Fig. 1 · Structure
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Lotusine
α-amylase Inhibitor, α-glucosidase Inhibitor
Lotusine is an α-amylase and α-glucosidase inhibitor, demonstrating IC50 values of 30.60 μg/mL and 36.15 μg/mL, respectively. This compound modulates the EGFR-Akt-ERK signaling pathway by lowering the levels of phosphorylated EGFR, Akt, and ERK, leading to apoptosis, G0/G1 cell cycle arrest, and reduced cancer cell proliferation. Additionally, Lotusine decreases lipid peroxidation and enhances the activities of antioxidant enzymes such as SOD, CAT, and GPx. Its potential applications include research in non-small cell lung cancer, type 2 diabetes, and autism spectrum disorder.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 6871-67-6 |
| Applications | α-amylase Inhibitor, α-glucosidase Inhibitor |
| Formula | C19H24NO3 |
| Molecular Weight | 314.40 |
| SMILES | C[N+]1(C)[C@H](CC2=CC=C(O)C=C2)C3=C(C=C(O)C(OC)=C3)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.