Glucosidase

Cat. No.

A69501

CAS No.

607-11-4

Sekikaic acid

Sekikaic acid is a potent inhibitor of α-glucosidase and α-amylase, playing a significant role in the management of carbohydrate metabolism. Its biological activities include hypolipidemic and antioxidant effects, as well as antidiabetic properties, making it a valuable compound for research into metabolic disorders. Sekikaic acid has been shown to significantly reduce LDL cholesterol, total cholesterol, and triglyceride levels, while also promoting the regeneration of pancreatic beta cells. This compound is an essential tool for studies focused on diabetes and lipid metabolism.

Cat. No.

A69502

CAS No.

1799667-33-6

α-Amylase-IN-12

α-Amylase-IN-12 is a selective inhibitor of α-amylase, exhibiting a mixed inhibition mechanism with an IC50 value of 0.15 mM. It also demonstrates an IC50 of 9.40 mM against α-glucosidase. This compound promotes glucose uptake in yeast cells and shows notable antiglycation activity at elevated concentrations. α-Amylase-IN-12 is applicable in diabetes research, providing insights into carbohydrate metabolism and potential therapeutic strategies.

Cat. No.

A69504

CAS No.

1621988-60-0

2,7"-Phloroglucinol-6,6'-bieckol

2,7"-Phloroglucinol-6,6'-bieckol functions as a dual inhibitor of α-glucosidase and α-amylase, exhibiting IC50 values of 6.94 μM and 23.35 μM, respectively. This compound has demonstrated the ability to mitigate postprandial hyperglycemia in diabetic mouse models. 2,7"-Phloroglucinol-6,6'-bieckol is valuable for research focused on diabetes and glucose metabolism.

Cat. No.

A69505

CAS No.

1038094-94-8

α-Amylase/α-Glucosidase-IN-7

α-Amylase/α-Glucosidase-IN-7 is a competitive dual inhibitor targeting α-glucosidase and α-amylase, demonstrating IC50 values of 18.52 µM and 20.25 µM, respectively. Additionally, this compound effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 9.25 µM and 10.06 µM. α-Amylase/α-Glucosidase-IN-7 is valuable for research applications related to diabetes and Alzheimer’s disease.

Cat. No.

A69507

CAS No.

99523-99-6

3,4,6-Tri-O-galloyl-D-glucose

Synonyms: 3,4,6-Trigalloylglucose

3,4,6-Tri-O-galloyl-D-glucose is a mixed-type inhibitor of α-amylase and α-glucosidase, with an IC50 of 334.6 μM against porcine α-amylase and 46.5 μM against yeast α-glucosidase. This compound demonstrates free radical scavenging capabilities, ferric-reducing power, and significant antioxidant activity. Its properties make it a valuable tool for research focused on diabetes and related metabolic disorders.

Cat. No.

A69508

CAS No.

2152667-21-3

Antidiabetic agent 5

Antidiabetic Agent 5 is an inhibitor of α-glucosidase and α-amylase, demonstrating IC50 values of 3.91 μM and 8.89 μM, respectively. This compound effectively reduces sugar levels in biological systems, making it a valuable tool for the study of type II diabetes. Antidiabetic Agent 5 offers potential insights into therapeutic strategies for managing glycemic control and advancing diabetes research.

Cat. No.

A72279

CAS No.

100991-92-2

1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride

1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride is an endogenous metabolite that functions as an inhibitor of glycogen phosphorylase and α-glucosidases. This naturally occurring pyrrolidine alkaloid, isolated from Arachniodes standishii and Angylocalyx boutiqueanus, plays a critical role in carbohydrate metabolism. Its unique inhibitory properties make it valuable for research applications in studying metabolic disorders and enzyme regulation.

Cat. No.

A72539

CAS No.

22384-63-0

Pedalitin

Pedalitin is a dual inhibitor of tyrosinase (IC50 = 0.28 mM) and α-glucosidase (IC50 = 0.29 mM). This compound demonstrates significant biological activity in the regulation of melanin production and glucose metabolism. Pedalitin is suitable for research applications exploring skin pigmentation disorders and metabolic diseases.

Cat. No.

A73780

CAS No.

199331-36-7

Glyurallin A

Glyurallin A is a potent α-glucosidase inhibitor, effectively isolated from Glycyrrhiza uralensis. With an IC50 value of 0.3 μM, it demonstrates significant inhibitory activity against α-glucosidase, making it a valuable compound for research on anti-diabetic mechanisms. Glyurallin A is suitable for studies focusing on glucose metabolism and potential therapeutic applications in diabetes management.

Cat. No.

A73985

CAS No.

1987871-73-7

(6-O-p-Coumaroyl)-β-D-glucopyranosyl-2-O-(4-hydroxybenzoyl)-4-O-β-D-glucopyranosyl-6-hydroxyphenylacetate

(6-O-p-Coumaroyl)-β-D-glucopyranosyl-2-O-(4-hydroxybenzoyl)-4-O-β-D-glucopyranosyl-6-hydroxyphenylacetate functions as a selective α-glucosidase inhibitor, exhibiting an IC50 of 10.53 μg/mL. This compound demonstrates significant anti-hepatic fibrosis and anti-diabetic activities, while also inhibiting the proliferation of mouse hepatic stellate cells (t-HSC/Cl-6) with an IC50 of 109.2 μg/mL. Isolated from the ester derivatives of Impatiens balsamina L. flowers, it serves as a valuable reagent for research focusing on hepatic fibrosis and type 2 diabetes.

Cat. No.

A74059

CAS No.

2365493-59-8

2,3-Indolobetulin

2,3-Indolobetulin is a pentacyclic triterpene and a derivative of betulin that acts as an α-glucosidase inhibitor. This compound demonstrates significant biological activity in modulating carbohydrate metabolism and is applicable in research focused on diabetes management and glycemic control. Its potential as a therapeutic agent in glucose regulation makes it valuable for studies on metabolic disorders.

Cat. No.

A74076

CAS No.

35301-24-7

Cedefingol

Cedefingol is an endogenous metabolite that acts as an α-glucosidase inhibitor. This compound demonstrates antitumor properties and exhibits diverse bioactivities influenced by the fermentation time of dark tea samples. Additionally, cedefingol displays antioxidant activity, as evidenced by its effectiveness in the DPPH assay. Research applications include studies on metabolic pathways, enzymatic processes, and potential therapeutic effects in cancer research.

Cat. No.

A74938

CAS No.

1383152-30-4

IHVR-11029

IHVR-11029 is a potent small molecule inhibitor of ER α-glucosidases, demonstrating an EC50 of 0.09 μM. This compound is primarily utilized in research for exploring glucosidase enzymatic activity and its implications in metabolic disorders. Its specificity and efficacy make it a valuable tool for studies investigating glycosylation processes and related pathways.

Cat. No.

A74942

CAS No.

1159614-57-9

CM-10-18

CM-10-18 is a potent inhibitor of α-glucosidases I and II, demonstrating significant activity in vitro and in animal models. This compound also exhibits antiviral properties by inhibiting dengue virus (DENV) infection in cultured human cells, while effectively reducing peak viremia in mice. CM-10-18 is valuable for research applications related to glycosidase inhibition and viral pathogenesis.

Cat. No.

A74980

CAS No.

111316-33-7

α-Glucosidase-IN-5

α-Glucosidase-IN-5 is a potent α-glucosidase inhibitor, exhibiting an IC50 of 57.9 µM. This compound is valuable for studying the modulation of carbohydrate metabolism and has potential applications in diabetes mellitus research. By inhibiting α-glucosidase, α-Glucosidase-IN-5 may aid in the investigation of glycemic control and the development of therapeutic strategies for diabetes management.

Cat. No.

A75026

CAS No.

528-21-2

Gallacetophenone

Gallacetophenone is a potent inhibitor of α-glucosidase, displaying an IC50 value of 408.6 μM. This compound demonstrates synergistic effects on mammalian α-glucosidase when combined with 1-Deoxynojirimycin at elevated concentrations. Gallacetophenone is valuable for research into metabolic disorders, particularly type 2 diabetes, by facilitating the understanding of carbohydrate metabolism and its implications in glycemic control.

Cat. No.

A75030

CAS No.

79831-76-8

Castanospermine

Castanospermine is a natural alkaloid primarily recognized for its role as an α/β-glucosidase inhibitor. This compound exhibits significant biological activities, including anti-inflammatory and antiviral properties, as well as the potential to impede metastatic progression in prostate cancer. Additionally, Castanospermine has applications as an immunosuppressant, proving useful in preventing transplant rejection. Its diverse functionalities make it a valuable tool in various areas of biochemical research.

Cat. No.

A75042

CAS No.

2140-29-6

Kojibiose

Kojibiose is an α-glucosidase I inhibitor that functions as an orally active prebiotic disaccharide. It specifically inhibits the activity of α-glucosidase I, promoting the proliferation of beneficial gut bacteria such as Bifidobacterium and lactic acid bacteria. Additionally, kojibiose serves as a low-calorie sweetener that enhances iron absorption and exhibits antitoxic properties. In vivo studies demonstrate its ability to reduce hepatic expression of inflammatory markers, highlighting its potential applications in metabolic and gastrointestinal research.

Cat. No.

A75043

CAS No.

6665-67-4

4',5-Dihydroxyflavone

4',5-Dihydroxyflavone is a potent inhibitor of collagenase A (ColA), with an IC50 value of less than 1 μM. This flavonoid compound also shows inhibitory activity against α-glucosidase and soybean lipoxygenase-1, making it valuable in biochemical research. Its applications include studies focused on anti-toxicity and anti-diabetes, highlighting its potential therapeutic benefits in metabolic and inflammatory disorders.

Cat. No.

A75044

CAS No.

38963-95-0

Resveratroloside

Synonyms: Resveratrol glycoside; trans-Resveratrol 4'-O-β-D-glucopyranoside

Resveratroloside is an orally active competitive inhibitor of α-glucosidase. It exhibits hypoglycemic and cardioprotective effects, making it a valuable compound for research into diabetes and cardiovascular diseases. This glycoside form of resveratrol facilitates investigations into its potential therapeutic applications in managing glucose metabolism and promoting heart health.

Cat. No.

A75046

CAS No.

99217-63-7

Kushenol A

Synonyms: Leachianone E

Kushenol A, a non-competitive inhibitor of tyrosinase, effectively blocks the conversion of L-tyrosine to L-DOPA, with IC50 and Ki values of 1.1 μM and 0.4 μM, respectively. Isolated from the root of Sophora flavescens, Kushenol A exhibits antioxidant properties and also inhibits alpha-glucosidase (IC50: 45 μM; Ki: 6.8 μM) and β-amylase. This compound is valuable for research focused on skin whitening and anti-aging applications due to its enzyme inhibitory effects.

Cat. No.

A75047

CAS No.

511-96-6

Gitogenin

Gitogenin is a natural steroid derived from the plant Tribulus longipetalus, serving as a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and α-glucosidase. It exhibits an IC50 of 0.69 μM for UGT1A4 using trifluoperazine as a substrate, and an IC50 of 37.2 μM for α-glucosidase. Gitogenin does not interfere with the activities of major human cytochrome P450 isoforms, making it a valuable reagent for studies in metabolic enzyme pathways and potential therapeutic applications related to glycemic control.

Cat. No.

A75049

CAS No.

77-54-3

Cedryl acetate

Cedryl acetate is a tricyclic sesquiterpene with notable α-glucosidase inhibitory activity. This compound is isolated from the plant Cunninghamia lanceolata and is valuable in research focused on carbohydrate metabolism and glycosidase inhibition. Its biological activity makes it an important tool for studying metabolic disorders and potential therapeutic interventions.

Cat. No.

A75053

CAS No.

22149-35-5

Kaempferol 3-O-gentiobioside

Kaempferol 3-O-gentiobioside is a flavonoid that functions as an α-glucosidase inhibitor. Isolated from the leaves of C. alata, this compound demonstrates significant antidiabetic activity by inhibiting carbohydrate enzyme activity, with an IC50 value of 50.0 µM. It serves as a valuable tool for research into glucose metabolism and diabetes treatment applications.

Cat. No.

A75055

CAS No.

116709-70-7

Glycyrrhisoflavone

Glycyrrhisoflavone is a potent α-glucosidase inhibitor that acts primarily by blocking the enzyme's activity, thereby modulating carbohydrate metabolism. This natural prenylflavonoid exhibits significant biological activity, making it useful in research related to diabetes management and metabolic disorders. Its ability to influence glycemic control highlights its potential applications in pharmacological studies and nutraceutical development.