Gcase Activator 2 is a pyrrolo[2,3-b]pyrazine that serves as a potent activator of β-glucocerebrosidase (GCase), with an EC50 of 3.8 μM. This compound facilitates GCase dimerization, promoting both K-type and V-type interactions. Gcase Activator 2 displays low metabolic clearance in both human and mouse systems, making it a valuable tool for research into GCase-related biological pathways and potential therapeutic applications in lysosomal storage disorders.
Gcase Activator 2 is a pyrrolo[2,3-b]pyrazine that serves as a potent activator of β-glucocerebrosidase (GCase), with an EC50 of 3.8 μM. This compound facilitates GCase dimerization, promoting both K-type and V-type interactions. Gcase Activator 2 displays low metabolic clearance in both human and mouse systems, making it a valuable tool for research into GCase-related biological pathways and potential therapeutic applications in lysosomal storage disorders.
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