Catalog No.
Product Name
Application
Product Information
Citations
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Phenol
2-Methylcardol triene is a phenolic compound that exhibits potent α-glucosidase inhibition with an IC50 of 39.6 μM. Notably, this compound demonstrates schistosomicidal activity, effectively eliminating 100% of adult Schistosoma mansoni worms within 24 hours at concentrations of 100 and 200 μM. Additionally, 2-Methylcardol triene serves as a valuable precursor for synthesizing mono- and bis-benzoxazines, making it a versatile reagent for various chemical and biological research applications. -
ChE Inhibitor
N-p-trans-Coumaroyltyramine is a natural phenolic amide compound that acts as an inhibitor of acetylcholinesterase (AChE) with an IC50 of 122 μM and α-glucosidase with an IC50 of 2.7 μM. It demonstrates significant anti-trypanosomal activity, exhibiting an IC50 of 13.3 µM against Trypanosoma brucei rhodesiense. This compound is valuable for research into neurodegenerative diseases such as Alzheimer's disease, as well as for studies focusing on trypanosomiasis. -
trans-cinnamic acid Derivative
trans-2-Methoxycinnamic acid is a derivative of trans-cinnamic acid that primarily targets α-glucosidase. This compound exhibits inhibitory activity with an IC50 of 4.34 mM. It is relevant for research applications involving HIV infection and hyperglycemia, making it a valuable tool for studying metabolic disorders and viral pathogenesis. -
DPPH Scavenger
Epicoccone B is a potent DPPH radical scavenger, exhibiting an IC50 value of 10.8 μM, indicating its effectiveness in neutralizing free radicals. This compound, isolated from C. globosum, also demonstrates significant α-glucosidase inhibition with an IC50 value of 27.3 μM. Additionally, Epicoccone B has been noted for its anti-HIV activity, making it a valuable reagent for oxidative stress studies and diabetes research. -
α-Glucosidase/HMG-CoA reductase Dual Inhibitor
Ganomycin I is a dual inhibitor targeting α-Glucosidase and HMG-CoA reductase. It demonstrates significant anti-diabetic properties and inhibits HIV protease, contributing to its potential as an antiviral agent. Additionally, Ganomycin I shows effectiveness in preventing osteoclastogenesis, making it a valuable reagent for research in diabetes and bone metabolism. -
α-Glucosidase I Inhibitor
Celgosivir hydrochloride is an α-glucosidase I inhibitor that demonstrates significant antiviral activity by inhibiting bovine viral diarrhoea virus (BVDV) with an IC50 value of 1.27 μM in in vitro assays. This compound is valuable for researchers studying viral infections and exploring potential therapeutic strategies through glycosidase inhibition. Its ability to modulate glycosylation processes makes it a relevant tool for biochemical and pharmacological investigations. -
ER α-glucosidases I/II Inhihitor
IHVR-19029 is a potent inhibitor of endoplasmic reticulum α-glucosidases I and II, exhibiting an IC50 of 0.48 μM for α-glucosidase I. This compound demonstrates significant antiviral activity by effectively blocking the replication of various hemorrhagic fever viruses, including Dengue virus (DENV), Ebola virus (EBOV), and Rift Valley fever virus. Research applications include the exploration of antiviral strategies, especially in combination therapies, such as enhancing the efficacy of Favipiravir. -
Endoplasmic Reticulum α-glucosidase II (GluII) Inhibitor
ToP-DNJ is a specific inhibitor of endoplasmic reticulum α-glucosidase II (GluII), demonstrating an IC50 value of 9.0 μM. It selectively interferes with both catalytic reactions of GluII, showing enhanced activity in the initial conversion of di-glycosylated to mono-glycosylated glycans. Additionally, ToP-DNJ exhibits anti-DENV activity, making it a valuable tool for research into dengue virus infection and related glycobiology studies. -
Influenza Viru Inhibitor
SP187 hydrochloride is a host-targeting iminosaccharide that primarily inhibits endoplasmic reticulum glucosidase, rendering it effective against filovirus infections. This compound demonstrates antiviral activity, notably against the Dengue virus, in vivo. SP187 hydrochloride is a valuable tool for researchers investigating antiviral mechanisms and developing therapeutic strategies against viral infections. -
Glucosidase Inhibitor
Ganoderic acid Y is an α-glucosidase inhibitor, exhibiting an IC50 of 170 μM against yeast α-glucosidase. This compound demonstrates antiviral properties by inhibiting the replication of enterovirus 71 (EV71) through the disruption of the virus uncoating process. Ganoderic acid Y is relevant for research applications investigating glycosidase activity and antiviral strategies. -
α-Glucosidase Inhibitor
Isosojagol is an α-Glucosidase inhibitor with an IC50 of 32.2 μM, demonstrating significant potential in modulating carbohydrate metabolism. Isolated from the roots of Dolichos trilobus, Isosojagol exhibits anti-inflammatory properties by inhibiting LPS-induced nitric oxide production in RAW264.7 cells. This reagent is relevant for research into fracture healing, soft tissue injuries, and rheumatoid arthritis, providing a valuable tool for understanding the underlying biological mechanisms. -
Hepatoprotective Agent
Tetrahydro bellidifolin is a hepatoprotective agent derived from the hydrolysis of tetrahydroswertianolin by β-glucosidase. It demonstrates significant hepatoprotective activity, effectively reducing serum alanine aminotransferase (ALT) levels. This compound is valuable for research focused on liver injury and its protective mechanisms. -
α-Amylase/α-Glucosidase Inhibitor
α-Amylase/α-Glucosidase-IN-23 is a potent inhibitor of α-amylase and α-glucosidase, demonstrating IC50 values of 73.68 nM and 146.18 nM, respectively. This compound is valuable for research focused on glucose metabolism and the management of hypoglycemia. Its ability to inhibit carbohydrate-hydrolyzing enzymes makes it a useful tool for studies investigating glycemic control and related metabolic disorders. -
α-Amylase Substrate
Ethylidene-4-nitrophenyl-α-D-maltoheptaoside serves as a substrate for α-amylase, facilitating the assessment of enzyme activity. Upon degradation by α-amylase, along with auxiliary enzymes like α-glucosidase, it releases a chromophore that enables quantification of amylase activity. This reagent is particularly valuable in the diagnosis of pancreatitis and other related disorders. -
α-Glucosidase Inhibitor
Quinoline-2-carboxylic acid functions as an α-glucosidase inhibitor, demonstrating significant potential in the modulation of glucose metabolism. This compound is of interest for its antidiabetic properties and serves as a valuable intermediate for the synthesis of various biologically active compounds in chemical research. Its role in enzyme inhibition makes it a relevant agent for studies aimed at understanding carbohydrate metabolism and diabetes management. -
Flavonoid
Chrysin-7-O-glucuronide is a flavonoid that targets α-glucosidase and α-amylase, exhibiting inhibitory activity with IC50 values of 612.13 and 980.73 μg/mL, respectively. This compound is known to suppress NF-κB signaling and possesses free radical scavenging abilities, functioning as a protectant for tight junctions and alleviating intestinal mucosal barrier injury. Chrysin-7-O-glucuronide is relevant for research focused on type 2 diabetes and the impacts of severe acute pancreatitis on intestinal health. -
Alkaloid
Lotusine hydroxide is an alkaloid that functions as a signaling pathway modulator and enzyme inhibitor. It exhibits notable inhibitory activity against α-amylase and α-glucosidase, with IC50 values of 30.60 μg/mL and 36.15 μg/mL, respectively. Lotusine hydroxide effectively inhibits the EGFR-Akt-ERK signaling pathway by decreasing phosphorylated levels of EGFR, Akt, and ERK, leading to apoptosis, G0/G1 cell cycle arrest, and reduced cancer cell proliferation. Additionally, it enhances antioxidant enzyme activities and is relevant for research on non-small cell lung cancer, type 2 diabetes, and autism spectrum disorder. -
α-Glucosidase Inhibitors
2,4,6-Triphenylaniline serves as an α-glucosidase inhibitor, demonstrating significant anti-diabetic properties. Its formulation in nano-emulsions enhances stability and bioavailability, enabling more efficient inhibition of both α-glucosidase and α-amylase enzymes. This compound is valuable for research focused on glycemic control and potential therapeutic strategies for diabetes management. -
α-amylase Inhibitor, α-glucosidase Inhibitor
Lotusine is an α-amylase and α-glucosidase inhibitor, demonstrating IC50 values of 30.60 μg/mL and 36.15 μg/mL, respectively. This compound modulates the EGFR-Akt-ERK signaling pathway by lowering the levels of phosphorylated EGFR, Akt, and ERK, leading to apoptosis, G0/G1 cell cycle arrest, and reduced cancer cell proliferation. Additionally, Lotusine decreases lipid peroxidation and enhances the activities of antioxidant enzymes such as SOD, CAT, and GPx. Its potential applications include research in non-small cell lung cancer, type 2 diabetes, and autism spectrum disorder. -
α-Amylase/α-Glucosidase Inhibitor
α-Amylase/α-Glucosidase-IN-19 is a dual inhibitor targeting α-amylase and α-glucosidase, exhibiting IC50 values of 170.7 μM and 60.37 μM, respectively. This compound demonstrates significant inhibitory activity that may be beneficial in the study of carbohydrate metabolism and the management of diabetes. Its applications include examining mechanisms of enzyme inhibition and exploring potential therapeutic strategies for controlling postprandial glucose levels. -
α-amylase/α-glucosidase Inhibitor
ABCB1-IN-4 is a potent dual inhibitor of α-amylase and α-glucosidase, exhibiting IC50 values of 1.63 μM and 0.14 μM, respectively. This compound demonstrates significant potential in the study of diabetes by modulating carbohydrate metabolism. Its orally active nature makes it a valuable tool for research applications focused on glycemic control and related metabolic pathways. -
HPA Inhibitor
HPA-IN-2 is a potent and selective inhibitor of human pancreatic α-amylase (HPA) with an IC50 value of 8.2 μM, demonstrating its efficacy in modulating carbohydrate digestion. In contrast, it shows significantly weaker inhibition of α-glucosidase with an IC50 of 450.7 μM. This compound is utilized in research focused on diabetes and metabolic disorders, particularly in understanding the regulation of carbohydrate metabolism. -
α-glucosidase/α-amylase Inhibitor
Sekikaic acid is a potent inhibitor of α-glucosidase and α-amylase, playing a significant role in the management of carbohydrate metabolism. Its biological activities include hypolipidemic and antioxidant effects, as well as antidiabetic properties, making it a valuable compound for research into metabolic disorders. Sekikaic acid has been shown to significantly reduce LDL cholesterol, total cholesterol, and triglyceride levels, while also promoting the regeneration of pancreatic beta cells. This compound is an essential tool for studies focused on diabetes and lipid metabolism. -
α-amylase Inhibitor
α-Amylase-IN-12 is a selective inhibitor of α-amylase, exhibiting a mixed inhibition mechanism with an IC50 value of 0.15 mM. It also demonstrates an IC50 of 9.40 mM against α-glucosidase. This compound promotes glucose uptake in yeast cells and shows notable antiglycation activity at elevated concentrations. α-Amylase-IN-12 is applicable in diabetes research, providing insights into carbohydrate metabolism and potential therapeutic strategies. -
α-glucosidase/α-amylase Dual Inhibitor
2,7"-Phloroglucinol-6,6'-bieckol functions as a dual inhibitor of α-glucosidase and α-amylase, exhibiting IC50 values of 6.94 μM and 23.35 μM, respectively. This compound has demonstrated the ability to mitigate postprandial hyperglycemia in diabetic mouse models. 2,7"-Phloroglucinol-6,6'-bieckol is valuable for research focused on diabetes and glucose metabolism. -
α-glucosidase/α-amylase enzyme Dual Inhibitor
α-Amylase/α-Glucosidase-IN-7 is a competitive dual inhibitor targeting α-glucosidase and α-amylase, demonstrating IC50 values of 18.52 µM and 20.25 µM, respectively. Additionally, this compound effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 9.25 µM and 10.06 µM. α-Amylase/α-Glucosidase-IN-7 is valuable for research applications related to diabetes and Alzheimer’s disease. -
α-Amylase/α-Glucosidase Inhibitor
3,4,6-Tri-O-galloyl-D-glucose is a mixed-type inhibitor of α-amylase and α-glucosidase, with an IC50 of 334.6 μM against porcine α-amylase and 46.5 μM against yeast α-glucosidase. This compound demonstrates free radical scavenging capabilities, ferric-reducing power, and significant antioxidant activity. Its properties make it a valuable tool for research focused on diabetes and related metabolic disorders. -
Antidiabetic Agent
Antidiabetic Agent 5 is an inhibitor of α-glucosidase and α-amylase, demonstrating IC50 values of 3.91 μM and 8.89 μM, respectively. This compound effectively reduces sugar levels in biological systems, making it a valuable tool for the study of type II diabetes. Antidiabetic Agent 5 offers potential insights into therapeutic strategies for managing glycemic control and advancing diabetes research. -
Triterpenoid Saponin
Ladyginoside A is a triterpenoid saponin derived from the leaves of Polyscias fruticosa. It exhibits inhibitory activity against α-amylase and α-glucosidase, making it relevant for the regulation of carbohydrate metabolism. Additionally, Ladyginoside A shows potential anti-inflammatory properties and may stabilize mast cells. This compound is suitable for investigations into inflammation and metabolic disorders, including diabetes. -
Component Of Phospholipids
Docosapentaenoic acid (22n-3) sodium is a key component of phospholipids, influencing cell membrane integrity and function. It exhibits inhibitory activity against α-amylase and α-glucosidase with IC50 values of 17 μg/mL and 22 μg/mL, respectively, contributing to its potential applications in metabolic research. Additionally, Docosapentaenoic acid (22n-3) sodium has been shown to enhance cell viability and demonstrates mild anti-inflammatory properties, making it useful for various biological studies. -
HMG-CoA Reductase (HMGCR)
Ganoderic acid SZ is a potent inhibitor of HMG-CoA reductase (HMGCR), demonstrating superior activity compared to atorvastatin. This natural compound also significantly inhibits α-glucosidase derived from yeast, with low nanomolar IC50 values. Additionally, Ganoderic acid SZ exhibits cytotoxic effects against K562 leukemia cells, with IC50 values ranging from 10 to 20 μM. These properties make Ganoderic acid SZ a valuable tool for research in cholesterol metabolism and cancer studies. -
ER α-glucosidases Inhibitor
IHVR-11029 is a potent small molecule inhibitor of ER α-glucosidases, demonstrating an EC50 of 0.09 μM. This compound is primarily utilized in research for exploring glucosidase enzymatic activity and its implications in metabolic disorders. Its specificity and efficacy make it a valuable tool for studies investigating glycosylation processes and related pathways. -
α-glucosidase Inhibitor
CM-10-18 is a potent inhibitor of α-glucosidases I and II, demonstrating significant activity in vitro and in animal models. This compound also exhibits antiviral properties by inhibiting dengue virus (DENV) infection in cultured human cells, while effectively reducing peak viremia in mice. CM-10-18 is valuable for research applications related to glycosidase inhibition and viral pathogenesis. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-5 is a potent α-glucosidase inhibitor, exhibiting an IC50 of 57.9 µM. This compound is valuable for studying the modulation of carbohydrate metabolism and has potential applications in diabetes mellitus research. By inhibiting α-glucosidase, α-Glucosidase-IN-5 may aid in the investigation of glycemic control and the development of therapeutic strategies for diabetes management. -
Anticoagulant/Cancer Agent
Fucoidan is a biologically active polysaccharide that functions as an anticoagulant and exhibits antitumor properties. It effectively inhibits α-amylase and α-glucosidase, contributing to its potential applications in metabolic disorder research. Additionally, Fucoidan demonstrates antioxidant and antisteatotic activities, making it a valuable tool for studying various disease processes and therapeutic interventions. -
α-glucosidase Inhibitor
Gallacetophenone is a potent inhibitor of α-glucosidase, displaying an IC50 value of 408.6 μM. This compound demonstrates synergistic effects on mammalian α-glucosidase when combined with 1-Deoxynojirimycin at elevated concentrations. Gallacetophenone is valuable for research into metabolic disorders, particularly type 2 diabetes, by facilitating the understanding of carbohydrate metabolism and its implications in glycemic control. -
β-glucosidase fluorogenic substrate
4-Methylumbelliferyl β-D-Glucopyranoside serves as a fluorogenic substrate specifically for β-glucosidase, facilitating the measurement of β-glucosidase activity in various biological assays. Upon enzymatic cleavage, it releases 4-methylumbelliferone, a highly fluorescent compound with an emission maximum between 445-454 nm. The excitation wavelength of 4-methylumbelliferone is influenced by pH, showing peaks at 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively, making it a valuable tool for studying enzyme kinetics and related research applications. -
α/β-Glucosidases Inhibitor
Castanospermine is a natural alkaloid primarily recognized for its role as an α/β-glucosidase inhibitor. This compound exhibits significant biological activities, including anti-inflammatory and antiviral properties, as well as the potential to impede metastatic progression in prostate cancer. Additionally, Castanospermine has applications as an immunosuppressant, proving useful in preventing transplant rejection. Its diverse functionalities make it a valuable tool in various areas of biochemical research. -
Hydrolytic Enzymatic Complex
Naringinase is a hydrolytic enzymatic complex that exhibits both α-L-rhamnosidase and β-D-glucosidase activities. This enzyme is widely distributed in nature and plays a crucial role in the biotransformation of glycosides as well as steroids and antibiotics. Naringinase is valuable in research applications involving the hydrolysis of glycosides, facilitating various biochemical studies and industrial processes. -
α-Glucosidase Substrate
4-Nitrophenyl α-D-glucopyranoside is a chromogenic substrate specifically designed for the measurement of α-glucosidase activity. Upon hydrolysis by α-glucosidase, this compound produces a yellow chromophore, allowing for quantitative assessment of enzyme activity. It is widely utilized in biochemical assays to study carbohydrate metabolism and investigate the role of α-glucosidase in various biological processes. -
Glycoside Hydrolase
β-Glucosidase, almond is a glycoside hydrolase that functions as a critical enzyme in cellulose degradation. This enzyme plays a significant role in the hydrolysis of β-glucosidic bonds, facilitating the breakdown of cellulose in various environments, including soils. Its activity is pivotal for assessing soil quality and understanding carbon cycling in ecosystems. Researchers utilize β-Glucosidase for studies related to plant biology, soil microbiology, and environmental monitoring. -
Antioxidant Agent
2-(2-Phenylethyl)chromone is an antioxidant agent that targets free radicals, particularly through the scavenging of ABTS·+. This compound exhibits a range of biological activities, including anti-inflammatory, neuroprotective, anti-tumor, and α-glucosidase inhibitory effects. It is valuable for research applications in inflammation-related diseases, cancer studies, and neurodegenerative disorders. -
α-glucosidase I Inhibitor
Kojibiose is an α-glucosidase I inhibitor that functions as an orally active prebiotic disaccharide. It specifically inhibits the activity of α-glucosidase I, promoting the proliferation of beneficial gut bacteria such as Bifidobacterium and lactic acid bacteria. Additionally, kojibiose serves as a low-calorie sweetener that enhances iron absorption and exhibits antitoxic properties. In vivo studies demonstrate its ability to reduce hepatic expression of inflammatory markers, highlighting its potential applications in metabolic and gastrointestinal research. -
ColA Inhibitor
4',5-Dihydroxyflavone is a potent inhibitor of collagenase A (ColA), with an IC50 value of less than 1 μM. This flavonoid compound also shows inhibitory activity against α-glucosidase and soybean lipoxygenase-1, making it valuable in biochemical research. Its applications include studies focused on anti-toxicity and anti-diabetes, highlighting its potential therapeutic benefits in metabolic and inflammatory disorders. -
α-Glucosidase Inhibitior
Resveratroloside is an orally active competitive inhibitor of α-glucosidase. It exhibits hypoglycemic and cardioprotective effects, making it a valuable compound for research into diabetes and cardiovascular diseases. This glycoside form of resveratrol facilitates investigations into its potential therapeutic applications in managing glucose metabolism and promoting heart health. -
Tyrosinase Inhibitor
Kushenol A, a non-competitive inhibitor of tyrosinase, effectively blocks the conversion of L-tyrosine to L-DOPA, with IC50 and Ki values of 1.1 μM and 0.4 μM, respectively. Isolated from the root of Sophora flavescens, Kushenol A exhibits antioxidant properties and also inhibits alpha-glucosidase (IC50: 45 μM; Ki: 6.8 μM) and β-amylase. This compound is valuable for research focused on skin whitening and anti-aging applications due to its enzyme inhibitory effects. -
Glucosidase Inhibitor
Gitogenin is a natural steroid derived from the plant Tribulus longipetalus, serving as a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and α-glucosidase. It exhibits an IC50 of 0.69 μM for UGT1A4 using trifluoperazine as a substrate, and an IC50 of 37.2 μM for α-glucosidase. Gitogenin does not interfere with the activities of major human cytochrome P450 isoforms, making it a valuable reagent for studies in metabolic enzyme pathways and potential therapeutic applications related to glycemic control. -
Glycosidase Inhibitor
Cedryl acetate is a tricyclic sesquiterpene with notable α-glucosidase inhibitory activity. This compound is isolated from the plant Cunninghamia lanceolata and is valuable in research focused on carbohydrate metabolism and glycosidase inhibition. Its biological activity makes it an important tool for studying metabolic disorders and potential therapeutic interventions. -
Fluorescent Substrate
4-Methylumbelliferyl-α-D-Glucopyranoside is a fluorescent substrate targeting α-glucosidase, which releases the fluorescent moiety 4-methylumbelliferyl (4-MU) upon enzymatic cleavage. This compound exhibits pH-dependent fluorescence, with excitation wavelengths of 320 nm in acidic conditions and 360 nm in alkaline conditions, while its emission increases between 445-455 nm as pH decreases. 4-Methylumbelliferyl-α-D-Glucopyranoside serves as a valuable biomarker for assessing α-glucosidase activity in infant blood spot samples, particularly in the context of Fabry and Pompe diseases. -
Glucosidase Inhibitor
Kaempferol 3-O-gentiobioside is a flavonoid that functions as an α-glucosidase inhibitor. Isolated from the leaves of C. alata, this compound demonstrates significant antidiabetic activity by inhibiting carbohydrate enzyme activity, with an IC50 value of 50.0 µM. It serves as a valuable tool for research into glucose metabolism and diabetes treatment applications.
