibiting an IC50 value of 103.58 μM. This compound is derived from Cuscuta reflexa and is relevant for research focused on glucose metabolism and diabetes. Its potential applications include studying carbohydrate absorption and metabolic disorders, making it a valuable reagent in biochemical investigations. -
α-Glucosidase Inhibitor
β-Hydroxypropiovanillone is an α-glucosidase inhibitor that demonstrates significant concentration-dependent inhibitory effects on this enzyme. With an IC50 value of 257.8 μg/mL, it is useful for studying carbohydrate metabolism and potential therapeutic applications in managing postprandial hyperglycemia. This compound may serve as a valuable research tool in the exploration of diabetes and related metabolic disorders. -
α-glucosidase Inhibitor
Magnoloside B is an α-glucosidase inhibitor with an IC50 value of 0.69 mM, derived from the stem bark of Magnolia officinalis. It exhibits moderate inhibitory activity against MGC-803 and HepG2 cancer cell lines. This compound is of significant interest for research applications related to cancer and diabetes. -
α-amylase/α-glucosidase/Acetylcholinesterase Inhibitor
Kaempferol-3,7-di-O-β-glucoside is a flavonol that acts as an inhibitor of α-amylase, α-glucosidase, and acetylcholinesterase. This compound has demonstrated protective effects on differentiating neuronal cells, specifically SH-SY5Y, against injury induced by Amyloid β peptide. Its enzyme inhibitory properties and neuroprotective effects indicate potential applications in Alzheimer's disease research and therapeutics. -
Alpha-glucosidase Inhibitor
(+)-Afzelechin is an alpha-glucosidase inhibitor derived from the rhizomes of Bergenia ligulata. It demonstrates an ID50 value of 0.13 mM, indicating its potency in inhibiting alpha-glucosidase activity. This compound effectively delays carbohydrate absorption, thereby reducing postprandial hyperglycemia and hyperinsulinemia. It serves as a valuable tool for research in metabolic disorders and glycemic control. -
α-glucosidase Inhibitor
Ganoderol B is a potent inhibitor of α-glucosidase, exhibiting significant enzymatic inhibition with an IC50 value of 48.5 μg/mL (119.8 μM). This compound is primarily utilized in research applications related to carbohydrate metabolism and glucose regulation, making it a valuable tool in studies of diabetes and postprandial hyperglycemia. Researchers may leverage Ganoderol B to explore mechanisms of glycemic control and to develop therapeutic strategies targeting α-glucosidase. -
α-Glucosidase Inhibitor
(-)-Pinoresinol 4-O-glucoside serves as a potent α-glucosidase inhibitor, exhibiting an IC50 value of 48.13 µM. This compound promotes cell migration and early differentiation of pre-osteoblasts while enhancing the protein levels of BMP2, phosphorylated Smad1/5/8, and RUNX2. Additionally, it demonstrates protective effects against oxidative stress, hyperglycemia, and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside is a valuable reagent for investigating osteoporosis and periodontal disease. -
β-D-mannopyranosidase Substrate
4-Nitrophenyl β-D-mannopyranoside is a specific substrate for the enzyme β-D-mannopyranosidase, facilitating the study of enzymatic activity in carbohydrate metabolism. It also serves as a substrate for GH1-glucosidase and α-L-rhamnosidase, making it a versatile reagent for various glycoside hydrolase assays. This compound is valuable for researchers focused on enzyme kinetics and carbohydrate enzymology. -
α-Glucosidase Inhibitor (AGI)
α-Glucosidase-IN-11 is a potent competitive inhibitor of α-glucosidase, exhibiting an IC50 value of 0.56 μM. This compound selectively binds to tryptophan residues in the enzyme, influencing its protein folding and activity. α-Glucosidase-IN-11 has potential applications in the regulation of carbohydrate metabolism and blood glucose control, making it a valuable tool for diabetes research and therapeutic development. -
Glycosidase Inhibitor
N-Methylmoranoline is a potent α-glucosidase inhibitor that modulates carbohydrate metabolism by interfering with enzyme activity. This compound demonstrates significant potential in research related to diabetes management and metabolic disorders by reducing glucose absorption. It is utilized in studies exploring glycemic control and the pharmacological effects of glycosidase inhibition. -
Glucosidase Inhibitor
Glucocerebrosidase-IN-1 hydrochloride is a potent and selective inhibitor of glucocerebrosidase (GCase), demonstrating an IC50 of 29.3 μM and a Ki of 18.5 μM. This compound is relevant for research applications concerning Gaucher disease and Parkinson's disease, as it influences cellular metabolism of glucocerebrosides. Its selective inhibition makes it a valuable tool for studying the biochemical pathways associated with these conditions. -
α-glucosidase Inhibitor
Carpachromene is a potent inhibitor of the α-glucosidase enzyme. It has been shown to ameliorate insulin resistance in HepG2 cells by modulating the IR/IRS1/PI3K/Akt/GSK3/FoxO1 signaling pathway. This compound is valuable for researching metabolic disorders and potential therapeutic strategies for diabetes management. -
Tryptophan Derivative
(S)-N-(1H-Indole-3-acetyl)tryptophan is a tryptophan derivative that serves as a weak inhibitor of β-D-glucosidase. Its biological activity may be leveraged in research focused on enzymatic pathways and metabolic processes where β-D-glucosidase plays a significant role. This compound can be utilized in various biochemical studies exploring the interactions and regulation of tryptophan derivatives in cellular contexts. -
α-Glucosidase Inhibitor
Casuarictin is a potent α-glucosidase inhibitor, exhibiting competitive inhibition with an IC50 of 0.21 μg/mL. It also acts as an inhibitor of presenilin stabilization factor-like protein (PSFL). This compound is valuable for research applications related to Alzheimer's disease and metabolic disorders, providing insights into therapeutic strategies targeting carbohydrate metabolism. -
β-glucosidase Inhibitor
Validamine is a competitive inhibitor of β-glucosidase, demonstrating pH-dependent and dose-dependent inhibition with an IC50 value of 2.92 mM. Its maximum inhibitory effect occurs at the enzyme's optimal pH, making it a valuable tool for studying β-glucosidase function and regulation. This compound can be utilized in research applications focused on carbohydrate metabolism and related pathways. -
α-Glucosidase/α-Aamylase Inhibitor
Diphlorethohydroxycarmalol is a phlorotannin that serves as an inhibitor of α-glucosidase and α-amylase, exhibiting IC50 values of 0.16 mM and 0.53 mM, respectively. This compound demonstrates significant anti-diabetic activity, making it relevant for research focused on glucose metabolism and diabetes management. Its mechanism of action highlights its potential application in developing therapeutic strategies for metabolic disorders. -
α-glucosidase Inhibitor
p-Hydroxyphenethyl trans-ferulate is an α-glucosidase inhibitor known for its anti-hyperglycemic properties, exhibiting an IC50 value of 19.24 ± 1.73 µM against yeast α-glucosidase. This compound also demonstrates antioxidant and anti-inflammatory activities, making it a valuable tool in the study of metabolic disorders. Additionally, p-Hydroxyphenethyl trans-ferulate has shown potential in inhibiting cancer cell proliferation and modulating serotonergic activity, supporting its application in cancer and neurological research. -
GCase Modulator
GCase modulator-1 is a Quinazoline derivative targeting GCase (Glucosidase) with an AC50 of 2.23 μM. This compound serves as a potent modulator, influencing GCase activity and its associated metabolic pathways. It is primarily utilized in research focused on lysosomal storage disorders and potential therapeutic strategies for related conditions. -
Endoplasmic Reticulum α-Glucosidases I and II Inhibitor
EB-0156 is a potent inhibitor of endoplasmic reticulum α-glucosidases I and II, exhibiting IC50 values of 0.0479 μM and less than 0.001 μM, respectively. Derived from valiolamine, this compound demonstrates broad-spectrum antiviral activity. EB-0156 is valuable for research focused on developing therapeutic agents against both existing and emerging viral pathogens. -
Glycosidase Inhibitor
1,3-Dipalmitoleoyl glycerol is an α-glucosidase inhibitor with significant biological activity derived from sea cucumber viscera. This compound demonstrates varying degrees of inhibitory effects on α-glucosidase from diverse sources, making it valuable for research into carbohydrate metabolism and related disorders. Its application in studying glycosidase functions can provide insights into metabolic pathways and potential therapeutic targets. -
GAA Agonist
N-4′-(p-Trifluoromethylphenyl)butyl-DAB is a potent agonist of lysosomal acid α-glucosidase (GAA). This compound enhances intracellular GAA activity in a dose-dependent manner, specifically in fibroblasts from Pompe disease patients harboring the M519V mutation. It serves as a valuable tool for research into enzyme replacement therapies and the cellular mechanisms underlying lysosomal storage disorders. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-6 is a competitive inhibitor of α-glucosidase, exhibiting an IC50 of 5.69 µM. This compound demonstrates potential anti-diabetic activity by modulating carbohydrate metabolism. It is applicable in research focused on diabetes treatment and metabolic disorders. -
α-Glucosidase Inhibitor
Flaccidoside III is a triterpenoid compound that functions as an α-glucosidase inhibitor, exhibiting an IC50 value of 256.7 μM. It demonstrates significant potential for antioxidant and antidiabetic activities, making it a valuable reagent in metabolic research and studies aimed at understanding glucose regulation. Its effects on α-glucosidase modulation contribute to its implications in diabetes management research. -
α-Glucosidase Inhibitor
3-Oxo-hop-22(29)-ene is a potent inhibitor of α-glucosidase, predominantly affecting yeast enzymes. This compound exhibits moderate inhibitory effects on the viability of Trichomonas cruzi and Leishmania mexicana, suggesting its potential as a therapeutic agent against these pathogens. Additionally, 3-Oxo-hop-22(29)-ene displays marginal anti-inflammatory activity, highlighting its multifaceted biological applications in research. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-4 is a reversible, mixed-type inhibitor of α-glucosidase, exhibiting an IC50 value of 12.98 μM. This compound serves as a valuable tool for studying carbohydrate metabolism and its associated disorders, including diabetes and obesity. Its ability to modulate α-glucosidase activity makes it suitable for research into therapeutic strategies targeting glycemic control. -
Natural product
6-Prenylquercetin-3-Me ether is a natural product extracted from the leaves of Glycyrrhiza uralensis. It exhibits potent radical scavenging activity against DPPH, indicating its potential as an antioxidant. Additionally, this compound displays inhibitory activity against α-glucosidase, making it valuable for research in diabetes and metabolic disorders. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-12 is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 10.20 μM. This compound effectively modulates carbohydrate digestion and absorption, making it valuable for research on metabolic disorders such as type 2 diabetes and obesity. Its use in biochemical assays provides insights into enzymatic activity and potential therapeutic strategies. -
α-glucosidase/Acetylcholinesterase Inhibitor
7β-Hydroxybufalin is a bufadienolide that acts as a potent inhibitor of α-glucosidase and acetylcholinesterase. Isolated from the venom of Bufo bufo gargarizans, this compound demonstrates significant biological activity relevant to the modulation of carbohydrate and neurotransmitter metabolism. 7β-Hydroxybufalin is utilized in research applications focused on metabolic disorders and neurodegenerative diseases. -
α-glucosidase inhibitor
α-Homonojirimycin is a potent inhibitor of α-glucosidase, an enzyme involved in carbohydrate metabolism. By blocking α-glucosidase activity, it effectively modulates glucose absorption, making it a valuable compound for research in diabetes and metabolic disorder studies. Its inhibitory properties are also applicable in exploring the roles of glycosidases in various biological processes. -
α-Glucosidase Inhibitor
4-Ethoxy-5,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one is a naphthalene derivative that functions as a weak α-glucosidase inhibitor. This compound, which can be isolated from the leaves of Cyclocarya paliurus, is relevant in the study of diabetes management. Its inhibitory activity on α-glucosidase suggests potential applications in carbohydrate metabolism research and glycemic control studies. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-16 is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 3.28 μM. This compound effectively lowers blood glucose levels in Streptozotocin-induced diabetic rats, demonstrating significant antidiabetic properties. Its use in research facilitates the exploration of therapeutic strategies for managing diabetes and related metabolic disorders. -
α-glucosidase Inhibitor
α-Glucosidase-IN-54 is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 0.011 mM. This compound, derived from Syzygium jambos, is valuable for research focused on glucose metabolism and diabetes management. Its inhibitory action makes it a useful tool for studying the mechanisms of carbohydrate digestion and potential therapeutic interventions for hyperglycemia. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-29 is a potent inhibitor of α-glucosidase, displaying an IC50 value of 1.21 μM and a Ki value of 1.80 μM. This compound is primarily utilized in research focused on diabetes and associated metabolic disorders, where modulation of carbohydrate absorption is critical. Its mechanistic action allows for potential exploration in understanding the therapeutic effects against glycemic control and related physiological impacts. -
Endoplasmic Reticulum α-Glucosidases I and II inhibitor
EB-0176 is a potent inhibitor of endoplasmic reticulum α-glucosidases I and II, exhibiting IC50 values of 0.6439 μM and 0.0011 μM, respectively. This N-substituted derivative of valiolamine demonstrates broad-spectrum antiviral activity, positioning it as a valuable tool for research into antiviral agents targeting both existing and emerging viruses. Its ability to inhibit key glycosylation processes makes it significant for studies in virology and therapeutic development. -
Alpha-Glucosidase Inhibitor
Vitexin-2''-O-glucoside is a selective inhibitor of alpha-glucosidase, primarily extracted from flavonoids in hawthorn leaves. It reversibly inhibits α-glucosidase activity at the brush border of the small intestine, demonstrating a potent inhibitory effect. This compound is widely utilized in research related to type 2 diabetes and may serve as a promising candidate for therapeutic development in glycemic control. -
α-Glucosidase Inhibitor
PBI-6DNJ is a potent α-glucosidase inhibitor that functions as a multivalent glycosidase inhibitor. It demonstrates significant inhibitory activity against mouse α-glucosidase, with an affinity constant (Ki) of 0.14 μM. The compound also exhibits notable hypoglycemic effects, making it a valuable tool for research related to type 2 diabetes. -
α-Glucosidase Inhibitor
16-Oxoserratenediol is a serratene-type triterpenoid that functions as an α-glucosidase inhibitor, demonstrating an inhibition rate of 43.93% at a concentration of 100 μM. This compound is derived from Lycopodium cernuum L. and is primarily utilized in research related to diabetes management and metabolic disorders. Its mechanism of action contributes to the regulation of carbohydrate metabolism, making it a valuable tool for studying glycemic control in various biological contexts. -
α-glucosidase Inhibitor
Deacylhericene is an α-glucosidase inhibitor that demonstrates a potent inhibitory effect with an IC50 of 12.5 μM. This compound functions by effectively reducing the activity of α-glucosidase, making it a valuable reagent for studying carbohydrate metabolism. Its application is particularly relevant in diabetes research and the exploration of glycemic control mechanisms. -
α-Glucosidase Inhibitor
2,3-Indolobetulonic acid functions as an α-glucosidase inhibitor, exhibiting an IC50 of 1.8 µM. This triterpenoid compound is significant in research related to glucose metabolism and diabetes management. It is valuable for studies focusing on carbohydrate digestion and its modulation within metabolic pathways. -
Antioxidant Agent
Tachioside is a potent antioxidant agent that inhibits nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells, exhibiting an IC50 value of 12.14 μM. This compound demonstrates notable anti-obesity effects and possesses α-glucosidase inhibitory activity, making it a valuable reagent for research in oxidative stress, metabolic disorders, and inflammation. -
Hydrolase
Oligo-α-1,6-Glucosidase from Bacillus cereus ATCC7064 is a hydrolase enzyme that specifically targets and hydrolyzes oligosaccharides containing α-1,6-glycosidic bonds. This enzyme catalyzes the exo hydrolysis of α-1,6-glucoside linkages from nonreducing ends of substrates such as panose, palatinose, α-limit dextrins, and isomaltooligosaccharides. Oligo-α-1,6-Glucosidase plays a crucial role in the degradation of starch and glycogen, complementing the activity of α-amylase in the complete hydrolysis of amylopectin. Its applications include studies of carbohydrate metabolism and enzymatic processes involved in starch breakdown. -
α-Glucosidase Inhibitor
(-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid serves as a potent α-Glucosidase inhibitor, demonstrating an IC50 value of 577.7 µM. This compound is valuable in research focused on carbohydrate metabolism and the management of postprandial hyperglycemia. Its ability to modulate α-glucosidase activity makes it a useful tool in studies related to diabetes and metabolic disorders. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-38 is a potent inhibitor of α-glucosidase, with an IC50 value of 12.44±0.38 μM. This compound is significant for its role in the management of Diabetes Mellitus (DM) by reducing carbohydrate absorption in the intestines. It is useful for research applications focused on metabolic disorders and the development of diabetes therapies.
