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Catalog No.
Product Name
Application
Product Information
Citations
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Alpha-glucosidase Inhibitor
6,8-Dihydroxy-1,2,7-trimethoxy-3-methylanthraquinone is an anthraquinone that serves as an α-glucosidase inhibitor, exhibiting an IC50 value of 185 μM. This compound, which can be isolated from Cassia seeds, is valuable for investigating carbohydrate metabolism and potential therapeutic applications in managing diabetes. Its inhibitory activity makes it a suitable candidate for research focused on the modulation of glucose absorption. -
α-Glucosidase Inhibitor
Ganoderlactone D is a potent inhibitor of α-Glucosidase, demonstrating an IC50 value of 41.7 μM in yeast models. This compound is utilized in research to explore its potential effects on carbohydrate metabolism and its role in the management of postprandial hyperglycemia. Its inhibitory action provides a valuable tool for studying the modulation of glucose absorption and its implications in diabetes research. -
α-Glucosidase Inhibitor
(2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid is a natural saponin extracted from Rubus ellipticus var. obcordatus that acts as an α-Glucosidase inhibitor. This compound exhibits an inhibitory activity with an IC50 of 1.68 mM, making it a valuable tool for research focused on carbohydrate metabolism and diabetes management. Its biological properties facilitate studies exploring the regulation of glucose absorption and potential therapeutic approaches in glycemic control. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-18 is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 3.96 μM. This compound demonstrates significant antidiabetic activity, making it a valuable tool for research in glucose metabolism and diabetes treatment. Its oral bioavailability supports its potential applications in pharmacological studies targeting carbohydrate digestion and postprandial blood glucose regulation. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-23 is a potent inhibitor of α-glucosidase, demonstrating an IC50 value of 4.48 μM. This compound effectively lowers blood glucose levels by inhibiting the enzyme α-glucosidase, making it a valuable tool in diabetes research. α-Glucosidase-IN-23 is suitable for studies focused on glucose metabolism and the development of therapeutic strategies for diabetes management. -
α‐Glucosidase Inhibitor
α-Glucosidase-IN-56 is a potent inhibitor of α-glucosidase, with an IC50 value of 45.86 μM. This compound exhibits significant anti-glycation activity, making it a valuable tool for research in the fields of diabetes and metabolic disorders. Its ability to inhibit carbohydrate digestion positions it as a candidate for further studies aimed at understanding and managing glycemic responses. -
Alpha-glucosidase Inhibitor
α-Glucosidase-IN-13 is an α-glucosidase inhibitor, demonstrating an IC50 value of 5.69 μM. This compound effectively interferes with the enzyme's activity, making it a valuable tool for studying carbohydrate metabolism and the regulation of blood glucose levels. Its applications extend to diabetes research and the development of therapeutic strategies targeting glycemic control. -
α-glucosidase Inhibitor
α-Glucosidase-IN-30 is a competitive inhibitor of α-glucosidase, exhibiting a Ki value of 40.0 µM and an IC50 of 49.0 µM. This reagent demonstrates non-cytotoxicity in both cancer (MCF-7) and normal (HDF) cell lines, making it suitable for research applications in Type 2 diabetes studies. Its oral bioactivity and selectivity position it as an important tool for exploring therapeutic interventions targeting carbohydrate metabolism. -
α-glucosidase Inhibitor
α-Glucosidase-IN-100 is a potent inhibitor of α-glucosidase, a key enzyme involved in carbohydrate metabolism. This compound is instrumental in exploring metabolic disorders, particularly diabetes, by modulating glucose absorption and metabolism. Its use in research may provide insights into therapeutic strategies for managing hyperglycemia and associated metabolic conditions. -
Alpha-Glucosidase Inhibitor
Valienamine is an alpha-glucosidase inhibitor that plays a crucial role in the regulation of carbohydrate metabolism. This compound is a fundamental structural component of various natural glycosidase inhibitors, including the agricultural fungicide validamycin A and the antidiabetic drug acarbose. Valienamine is primarily utilized in research applications focused on diabetes management and crop protection strategies. -
α-Glucosidase Inhibitor
1,6,8-Trihydroxy-2,7-dimethoxy-3-methylanthraquinone is a potent α-glucosidase inhibitor isolated from Cassia obtusefolia. It demonstrates a significant inhibitory effect with an IC50 value of 120.65 μg/mL. This compound is valuable for research into diabetic mechanisms and potential therapeutic interventions. Its efficacy in modulating carbohydrate metabolism makes it a useful tool in the study of metabolic disorders. -
α-Glucosidase Inhibitor
α-Amylase-IN-2 is an oleanolic acid oxime ester derivative that acts as a potent α-glucosidase inhibitor, exhibiting an IC50 value of 1.28 µM. Additionally, it demonstrates inhibitory activity against α-amylase with an IC50 of 3.8 µM. This compound is valuable for research applications focused on metabolic disorders such as diabetes, where modulation of carbohydrate digestion is critical. -
alpha-glucosidase Inhibitor
6β-Hydroxyipolamiide is an α-glucosidase inhibitor identified in the methanolic extract of S. jamaicensis leaves. It demonstrates significant inhibitory activity with an IC50 of 539.17 μg/mL. This compound is relevant for research focused on carbohydrate metabolism and the management of conditions related to glycemic control. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-68 is a selective inhibitor of α-glucosidase, demonstrating an IC50 of 0.251 μM, along with inhibition of AChE and BChE at 0.774 μM and 0.793 μM, respectively. This compound exhibits strong antioxidant properties, with IC50 values of 0.69 μM in the DPPH assay and 0.02 μM in the ABTS assay. Additionally, α-Glucosidase-IN-68 has been shown to have an antidiabetic effect in streptozotocin-induced diabetic rat models, making it a valuable tool for research in diabetes and related metabolic disorders. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-2 is a potent inhibitor of α-Glucosidase, exhibiting an IC50 of 9.48 µM. This compound demonstrates significant antidiabetic activity by impeding carbohydrate digestion and absorption, thereby lowering postprandial blood glucose levels. It serves as a valuable tool for research in diabetes management and metabolic studies. -
α-Amylase/α-Glucosidase Inhibitor
α-Amylase/α-Glucosidase-IN-2 is a potent dual inhibitor of α-amylase and α-glucosidase, demonstrating IC50 values of 13.02 µM and 13.09 µM, respectively. This compound is primarily utilized in research investigating diabetic complications, offering significant insights into glucose metabolism and potential therapeutic strategies for managing diabetes. Its dual mechanism of action makes it a valuable tool for studying carbohydrate digestion and its implications in hyperglycemia. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-41 is a potent inhibitor of α-glucosidase, functioning by altering the secondary structure of the enzyme to impede its catalytic activity. This compound is valuable in research focused on diabetes mellitus, providing insights into carbohydrate metabolism and potential therapeutic strategies. Its efficacy in modulating enzyme activity makes it a pertinent tool for studying glycemic control and related metabolic disorders. -
α-Glucosidase Inhibitor
(E)-p-Coumaramide acts as an α-Glucosidase inhibitor, playing a significant role in carbohydrate metabolism regulation. This compound, which can be isolated from Welsh onion, demonstrates potential biological activity in managing glucose levels and may contribute to diabetes research. Its application extends to studies aimed at understanding the mechanisms of glycosidase enzymes in metabolic disorders. -
α-Glucosidase Inhibitor
5-C-phenethyl-DNJ is a selective α-glucosidase inhibitor, targeting glycosylation pathways with a Ki value of 0.81 μM for recombinant human acid α-glucosidase (rhGAA). This compound demonstrates notable selectivity for glycosyltransferases GANAB, GBA1, and GBA2. 5-C-phenethyl-DNJ is particularly valuable in the research of Pompe disease, enabling insights into enzymatic deficiencies and potential therapeutic strategies. -
α-glucosidase Inhibitor
2'-Rhamnoechinacoside (Michelioside A) is an α-glucosidase inhibitor derived from Phlomis stewartii, demonstrating notable anti-tumor activity. This phenylethanoid glycoside can be utilized in research focused on UV absorption and cancer biology, offering insights into therapeutic strategies against glucose-related disorders. Its mechanism of action and biological activity make it a valuable tool for studying metabolic processes and developing potential cancer treatments. -
α-Glucosidase Inhibitor
Lucidal is a natural lanosto-type triterpene aldehyde that functions as an inhibitor of α-glucosidase, exhibiting an IC50 of 0.635 mM. This compound demonstrates significant biological activities, including anticancer and antidiabetic effects. It is useful for research applications targeting metabolic disorders and cancer biology. -
α-glucosidase Inhibitor
Giffonin P is a selective inhibitor of α-glucosidase, exhibiting an IC50 value of 55.3 μM. This compound effectively delays carbohydrate hydrolysis and glucose absorption, contributing to its anti-hyperglycemic properties. Giffonin P is primarily utilized in research related to type 2 diabetes, particularly in studies focused on managing postprandial blood glucose levels. -
α-glucosidase Inhibitor
α-Glucosidase-IN-8 is a potent competitive inhibitor of α-glucosidase, exhibiting an IC50 value of 0.18 µg/mL. This compound effectively blocks the enzymatic activity of α-glucosidase, which plays a crucial role in carbohydrate metabolism. Its primary applications include studying glucose absorption and management of conditions like diabetes, making it valuable for research in metabolic disease and pharmacology. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-36 is a selective inhibitor of α-glucosidase, exhibiting an IC50 value of 6.69 ± 0.18 μM and Ki and Kis values of 1.65 μM and 4.54 μM, respectively. This compound functions by binding to the active site of α-glucosidase, leading to alterations in its secondary structure, which subsequently inhibits enzyme activity. α-Glucosidase-IN-36 is valuable for research applications related to type 2 diabetes mellitus (T2DM), enabling investigations into carbohydrate metabolism and glycemic control. -
α-glucosidase Inhibitor
MDL-25637 is an α-glucosidase inhibitor that effectively inhibits the activity of enzymes such as sucrose, maltase, isomaltase, glucose amylase, and trehalose in the intestinal tract. This compound is primarily utilized in diabetes research to investigate the regulation of carbohydrate absorption and its implications for glucose homeostasis. Its ability to modulate enzymatic activity makes it a valuable tool for studying metabolic disorders associated with diabetes. -
α-Amylase/α-Glucosidase Inhibitor
α-Amylase/α-Glucosidase-IN-1 is a potent inhibitor of both α-amylase and α-glucosidase, exhibiting IC50 values of 2.01 µM and 2.09 µM, respectively. This compound is utilized in biochemical research to investigate mechanisms of glycemic control and has potential applications in the management of hyperglycemia. The inhibitory activity of α-Amylase/α-Glucosidase-IN-1 makes it a valuable tool for studying carbohydrate metabolism and related metabolic disorders. -
α-Glucosidase Inhibitor
Mortatarin G is a prenylated flavonoid that functions as an α-glucosidase inhibitor. It demonstrates significant inhibitory activity against α-glucosidase, with an IC50 value of 20.4±1.4 μM. This compound is useful for research applications focused on carbohydrate metabolism and potential therapeutic strategies for managing diabetes and related metabolic disorders. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-3 is an oleanolic acid oxime ester derivative that acts as an inhibitor of α-glucosidase, exhibiting an IC50 value of 0.35 µM. This compound also demonstrates inhibitory activity against α-amylase, making it a valuable tool for studies focused on carbohydrate metabolism. Its potential applications include investigating the mechanisms of diabetes management and exploring the therapeutic effects of glycosidase inhibition in metabolic disorders. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-28 is a potent α-glucosidase inhibitor, exhibiting an IC50 of 0.62 μM and a Ki of 3.93 μM. This compound selectively binds to the original binding site of α-glucosidase, engaging in multiple hydrophobic interactions with adjacent amino acids. α-Glucosidase-IN-28 is primarily utilized in research related to diabetes and its associated metabolic disorders, providing valuable insights into glucose regulation and enzyme modulation. -
Alpha-glucosidase Inhibitor
α-Glucosidase-IN-15 is a potent inhibitor of α-glucosidase, demonstrating an IC50 value of 3.34 μM. This compound exhibits significant antidiabetic activity by preventing the hydrolysis of carbohydrates, thereby reducing postprandial blood glucose levels. It is suitable for research applications focused on diabetes management and metabolic disorders. -
α-Glucosidase Inhibitor
Kouitchenside G is a natural inhibitor of α-Glucosidase, isolated from the plant Swertia kouitchensis. It demonstrates inhibitory activity with an IC50 value of 956 μM, making it a valuable tool for studying carbohydrate metabolism and enzyme modulation. This compound is pertinent for research applications focused on diabetes and metabolic disorders. -
α-Glucosidase Inhibitor
Resinacein L is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 0.635 mM. By impeding the digestion and absorption of carbohydrates in the gastrointestinal tract, Resinacein L effectively reduces postprandial blood glucose levels. This compound is valuable in research applications focused on diabetes management and the study of carbohydrate metabolism. -
Glycosidase Inhibitor
Glycosidase-IN-1 is a glycosidase inhibitor derived from D-mannose. This compound exhibits hypoglycemic activity and holds potential for the synthesis of immunosuppressive agents and β-glucosidase inhibitors. Its ability to modulate glycosidase activity makes it a valuable tool in biochemical research focused on carbohydrate metabolism and related diseases. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-10 is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 92.7 μM. This compound serves as a valuable tool for investigating the modulation of carbohydrate metabolism and is particularly relevant for research in type II diabetes. Its ability to effectively inhibit α-glucosidase makes it suitable for studies focused on glucose absorption regulation and diabetes management strategies. -
α-glucosidase Inhibitor
Bisabolone oxide A is an α-glucosidase inhibitor that modulates carbohydrate metabolism by delaying the absorption of glucose in the intestine. This compound demonstrates significant potential in research applications related to diabetes management and glycemic control. Its ability to influence α-glucosidase activity makes it a valuable tool for studies focused on metabolic disorders and enzymatic regulation. -
Alpha-glucosidase Inhibitor
α-Glucosidase-IN-17 is a potent inhibitor of α-glucosidase, displaying an IC50 value of 3.79 μM. This compound demonstrates significant antidiabetic activity, making it a valuable research tool for studying the regulation of carbohydrate metabolism and the management of diabetes. It can be utilized in pharmacological studies aimed at exploring the modulation of blood glucose levels. -
α-glucosidase Inhibitor
α-Glucosidase-IN-21 is a potent inhibitor of α-glucosidase, demonstrating an IC50 of 2.62 μM. This compound exhibits significant anti-diabetic activity, making it valuable for research into glycemic control and obesity-related metabolic disorders. Its efficacy as an α-glucosidase inhibitor supports its use in studies targeting carbohydrate metabolism and related therapeutic applications. -
α-glucosidase Inhibitor
α-Glucosidase-IN-20 is a potent orally active inhibitor of α-glucosidase, with an IC50 value of 3.01 μM. This compound demonstrates significant anti-diabetic activity by modulating carbohydrate metabolism and reducing postprandial glucose levels. It is suitable for research applications aimed at exploring therapeutic strategies for managing type 2 diabetes and related metabolic disorders. -
α-glucosidase Inhibitor
(+)-Cembrene A is an α-glucosidase inhibitor, exhibiting an IC50 of 30.31 μM. This compound demonstrates nontoxicity towards human normal hepatocyte (LO2) cells, making it a suitable candidate for research in metabolic disorders and carbohydrate metabolism regulation. Its ability to modulate α-glucosidase activity suggests potential applications in studies focused on diabetes and related pathophysiological conditions. -
Glucosidase Inhibitor
Afegostat tartrate is a potent glucosidase inhibitor that selectively binds to acid-β-glucosidase (GCase) within the endoplasmic reticulum, functioning as a pharmacological chaperone. This compound enhances enzyme stability and promotes proper folding, making it valuable for research related to Gaucher disease and other lysosomal storage disorders. Its ability to influence GCase activity makes it an important tool for studies aimed at understanding enzyme deficiencies and developing therapeutic strategies. -
α-Glucosidase Inhibitor
Saponin QS-L1 is a triterpenoid saponin that acts as an α-glucosidase inhibitor, exhibiting an IC50 value of 23.1 μM. This compound is valuable for research into diabetes management and glucose regulation. Its inhibition of α-glucosidase may provide insights into therapeutic strategies for glycemic control in diabetic patients. -
alpha-Glucosidase Inhibitor
9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one is a mixed competitive inhibitor of alpha-glucosidase, primarily targeting the enzyme from Bacillus stearothermophilus, with an IC50 value of 3.86 mg/L. This compound exhibits potential as a phytoalexin, demonstrating biological activity relevant for research in glycemic control and carbohydrate metabolism. Its inhibitory properties make it suitable for studies investigating the modulation of glucose absorption and related metabolic disorders. -
Glycosidase Inhibitor
Panosialin wA is a potent glycosidase inhibitor that selectively targets α,β-glucosidase and mannose glycosidase. Its ability to modulate these enzymes may have applications in research related to carbohydrate metabolism and pathogen interaction. While Panosialin wA does not inhibit the influenza virus, it exhibits a weak anti-microbial effect, making it a useful tool in studies of microbial activity. -
α-Glucosidase Inhibitor
N-Methyltetrachlorophthalimide is a potent inhibitor of α-glucosidase, exhibiting an IC50 of 22.1 μM. This compound is valuable for research focused on anti-diabetic mechanisms as well as antiviral applications, enabling the exploration of therapeutic strategies against conditions related to glycemic control and viral infections. -
α-Glucosidase inhibitor
α-Glucosidase-IN-45 is an inhibitor targeting α-glucosidase, a key enzyme involved in carbohydrate metabolism. This novel indol-fused pyrano[2,3-D]pyrimidine compound exhibits significant biological activity by obstructing the enzyme's function, thereby influencing glucose absorption and metabolism. It is suitable for research applications related to diabetes, metabolic disorders, and carbohydrate enzyme modulation. -
α-glucosidase Inhibitor
1'-O-Methyl neochebulinate is a hydrolyzable tannin that functions as an α-glucosidase inhibitor, exhibiting an IC50 value of 59.5 μM. Isolated from the fruits of Terminalia chebula Retz, this compound significantly impedes the activity of α-glucosidase, making it relevant for studies in diabetes management and carbohydrate metabolism. Its inhibitory properties provide a useful tool for investigating potential therapeutic strategies for controlling postprandial glucose levels. -
Glucosidase Inhibitor
N-5-Carboxypentyl-1-deoxynojirimycin is an alpha-glucosidase inhibitor with significant potential in glycosidase research. This compound is utilized for its ability to selectively inhibit glucosidase enzymes, making it valuable in studies exploring carbohydrate metabolism and related pathways. Additionally, it serves as a precursor for the preparation of affinity matrices, facilitating the binding of target proteins to resins for purification and analysis. -
α-Glucosidase Inhibitor
Sativanone is a potent α-glucosidase inhibitor, exhibiting an EC50 value of 0.357 mg/mL for rat α-glucosidase. Isolated from Dalbergia tonkinensis, this compound demonstrates antibacterial activity against Ralstonia solanacearum. Additionally, Sativanone exhibits anti-senescent and antioxidant properties, making it a valuable reagent for research in metabolic disorders, bacterial infections, and oxidative stress-related studies. -
Glycosidase Inhibitor
Panosialin D is a glycosidase inhibitor that selectively targets α,β-glucosidase and mannose glycosidase. This compound does not exhibit activity against the influenza virus; however, it demonstrates weak antimicrobial properties. It serves as a valuable reagent for research focused on glycosidase-related pathways and antimicrobial studies. -
α-glucosidase Inhibitor
Enhydrin is a naturally occurring α-glucosidase inhibitor derived from the leaves of Smallanthus sonchifolius. It demonstrates potent inhibitory activity with an IC50 value of 34.17 μg/mL, making it relevant for the management of postprandial hyperglycemia. Research indicates that Enhydrin can effectively reduce blood glucose levels in diabetic rat models, supporting its potential application in diabetes research and therapy development.
