Catalog No.
Product Name
Application
Product Information
Citations
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Phospholipid
DSPE-alkyne is a phospholipid functioning as a click chemistry reagent, characterized by the presence of an alkyne group. This compound is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. DSPE-alkyne is widely utilized in bioconjugation applications, facilitating the formation of stable links between biomolecules for advanced research in drug delivery and molecular imaging. -
Alkyne Lipid
Alkyne Cholesterol is a modified lipid featuring a terminal alkyne group, designed for click chemistry applications. This reagent facilitates highly specific conjugation reactions with azide-containing compounds in the presence of copper catalysts. Alkyne Cholesterol is instrumental for studying cellular cholesterol metabolism and localization, enabling detailed insights into lipid biology. -
ω Alkynyl Lipid Surrogates
Arachidonic acid-alkyne is a ω-alkynyl lipid surrogate specifically designed for polyunsaturated fatty acid research. This compound demonstrates low oxidation rates, making it suitable for studies involving the tracking and analysis of polyunsaturated fatty acids in biological systems. Its unique chemical properties facilitate investigations into lipid metabolism and signaling pathways, expanding its utility in various biochemical and pharmacological applications. -
PROTAC Linker
Biotin-PEG4-amide-Alkyne is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne functionality that enables participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its unique properties facilitate targeted protein degradation research, making it a valuable tool for bioconjugation and drug discovery applications. -
PROTAC Linker
Dde Biotin-PEG4-alkyne is a PEG-based PROTAC linker featuring an alkyne group, facilitating the synthesis of PROTACs. This compound serves as a click chemistry reagent, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in the design of bifunctional molecules allows for enhanced targeted degradation of proteins, making it a valuable tool in chemical biology and therapeutic research. -
PROTAC Linker
Diazo Biotin-PEG3-alkyne is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an alkyne group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its applications extend to the development of targeted protein degradation methods, facilitating the exploration of protein interactions and degradation pathways in chemical biology research. -
PROTAC Linker
PEG2-bis(Alkyne) is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the construction of bifunctional molecules that selectively degrade target proteins via the ubiquitin-proteasome system. Its unique alkyne functionality enables efficient click chemistry, making it suitable for various research applications in targeted protein degradation studies and drug discovery. -
PROTAC Linkers
Biotin alkyne is a PEG-based linker designed for the synthesis of PROTACs, targeting the ubiquitin-proteasome system. As a click chemistry reagent, it features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. This functionality facilitates the efficient assembly of bifunctional degraders, advancing research in targeted protein degradation and therapeutic development. -
PROTAC Linker
Biotin-PEG4-alkyne is a biotin-functionalized linker designed for use in the synthesis of PROTACs, targeting protein degradation pathways. This PEG-based compound features an alkyne functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling the efficient conjugation with azide-containing molecules. Its application is vital in developing PROTACs for targeted protein degradation studies and therapeutic interventions. -
PROTAC Linker
Alkyne-PEG4-maleimide is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application as a linker facilitates the creation of bifunctional molecules for targeted protein degradation studies and other advanced research applications in chemical biology. -
Ligand for E3 Ligase
Desamino lenalidomide-alkynes specifically targets cereblon (CRBN), an E3 ubiquitin ligase, facilitating the recruitment of this protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimeric molecule (PROTAC). It is instrumental in studies aimed at modulating protein levels and exploring targeted protein degradation mechanisms. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-O-C2-alkyne is a conjugate consisting of an E3 ligase ligand derived from cereblon (CRBN) and a C2 alkyne linker. This reagent is designed for the synthesis of PROteolysis TArgeting Chimeras (PROTACs), facilitating targeted protein degradation pathways. Its application enables the modulation of specific protein targets, making it a valuable tool in chemical biology research. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-5-NH-C-alkyne is an E3 ligase ligand-linker conjugate featuring a terminal alkyne functional group. This compound facilitates the conjugation to target proteins, supporting the development of PROTAC (Proteolysis Targeting Chimeras) for targeted protein degradation studies. Its unique structure enables enhanced interaction with E3 ligases, making it a valuable tool for researchers investigating protein regulation and degradation pathways. -
E3 Ligase Ligand-Linker Conjugates
2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe-alkyne-C6-OMs is an E3 ligase ligand-linker conjugate designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound effectively facilitates the recruitment of E3 ligases, enabling targeted degradation of specific proteins. Its unique linker structure and ligand properties make it a valuable tool in chemical research focused on protein modification and regulation. Use this reagent to explore novel pathways in targeted protein degradation and therapeutic development. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-alkyne-C4-NHBoc is an E3 Ligase Ligand-Linker Conjugate designed for targeted protein degradation applications. This compound facilitates the synthesis of PROTAC JAK1 degrader 1, enabling the selective degradation of the JAK1 protein. Its utility in research includes studying protein turnover and the therapeutic potential of targeted protein degradation in various diseases. -
E3 Ligase Ligand-Linker Conjugates
(S,R,S)-Me-AHPC-amide-C3-alkyne is an E3 ligase ligand-linker conjugate that facilitates the construction of targeted molecular assemblies. This compound is designed to enhance the efficacy of E3 ligase-mediated ubiquitination processes, making it invaluable for research applications in protein degradation and modulation of cellular pathways. Its utility in synthesizing compounds such as JWZ-5-13 underscores its significance in chemical biology studies involving targeted protein elimination. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-O-CONH-alkyne is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN) ligand and a spacer moiety. This compound is designed for the synthesis of PROTACs (proteolysis-targeting chimeras), which facilitate targeted degradation of proteins by harnessing the ubiquitin-proteasome system. Its utility in drug discovery and therapeutic development makes it a valuable tool for researchers investigating targeted protein modulation. -
E3 Ligase Ligand-Linker Conjugate
2-(2,6-Dioxopiperidin-3-yl)phthalimidine-alkyne-piperidine is an E3 ligase ligand-linker conjugate designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a CRBN-based ligand that interacts with E3 ligases to facilitate targeted protein degradation. Its application in chemical biology enables researchers to explore novel therapeutic strategies and enhance drug development through the modulation of protein levels in various biological systems. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-NH-C2-alkyne serves as an E3 ligase ligand-linker conjugate, featuring an alkyl linker and a terminal alkyne group. This compound is designed for efficient conjugation to target proteins, facilitating the development of PROTAC (Proteolysis Targeting Chimera) research. Thalidomide-NH-C2-alkyne is instrumental in studies aimed at exploring targeted protein degradation pathways, contributing to advancements in therapeutic strategies. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-O-PEG5-alkyne is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN) ligand and a polyethylene glycol (PEG) linker. This compound is designed to facilitate the synthesis of Proteolysis Targeting Chimeras (PROTACs), enabling targeted degradation of specific proteins within cellular contexts. Its use is essential in research applications focusing on targeted protein degradation and the modulation of protein levels for therapeutic purposes. -
E3 Ligase Ligand-Linker Conjugate
Desamino lenalidomide-alkyne-C-piperazin is an E3 ligase ligand-linker conjugate designed for targeted protein degradation applications. This compound features a CRBN-based ligand that enables the selective recruitment of E3 ligases for the formation of PROTACs. It serves as a valuable tool for research in protein modulation and therapeutic discovery, facilitating the study of protein homeostasis and degradation pathways. -
E3 Ligase Ligand-Linker Conjugate
Pomalidomide-C3-alkyne is an E3 ligase ligand-linker conjugate that incorporates a ceramide-based ligand (CRBN) and a linker moiety, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables selective protein degradation by harnessing the ubiquitin-proteasome system, making it valuable for studies in targeted therapy and drug development. Its utility in research applications includes investigating protein-protein interactions and exploring new therapeutic strategies for various diseases. -
PROTAC Linkers
Pip-alkyne-Ph-COOCH3 is a versatile PROTAC linker designed for the synthesis of PROTAC ARD-266. This compound features an alkyne group, facilitating its use in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc). It plays a critical role in forming stable linkages between target proteins and E3 ligases, supporting research in targeted protein degradation and related therapeutic applications. -
PROTAC Linker
Carboxyrhodamine 110-PEG4-alkyne is a PEG (polyethylene glycol)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). It facilitates the effective conjugation of target proteins to an E3 ligase for selective degradation. This compound is essential for researchers investigating targeted protein degradation mechanisms and developing novel therapeutic strategies. Its properties enable precise modulation of biological activity in various cellular contexts. -
PROTAC Linkers
Boc-Pip-alkyne-Ph-COOH is a PROTAC linker designed for use in the synthesis of targeted protein degraders. It facilitates the development of PROTACs, including ARD-266, which effectively promotes degradation of the androgen receptor in AR-positive prostate cancer cell lines such as LNCaP, VCaP, and 22Rv1, exhibiting DC50 values of 0.2-1 nM. This compound features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it essential for click chemistry applications in chemical biology research. -
PROTAC Linker
Cbz-NH-PEG-alkyne is a versatile PROTAC linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This linker facilitates the selective degradation of target proteins through the recruitment of E3 ubiquitin ligases, enabling targeted therapeutic applications in cancer and other diseases. Its unique alkyne group allows for efficient conjugation and modification, making it an essential reagent for chemical biology researchers investigating targeted protein degradation. -
PROTAC Linker
Alkyne-PEG4-I is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its alkyne functionality facilitates the formation of stable covalent bonds, enabling efficient engagement of target proteins for degradation. This linker is integral for researchers investigating targeted protein degradation pathways and developing novel therapeutic agents. -
PROTAC Linker
Ts-PEG3-O-C-alkynes-TBS is a linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of target proteins to the ubiquitin-proteasome system, enabling selective protein degradation. It serves as a pivotal component in PROTAC development, enhancing the efficacy of targeted protein modulation for various research applications, including cancer biology and therapeutic discovery. -
PROTAC Linker
TBS-PEG4-O-alkyne is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of protein ligands to an E3 ubiquitin ligase, allowing for targeted degradation of specific proteins. Its key biological activity lies in enhancing the solubility and bioavailability of PROTACs, making it an essential component in targeted protein degradation research. TBS-PEG4-O-alkyne is widely utilized in pharmacological studies and drug discovery applications. -
PROTAC Linker
Methyltetrazine-PEG5-alkyne is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted protein degradation. It is suitable for applications in drug discovery and development, enabling researchers to investigate protein function and therapeutic potential in various biological contexts. -
PROTAC Linkers
Methyltetrazine-amido-PEG5-alkyne is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the selective degradation of target proteins through the recruitment of E3 ubiquitin ligases. Its application in PROTAC development enables enhanced therapeutic strategies in the field of targeted protein degradation for various diseases, including cancer. -
PROTAC Linker
Aldehyde-benzyl-PEG5-alkyne serves as a PEG-based linker for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an alkyne group that enables its use in click chemistry reactions, specifically undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-bearing molecules. Its utility in synthesizing novel PROTACs makes it valuable for biochemical research applications focused on protein modulation and degradation pathways. -
PROTAC Linker
Folate-PEG3-alkyne is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Folate-PEG3-alkyne is essential for developing targeted therapeutic strategies in chemical biology and drug discovery. -
PROTAC Linker
Biotin-PEG2-C4-alkyne is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne functionality, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in PROTAC development facilitates targeted protein degradation, making it essential for research in therapeutic protein modulation and drug discovery. -
PROTAC linker
Alkyne-ethyl-PEG1-Boc is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne moiety, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. Its application in PROTAC development supports targeted protein degradation studies and drug discovery research. -
PROTAC Linkers
APN-C3-PEG4-alkyne is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an alkyne group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its application facilitates the development of novel therapeutic agents by promoting targeted protein degradation and enhancing the specificity of biomolecule interactions in chemical biology research. -
PROTAC Linker
Alkyne-C6-OMs is a sophisticated PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the targeted degradation of specific proteins through the recruitment of E3 ligases, enhancing the efficacy of targeted therapies. Its structural properties make it a valuable tool for researchers exploring novel protein modulation strategies in various biological studies. -
PROTAC Linkers
m-PEG8-O-alkyne is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling the effective conjugation of azide-containing molecules. m-PEG8-O-alkyne is instrumental in the development of targeted protein degradation strategies, making it valuable for probing cellular mechanisms and therapeutic interventions in various biological contexts. -
APEX2 Probe
Alkyne-phenol is a clickable probe specifically designed for use with ascorbate peroxidase 2 (APEX2). This reagent significantly enhances APEX-labeling efficiency in intact yeast cells due to its improved permeability through cell walls compared to traditional APEX2 substrates. Alkyne-phenol aids in the identification of APEX-labeling sites, providing clear insights into the membrane topology of mitochondrial proteins. Additionally, it features an alkyne group that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a versatile tool for click chemistry applications in biological research. -
Biochemical Assay Reagent
Carboxyl diazirine alkyne is a protein cross-linking compound that enables the study of protein interactions and modifications. This reagent is particularly valuable in biochemical assays focused on the inhibition and labeling of the FTO protein using fluorescein derivatives, facilitating advanced research in metabolism and epigenetics. Its unique properties allow for covalent bonding, thereby enhancing the specificity and sensitivity of detection methods in various biological applications. -
APEX2 Probe
Tyramide alkyne serves as a novel labeling substrate for APEX2 probes, effectively facilitating the detection and enrichment of specific biomolecules. It can be conjugated to various detection moieties through a Copper-catalyzed Azide/Alkyne Cycloaddition (CuAAC) "click" reaction. This compound is instrumental in enhancing spatial resolution in biological imaging and is utilized in advanced proteomics and cellular studies. -
Biochemical Assay Reagent
TAMRA alkyne, 5-isomer is an alkyne derivative of the fluorescent dye TAMRA, primarily used as a biochemical assay reagent. It enables the enrichment, in-gel fluorescence detection, and identification of O-GlcNAc-modified proteins. This compound participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules and is also reactive in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it valuable for bioconjugation applications in protein labeling and visualization. -
Spermidine Probe
Spermidine-alkyne is a derivative of spermidine featuring an alkyne functional group, serving as a valuable probe for studying spermidine interactions. This compound enables the investigation of spermidine binding to cellular proteins, providing insights into cellular processes and signaling pathways. Researchers can utilize spermidine-alkyne in various applications, including proteomics and chemical biology studies, to delineate the role of spermidine in biological systems. -
Azide
4-Hydroxynonenal alkyne is a click chemical reagent that features alkynes and targets azides for bioorthogonal labeling. This compound induces heme oxygenase activity and promotes apoptosis in colon cancer (RKO) cells, making it a valuable tool for investigating oxidative stress and related cellular processes. Its applications extend to studying lipid peroxidation and the mechanism of action in cancer research. -
Biochemical Assay Reagent
Desthiobiotin-PEG4-alkyne is a biotinylated biochemical reagent designed for use in click chemistry applications. This compound enables the selective labeling and enrichment of specific tRNAs, facilitating the study of tRNA dynamics and interactions. It is a valuable tool for researchers exploring RNA biology and related biochemical pathways. -
Sphingosine Alkyne
Sphingosine (d18:1) alkyne is an alkyne-modified sphingosine derivative designed for applications in click chemistry. This compound facilitates the study of sphingolipid metabolism and signaling pathways by allowing researchers to label sphingosine in cellular systems. Its structure enables selective and efficient conjugation with various biomolecules, expanding the toolkit for investigating lipid interactions and functions in biological research. -
Click Chemistry Compound
(3aS,4S,6aR)-Biotin-PEG4-Alkyne is a biotinylation reagent featuring an alkyne functional group, designed for applications in click chemistry. This compound facilitates the conjugation of azides through a copper-catalyzed click reaction, enabling the labeling of biomolecules with biotin. The resulting biotinylated constructs can effectively interact with avidin or streptavidin, making this reagent valuable for purification and detection assays in biochemical research. -
Click Chemistry Compound
Biotin-PEG8-Alkyne is a click chemistry compound designed for efficient bioconjugation through azide-alkyne cycloaddition. This reagent facilitates the direct labeling of biomolecules and can be utilized in various applications, including protein tagging, cellular imaging, and the development of bioconjugates. Its biotinylated structure enhances binding affinity to streptavidin, making it a powerful tool for studying protein interactions and tracking biomolecules in complex biological systems. -
Biochemical Assay Reagent
Biotin-PEG2-alkyne is a biochemical assay reagent designed to facilitate affinity-based applications. This compound features a biotin group for effective binding in assays such as pull-down assays, combined with a terminal alkyne that allows for copper (I) catalyzed click chemistry with azides. It is suitable for various research applications, including protein labeling and tracking. -
click chemistry reagent
PreQ1-alkyne is a click chemistry reagent featuring an alkyne functionality that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions. This compound is pivotal for bioconjugation applications, allowing for the selective labeling and modification of biomolecules containing azide groups. Its utility extends to the synthesis of complex biomolecular structures in chemical biology and materials science research.
