PFB-FDGlu is a highly selective substrate for lysosomal Glucocerebrosidase (GCase), engineered to be metabolized into fluorescein upon GCase activity. This compound is cell permeable, facilitating its use in flow cytometry to measure GCase activity in living cells at the single-cell level. PFB-FDGlu serves as an essential tool for studying GCase function in various biological contexts and is particularly relevant in research related to lysosomal storage disorders.
PFB-FDGlu is a highly selective substrate for lysosomal Glucocerebrosidase (GCase), engineered to be metabolized into fluorescein upon GCase activity. This compound is cell permeable, facilitating its use in flow cytometry to measure GCase activity in living cells at the single-cell level. PFB-FDGlu serves as an essential tool for studying GCase function in various biological contexts and is particularly relevant in research related to lysosomal storage disorders.
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