Glucosidase

Cat. No.

A12797

CAS No.

210110-90-0

Miglustat hydrochloride

Synonyms: NB-DNJ

Miglustat hydrochloride is an orally active α-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor.

Cat. No.

A12108

CAS No.

58543-16-1

Rebaudioside A

Rebaudioside A is an α-glucosidase inhibitor that demonstrates an IC50 value of 35.01 μg/mL. This steviol glycoside enhances insulin secretion in pancreatic β cells through a glucose-dependent mechanism, which involves the inhibition of KATP channels and subsequent depolarization and calcium influx. Additionally, Rebaudioside A regulates cholesterol metabolism by activating the SREBP signaling pathway and inhibiting HMGCR, leading to increased LDL receptor expression. It is suitable for research in the areas of blood glucose and lipid regulation, as well as obesity management.

Cat. No.

A13118

CAS No.

121104-96-9

Celgosivir

Synonyms: MDL 28574

Celgosivir is an alpha-glucosidase I inhibitor for the potential treatment of HCV infection.

Cat. No.

A14383

CAS No.

19130-96-2

Deoxynojirimycin

Synonyms: Duvoglustat; Moranolin; Moranoline; 1-Deoxynojirimycin

Deoxynojirimycin is a Maltase-glucoamylase (a-glucosidase I and II) inhibitor. It interferes with N-linked glycosylation.

Cat. No.

A14385

CAS No.

957230-65-8

Afegostat D-tartrate

Synonyms: Isofagomine D-Tartrate; D-Isofagomine; iso-Fagomine

Afegostat D-tartrate was an experimental drug for the treatment of certain forms of Gaucher's disease. The substance was used in form of the tartrate. Isofagomine (IFG) is an acid β-glucosidase (GCase) active site inhibitor that acts as a pharmacological chaperone.

Cat. No.

A14633

CAS No.

551-08-6

3-Butylidenephthalide

Synonyms: n-Butylidenephthalide; (E)+(Z)

3-butylidenephthalide from Ligusticum porteri , an α-glucosidase inhibitor.

Cat. No.

A14945

CAS No.

83480-29-9

Voglibose

Voglibose is an N-substituted derivative of valiolamine, excellent inhibitory activity against alpha-glucosidases and its action against hyperglycemia and various disorders caused by hyperglycemia.

Cat. No.

A16573

CAS No.

136-77-6

Hexylresorcinol

Synonyms: 4-Hexylresorcinol

Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of α-glucosidase. Hexylresorcinol has protective effects against oxidative DNA damage.

Cat. No.

A17580

CAS No.

26973-24-0

Ceftezole

Synonyms: CTZ

Ceftezole is a broad-spectrum cephem antibiotic that effectively targets both gram-positive and gram-negative bacteria. Its primary mechanism involves inhibiting bacterial cell wall synthesis, making it valuable in combating various bacterial infections. Additionally, Ceftezole acts as an alpha-glucosidase inhibitor, demonstrating potential in in vivo anti-diabetic applications. It is suitable for use in microbiological research and studies related to diabetes management.

Cat. No.

A17597

CAS No.

41136-22-5

Ceftezole sodium

Synonyms: CTZ sodium

Ceftezole sodium is a broad-spectrum cephem antibiotic primarily targeting various gram-positive and gram-negative bacteria. Its mechanism of action involves inhibiting bacterial cell wall synthesis, leading to cell lysis and death. Additionally, ceftezole sodium demonstrates alpha-glucosidase inhibition, contributing to its in vivo anti-diabetic effects. This compound is relevant for research in microbial resistance and diabetes therapeutic development.

Cat. No.

A19963

CAS No.

81117-35-3

N-Nonyldeoxynojirimycin

Synonyms: NN-DNJ; Nonyl-DNJ

N-Nonyldeoxynojirimycin (NN-DNJ) is a potent inhibitor of alpha-glucosidase and alpha-1,6-glucosidase (IC50s, 0.42, 8.4 μM, respectively), inhibits glycogen breakdown.

Cat. No.

A20335

CAS No.

6090-95-5

Conduritol B epoxide

Synonyms: CBE

Conduritol B epoxide is an irreversible covalently bound acid β-glucosidase (GCase) inhibitor.

Cat. No.

A22122

CAS No.

1380716-06-2

ML198

ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase.

Cat. No.

A22126

CAS No.

1462267-07-7

NCGC607

NCGC607 is a a noninhibitory chaperone of glucocerebrosidase (GCase).

Cat. No.

A22689

CAS No.

17851-53-5

Butyl isobutyl phthalate

Butyl isobutyl phthalate is isolated from the rhizoid of Laminaria japonica. Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor with an IC50 value of 38 μM.

Cat. No.

A22712

CAS No.

117278-74-7

Tangshenoside I

Tangshenoside I, isolated from the roots of Codonopsis lanceolata, exhibits weak α-glucosidase inhibitory activities in vitro with an IC50 of 1.4 mM.

Cat. No.

A24067

CAS No.

86361-55-9

Gnetol

Gnetol is a bioactive phenolic compound isolated from the root of *Gnetum montanum* with diverse pharmacological properties. It potently inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 0.78 μM and exhibits histone deacetylase (HDAC) inhibitory activity. Gnetol is also a strong tyrosinase inhibitor, with an IC₅₀ of 4.5 μM against murine tyrosinase, leading to suppression of melanin biosynthesis. In addition to its antioxidant, antiproliferative, anticancer, and hepatoprotective effects, Gnetol modulates metabolic enzymes in a concentration-dependent manner, including α-amylase, α-glucosidase, and adipogenesis pathways, making it a promising candidate for research in oncology, dermatology, and metabolic disorders.

Cat. No.

A28354

CAS No.

638-97-1

β-Amyrone

Synonyms: β-Amyron

β-Amyrone is a triterpene compound recognized for its anti-inflammatory properties, primarily through the inhibition of cyclooxygenase-2 (COX-2) expression. It demonstrates significant antifungal activity and exhibits antiviral effects against the Chikungunya virus. Additionally, β-Amyrone inhibits α-glucosidase and acetylcholinesterase (AChE) activities, making it a valuable compound for research in inflammation, infectious diseases, and obesity-related studies.

Cat. No.

A31189

CAS No.

81446-29-9

(-)-Pinoresinol

(-)-Pinoresinol is a plant-derived tetrahydrofuran lignan that serves as an anti-inflammatory agent through the inhibition of α-glucosidase. This compound exhibits hypoglycemic properties and demonstrates chemopreventive potential by inducing apoptosis and causing G2/M phase cell cycle arrest. Its biological activities make it a valuable tool for research in inflammation and metabolic disorders.

Cat. No.

A31404

CAS No.

63335-24-0

Malabaricone B

Malabaricone B is a naturally occurring phenolic compound that functions as an α-glucosidase inhibitor, exhibiting an IC50 of 63.7 µM. This compound demonstrates significant biological activities, including anticancer, antimicrobial, antioxidant, and antidiabetic effects. It is suitable for research applications focused on metabolic regulation and the investigation of glycemic control.

Cat. No.

A31629

CAS No.

178765-54-3

3-Hydroxybakuchiol

3-Hydroxybakuchiol is an electron transport chain (ETC) inhibitor known for its antitumor properties. It effectively induces apoptosis in tumor cells, contributing to its potential as a therapeutic agent in cancer research. Additionally, 3-Hydroxybakuchiol exhibits moderate inhibitory activity against α-glucosidase, with an IC50 value of 345 μM, further expanding its applications in biological studies.

Cat. No.

A36227

CAS No.

109163-69-1

Caffeoyltryptophan

Caffeoyltryptophan is a competitive inhibitor of protein tyrosine phosphatase 1B (PTP1B), exhibiting an IC50 of 16.99 μM. Additionally, it demonstrates inhibitory effects on α-glucosidase, linoleic acid peroxidation, and hemolysis. This compound is primarily utilized in research related to type 2 diabetes, offering insights into metabolic regulation and potential therapeutic avenues.

Cat. No.

A36337

CAS No.

3052242-32-4

Antidiabetic agent 2

Antidiabetic agent 2 is a potent DPP-4 inhibitor that effectively promotes glucose uptake. This compound also inhibits PTP-1B, α-amylase, and α-glucosidase, exhibiting IC50 values of 0.036, 0.042, 0.241, and 0.185 μM, respectively. By decreasing blood glucose levels, Antidiabetic agent 2 serves as a valuable tool for research focused on diabetes management and the modulation of glucose homeostasis.

Cat. No.

A36349

CAS No.

143051-74-5

Ethyl-3,5-di-O-caffeoylquinate

Ethyl-3,5-di-O-caffeoylquinate is a derivative of ethyl caffeoylquinate, primarily targeting α-glucosidase and PTP1B enzymes. This compound demonstrates potential as an inhibitor of these critical enzymes, making it valuable for research in metabolic disorders and diabetes management. Isolated from the flower buds of Lonicera macranthoides, it also serves as an isomer of chlorogenic acid (ethyl dicaffeoylquinate), expanding its relevance in phytochemical studies and pharmacological applications.

Cat. No.

A36377

CAS No.

120181-07-9

Chrysophanol triglucoside

Chrysophanol triglucoside is an anthraquinone with a specific inhibitory action on protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase, demonstrating IC50 values of 80.17 µM and 197.06 µM, respectively. This compound is derived from Cassia obtusifolia and has potential applications in diabetes research, particularly in the study of glucose metabolism and insulin signaling pathways.