Catalog No.
Product Name
Application
Product Information
Citations
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S-IIP inhibitor/KRASG12C Probe
ARS-1323-Alkyne is a novel KRASG12C occupancy probe. -
NAT10 Inhibitor
CPTH2-Alkyne is a selective inhibitor of N-acetyltransferase 10 (NAT10), which plays a crucial role in cellular processes. This compound exhibits distinctive localization, accumulating in nucleoli and associating with the nuclear periphery and cytoplasm. CPTH2-Alkyne is utilized in research focused on nuclear architecture and has potential applications in the study of laminopathies, aiding the understanding of cellular structural dynamics. -
Btk Inhibitor
(Rac)-Ibrutinib alkyne is a potent Bruton's tyrosine kinase (Btk) inhibitor with an IC50 of 0.72 nM. This compound effectively disrupts B-cell receptor signaling, demonstrated by an IC50 of 9 nM for inhibiting calcium flux in Ramos cells. (Rac)-Ibrutinib alkyne is suitable for investigating various Btk-related pathologies, including rheumatoid arthritis and other immune disorders. -
Phosphatase Marker
5-FAM-Alkyne is a selective fluorescent biosensor targeting alkaline phosphatase (ALP) activity. This compound incorporates an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its high sensitivity makes it a valuable tool for studying ALP-related biological processes and for applications in bioorthogonal labeling in chemical biology research. -
Click Reaction Agent
Mivebresib-alkyne functions as a Click Reaction Agent, facilitating the synthesis of BRD4-targeted PROTACs. This derivative of Mivebresib serves as an important tool for researchers investigating targeted protein degradation pathways and their potential therapeutic applications. Its unique alkyne functionality enables efficient conjugation reactions, enhancing the versatility of PROTAC development in chemical biology studies. -
Near-Infrared Fluorescent Dye
Cyanine5.5 alkyne chloride is a near-infrared fluorescent dye that exhibits excitation at 678 nm and emission at 694 nm. This alkynyl-modified compound is particularly effective for click chemistry applications, enabling efficient labeling through reactions with azides. Its properties make it suitable for a variety of biological research applications, including imaging and tracking in live cells and tissues. -
Dye
Alkyne MegaStokes dye 608 is a versatile fluorescent dye that enables effective labeling and visualization of biological samples. This dye is crucial for observing cell structures, tracking biomolecules, and evaluating various cellular functions. It can distinguish cell types, detect biomolecules, and study tissue pathology, making it valuable for both basic scientific research and clinical diagnostics. Additionally, Alkyne MegaStokes dye 608 finds applications in functional textile processing, food pigments, and dye-sensitized solar cells. -
Dye
Alkyne MegaStokes dye 735 is a multifunctional dye that serves as a critical tool for biological experiments. It facilitates the observation and analysis of cellular structures, tracking of biomolecules, and evaluation of cell functions. This dye is valuable for distinguishing cell types, detecting biomolecules, studying tissue pathology, and monitoring microorganisms. Its diverse applications extend from fundamental scientific research to clinical diagnostics and emerging fields such as functional textiles and dye-sensitized solar cells. -
Click Chemistry Reagent
Trisulfo-Cy5-Alkyne is a versatile click chemistry reagent featuring an alkyne group suitable for copper-catalyzed reactions. This compound exhibits near-infrared (NIR) fluorescence, making it ideal for biological imaging applications. Trisulfo-Cy5-Alkyne is primarily used in the conjugation of biomolecules, facilitating studies in cellular localization and molecular interactions within complex biological systems. -
Click Chemistry Reagent
Trisulfo-Cy5.5-Alkyne is a click chemistry reagent featuring an azide functional group, enabling its use in copper-catalyzed click reactions. This compound exhibits near-infrared (NIR) fluorescence, making it a valuable tool for various biological imaging applications. It is particularly useful for labeling biomolecules in live-cell studies, facilitating the visualization of cellular processes and interactions. -
Fluorescent Probe
Alkyne-probe 1 is a fluorescent probe designed for click chemistry applications. Featuring an alkyne group, this reagent is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its ability to facilitate efficient labeling makes it a valuable tool for studying biomolecular interactions and visualizing cellular processes in various research applications. -
OXPHOS Inhibitor
Cyanine5 alkyne is a fluorescent dye that functions as an OXPHOS inhibitor, targeting mitochondrial respiration. This compound is primarily utilized in click chemistry applications, allowing for the labeling of azide-containing proteins and analysis of post-translational modifications, including glycosylation. Additionally, Cyanine5 alkyne has demonstrated potential to inhibit the growth of cancer stem cells, making it a valuable tool in cancer research and cellular biology studies. -
Alkyne BODIPY
BODIPY-X-Alkyne is an alkyne-modified BODIPY derivative that exhibits strong fluorescence with excitation and emission maxima at 526 nm and 540 nm, respectively. This compound is specifically designed to undergo copper-catalyzed click reactions with azides, enabling versatile applications in bioconjugation and labeling studies. BODIPY-X-Alkyne is ideal for researchers investigating cellular imaging, biomolecular interactions, and the development of novel fluorescent probes. -
BODIPY Fluorophore
BODIPY FL alkyne is a bioorthogonal labeling reagent that targets azide groups on intracellular glycoconjugates through strain-promoted azide-alkyne cycloaddition (SPAAC). This alkyne-containing BODIPY fluorophore exhibits low toxicity and minimal non-specific reactivity, making it ideal for fluorescent bioimaging applications. BODIPY FL alkyne enables site-specific conjugation with proteins, such as IL-33, and supports positive cross-linking with probes for dual labeling studies. Its high specificity and low background interference make it valuable for researching conditions like asthma, atopic dermatitis, and inflammatory bowel disease. -
Click Chemistry Reagent
DiSulfo-Cy5 alkyne is a click chemistry reagent featuring a fluorescent dye. It enables efficient labeling of biomolecules through the copper-catalyzed azide-alkyne cycloaddition reaction. This compound is particularly useful in applications such as live-cell imaging, bioconjugation, and the development of fluorescent biosensors. Its strong fluorescence properties enhance the visibility of targeted structures in diverse biological research settings. -
Dye
Alkyne cyanine dye 718 is a multifunctional dye primarily utilized for fluorescence labeling in biological research. This dye enables researchers to visualize and analyze cellular structures, monitor biomolecular interactions, and distinguish between different cell types. Its versatility extends to applications in tissue pathology studies, microbial detection, and a variety of diagnostics in both basic and clinical research. Additionally, Alkyne cyanine dye 718 is relevant in innovative fields such as functional textiles, food coloring, and dye-sensitized solar cells. -
Protein Label
diSulfo-Cy3 alkyne is a water-soluble dye that functions as a Click Chemistry reagent featuring an alkyne group. With absorption and emission characteristics comparable to those of the Cy3 fluorophore, it is suitable for precise labeling of proteins and other biological structures in aqueous environments. This compound is valuable for applications in fluorescence microscopy and bioconjugation studies, enhancing visualization and tracking of target biomolecules in diverse biological research. -
Alkyne Modified BODIPY TMR-X
BODIPY TMR-X alkyne is an alkyne-modified fluorescent dye that exhibits strong orange fluorescence. It is designed to react with azides through the copper-catalyzed click reaction, enabling specific labeling and tracking in biological systems. With its stable properties across various pH conditions, BODIPY TMR-X alkyne is suitable for a range of applications in live-cell imaging, chemical biology, and other research requiring fluorescent tagging and detection. -
Dye
Dde Biotin-PEG4-TAMRA-PEG4 Alkyne is a dye derivative of TAMRA designed for fluorescent applications, featuring a cleavable biotin moiety. This compound contains alkyne groups that facilitate copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling its use in a variety of conjugation strategies. It is ideal for research applications involving biomolecular labeling and tracking in cellular and molecular studies. -
Dye
TAMRA-PEG4-Alkyne is a fluorescent dye derivative of TAMRA that incorporates four PEG units, enhancing its solubility and biocompatibility. This compound features alkyne functional groups, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with azide-containing molecules. Its unique properties make it valuable for various biological applications, including the labeling of biomolecules and the study of cellular processes through fluorescence imaging. -
Fluorescent Dye
OG 488 alkyne is a highly sensitive green-fluorescent dye designed for imaging azide-labeled biomolecules. It participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) to create a stable triazole linkage. This reagent is valuable for visualizing biomolecular interactions and dynamics, making it suitable for various applications in cellular imaging and bioconjugation studies. -
Fluorescent Dye
ROX alkyne, 6-isomer is an alkyne derivative of the red-emitting fluorescent dye ROX (Rhodamine X, Rhodamine 101), known for its high quantum yield. This compound is particularly useful for fluorescent labeling of azide-containing biomolecules through copper-catalyzed click chemistry. Its applications include quantitative PCR and microscopy, making it an essential reagent for advanced imaging and detection in biochemical research. -
Fluorescent Dye
Cy7 alkyne chloride is a fluorescent dye derivative of Cyanine 7 (Cy7) featuring an alkyne functional group, with an excitation/emission wavelength of 740/770 nm. This reagent can undergo click chemistry reactions with azide-containing molecules, enabling the formation of stable covalent bonds. It is widely utilized in fluorescence imaging, bioconjugation applications, and cellular labeling studies, making it a valuable tool for researchers in bioorthogonal chemistry and related fields. -
click chemistry
FAM alkyne, 6-isomer is a click chemistry reagent designed for specific applications in 1,3-dipolar cycloaddition reactions with azido-labeled compounds. It facilitates the efficient formation of stably linked conjugates, making it a vital tool for bioconjugation studies and labeling in biological research. This compound is suitable for various applications, including imaging, drug delivery, and the development of biosensors. -
Alkyne-conjugated Benzylguanine
Alkyne-SNAP is an alkyne-conjugated benzylguanine that serves as a reactive probe for SNAP-tag fusion proteins. The benzylguanine component enables irreversible and covalent labeling, facilitating the study of protein dynamics and interactions. This reagent is particularly valuable for applications involving click chemistry, allowing the introduction of further functional groups for bioconjugation and subsequent analyses in various biological research contexts. -
PROTAC Linker
PC Alkyne-PEG4-NHS ester is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs). Functioning as a PROTAC linker, this reagent features an alkyne group and participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions. Its unique structure enhances the specificity and efficiency of conjugating azide-containing molecules, making it valuable for various chemical biology applications, including targeted drug delivery and proteolysis targeting chimera (PROTAC) development. -
Click Chemistry Reagent
ICG-alkyne is a click chemistry reagent characterized by the presence of an alkyne functional group, enabling efficient conjugation through the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. This reagent facilitates the labeling and visualization of biomolecules, making it a valuable tool in bioconjugation and imaging applications. Its utility spans various research fields, including chemical biology, biochemistry, and nanotechnology, where precise molecular interactions are essential for experimental outcomes. -
Click Chemistry Reagent
Alkyne-PEG2-iodide is a click chemistry reagent featuring a terminal alkyne and an alkyl iodide moiety. This compound serves as a versatile tool for biomolecular labeling and conjugation due to its ability to undergo efficient cycloaddition reactions. It is particularly useful in various applications, including bioconjugation, proteomics, and the development of novel therapeutics. -
ADC Linker
PC Biotin-PEG3-alkyne is a cleavable antibody-drug conjugate (ADC) linker featuring a three-unit polyethylene glycol (PEG) chain. This linker incorporates an alkyne group that enables click chemistry reactions, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing compounds. It is designed for the synthesis of ADCs, facilitating targeted drug delivery in various biological research applications. -
ADC Linker
DBCO-PEG4-alkyne is a non-cleavable linker designed for antibody-drug conjugates (ADCs), featuring a 4-unit polyethylene glycol (PEG) chain. This compound serves as a versatile click chemistry reagent, incorporating an alkyne functional group that enables the efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in ADC synthesis facilitates the stable conjugation of therapeutic agents, enhancing the efficacy and selectivity of targeted cancer treatments. -
Alkynes Compound
beta-Glc-TEG-Alkyne is an alkyne-containing click chemistry reagent that facilitates the formation of covalent bonds through the copper-catalyzed azide-alkyne cycloaddition (CuAAC) mechanism. This compound exhibits significant utility in biochemical research for labeling biomolecules, studying cellular interactions, and developing bioconjugates. Its unique properties make it a valuable tool for applications in chemical biology and biopharmaceutical development. -
Alkyne Compound
Biotin-PEG(4)-SS-Alkyne is an alkyne-containing click chemistry reagent that facilitates bioconjugation via a bioorthogonal reaction. This compound features a biotin moiety, enabling the labeling and detection of biomolecules in various biochemical assays. Its primary applications include studying protein interactions, cellular imaging, and the development of targeted therapies, providing a valuable tool in biochemical research. -
Alkyne Compound
Alkyne-SS-COOH is an alkyne-functionalized reagent designed for click chemistry applications. This compound facilitates the formation of covalent bonds in a variety of biochemical contexts, enabling applications such as protein labeling, bioconjugation, and cellular imaging. Its versatile reactivity makes it a valuable tool for researchers in chemical biology and materials science. -
ADC Linker
Alkyne-Val-Cit-PAB-OH is a cleavable linker designed for antibody-drug conjugates (ADCs). This compound facilitates the selective release of drug payloads within target cells, enhancing therapeutic efficacy while minimizing off-target effects. Its hydrophilic properties and favorable stability make it suitable for various ADC applications, including cancer therapy and targeted drug delivery research. -
ADC Linker
Alkyne-Val-Cit-PAB-PNP is a cleavable linker designed for antibody-drug conjugates (ADCs). This compound facilitates stable attachment of cytotoxic agents to antibodies while enabling release in the target tissues or cells via specific enzymatic cleavage. Its properties make it suitable for research applications focused on enhancing the efficacy and selectivity of ADCs in cancer therapy and related studies. -
Azide Compound
DecarboxyBiotin-Alkyne is a click chemistry reagent featuring an azide group that facilitates bioconjugation reactions. This compound demonstrates high specificity and yield when used for labeling nucleic acids, lipids, and proteins. It is particularly valuable in diverse research applications, including cellular imaging and biomolecular interaction studies, allowing for efficient tagging and tracking of biomolecules. -
Fluorescent Dye
Sulfo-cyanine7 alkyne is a water-soluble near-infrared fluorescent dye designed for use in copper-catalyzed click chemistry. This compound features a sulfonated terminal alkyne, enabling efficient conjugation with azides in aqueous conditions. Sulfo-cyanine7 alkyne is ideal for biological imaging applications and can enhance the visualization of biomolecules in various research settings. -
Fluorescent Dye
Sulfo-cyanine7 alkyne potassium is a water-soluble near-infrared fluorescent dye designed for applications in copper-catalyzed click chemistry. Its sulfonated terminal alkyne enables efficient conjugation with azides under aqueous conditions. This compound is ideal for use in biological imaging and labeling studies, providing enhanced detection of biomolecules in various research applications. -
Fluorescent Dye
Bodipy TR alkyne is a boron dipyrromethene-based fluorescent dye designed for applications in the ROX (Texas Red) channel. This versatile fluorophore exhibits strong fluorescence, making it suitable for use in microscopy and fluorescence polarization assays. The terminal alkyne moiety facilitates efficient incorporation into biomolecular probes via copper-catalyzed click chemistry, enabling a wide range of research applications including cellular imaging and labeling studies. -
Fluorescent Dye
5-ROX-alkyne is a rhodamine-based fluorescent dye designed for the labeling of DNA fragments. It exhibits strong fluorescence, facilitating the visualization of results in capillary electrophoresis genotyping and gel shift assays. This reagent is essential for applications in nucleic acid analysis and characterization, enabling researchers to obtain precise and reliable data in molecular biology experiments. -
Click Chemistry Reagent
Trisulfo-Cy3-Alkyne is a water-soluble click chemistry reagent containing an alkyne functional group, facilitating the attachment of trisulfated Cy3 to azide-bearing molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAc). This reagent exhibits significant biological activity as a fluorescent probe, characterized by its bright fluorescence and photostability, making it suitable for a variety of imaging techniques, including gel detection and microscopy. It is designed for use in research applications requiring precise labeling and tracking of biomolecules. -
TAMRA Linker
TAMRA alkyne, 6-isomer serves as a versatile linker that enables the conjugation of TAMRA to various biomolecules. Its unique structure facilitates efficient labeling of proteins and nucleic acids, enhancing fluorescence detection and imaging applications. This reagent is essential for researchers utilizing fluorescence in assays, cellular imaging, and other applications requiring precise biomolecular visualization. -
SARS-CoV-2 RNA Degrader
MTDB-Alkyne is an alkyne-functionalized reagent designed for click chemistry applications. It serves as a synthetic precursor for Proximity-Induced Nucleic Acid Degraders (PINAD), facilitating the targeted degradation of SARS-CoV-2 RNA. Its unique mechanism allows for effective RNA manipulation, making it a valuable tool in antiviral research and therapies aimed at combating COVID-19. -
ADC Linker
PTAD-PEG4-alkyne is a cleavable linker designed for use in antibody-drug conjugate (ADC) synthesis. This 4-unit polyethylene glycol (PEG) linker features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing compounds. Its unique properties facilitate the targeted delivery of therapeutic agents, making it a valuable tool in the development of ADCs for research applications in cancer therapeutics and other fields. -
Zanamivir-Linker
Di(zanamivir-amide(N-Me)-PEG1)-N-PEG4-alkyne is a conjugated compound featuring Zanamivir, a potent neuraminidase inhibitor. This compound facilitates the study of viral infections through its unique linker structure, enabling enhanced application in biochemical and biophysical assays. Researchers can utilize Di(zanamivir-amide(N-Me)-PEG1)-N-PEG4-alkyne for exploring therapeutic strategies and mechanisms related to viral pathogenesis. -
Integrin Ligand
Alkyne-cRGD is an integrin ligand that facilitates targeted binding to integrin proteins. This compound is valuable in the study of protein degraders and can be utilized in copper-catalyzed azide-alkyne cycloaddition reactions for bioconjugation applications. Its ability to selectively interact with integrins makes it a key tool in cancer research and various therapeutic studies. -
STING Inhibitor
H-151 Alkyne is a selective inhibitor of STING (Stimulator of Interferon Genes). This compound demonstrates potential for modulating immune responses, making it valuable in the study of autoimmune diseases such as systemic lupus erythematosus and scleroderma, as well as autoinflammatory conditions. Its ability to interfere with STING pathways allows researchers to explore therapeutic strategies targeting these diseases. -
CD38 Inhibitor
6-Alkyne-F-araNAD is an irreversible inhibitor of CD38, a critical enzyme involved in the regulation of cyclic ADP-ribose and NAD metabolism. This compound enhances the efficacy of fluorescent probes, such as SR101-F-araNMN, allowing for improved visualization of intracellular CD38 localization. It serves as a valuable tool in studies related to immune signaling and cellular response mechanisms. -
Oleic Acid Analog
Oleic acid alkyne is an oleic acid analog featuring a terminal acetylene group. This modification enables its use in click chemistry, facilitating chemical ligation reactions. It allows for the hydroxylation of oleic acid by a microsomal cytochrome P-450-dependent system (ω-OAH). Through these reactions, fluorescent or biotin-labeled variants can be synthesized, making it a valuable tool for studying oleic acid metabolism and biological activity in various research applications. -
TRPC Agonist
IA-Alkyne is a TRPC channel (TRPC) agonist that facilitates the investigation of respiratory infections through enhanced channel activity. This compound serves as a versatile chemical probe for quantitative profiling of cysteine reactivity, enabling isotopic tagging. Additionally, IA-Alkyne features an alkyne functional group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool for click chemistry applications in various biological research studies.
