- Cat. No.
- A10120
Baicalein
Baicalein is a flavonoid originally isolated from the roots of Scutellaria baicalensis Georgi. Baicalein inhibits lipid peroxidation, as assessed by production of TBARS, with an IC50 value of 5 µM.
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- Cat. No.
- A11697
Licofelone
Licofelone is a dual COX/LOX inhibitor, being considered as a treatment for osteoarthritis. It may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX (cyclooxygenase). Licofelone is the first drug to inhibit both.
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- Cat. No.
- A11007
Zileuton
Synonyms: A 64077; Abbott 64077
Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.
In stock View Details -
- Cat. No.
- A12465
ICI 211965
Synonyms: ZM-211965
ICI 211965 (ZM-211965) is a selective and orally potent 5-Lipoxygenase (5-LPO) inhibitor.
In stock View Details -
- Cat. No.
- A12879
Tepoxalin
Tepoxalin is a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile
In stock View Details -
- Cat. No.
- A13346
MK 886
Synonyms: L-663,536; L663536
MK-886 is an inhibitor of leukotriene biosynthesis (IC50 = 3 nM in human polymorphonuclear leukocytes).
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- Cat. No.
- A13347
PD146176 (NSC168807)
Synonyms: NSC 168807
PD146176 (NSC168807) is a 15-Lipoxygenase (15-LO) inhibitor, which inhibits rabbit reticulocyte 15-LO with a Ki of 197 nM. PD146176 (NSC168807) has a dramatic effect in reducing atherogenesis.
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- Cat. No.
- A14553
6,7-Dihydroxycoumarin
Synonyms: Aesculetin; Cichorigenin
Esculetin, a phenolic compound, acts as a 5-LO (5-lipoxygenase, 5-LOX) inhibitor.
In stock View Details -
- Cat. No.
- A15190
Nordihydroguaiaretic acid
Synonyms: NDGA
Nordihydroguaiaretic acid is a natural phenolic compound isolated from the creosote bush Larrea divaricata, which has anti-tumor activities both in vitro and in vivo. Its analogs are in clinical development for use in refractory solid tumors.
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- Cat. No.
- A16911
LOXL2-IN-1 HCl
LOXL2-IN-1 HCl is a selective LOXL2 inhibitor with an IC50 of 126 nM.
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- Cat. No.
- A17108
Timegadine
Synonyms: SR 1368
Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets.
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- Cat. No.
- A18349
ML355
ML355 is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 0.34 μM, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties.
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- Cat. No.
- A18623
Atreleuton
Synonyms: ABT-761; VIA 2291; A-85761; Abbott-85761.
Atreleuton (ABT-761) is a selective, reversible, and orally bioavailable 5-Lipoxygenase (5-LO) inhibitor. Atreleuton (ABT-761) exhibits potent and selective inhibition of leukotriene formation.
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- Cat. No.
- A18757
PXS-5153A
Synonyms: PXS-5153
PXS-5153A is a novel mechanism based, fast-acting, dual LOXL2/LOXL3 inhibitor, which was used to interrogate the role of these enzymes in models of collagen crosslinking and fibrosis.
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- Cat. No.
- A18777
PF-4191834
Synonyms: PF-04191834; PF 4191834.
PF-4191834 is a novel, potent and selective non-redox 5-lipoxygenase inhibitor effective in inflammation and pain with an IC50=229 nM. displays ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX, shows no activity toward the cyclooxygenase enzymes.
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- Cat. No.
- A19008
Eicosatetraynoic acid
Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID50=8 μM and 4 μM, respectively). Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 µM??
In stock View Details -
- Cat. No.
- A19263
PGS-IN-1
Synonyms: KME-4
PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM.
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- Cat. No.
- A19333
LY 178002
LY 178002 is a potent inhibitor of 5-lipoxygenase, phospholipase A2, with IC50 of 0.6 μM for 5-1ipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.
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- Cat. No.
- A19417
A-69412
A-69412 is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase (5-LO).
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- Cat. No.
- A19602
Cirsiliol
Cirsiliol is a potent and selective 5-lipoxygenase inhibitor and a competitive low affinity benzodiazepine receptor ligand.
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- Cat. No.
- A20252
Lenumlostat (PAT-1251)
Synonyms: PAT-1251
PAT-1251 is a potent, selective and oral Lysyl Oxidase-Like 2 (LOXL2) inhibitor.
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- Cat. No.
- A20699
S-2474
S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (5-LO), with IC50s of 11 nM and 27 μM for COX-2 and COX-1 in human intact cells, and used as a nonsteroidal anti-inflammatory drug.
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- Cat. No.
- A21493
Docebenone
Synonyms: AA 861
Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
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- Cat. No.
- A21831
Zileuton sodium
Synonyms: A 64077 sodium; Abbott 64077 sodium; A64077
Zileuton sodium (A 64077 sodium) is a potent and selective inhibitor of 5-lipoxygenase, exhibiting inflammatory activities.
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- Cat. No.
- A21969
PAT-1251 Hydrochloride
Synonyms: PAT 1251
PAT-1251 Hydrochloride is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively).
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