Catalog No.
Product Name
Application
Product Information
Citations
-
Cephalosporin Antibiotic
Cefetecol is a broad-spectrum cephalosporin antibiotic that targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall synthesis, leading to cell lysis. In addition to its antibacterial properties, Cefetecol also acts as an α-glucosidase inhibitor, demonstrating in vivo anti-diabetic activity in diabetic mouse models. This compound is suitable for research applications in both antibacterial and anti-diabetic studies. -
DPPH Scavenger
Epicoccone B is a potent DPPH radical scavenger, exhibiting an IC50 value of 10.8 μM, indicating its effectiveness in neutralizing free radicals. This compound, isolated from C. globosum, also demonstrates significant α-glucosidase inhibition with an IC50 value of 27.3 μM. Additionally, Epicoccone B has been noted for its anti-HIV activity, making it a valuable reagent for oxidative stress studies and diabetes research. -
α-Glucosidase/HMG-CoA reductase Dual Inhibitor
Ganomycin I is a dual inhibitor targeting α-Glucosidase and HMG-CoA reductase. It demonstrates significant anti-diabetic properties and inhibits HIV protease, contributing to its potential as an antiviral agent. Additionally, Ganomycin I shows effectiveness in preventing osteoclastogenesis, making it a valuable reagent for research in diabetes and bone metabolism. -
α-Glucosidase I Inhibitor
Celgosivir hydrochloride is an α-glucosidase I inhibitor that demonstrates significant antiviral activity by inhibiting bovine viral diarrhoea virus (BVDV) with an IC50 value of 1.27 μM in in vitro assays. This compound is valuable for researchers studying viral infections and exploring potential therapeutic strategies through glycosidase inhibition. Its ability to modulate glycosylation processes makes it a relevant tool for biochemical and pharmacological investigations. -
ER α-glucosidases I/II Inhihitor
IHVR-19029 is a potent inhibitor of endoplasmic reticulum α-glucosidases I and II, exhibiting an IC50 of 0.48 μM for α-glucosidase I. This compound demonstrates significant antiviral activity by effectively blocking the replication of various hemorrhagic fever viruses, including Dengue virus (DENV), Ebola virus (EBOV), and Rift Valley fever virus. Research applications include the exploration of antiviral strategies, especially in combination therapies, such as enhancing the efficacy of Favipiravir. -
Endoplasmic Reticulum α-glucosidase II (GluII) Inhibitor
ToP-DNJ is a specific inhibitor of endoplasmic reticulum α-glucosidase II (GluII), demonstrating an IC50 value of 9.0 μM. It selectively interferes with both catalytic reactions of GluII, showing enhanced activity in the initial conversion of di-glycosylated to mono-glycosylated glycans. Additionally, ToP-DNJ exhibits anti-DENV activity, making it a valuable tool for research into dengue virus infection and related glycobiology studies. -
Influenza Viru Inhibitor
SP187 hydrochloride is a host-targeting iminosaccharide that primarily inhibits endoplasmic reticulum glucosidase, rendering it effective against filovirus infections. This compound demonstrates antiviral activity, notably against the Dengue virus, in vivo. SP187 hydrochloride is a valuable tool for researchers investigating antiviral mechanisms and developing therapeutic strategies against viral infections. -
Glucosidase Inhibitor
Ganoderic acid Y is an α-glucosidase inhibitor, exhibiting an IC50 of 170 μM against yeast α-glucosidase. This compound demonstrates antiviral properties by inhibiting the replication of enterovirus 71 (EV71) through the disruption of the virus uncoating process. Ganoderic acid Y is relevant for research applications investigating glycosidase activity and antiviral strategies. -
Phenol
2-Methylcardol triene is a phenolic compound that exhibits potent α-glucosidase inhibition with an IC50 of 39.6 μM. Notably, this compound demonstrates schistosomicidal activity, effectively eliminating 100% of adult Schistosoma mansoni worms within 24 hours at concentrations of 100 and 200 μM. Additionally, 2-Methylcardol triene serves as a valuable precursor for synthesizing mono- and bis-benzoxazines, making it a versatile reagent for various chemical and biological research applications. -
α-Glucosidase Inhibitor
DNJ-20 is an α-glucosidase inhibitor with an IC50 of 55.3 μg/mL, demonstrating significant broad-spectrum activity against SARS-CoV-2. It disrupts the endoplasmic reticulum-associated glycoprotein folding process, inhibiting proper processing of viral glycoproteins and consequently blocking viral particle formation and infection. DNJ-20 exhibits IC50 values as low as 1.49 μM against various SARS-CoV-2 variants, as well as HCoV-229E and HCoV-OC43. This inhibitor is suited for pan-coronavirus research applications. -
Hepatoprotective Agent
Tetrahydro bellidifolin is a hepatoprotective agent derived from the hydrolysis of tetrahydroswertianolin by β-glucosidase. It demonstrates significant hepatoprotective activity, effectively reducing serum alanine aminotransferase (ALT) levels. This compound is valuable for research focused on liver injury and its protective mechanisms. -
α-Glucosidase Inhibitor
Isosojagol is an α-Glucosidase inhibitor with an IC50 of 32.2 μM, demonstrating significant potential in modulating carbohydrate metabolism. Isolated from the roots of Dolichos trilobus, Isosojagol exhibits anti-inflammatory properties by inhibiting LPS-induced nitric oxide production in RAW264.7 cells. This reagent is relevant for research into fracture healing, soft tissue injuries, and rheumatoid arthritis, providing a valuable tool for understanding the underlying biological mechanisms. -
Metabolic Enzyme
Amyloglucosidase, derived from Aspergillus niger, is a metabolic enzyme that catalyzes the hydrolysis of starch into glucose. Its primary application lies in the saccharification of starch, making it essential for various industrial processes such as brewing and distilling. This enzyme enhances the efficiency of carbohydrate conversion and is valuable for researchers studying enzymatic activity and carbohydrate metabolism. -
Carbohydrate Hydrolyzing Enzyme
α-Glucosidase, Yeast is a carbohydrate hydrolyzing enzyme that catalyzes the release of α-glucose from the non-reducing end of carbohydrate substrates. This enzyme plays a crucial role in glucose absorption in the small intestine. Inhibition of α-glucosidase is a well-established strategy for the management of non-insulin-dependent diabetes mellitus (NIDDM), making it a valuable tool for biochemical research and therapeutic development targeting glycemic control. -
β-glycosidic linkage (between glucose and ceramide) Cleaver\nGlycosphingolipid Glycan Releaser\nEGCase II Conformational Stabilizer
Endoglycoceramidase II (EGCase II) is an endo-β-glucosidase that specifically cleaves β-glycosidic linkages between glucose and ceramide in glycosphingolipids. This enzyme catalyzes the hydrolysis of these linkages, thereby releasing intact glycans from ceramides. EGCase II is instrumental in glycosphingolipid research, facilitating the structural analysis and functional studies of glycoconjugates in various biological contexts. It serves as a valuable tool in understanding glycan-mediated cellular processes and their implications in health and disease. -
Degradative Product of Starch
Maltose monohydrate is a degradative product of starch and serves as a substrate for α-glucosidase, which hydrolyzes maltose into glucose. This compound plays a significant role in various biological processes, including carbohydrate metabolism. Additionally, maltose monohydrate demonstrates protective effects on proteins, membranes, and the photosynthetic electron transport chain under conditions of heat stress and freezing stress, making it valuable for research into stress responses in biological systems. -
Endogenous Metabolite
1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride is an endogenous metabolite that functions as an inhibitor of glycogen phosphorylase and α-glucosidases. This naturally occurring pyrrolidine alkaloid, isolated from Arachniodes standishii and Angylocalyx boutiqueanus, plays a critical role in carbohydrate metabolism. Its unique inhibitory properties make it valuable for research applications in studying metabolic disorders and enzyme regulation. -
Tyrosinase/α-glucosidase Inhibitor
Pedalitin is a dual inhibitor of tyrosinase (IC50 = 0.28 mM) and α-glucosidase (IC50 = 0.29 mM). This compound demonstrates significant biological activity in the regulation of melanin production and glucose metabolism. Pedalitin is suitable for research applications exploring skin pigmentation disorders and metabolic diseases. -
α-Glucosidase Inhibitor
Glyurallin A is a potent α-glucosidase inhibitor, effectively isolated from Glycyrrhiza uralensis. With an IC50 value of 0.3 μM, it demonstrates significant inhibitory activity against α-glucosidase, making it a valuable compound for research on anti-diabetic mechanisms. Glyurallin A is suitable for studies focusing on glucose metabolism and potential therapeutic applications in diabetes management. -
α-Glucosidase Inhibitor
(6-O-p-Coumaroyl)-β-D-glucopyranosyl-2-O-(4-hydroxybenzoyl)-4-O-β-D-glucopyranosyl-6-hydroxyphenylacetate functions as a selective α-glucosidase inhibitor, exhibiting an IC50 of 10.53 μg/mL. This compound demonstrates significant anti-hepatic fibrosis and anti-diabetic activities, while also inhibiting the proliferation of mouse hepatic stellate cells (t-HSC/Cl-6) with an IC50 of 109.2 μg/mL. Isolated from the ester derivatives of Impatiens balsamina L. flowers, it serves as a valuable reagent for research focusing on hepatic fibrosis and type 2 diabetes. -
α-glucosidase
2,3-Indolobetulin is a pentacyclic triterpene and a derivative of betulin that acts as an α-glucosidase inhibitor. This compound demonstrates significant biological activity in modulating carbohydrate metabolism and is applicable in research focused on diabetes management and glycemic control. Its potential as a therapeutic agent in glucose regulation makes it valuable for studies on metabolic disorders. -
Endogenous Metabolite
Cedefingol is an endogenous metabolite that acts as an α-glucosidase inhibitor. This compound demonstrates antitumor properties and exhibits diverse bioactivities influenced by the fermentation time of dark tea samples. Additionally, cedefingol displays antioxidant activity, as evidenced by its effectiveness in the DPPH assay. Research applications include studies on metabolic pathways, enzymatic processes, and potential therapeutic effects in cancer research. -
Transglucosidase
Sucrose phosphorylase is a bacterial transglucosidase that facilitates the conversion of sucrose and phosphate into α-D-glucose-1-phosphate and D-fructose. This enzyme can also hydrolyze the glucosylated product into α-D-glucose or transfer the glucosyl moiety to hydroxyl groups of acceptors, leading to the formation of novel α-D-glucoside compounds. Sucrose phosphorylase exhibits specific enzymatic activity, making it valuable for applications in carbohydrate synthesis and bioconversion research. -
Tyrosinase Inhibitor
Methyl rosmarinate is a noncompetitive inhibitor of tyrosinase, effectively isolated from Rabdosia serra, with an IC50 value of 0.28 mM for mushroom tyrosinase. Additionally, it demonstrates inhibitory activity against α-glucosidase. This compound is valuable for research in pigmentation, skin disorders, and carbohydrate metabolism. -
AChE Inhibitor
AChE-IN-20 is a potent acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 value of 397.32 nM and a Ki value of 335.76 nM. In addition to its primary target, AChE-IN-20 exhibits significant inhibitory activity against human carbonic anhydrases I and II, and α-glucosidase, with IC50 values of 84.14 nM, 69.24 nM, and 52.08 nM, respectively. This compound is valuable for research into neurodegenerative diseases and enzymatic regulation, providing insights into potential therapeutic strategies. -
Anti-inflammatory Compound
Cuminaldehyde, a primary component of Cuminum cyminum, is recognized for its anti-inflammatory properties. This compound exhibits various biological activities, including inhibition of aldose reductase (IC50 = 0.00085 mg/mL), α-glucosidase (IC50 = 0.5 mg/mL), and lipoxygenase (IC50 = 1370 μM). Additionally, cuminaldehyde inhibits the fibrillation and aggregation of α-synuclein, indicating its potential application in the study of neurodegenerative diseases, cancer, diabetes, and neuropathic pain disorders. -
ER α-glucosidases Inhibitor
IHVR-11029 is a potent small molecule inhibitor of ER α-glucosidases, demonstrating an EC50 of 0.09 μM. This compound is primarily utilized in research for exploring glucosidase enzymatic activity and its implications in metabolic disorders. Its specificity and efficacy make it a valuable tool for studies investigating glycosylation processes and related pathways. -
α-glucosidase Inhibitor
CM-10-18 is a potent inhibitor of α-glucosidases I and II, demonstrating significant activity in vitro and in animal models. This compound also exhibits antiviral properties by inhibiting dengue virus (DENV) infection in cultured human cells, while effectively reducing peak viremia in mice. CM-10-18 is valuable for research applications related to glycosidase inhibition and viral pathogenesis. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-5 is a potent α-glucosidase inhibitor, exhibiting an IC50 of 57.9 µM. This compound is valuable for studying the modulation of carbohydrate metabolism and has potential applications in diabetes mellitus research. By inhibiting α-glucosidase, α-Glucosidase-IN-5 may aid in the investigation of glycemic control and the development of therapeutic strategies for diabetes management. -
Anticoagulant/Cancer Agent
Fucoidan is a biologically active polysaccharide that functions as an anticoagulant and exhibits antitumor properties. It effectively inhibits α-amylase and α-glucosidase, contributing to its potential applications in metabolic disorder research. Additionally, Fucoidan demonstrates antioxidant and antisteatotic activities, making it a valuable tool for studying various disease processes and therapeutic interventions. -
α-glucosidase Inhibitor
Gallacetophenone is a potent inhibitor of α-glucosidase, displaying an IC50 value of 408.6 μM. This compound demonstrates synergistic effects on mammalian α-glucosidase when combined with 1-Deoxynojirimycin at elevated concentrations. Gallacetophenone is valuable for research into metabolic disorders, particularly type 2 diabetes, by facilitating the understanding of carbohydrate metabolism and its implications in glycemic control. -
β-glucosidase fluorogenic substrate
4-Methylumbelliferyl β-D-Glucopyranoside serves as a fluorogenic substrate specifically for β-glucosidase, facilitating the measurement of β-glucosidase activity in various biological assays. Upon enzymatic cleavage, it releases 4-methylumbelliferone, a highly fluorescent compound with an emission maximum between 445-454 nm. The excitation wavelength of 4-methylumbelliferone is influenced by pH, showing peaks at 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively, making it a valuable tool for studying enzyme kinetics and related research applications. -
α/β-Glucosidases Inhibitor
Castanospermine is a natural alkaloid primarily recognized for its role as an α/β-glucosidase inhibitor. This compound exhibits significant biological activities, including anti-inflammatory and antiviral properties, as well as the potential to impede metastatic progression in prostate cancer. Additionally, Castanospermine has applications as an immunosuppressant, proving useful in preventing transplant rejection. Its diverse functionalities make it a valuable tool in various areas of biochemical research. -
Hydrolytic Enzymatic Complex
Naringinase is a hydrolytic enzymatic complex that exhibits both α-L-rhamnosidase and β-D-glucosidase activities. This enzyme is widely distributed in nature and plays a crucial role in the biotransformation of glycosides as well as steroids and antibiotics. Naringinase is valuable in research applications involving the hydrolysis of glycosides, facilitating various biochemical studies and industrial processes. -
α-Glucosidase Substrate
4-Nitrophenyl α-D-glucopyranoside is a chromogenic substrate specifically designed for the measurement of α-glucosidase activity. Upon hydrolysis by α-glucosidase, this compound produces a yellow chromophore, allowing for quantitative assessment of enzyme activity. It is widely utilized in biochemical assays to study carbohydrate metabolism and investigate the role of α-glucosidase in various biological processes. -
Glycoside Hydrolase
β-Glucosidase, almond is a glycoside hydrolase that functions as a critical enzyme in cellulose degradation. This enzyme plays a significant role in the hydrolysis of β-glucosidic bonds, facilitating the breakdown of cellulose in various environments, including soils. Its activity is pivotal for assessing soil quality and understanding carbon cycling in ecosystems. Researchers utilize β-Glucosidase for studies related to plant biology, soil microbiology, and environmental monitoring. -
Antioxidant Agent
2-(2-Phenylethyl)chromone is an antioxidant agent that targets free radicals, particularly through the scavenging of ABTS·+. This compound exhibits a range of biological activities, including anti-inflammatory, neuroprotective, anti-tumor, and α-glucosidase inhibitory effects. It is valuable for research applications in inflammation-related diseases, cancer studies, and neurodegenerative disorders. -
α-glucosidase I Inhibitor
Kojibiose is an α-glucosidase I inhibitor that functions as an orally active prebiotic disaccharide. It specifically inhibits the activity of α-glucosidase I, promoting the proliferation of beneficial gut bacteria such as Bifidobacterium and lactic acid bacteria. Additionally, kojibiose serves as a low-calorie sweetener that enhances iron absorption and exhibits antitoxic properties. In vivo studies demonstrate its ability to reduce hepatic expression of inflammatory markers, highlighting its potential applications in metabolic and gastrointestinal research. -
ColA Inhibitor
4',5-Dihydroxyflavone is a potent inhibitor of collagenase A (ColA), with an IC50 value of less than 1 μM. This flavonoid compound also shows inhibitory activity against α-glucosidase and soybean lipoxygenase-1, making it valuable in biochemical research. Its applications include studies focused on anti-toxicity and anti-diabetes, highlighting its potential therapeutic benefits in metabolic and inflammatory disorders. -
α-Glucosidase Inhibitior
Resveratroloside is an orally active competitive inhibitor of α-glucosidase. It exhibits hypoglycemic and cardioprotective effects, making it a valuable compound for research into diabetes and cardiovascular diseases. This glycoside form of resveratrol facilitates investigations into its potential therapeutic applications in managing glucose metabolism and promoting heart health. -
Tyrosinase Inhibitor
Kushenol A, a non-competitive inhibitor of tyrosinase, effectively blocks the conversion of L-tyrosine to L-DOPA, with IC50 and Ki values of 1.1 μM and 0.4 μM, respectively. Isolated from the root of Sophora flavescens, Kushenol A exhibits antioxidant properties and also inhibits alpha-glucosidase (IC50: 45 μM; Ki: 6.8 μM) and β-amylase. This compound is valuable for research focused on skin whitening and anti-aging applications due to its enzyme inhibitory effects. -
Glucosidase Inhibitor
Gitogenin is a natural steroid derived from the plant Tribulus longipetalus, serving as a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and α-glucosidase. It exhibits an IC50 of 0.69 μM for UGT1A4 using trifluoperazine as a substrate, and an IC50 of 37.2 μM for α-glucosidase. Gitogenin does not interfere with the activities of major human cytochrome P450 isoforms, making it a valuable reagent for studies in metabolic enzyme pathways and potential therapeutic applications related to glycemic control. -
Glycosidase Inhibitor
Cedryl acetate is a tricyclic sesquiterpene with notable α-glucosidase inhibitory activity. This compound is isolated from the plant Cunninghamia lanceolata and is valuable in research focused on carbohydrate metabolism and glycosidase inhibition. Its biological activity makes it an important tool for studying metabolic disorders and potential therapeutic interventions. -
Fluorescent Substrate
4-Methylumbelliferyl-α-D-Glucopyranoside is a fluorescent substrate targeting α-glucosidase, which releases the fluorescent moiety 4-methylumbelliferyl (4-MU) upon enzymatic cleavage. This compound exhibits pH-dependent fluorescence, with excitation wavelengths of 320 nm in acidic conditions and 360 nm in alkaline conditions, while its emission increases between 445-455 nm as pH decreases. 4-Methylumbelliferyl-α-D-Glucopyranoside serves as a valuable biomarker for assessing α-glucosidase activity in infant blood spot samples, particularly in the context of Fabry and Pompe diseases. -
Glucosidase Inhibitor
Kaempferol 3-O-gentiobioside is a flavonoid that functions as an α-glucosidase inhibitor. Isolated from the leaves of C. alata, this compound demonstrates significant antidiabetic activity by inhibiting carbohydrate enzyme activity, with an IC50 value of 50.0 µM. It serves as a valuable tool for research into glucose metabolism and diabetes treatment applications. -
Glycosidase Inhibitor
Glycyrrhisoflavone is a potent α-glucosidase inhibitor that acts primarily by blocking the enzyme's activity, thereby modulating carbohydrate metabolism. This natural prenylflavonoid exhibits significant biological activity, making it useful in research related to diabetes management and metabolic disorders. Its ability to influence glycemic control highlights its potential applications in pharmacological studies and nutraceutical development. -
Sweetener
Erlose is a trisaccharide sucrose derivative and low-calorie sweetener, synthesized through an α-glucosidase-mediated transglycosylation of glucose and sucrose. It possesses approximately half the sweetness of sucrose while maintaining a comparable taste profile. Erlose is primarily employed as a marker for detecting artificial sucrose adulteration in honey and demonstrates efficacy in inhibiting crystal formation and browning reactions during food heat treatment. This compound is valuable in research applications focused on food science and sweetener development. -
Cyclophenyl Alcohol
Cyclophellitol aziridine is a cyclophenol analogue that acts as a potent inhibitor of β-glucosidase. This compound demonstrates significant potential in studying carbohydrate metabolism and related enzymatic pathways. Its inhibitory activity makes it a valuable tool for investigating β-glucosidase-related diseases and for screening potential therapeutic agents. -
Alpha-glucosidase Inhibitor
Valiolamine is an aminocyclitol that functions as an alpha-glucosidase inhibitor. It exhibits significant inhibitory activity against porcine intestinal sucrase and maltase, with Ki values of 30 nM and 350 nM, respectively. This compound is valuable for research applications focused on carbohydrate metabolism, specifically in studying the modulation of glucose absorption and the potential therapeutic approaches to disorders such as diabetes. -
UV Filter
Benzophenone-2 is an organic ultraviolet absorber that serves as a UV filter in various personal care and industrial products, including plastics and coatings. It functions as an endocrine disruptor, impacting estrogen receptor (ERα) and pregnane X receptor (PXR) activity, which may contribute to reproductive toxicity, immune disorders, and metabolic abnormalities. Additionally, Benzophenone-2 exhibits inhibitory activity against α-glucosidase (IC50 = 49.72 μM), making it relevant for research in diabetes mellitus and related metabolic studies.
