Thalidomide-O-CONH-alkyne is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN) ligand and a spacer moiety. This compound is designed for the synthesis of PROTACs (proteolysis-targeting chimeras), which facilitate targeted degradation of proteins by harnessing the ubiquitin-proteasome system. Its utility in drug discovery and therapeutic development makes it a valuable tool for researchers investigating targeted protein modulation.
Thalidomide-O-CONH-alkyne is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN) ligand and a spacer moiety. This compound is designed for the synthesis of PROTACs (proteolysis-targeting chimeras), which facilitate targeted degradation of proteins by harnessing the ubiquitin-proteasome system. Its utility in drug discovery and therapeutic development makes it a valuable tool for researchers investigating targeted protein modulation.
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