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Catalog No.
Product Name
Application
Product Information
Citations
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α-Glucosidase Inhibitor
Cembrene A is an α-glucosidase inhibitor derived from the soft coral S. crassa, demonstrating an IC50 value of 30.31 μM. This compound exhibits minimal cytotoxicity in human normal hepatocyte (LO2) cells, with an IC50 greater than 100 μM. Cembrene A is a valuable reagent for research focused on diabetes and the modulation of carbohydrate metabolism. -
Alpha-Glucosidase Inhibitor
Acarbose sulfate is a potent alpha-glucosidase inhibitor, exhibiting an IC50 of 11 nM. This antihyperglycemic agent is utilized in research to investigate its potential to enhance the hypoglycemic effects of sulfonylureas or insulin. Its mechanism of action involves the modulation of carbohydrate absorption, making it valuable in studies related to diabetes and blood glucose regulation. -
α-Glucosidase Inhibitor
Arisanschinin D is an inhibitor of α-Glucosidase, a critical enzyme involved in carbohydrate metabolism. This compound can be isolated from Schisandra arisanensis and is of particular interest for research in diabetes management and metabolic disorders. Its ability to modulate enzyme activity makes it a valuable tool for studying the effects of carbohydrate absorption and glucose homeostasis. -
Glycosidase Inhibitor
Cefetrizole is an α-Glucosidase inhibitor that exhibits potent enzymatic activity, with an IC50 of 2.1 μM and a Ki value of 0.578 μM. This compound is primarily utilized in research applications focused on carbohydrate metabolism and associated disorders. Its ability to inhibit glycosidase activity makes it a valuable tool for investigating enzymatic pathways and developing therapeutic strategies. -
α-Amylase/α-Glucosidase Inhibitor
α-Amylase/α-Glucosidase-IN-23 is a potent inhibitor of α-amylase and α-glucosidase, demonstrating IC50 values of 73.68 nM and 146.18 nM, respectively. This compound is valuable for research focused on glucose metabolism and the management of hypoglycemia. Its ability to inhibit carbohydrate-hydrolyzing enzymes makes it a useful tool for studies investigating glycemic control and related metabolic disorders. -
α-Glucosidase Inhibitor
Quinoline-2-carboxylic acid functions as an α-glucosidase inhibitor, demonstrating significant potential in the modulation of glucose metabolism. This compound is of interest for its antidiabetic properties and serves as a valuable intermediate for the synthesis of various biologically active compounds in chemical research. Its role in enzyme inhibition makes it a relevant agent for studies aimed at understanding carbohydrate metabolism and diabetes management. -
α-Glucosidase Inhibitors
2,4,6-Triphenylaniline serves as an α-glucosidase inhibitor, demonstrating significant anti-diabetic properties. Its formulation in nano-emulsions enhances stability and bioavailability, enabling more efficient inhibition of both α-glucosidase and α-amylase enzymes. This compound is valuable for research focused on glycemic control and potential therapeutic strategies for diabetes management. -
α-amylase Inhibitor, α-glucosidase Inhibitor
Lotusine is an α-amylase and α-glucosidase inhibitor, demonstrating IC50 values of 30.60 μg/mL and 36.15 μg/mL, respectively. This compound modulates the EGFR-Akt-ERK signaling pathway by lowering the levels of phosphorylated EGFR, Akt, and ERK, leading to apoptosis, G0/G1 cell cycle arrest, and reduced cancer cell proliferation. Additionally, Lotusine decreases lipid peroxidation and enhances the activities of antioxidant enzymes such as SOD, CAT, and GPx. Its potential applications include research in non-small cell lung cancer, type 2 diabetes, and autism spectrum disorder. -
α-Amylase/α-Glucosidase Inhibitor
α-Amylase/α-Glucosidase-IN-19 is a dual inhibitor targeting α-amylase and α-glucosidase, exhibiting IC50 values of 170.7 μM and 60.37 μM, respectively. This compound demonstrates significant inhibitory activity that may be beneficial in the study of carbohydrate metabolism and the management of diabetes. Its applications include examining mechanisms of enzyme inhibition and exploring potential therapeutic strategies for controlling postprandial glucose levels. -
α-amylase/α-glucosidase Inhibitor
ABCB1-IN-4 is a potent dual inhibitor of α-amylase and α-glucosidase, exhibiting IC50 values of 1.63 μM and 0.14 μM, respectively. This compound demonstrates significant potential in the study of diabetes by modulating carbohydrate metabolism. Its orally active nature makes it a valuable tool for research applications focused on glycemic control and related metabolic pathways. -
HPA Inhibitor
HPA-IN-2 is a potent and selective inhibitor of human pancreatic α-amylase (HPA) with an IC50 value of 8.2 μM, demonstrating its efficacy in modulating carbohydrate digestion. In contrast, it shows significantly weaker inhibition of α-glucosidase with an IC50 of 450.7 μM. This compound is utilized in research focused on diabetes and metabolic disorders, particularly in understanding the regulation of carbohydrate metabolism. -
α-glucosidase/α-amylase Inhibitor
Sekikaic acid is a potent inhibitor of α-glucosidase and α-amylase, playing a significant role in the management of carbohydrate metabolism. Its biological activities include hypolipidemic and antioxidant effects, as well as antidiabetic properties, making it a valuable compound for research into metabolic disorders. Sekikaic acid has been shown to significantly reduce LDL cholesterol, total cholesterol, and triglyceride levels, while also promoting the regeneration of pancreatic beta cells. This compound is an essential tool for studies focused on diabetes and lipid metabolism. -
α-amylase Inhibitor
α-Amylase-IN-12 is a selective inhibitor of α-amylase, exhibiting a mixed inhibition mechanism with an IC50 value of 0.15 mM. It also demonstrates an IC50 of 9.40 mM against α-glucosidase. This compound promotes glucose uptake in yeast cells and shows notable antiglycation activity at elevated concentrations. α-Amylase-IN-12 is applicable in diabetes research, providing insights into carbohydrate metabolism and potential therapeutic strategies. -
α-glucosidase/α-amylase Dual Inhibitor
2,7"-Phloroglucinol-6,6'-bieckol functions as a dual inhibitor of α-glucosidase and α-amylase, exhibiting IC50 values of 6.94 μM and 23.35 μM, respectively. This compound has demonstrated the ability to mitigate postprandial hyperglycemia in diabetic mouse models. 2,7"-Phloroglucinol-6,6'-bieckol is valuable for research focused on diabetes and glucose metabolism. -
α-glucosidase/α-amylase enzyme Dual Inhibitor
α-Amylase/α-Glucosidase-IN-7 is a competitive dual inhibitor targeting α-glucosidase and α-amylase, demonstrating IC50 values of 18.52 µM and 20.25 µM, respectively. Additionally, this compound effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 9.25 µM and 10.06 µM. α-Amylase/α-Glucosidase-IN-7 is valuable for research applications related to diabetes and Alzheimer’s disease. -
α-Amylase/α-Glucosidase Inhibitor
3,4,6-Tri-O-galloyl-D-glucose is a mixed-type inhibitor of α-amylase and α-glucosidase, with an IC50 of 334.6 μM against porcine α-amylase and 46.5 μM against yeast α-glucosidase. This compound demonstrates free radical scavenging capabilities, ferric-reducing power, and significant antioxidant activity. Its properties make it a valuable tool for research focused on diabetes and related metabolic disorders. -
α-Glucosidase Inhibitor
Glyurallin A is a potent α-glucosidase inhibitor, effectively isolated from Glycyrrhiza uralensis. With an IC50 value of 0.3 μM, it demonstrates significant inhibitory activity against α-glucosidase, making it a valuable compound for research on anti-diabetic mechanisms. Glyurallin A is suitable for studies focusing on glucose metabolism and potential therapeutic applications in diabetes management. -
α-Glucosidase Inhibitor
Rebaudioside A is an α-glucosidase inhibitor that demonstrates an IC50 value of 35.01 μg/mL. This steviol glycoside enhances insulin secretion in pancreatic β cells through a glucose-dependent mechanism, which involves the inhibition of KATP channels and subsequent depolarization and calcium influx. Additionally, Rebaudioside A regulates cholesterol metabolism by activating the SREBP signaling pathway and inhibiting HMGCR, leading to increased LDL receptor expression. It is suitable for research in the areas of blood glucose and lipid regulation, as well as obesity management. -
Bacterial Inhibitor
Ceftezole is a broad-spectrum cephem antibiotic that effectively targets both gram-positive and gram-negative bacteria. Its primary mechanism involves inhibiting bacterial cell wall synthesis, making it valuable in combating various bacterial infections. Additionally, Ceftezole acts as an alpha-glucosidase inhibitor, demonstrating potential in in vivo anti-diabetic applications. It is suitable for use in microbiological research and studies related to diabetes management. -
Bacterial Inhibitor
Ceftezole sodium is a broad-spectrum cephem antibiotic primarily targeting various gram-positive and gram-negative bacteria. Its mechanism of action involves inhibiting bacterial cell wall synthesis, leading to cell lysis and death. Additionally, ceftezole sodium demonstrates alpha-glucosidase inhibition, contributing to its in vivo anti-diabetic effects. This compound is relevant for research in microbial resistance and diabetes therapeutic development. -
α-glucosidase/α-amylase Inhibitor
2-Hydroxyquinoline is a selective inhibitor of α-glucosidase and α-amylase, exhibiting IC50 values of 64.4 µg/mL and 130.5 µg/mL, respectively. This compound is valuable for investigating carbohydrate metabolism and can be utilized in research related to diabetes management and treatment strategies. Its inhibitory effects contribute to a deeper understanding of enzymatic roles in glucose absorption and metabolism. -
α-glucosidase Inhibitor
3,4-Methylenedioxychalcone is an α-glucosidase inhibitor with a reported IC50 of 1870 μM. This compound is relevant for research applications focused on type 2 diabetes, as it may help modulate carbohydrate metabolism by delaying the breakdown of complex carbohydrates. Its potential to influence glucose absorption can be valuable for studies aimed at understanding and treating metabolic disorders.
