Lipoxygenase

Cat. No.

A10120

CAS No.

491-67-8

Baicalein

Baicalein is a flavonoid originally isolated from the roots of Scutellaria baicalensis Georgi. Baicalein inhibits lipid peroxidation, as assessed by production of TBARS, with an IC50 value of 5 µM.

Cat. No.

A11697

CAS No.

156897-06-2

Licofelone

Licofelone is a dual COX/LOX inhibitor, being considered as a treatment for osteoarthritis. It may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX (cyclooxygenase). Licofelone is the first drug to inhibit both.

Cat. No.

A11007

CAS No.

111406-87-2

Zileuton

Synonyms: A 64077; Abbott 64077

Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.

Cat. No.

A11725

CAS No.

89-25-8

Edaravone (MCI-186)

Synonyms: Radicut; MCI-186

Edaravone is a free radical scavenger with diverse protective effects that inhibits production of reactive oxygen species, apoptosis and the lipoxygenase system.

Cat. No.

A12061

CAS No.

481-46-9

Ginkgetin

Ginkgetin, a Biflavone from Ginko biloba leaves, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.

Cat. No.

A12465

CAS No.

129424-08-4

ICI 211965

Synonyms: ZM-211965

ICI 211965 (ZM-211965) is a selective and orally potent 5-Lipoxygenase (5-LPO) inhibitor.

Cat. No.

A12879

CAS No.

103475-41-8

Tepoxalin

Tepoxalin is a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile

Cat. No.

A13346

CAS No.

118414-82-7

MK 886

Synonyms: L-663,536; L663536

MK-886 is an inhibitor of leukotriene biosynthesis (IC50 = 3 nM in human polymorphonuclear leukocytes).

Cat. No.

A13347

CAS No.

4079-26-9

PD146176 (NSC168807)

Synonyms: NSC 168807

PD146176 (NSC168807) is a 15-Lipoxygenase (15-LO) inhibitor, which inhibits rabbit reticulocyte 15-LO with a Ki of 197 nM. PD146176 (NSC168807) has a dramatic effect in reducing atherogenesis.

Cat. No.

A14553

CAS No.

305-01-1

6,7-Dihydroxycoumarin

Synonyms: Aesculetin; Cichorigenin

Esculetin, a phenolic compound, acts as a 5-LO (5-lipoxygenase, 5-LOX) inhibitor.

Cat. No.

A15190

CAS No.

500-38-9

Nordihydroguaiaretic acid

Synonyms: NDGA

Nordihydroguaiaretic acid is a natural phenolic compound isolated from the creosote bush Larrea divaricata, which has anti-tumor activities both in vitro and in vivo. Its analogs are in clinical development for use in refractory solid tumors.

Cat. No.

A16911

CAS No.

916210-98-5

LOXL2-IN-1 HCl

LOXL2-IN-1 HCl is a selective LOXL2 inhibitor with an IC50 of 126 nM.

Cat. No.

A17108

CAS No.

71079-19-1

Timegadine

Synonyms: SR 1368

Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets.

Cat. No.

A18349

CAS No.

1532593-30-8

ML355

ML355 is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 0.34 μM, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties.

Cat. No.

A18623

CAS No.

154355-76-7

Atreleuton

Synonyms: ABT-761; VIA 2291; A-85761; Abbott-85761.

Atreleuton (ABT-761) is a selective, reversible, and orally bioavailable 5-Lipoxygenase (5-LO) inhibitor. Atreleuton (ABT-761) exhibits potent and selective inhibition of leukotriene formation.

Cat. No.

A18633

CAS No.

466-61-5

Lycopodine

Lycopodine, a pharmacologically important bioactive component derived from Lycopodium clavatumspores, triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in refractory prostate cancer cells without modulating p53 activity. Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation.

Cat. No.

A18757

CAS No.

2125956-82-1

PXS-5153A

Synonyms: PXS-5153

PXS-5153A is a novel mechanism based, fast-acting, dual LOXL2/LOXL3 inhibitor, which was used to interrogate the role of these enzymes in models of collagen crosslinking and fibrosis.

Cat. No.

A18777

CAS No.

1029317-21-2

PF-4191834

Synonyms: PF-04191834; PF 4191834.

PF-4191834 is a novel, potent and selective non-redox 5-lipoxygenase inhibitor effective in inflammation and pain with an IC50=229 nM. displays ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX, shows no activity toward the cyclooxygenase enzymes.

Cat. No.

A19008

CAS No.

1191-85-1

Eicosatetraynoic acid

Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID50=8 μM and 4 μM, respectively). Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 µM??

Cat. No.

A19263

CAS No.

102271-49-8

PGS-IN-1

Synonyms: KME-4

PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM.

Cat. No.

A19333

CAS No.

107889-32-7

LY 178002

LY 178002 is a potent inhibitor of 5-lipoxygenase, phospholipase A2, with IC50 of 0.6 μM for 5-1ipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.

Cat. No.

A19417

CAS No.

123606-23-5

A-69412

A-69412 is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase (5-LO).

Cat. No.

A19602

CAS No.

34334-69-5

Cirsiliol

Cirsiliol is a potent and selective 5-lipoxygenase inhibitor and a competitive low affinity benzodiazepine receptor ligand.

Cat. No.

A20252

CAS No.

2007885-39-2

Lenumlostat (PAT-1251)

Synonyms: PAT-1251

PAT-1251 is a potent, selective and oral Lysyl Oxidase-Like 2 (LOXL2) inhibitor.

Cat. No.

A20699

CAS No.

158089-95-3

S-2474

S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (5-LO), with IC50s of 11 nM and 27 μM for COX-2 and COX-1 in human intact cells, and used as a nonsteroidal anti-inflammatory drug.