Lipoxygenase

Cat. No.

A64543

CAS No.

99134-29-9

L-651896

L-651896 is a potent inhibitor of 5-lipoxygenase, exhibiting significant anti-inflammatory and antiproliferative properties. By obstructing the production of leukotrienes and prostaglandins, L-651896 is useful in investigating skin diseases and various other inflammatory conditions. Its mechanism of action supports research aimed at understanding the role of lipid mediators in inflammatory pathways.

Cat. No.

A64544

CAS No.

121502-05-4

PD 127443

PD 127443 is an inhibitor of both 5-lipoxygenase and cyclooxygenase, targeting critical enzymes involved in the inflammatory response. This compound exhibits significant anti-inflammatory activity, making it a valuable tool for research applications focused on understanding the mechanisms of inflammation and exploring potential therapeutic interventions in inflammatory diseases.

Cat. No.

A64552

CAS No.

1051931-39-5

ZLJ-6

ZLJ-6 is a dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX), demonstrating potent oral bioactivity. With IC50 values of 0.73 μM for COX-1, 0.31 μM for COX-2, and 0.99 μM for 5-LOX, ZLJ-6 exhibits significant anti-inflammatory and analgesic properties. This compound is suitable for research applications aimed at investigating inflammatory pathways and potential therapeutic interventions.

Cat. No.

A64558

CAS No.

55511-07-4

(-)-Bornyl ferulate

(-)-Bornyl ferulate serves as a dual inhibitor of 5-lipoxygenase (5-LOX) and cyclooxygenase (COX), displaying IC50 values of 10.4 μM and 12.0 μM, respectively. This compound demonstrates significant anti-inflammatory potential, making it useful for research focused on inflammation-related pathways and conditions. Its ability to modulate leukotriene and prostaglandin synthesis positions it as a valuable tool in the study of various inflammatory diseases and therapeutic interventions.

Cat. No.

A65100

CAS No.

23838-17-7

Umbelliprenin

Umbelliprenin is a prenylated coumarin that functions as a lipoxygenase inhibitor. It exhibits significant antioxidant properties along with anticancer, anti-inflammatory, and immunomodulatory activities. This compound effectively suppresses nitric oxide production in inflammatory macrophages, as well as inhibiting the expression of inducible nitric oxide synthase (iNOS). Umbelliprenin holds promise for research applications in the fields of inflammation, cancer biology, and immunology.

Cat. No.

A65410

CAS No.

1492060-44-2

5-LO/mPGES1-IN-1

5-LO/mPGES1-IN-1 is a dual inhibitor of 5-lipoxygenase (5-LO) and microsomal prostaglandin E2 synthase-1 (mPGES-1), exhibiting IC50 values of 0.3 μM and 0.4 μM, respectively. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research in inflammatory pathways. Applications include studies focused on the modulation of inflammatory responses, providing insights into potential therapeutic strategies for related diseases.

Cat. No.

A71173

CAS No.

103-85-5

Phenylthiourea

Synonyms: Phenylthiocarbamide

Phenylthiourea, a phenoloxidase inhibitor, effectively blocks the enzymatic oxidation of DOPA with a Ki value of 0.21 μM. This compound is recognized as a potent inhibitor of tyrosinase, making it valuable in research focused on melanin synthesis and pigmentation processes. Its use can result in observable physiological effects, such as the graying of hair in black rats, highlighting its impact on melanin formation. Phenylthiourea is essential for studies investigating the roles of phenoloxidase and tyrosinase in various biological systems.

Cat. No.

A71505

CAS No.

3316-09-4

4-Nitrocatechol

4-Nitrocatechol is a potent inhibitor of lipoxygenase, an enzyme implicated in the metabolism of arachidonic acid and the biosynthesis of inflammatory mediators. This compound exhibits significant anti-inflammatory properties and is widely used in research to explore the roles of lipoxygenase in various biological processes. Its application extends to studies of oxidative stress and the development of novel therapeutic strategies targeting inflammatory diseases.

Cat. No.

A76410

CAS No.

133430-69-0

ETH-615

ETH-615 is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the biosynthesis of leukotrienes, which play a significant role in inflammatory processes. This compound demonstrates key biological activity in reducing inflammation and may have implications for research into cardiovascular diseases and other inflammatory disorders. Its efficacy in modulating leukotriene synthesis makes ETH-615 valuable for studies aimed at understanding the underlying mechanisms of cardiovascular pathology.

Cat. No.

A76411

CAS No.

847163-28-4

ML351

ML351 is a potent inhibitor of 15-lipoxygenase-1 (15-LOX-1) with an IC50 of 200 nM, demonstrating exceptional selectivity with over 250-fold preference compared to related isozymes such as 5-LOX, platelet 12-LOX, and 15-LOX-2, as well as ovine COX-1 and human COX-2. This compound has shown significant biological activity in preventing dysglycemia and reducing β-cell oxidative stress in a nonobese diabetic mouse model of Type 1 Diabetes. ML351 is useful in studying the role of 15-LOX-1 in metabolic diseases and may have implications for therapeutic strategies targeting oxidative stress in diabetes.

Cat. No.

A76412

CAS No.

27686-84-6

Masoprocol

Synonyms: meso-Nordihydroguaiaretic acid; meso-NDGA

Masoprocol, a lipoxygenase inhibitor, demonstrates significant antihyperglycemic activity by effectively lowering glucose levels and hepatic triglycerides in vivo. This compound is particularly valuable for researching type II diabetes mechanisms and potential therapeutic strategies. Its ability to modulate metabolic pathways positions Masoprocol as an important reagent in diabetes research.

Cat. No.

A76413

CAS No.

2349374-37-2

15-LOX-1 inhibitor 1

15-LOX-1 inhibitor 1 is a selective inhibitor of 15-lipoxygenase-1 (15-LOX-1) with an IC50 value of 0.19 μM. This compound demonstrates protective effects on macrophages against cytotoxicity induced by lipopolysaccharide, while also inhibiting nitric oxide formation and lipid peroxidation. With its ability to modulate inflammatory pathways, 15-LOX-1 inhibitor 1 is valuable for research applications focused on inflammation and oxidative stress.

Cat. No.

A76414

CAS No.

20290-75-9

Stearidonic acid

Synonyms: 6Z,9Z; 12Z; 15Z-Octadecatetraenoic acid

Stearidonic acid (6Z,9Z,12Z,15Z-Octadecatetraenoic acid) is a polyunsaturated fatty acid that acts as a potent inhibitor of 5-lipoxygenase, thereby reducing the synthesis of leukotrienes and 5-HETE. This compound has been shown to enhance the levels of eicosapentaenoic acid (EPA) in red blood cells. Stearidonic acid is employed in research focusing on metabolic diseases and inflammatory pathways, making it a valuable tool for studying lipid metabolism and related disorders.

Cat. No.

A76418

CAS No.

132465-10-2

2-TEDC

2-TEDC is a potent inhibitor of 5-, 12-, and 15-lipoxygenase, demonstrating IC50 values of 0.09 μM, 0.013 μM, and 0.5 μM, respectively. This compound is valuable in the study of lipoxygenase pathways and their role in inflammatory processes. 2-TEDC is particularly relevant for research focused on atherosclerosis, providing insights into its mechanistic actions and potential therapeutic interventions.

Cat. No.

A76420

CAS No.

1202193-89-2

ThioLox

ThioLox is a competitive inhibitor of 15-lipoxygenase-1 (15-LOX-1) with a Ki value of 3.30 μM. This compound exhibits significant anti-inflammatory and neuroprotective effects, making it a valuable tool in research focused on inflammation-related disorders and neurodegenerative diseases. Its ability to modulate 15-LOX-1 activity facilitates the exploration of lipid metabolism and its impact on cellular health.

Cat. No.

A76421

CAS No.

132465-11-3

Cinnamyl-3,4-dihydroxy-α-cyanocinnamate

Synonyms: CDC

Cinnamyl-3,4-dihydroxy-α-cyanocinnamate is an effective inhibitor of 12/15-Lipoxygenases (LO). This compound demonstrates significant anti-inflammatory properties, making it a valuable tool for investigating the role of lipoxygenases in various diseases, including type 1 diabetes mellitus. Its specificity towards these enzymes provides researchers with a robust agent for studying inflammatory pathways and potential therapeutic interventions.

Cat. No.

A76422

CAS No.

179691-97-5

5-LOX-IN-2

5-LOX-IN-2 is a selective inhibitor of 5-lipoxygenase (5-LOX), exhibiting an IC50 value of 0.33 μM. This compound effectively inhibits 5-LOX activity in a dose-dependent manner and has demonstrated the ability to reduce cell viability in renal cancer cells while promoting apoptosis. Its potential applications in cancer research make it a valuable tool for studying the role of 5-LOX in tumor biology.

Cat. No.

A76423

CAS No.

939-19-5

3-Hydroxycoumarin

3-Hydroxycoumarin is a potent inhibitor of tyrosinase and lipoxygenase, exhibiting an IC50 of 26 μM against recombinant human tyrosinase and a Ki of 3.39 μM. It also demonstrates effective inhibition of lipoxygenase with an IC50 of 9.5 μM. Additionally, 3-Hydroxycoumarin displays significant DPPH free radical scavenging activity (IC50 = 31.2 μM) and offers photoprotective benefits for sea urchin zygotes and embryos, making it a valuable reagent for research in enzymatic inhibition and oxidative stress studies.

Cat. No.

A76424

CAS No.

179420-17-8

CJ-13,610

CJ-13,610 is a selective inhibitor of 5-lipoxygenase (5-LO), effectively disrupting the conversion of arachidonic acid (AA) into leukotrienes. This nonredox-type inhibitor demonstrates dose-dependent suppression of 5-LO product formation in ionophore A23187-stimulated polymorphonuclear leukocytes (PMNL), with an IC50 value of approximately 70 nM. CJ-13,610 is valuable in exploring pathways involving leukotriene synthesis and may aid in the research of inflammatory processes.

Cat. No.

A76425

CAS No.

13488-22-7

5,8,11-Eicosatriynoic acid

Synonyms: ETI

5,8,11-Eicosatriynoic acid is a potent lipoxygenase inhibitor that effectively disrupts the biosynthesis of leukotriene C4 (LTC4) in mast cell tumor cells. This compound is useful for researchers investigating the role of leukotrienes in inflammation and allergic responses. Additionally, it can be employed in studies focused on the modulation of lipoxygenase pathways in various biological systems.

Cat. No.

A76426

CAS No.

4684-32-6

Picrinine

Picrinine, a 5-lipoxygenase (5-LOX) inhibitor, is an alkaloid derived from the leaves of Alstonia scholaris. This compound demonstrates significant anti-inflammatory effects by targeting and inhibiting the activity of the 5-LOX enzyme. Picrinine is useful for research applications related to inflammation and may provide insights into therapeutic strategies for inflammatory diseases.

Cat. No.

A76428

CAS No.

91431-42-4

Lonapalene

Synonyms: RS4317

Lonapalene is a selective inhibitor of 5-lipoxygenase (5-LO). It exhibits significant anti-inflammatory activity by blocking the production of leukotrienes, which are mediators involved in various inflammatory conditions. This compound is primarily utilized in research aimed at understanding and exploring therapeutic interventions for diseases associated with leukotriene signaling.

Cat. No.

A76429

CAS No.

322666-76-2

MLS000545091

MLS000545091 is a potent and selective inhibitor of lipoxygenase-2 (LOX-2), demonstrating an IC50 value of 2.6 μM for the human enzyme h15-LOX-2. This compound is valuable for research into inflammatory processes and related diseases, facilitating investigations into the role of LOX-2 in various biological pathways. Its specificity makes it a useful tool for exploring therapeutic strategies targeting LOX-2-related conditions.

Cat. No.

A76431

CAS No.

125235-15-6

5-LOX-IN-4

5-LOX-IN-4 is a selective inhibitor of 5-Lipoxygenase (5-LOX), a key enzyme involved in the biosynthesis of leukotrienes. This compound plays a significant role in modulating inflammatory responses and is valuable for research applications targeting asthma, allergies, and other inflammatory diseases. Its inhibition of 5-LOX may contribute to understanding leukotriene-related pathways and exploring potential therapeutic strategies.

Cat. No.

A76433

CAS No.

910656-27-8

Setileuton

Synonyms: MK-0633

Setileuton is a selective inhibitor of 5-lipoxygenase, effectively modulating the oxidation of arachidonic acid. It demonstrates significant inhibition of leukotriene B4 (LTB4) production in calcium ionophore-stimulated human whole blood, with IC50 values of 3.9 nM and 52 nM, respectively. This compound is valuable for research applications focused on inflammatory pathways and leukotriene-mediated processes.