Glucosidase

Cat. No.

A39078

CAS No.

372955-18-5

Guavinoside B

Guavinoside B is an orally active α-glucosidase inhibitor, exhibiting an IC50 of 0.21 mM. It demonstrates significant biological activity by upregulating the expressions of Nrf2, GCLC, and NQO1 while downregulating p-JNK expression and reducing intracellular reactive oxygen species levels. Guavinoside B effectively decreases serum TNF-α levels associated with Acetaminophen, alleviating hepatocellular infiltration and necrosis, and improving liver-related biochemical parameters. This compound is relevant for research in diabetes and Acetaminophen-induced liver injury.

Cat. No.

A39282

CAS No.

57744-69-1

Aspulvinone H

Aspulvinone H is a potent inhibitor targeting pancreatic lipase, acetylcholinesterase, glutamic-oxaloacetic transaminase 1 (GOT1), and α-glucosidase, with IC50 values of 25.95 μM, 47.06 μM, 5.91/6.91 μM, and 4.6 μM, respectively. It demonstrates key biological activities including inhibition of cancer cell proliferation, disruption of glutamine metabolism, and induction of apoptosis in cancer cells. Additionally, Aspulvinone H lowers postprandial blood glucose levels in mice and exhibits antibacterial properties against Staphylococcus aureus. This compound is suitable for research into pancreatic ductal adenocarcinoma, diabetes management, and infectious diseases caused by Staphylococcus aureus.

Cat. No.

A39917

CAS No.

3542-72-1

Norathyriol

Synonyms: Mangiferitin

Norathyriol is a natural metabolite derived from Mangifera, exhibiting significant anti-inflammatory and anticancer properties. It functions as a noncompetitive inhibitor of α-glucosidase with an IC50 value of 3.12 μM. Additionally, Norathyriol inhibits the peroxisome proliferator-activated receptors (PPARs) α, β, and γ, with IC50s of 92.8 μM, 102.4 μM, and 153.5 μM, respectively. This compound demonstrates a range of biological activities, including antioxidant, antimicrobial, and antibacterial effects, making it valuable for diverse research applications in inflammation and cancer therapeutics.

Cat. No.

A41193

CAS No.

2375866-82-1

α-Glucosidase-IN-63

α-Glucosidase-IN-63 is a potent inhibitor of α-Glucosidase, displaying an IC50 value of 0.44 μM. Additionally, it inhibits human carbonic anhydrase II (hCA II) with a Ki of 7.0 nM. This compound is of interest for research applications focusing on glucose metabolism and enzymatic regulation in metabolic disorders. Its oral effectiveness enhances its utility in in vivo studies.

Cat. No.

A42349

CAS No.

83529-62-8

Leucosceptoside A

Leucosceptoside A is a phenylethanoid glycoside that functions as a selective inhibitor of Protein Kinase C alpha (PKCα). This compound demonstrates significant anti-hyperglycemic and anti-hypertensive effects and exhibits inhibitory activity against α-glucosidase, with an IC50 value of 19.0 μM. Leucosceptoside A is relevant for research into metabolic disorders and cardiovascular diseases, providing insights into therapeutic approaches targeting PKCα.

Cat. No.

A43572

CAS No.

98094-87-2

Lupinalbin A

Synonyms: Boeravinone L

Lupinalbin A, a dipeptidyl peptidase 4 (DPP4) and α-glucosidase inhibitor, demonstrates effective inhibition with IC50 values of 45.2 µM and 53.4 µM, respectively. This compound exhibits notable antidiabetic activity, making it a valuable tool for research in diabetes management and metabolic studies. Its dual inhibition profile supports investigations into glucose metabolism and insulin sensitivity.

Cat. No.

A46414

CAS No.

73285-50-4

1-Deoxynojirimycin hydrochloride

Synonyms: Duvoglustat hydrochloride

1-Deoxynojirimycin hydrochloride is a potent α-glucosidase inhibitor, primarily utilized for modulating postprandial blood glucose levels. This compound demonstrates notable antihyperglycemic and anti-obesity effects, making it valuable in diabetes mellitus research. Additionally, 1-Deoxynojirimycin hydrochloride exhibits antiviral properties, contributing to its diverse applicability in metabolic and infectious disease studies.

Cat. No.

A46732

CAS No.

117211-03-7

Cefetecol

Synonyms: GR69153

Cefetecol is a broad-spectrum cephalosporin antibiotic that targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall synthesis, leading to cell lysis. In addition to its antibacterial properties, Cefetecol also acts as an α-glucosidase inhibitor, demonstrating in vivo anti-diabetic activity in diabetic mouse models. This compound is suitable for research applications in both antibacterial and anti-diabetic studies.

Cat. No.

A49080

CAS No.

445010-62-8

CKD-711

CKD-711 is an orally active aminooligosaccharide that functions as a potent inhibitor of α-glucosidase, with an IC50 of 78 μg/mL. It also demonstrates inhibitory effects against porcine intestinal maltase and sucrose, with IC50 values of 2.5 and 0.5 μg/mL, respectively. Additionally, CKD-711 exhibits selective antibacterial activity against Comamonas terrigena. This compound is valuable for research into infections and metabolic disorders, including diabetes.

Cat. No.

A50694

CAS No.

141117-12-6

Celgosivir hydrochloride

Synonyms: MBI 3253 hydrochloride; MDL 28574 hydrochloride; MX3253 hydrochloride

Celgosivir hydrochloride is an α-glucosidase I inhibitor that demonstrates significant antiviral activity by inhibiting bovine viral diarrhoea virus (BVDV) with an IC50 value of 1.27 μM in in vitro assays. This compound is valuable for researchers studying viral infections and exploring potential therapeutic strategies through glycosidase inhibition. Its ability to modulate glycosylation processes makes it a relevant tool for biochemical and pharmacological investigations.

Cat. No.

A50703

CAS No.

1447464-73-4

IHVR-19029

IHVR-19029 is a potent inhibitor of endoplasmic reticulum α-glucosidases I and II, exhibiting an IC50 of 0.48 μM for α-glucosidase I. This compound demonstrates significant antiviral activity by effectively blocking the replication of various hemorrhagic fever viruses, including Dengue virus (DENV), Ebola virus (EBOV), and Rift Valley fever virus. Research applications include the exploration of antiviral strategies, especially in combination therapies, such as enhancing the efficacy of Favipiravir.

Cat. No.

A50730

CAS No.

1508303-85-2

ToP-DNJ

ToP-DNJ is a specific inhibitor of endoplasmic reticulum α-glucosidase II (GluII), demonstrating an IC50 value of 9.0 μM. It selectively interferes with both catalytic reactions of GluII, showing enhanced activity in the initial conversion of di-glycosylated to mono-glycosylated glycans. Additionally, ToP-DNJ exhibits anti-DENV activity, making it a valuable tool for research into dengue virus infection and related glycobiology studies.

Cat. No.

A50732

CAS No.

1333144-07-2

SP187 hydrochloride

Synonyms: MON-​DNJ hydrochloride; UV4 hydrochloride

SP187 hydrochloride is a host-targeting iminosaccharide that primarily inhibits endoplasmic reticulum glucosidase, rendering it effective against filovirus infections. This compound demonstrates antiviral activity, notably against the Dengue virus, in vivo. SP187 hydrochloride is a valuable tool for researchers investigating antiviral mechanisms and developing therapeutic strategies against viral infections.

Cat. No.

A50796

CAS No.

86377-52-8

Ganoderic acid Y

Ganoderic acid Y is an α-glucosidase inhibitor, exhibiting an IC50 of 170 μM against yeast α-glucosidase. This compound demonstrates antiviral properties by inhibiting the replication of enterovirus 71 (EV71) through the disruption of the virus uncoating process. Ganoderic acid Y is relevant for research applications investigating glycosidase activity and antiviral strategies.

Cat. No.

A51837

CAS No.

1191255-15-8

Ganomycin I

Ganomycin I is a dual inhibitor targeting α-Glucosidase and HMG-CoA reductase. It demonstrates significant anti-diabetic properties and inhibits HIV protease, contributing to its potential as an antiviral agent. Additionally, Ganomycin I shows effectiveness in preventing osteoclastogenesis, making it a valuable reagent for research in diabetes and bone metabolism.

Cat. No.

A52250

CAS No.

36417-86-4

N-p-trans-Coumaroyltyramine

N-p-trans-Coumaroyltyramine is a natural phenolic amide compound that acts as an inhibitor of acetylcholinesterase (AChE) with an IC50 of 122 μM and α-glucosidase with an IC50 of 2.7 μM. It demonstrates significant anti-trypanosomal activity, exhibiting an IC50 of 13.3 µM against Trypanosoma brucei rhodesiense. This compound is valuable for research into neurodegenerative diseases such as Alzheimer's disease, as well as for studies focusing on trypanosomiasis.

Cat. No.

A53445

CAS No.

3081926-49-7

DNJ-20

DNJ-20 is an α-glucosidase inhibitor with an IC50 of 55.3 μg/mL, demonstrating significant broad-spectrum activity against SARS-CoV-2. It disrupts the endoplasmic reticulum-associated glycoprotein folding process, inhibiting proper processing of viral glycoproteins and consequently blocking viral particle formation and infection. DNJ-20 exhibits IC50 values as low as 1.49 μM against various SARS-CoV-2 variants, as well as HCoV-229E and HCoV-OC43. This inhibitor is suited for pan-coronavirus research applications.

Cat. No.

A65152

CAS No.

94390-15-5

Isosojagol

Isosojagol is an α-Glucosidase inhibitor with an IC50 of 32.2 μM, demonstrating significant potential in modulating carbohydrate metabolism. Isolated from the roots of Dolichos trilobus, Isosojagol exhibits anti-inflammatory properties by inhibiting LPS-induced nitric oxide production in RAW264.7 cells. This reagent is relevant for research into fracture healing, soft tissue injuries, and rheumatoid arthritis, providing a valuable tool for understanding the underlying biological mechanisms.

Cat. No.

A69474

CAS No.

2093387-94-9

α-Amylase/α-Glucosidase-IN-23

α-Amylase/α-Glucosidase-IN-23 is a potent inhibitor of α-amylase and α-glucosidase, demonstrating IC50 values of 73.68 nM and 146.18 nM, respectively. This compound is valuable for research focused on glucose metabolism and the management of hypoglycemia. Its ability to inhibit carbohydrate-hydrolyzing enzymes makes it a useful tool for studies investigating glycemic control and related metabolic disorders.

Cat. No.

A69477

CAS No.

93-10-7

Quinoline-2-carboxylic acid

Quinoline-2-carboxylic acid functions as an α-glucosidase inhibitor, demonstrating significant potential in the modulation of glucose metabolism. This compound is of interest for its antidiabetic properties and serves as a valuable intermediate for the synthesis of various biologically active compounds in chemical research. Its role in enzyme inhibition makes it a relevant agent for studies aimed at understanding carbohydrate metabolism and diabetes management.

Cat. No.

A69483

CAS No.

6864-20-6

2,4,6-Triphenylaniline

2,4,6-Triphenylaniline serves as an α-glucosidase inhibitor, demonstrating significant anti-diabetic properties. Its formulation in nano-emulsions enhances stability and bioavailability, enabling more efficient inhibition of both α-glucosidase and α-amylase enzymes. This compound is valuable for research focused on glycemic control and potential therapeutic strategies for diabetes management.

Cat. No.

A69485

CAS No.

6871-67-6

Lotusine

Lotusine is an α-amylase and α-glucosidase inhibitor, demonstrating IC50 values of 30.60 μg/mL and 36.15 μg/mL, respectively. This compound modulates the EGFR-Akt-ERK signaling pathway by lowering the levels of phosphorylated EGFR, Akt, and ERK, leading to apoptosis, G0/G1 cell cycle arrest, and reduced cancer cell proliferation. Additionally, Lotusine decreases lipid peroxidation and enhances the activities of antioxidant enzymes such as SOD, CAT, and GPx. Its potential applications include research in non-small cell lung cancer, type 2 diabetes, and autism spectrum disorder.

Cat. No.

A69487

CAS No.

223505-23-5

α-Amylase/α-Glucosidase-IN-19

α-Amylase/α-Glucosidase-IN-19 is a dual inhibitor targeting α-amylase and α-glucosidase, exhibiting IC50 values of 170.7 μM and 60.37 μM, respectively. This compound demonstrates significant inhibitory activity that may be beneficial in the study of carbohydrate metabolism and the management of diabetes. Its applications include examining mechanisms of enzyme inhibition and exploring potential therapeutic strategies for controlling postprandial glucose levels.

Cat. No.

A69488

CAS No.

1500779-21-4

ABCB1-IN-4

ABCB1-IN-4 is a potent dual inhibitor of α-amylase and α-glucosidase, exhibiting IC50 values of 1.63 μM and 0.14 μM, respectively. This compound demonstrates significant potential in the study of diabetes by modulating carbohydrate metabolism. Its orally active nature makes it a valuable tool for research applications focused on glycemic control and related metabolic pathways.

Cat. No.

A69500

CAS No.

2885971-91-3

HPA-IN-2

HPA-IN-2 is a potent and selective inhibitor of human pancreatic α-amylase (HPA) with an IC50 value of 8.2 μM, demonstrating its efficacy in modulating carbohydrate digestion. In contrast, it shows significantly weaker inhibition of α-glucosidase with an IC50 of 450.7 μM. This compound is utilized in research focused on diabetes and metabolic disorders, particularly in understanding the regulation of carbohydrate metabolism.