Lipoxygenase

Cat. No.

A64434

CAS No.

2413565-15-6

COX-2/15-LOX-IN-1

COX-2/15-LOX-IN-1 is a dual inhibitor of cyclooxygenase-2 (COX-2) and 15-lipoxygenase (15-LOX), exhibiting IC50 values of 10.65 μM for COX-1, 0.075 μM for COX-2, and 2.98 μM for 15-LOX. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research into inflammatory pathways and related diseases. Its ability to modulate key enzymes involved in arachidonic acid metabolism positions COX-2/15-LOX-IN-1 as a promising candidate for therapeutic investigation in inflammatory conditions.

Cat. No.

A64470

CAS No.

203443-33-8

Atractylochromene

Atractylochromene is a dual inhibitor targeting 5-lipoxygenase (5-LOX) and cyclooxygenase-1 (COX-1), exhibiting IC50 values of 0.6 μM and 3.3 μM, respectively. This compound serves as a valuable tool in research related to inflammatory pathways and can facilitate the study of related conditions influenced by leukotrienes and prostaglandins. Its inhibitory effects position Atractylochromene as a potential candidate for therapeutic exploration in inflammatory diseases.

Cat. No.

A64471

CAS No.

2831329-35-0

XO/COX/LOX-IN-1

XO/COX/LOX-IN-1 is a potent inhibitor of xanthine oxidase, cyclooxygenases, and lipoxygenases. This compound exhibits significant anti-inflammatory activity, making it valuable for research in inflammation, cancer, and metabolic diseases. Its multifaceted inhibition profile positions XO/COX/LOX-IN-1 as a critical tool for exploring pathways involved in these pathological conditions.

Cat. No.

A64480

CAS No.

443919-96-8

COX-2/5-LOX-IN-4

COX-2/5-LOX-IN-4 is a potent dual inhibitor targeting both cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX), with IC50 values of 0.05 μM and 0.003 μM, respectively. By disrupting the arachidonic acid metabolism pathway, this compound effectively decreases the synthesis of prostaglandins and leukotrienes, leading to reduced inflammatory responses. In vivo studies using a rat ear edema model demonstrate its substantial anti-inflammatory activity, with intravenous doses resulting in up to 44% reduction in edema. COX-2/5-LOX-IN-4 is an important tool for investigating the mechanisms underlying inflammatory diseases.

Cat. No.

A64494

CAS No.

1860810-23-6

COX-2/15-LOX-IN-7

COX-2/15-LOX-IN-7 is a selective dual inhibitor targeting cyclooxygenase-2 (COX-2) and 15-lipoxygenase (15-LOX) with IC50 values of 0.022 and 1.19 μM, respectively. It also demonstrates inhibition of COX-1 with an IC50 of 28.081 μM. This compound exhibits low cytotoxicity in human colorectal cancer cell lines (HT-29 and HCT116) with IC50 values exceeding 100 μM, and shows a non-ulcerogenic profile. COX-2/15-LOX-IN-7 is valuable for cancer research applications, facilitating the study of inflammatory pathways and therapeutic interventions.

Cat. No.

A64500

CAS No.

130116-16-4

CI-986

CI-986 is a dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX), effectively preventing coronary vasoconstriction and the excessive production of leukotrienes, including LTB4 and LTC4. This compound exhibits notable anti-inflammatory and analgesic properties, making it a valuable tool for research into inflammation and cardiovascular diseases, including conditions like arthritis. CI-986's unique mechanism positions it as an important reagent in studies focused on the modulation of inflammatory pathways and vascular health.

Cat. No.

A64502

CAS No.

2410384-50-6

COX-2/5-LOX-IN-1

COX-2/5-LOX-IN-1 is a dual inhibitor targeting cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX), represented as a benzothiophen-2-yl pyrazole carboxylic acid derivative. This compound exhibits significant analgesic and anti-inflammatory properties, demonstrating enhanced efficacy compared to traditional nonsteroidal anti-inflammatory drugs. COX-2/5-LOX-IN-1 displays potent inhibition of COX-1, COX-2, and 5-LOX, with IC50 values of 12.13, 0.4, and 4.96 μM, respectively, making it a valuable tool for research in pain and inflammation pathways.

Cat. No.

A64507

CAS No.

219917-70-1

Speranskoside

Speranskoside is a dual inhibitor of cyclooxygenase-2 (COX-2) and lipoxygenase-15 (5-LOX), exhibiting an IC50 of 2.62 μg/mL for COX-2 and 5.51 μg/mL for 5-LOX. This compound demonstrates significant anti-inflammatory activity, making it valuable for the investigation of gastric ulcers and related disorders. Its unique mechanism of action provides a foundational tool for research into inflammatory pathways and therapeutic interventions.

Cat. No.

A64511

CAS No.

2481484-51-7

COX-2/5-LOX-IN-3

COX-2/5-LOX-IN-3 is a potent dual inhibitor of cyclooxygenase-2 (COX-2) and lipoxygenase (5-LOX), exhibiting IC50 values of 45.73 µM for COX-1, 5.45 µM for COX-2, and 4.33 µM for 5-LOX. This compound is valuable for studying inflammatory diseases, as it effectively modulates the associated biochemical pathways. Its dual inhibition may provide insights into the complex roles of COX-2 and 5-LOX in mediating inflammatory responses.

Cat. No.

A64539

CAS No.

130262-92-9

5'-Hydroxy meloxicam

5'-Hydroxy meloxicam is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) meloxicam, primarily involved in modulating cyclooxygenase (COX) enzyme activity. This compound exhibits anti-inflammatory properties and is essential for understanding the pharmacokinetics and metabolism of meloxicam in biological systems. Its study contributes to research on drug efficacy and safety profiles in chronic inflammatory conditions.

Cat. No.

A64543

CAS No.

99134-29-9

L-651896

L-651896 is a potent inhibitor of 5-lipoxygenase, exhibiting significant anti-inflammatory and antiproliferative properties. By obstructing the production of leukotrienes and prostaglandins, L-651896 is useful in investigating skin diseases and various other inflammatory conditions. Its mechanism of action supports research aimed at understanding the role of lipid mediators in inflammatory pathways.

Cat. No.

A64544

CAS No.

121502-05-4

PD 127443

PD 127443 is an inhibitor of both 5-lipoxygenase and cyclooxygenase, targeting critical enzymes involved in the inflammatory response. This compound exhibits significant anti-inflammatory activity, making it a valuable tool for research applications focused on understanding the mechanisms of inflammation and exploring potential therapeutic interventions in inflammatory diseases.

Cat. No.

A64552

CAS No.

1051931-39-5

ZLJ-6

ZLJ-6 is a dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX), demonstrating potent oral bioactivity. With IC50 values of 0.73 μM for COX-1, 0.31 μM for COX-2, and 0.99 μM for 5-LOX, ZLJ-6 exhibits significant anti-inflammatory and analgesic properties. This compound is suitable for research applications aimed at investigating inflammatory pathways and potential therapeutic interventions.

Cat. No.

A64558

CAS No.

55511-07-4

(-)-Bornyl ferulate

(-)-Bornyl ferulate serves as a dual inhibitor of 5-lipoxygenase (5-LOX) and cyclooxygenase (COX), displaying IC50 values of 10.4 μM and 12.0 μM, respectively. This compound demonstrates significant anti-inflammatory potential, making it useful for research focused on inflammation-related pathways and conditions. Its ability to modulate leukotriene and prostaglandin synthesis positions it as a valuable tool in the study of various inflammatory diseases and therapeutic interventions.

Cat. No.

A65100

CAS No.

23838-17-7

Umbelliprenin

Umbelliprenin is a prenylated coumarin that functions as a lipoxygenase inhibitor. It exhibits significant antioxidant properties along with anticancer, anti-inflammatory, and immunomodulatory activities. This compound effectively suppresses nitric oxide production in inflammatory macrophages, as well as inhibiting the expression of inducible nitric oxide synthase (iNOS). Umbelliprenin holds promise for research applications in the fields of inflammation, cancer biology, and immunology.

Cat. No.

A65410

CAS No.

1492060-44-2

5-LO/mPGES1-IN-1

5-LO/mPGES1-IN-1 is a dual inhibitor of 5-lipoxygenase (5-LO) and microsomal prostaglandin E2 synthase-1 (mPGES-1), exhibiting IC50 values of 0.3 μM and 0.4 μM, respectively. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research in inflammatory pathways. Applications include studies focused on the modulation of inflammatory responses, providing insights into potential therapeutic strategies for related diseases.

Cat. No.

A70200

CAS No.

117678-38-3

Levofloxacin N-oxide

Levofloxacin N-oxide is a minor metabolite of the fluoroquinolone antibiotic Levofloxacin, primarily functioning as an antibacterial agent targeting DNA gyrase and topoisomerase IV. It demonstrates minimal genotoxic risks, which may provide insights into the safety profile of Levofloxacin. This compound is valuable for research applications focused on antibiotic metabolism and the mechanistic studies of bacterial resistance.

Cat. No.

A70379

CAS No.

2194602-13-4

N-Dealkylated-mPEG7-Naloxol

N-Dealkylated-mPEG7-Naloxol is a metabolite of Naloxegol, functioning primarily as an opioid receptor antagonist. This compound is relevant for research involving opioid receptor modulation and can aid in investigating the pharmacokinetics and pharmacodynamics of Naloxegol. Its unique structural features make it suitable for applications in drug metabolism studies and the exploration of opioid receptor interactions.

Cat. No.

A70409

CAS No.

195454-31-0

Raloxifene N-Oxide

Raloxifene N-Oxide is an oxidative degradation product of Raloxifene, functioning primarily as a selective estrogen receptor modulator (SERM). This compound is of particular interest in research related to estrogen signaling pathways, as it may provide insights into the metabolism and pharmacokinetics of Raloxifene. Its biological activity allows for the exploration of estrogen receptor interactions and implications in conditions such as osteoporosis and breast cancer.

Cat. No.

A70436

CAS No.

84541-36-6

Raloxifene Bismethyl Ether hydrochloride

Raloxifene Bismethyl Ether hydrochloride is a metabolic derivative of Raloxifene, characterized by the absence of both hydroxyl groups, rendering it inactive at the estrogen receptor. This compound serves as a valuable tool for studying the pharmacokinetics and metabolic pathways of Raloxifene in various biological systems. It is particularly useful in research focused on estrogen receptor signaling and related physiological processes.

Cat. No.

A70469

CAS No.

182507-20-6

Raloxifene 6,4'-Bis-β-D-glucuronide

Raloxifene 6,4'-Bis-β-D-glucuronide is a metabolite of Raloxifene, functioning primarily as a selective estrogen receptor antagonist. This compound is significant in research related to osteoporosis prevention and estrogen receptor modulation. It serves as an important tool for studying the pharmacokinetics and biological effects of Raloxifene in various cellular contexts.

Cat. No.

A70967

CAS No.

234080-64-9

Moxifloxacin N-sulfate

Moxifloxacin N-sulfate is a metabolite of the fluoroquinolone antibiotic moxifloxacin. This compound is primarily used in pharmacokinetic studies to better understand the metabolism and excretion of moxifloxacin in biological systems. Its analysis plays a crucial role in toxicology, safety assessment, and the evaluation of therapeutic efficacy in various research applications.

Cat. No.

A71173

CAS No.

103-85-5

Phenylthiourea

Synonyms: Phenylthiocarbamide

Phenylthiourea, a phenoloxidase inhibitor, effectively blocks the enzymatic oxidation of DOPA with a Ki value of 0.21 μM. This compound is recognized as a potent inhibitor of tyrosinase, making it valuable in research focused on melanin synthesis and pigmentation processes. Its use can result in observable physiological effects, such as the graying of hair in black rats, highlighting its impact on melanin formation. Phenylthiourea is essential for studies investigating the roles of phenoloxidase and tyrosinase in various biological systems.

Cat. No.

A71505

CAS No.

3316-09-4

4-Nitrocatechol

4-Nitrocatechol is a potent inhibitor of lipoxygenase, an enzyme implicated in the metabolism of arachidonic acid and the biosynthesis of inflammatory mediators. This compound exhibits significant anti-inflammatory properties and is widely used in research to explore the roles of lipoxygenase in various biological processes. Its application extends to studies of oxidative stress and the development of novel therapeutic strategies targeting inflammatory diseases.

Cat. No.

A72342

CAS No.

70968-92-2

9-HETE

Synonyms: (±)9-HETE

9-HETE is a monohydroxy fatty acid and a key lipoxygenase metabolite derived from arachidonic acid. It plays a significant role in inflammatory processes and is involved in various signaling pathways. This compound is primarily utilized in research applications focused on lipid metabolism, inflammation, and the regulation of immune responses.