Catalog No.
Product Name
Application
Product Information
Citations
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DNA Polymerase Inhibitor
ddATP trisodium solution (100 mM) serves as a chain-elongating inhibitor of DNA polymerase. As an active metabolite of 2',3'-dideoxyinosine, it is primarily utilized in the Sanger method for DNA sequencing. Additionally, this reagent is valuable for studying viral infections and other applications in molecular biology research. -
DENV Polymerase Inhibitor
NITD-2 is a selective inhibitor of dengue virus (DENV) polymerase, specifically targeting the RNA-dependent RNA polymerase (RdRp) to impede RNA elongation. This compound exhibits potent antiviral activity against DENV, making it a valuable tool for research focused on understanding dengue virus replication and developing therapeutic strategies. Its limited ability to penetrate cell membranes can be an important consideration for in vitro experimental design. -
DNA/RNA Synthesis Inhibitor
DHPS-IN-1 is a potent inhibitor of dihydropteroate synthase (DHPS), exhibiting a remarkable inhibitory potency with an IC50 of 0.014 μM. This compound effectively impedes DNA and RNA synthesis, demonstrating significant anti-melanoma activity. DHPS-IN-1 is relevant for research applications focused on understanding metabolic pathways in cancer and developing targeted therapies against melanoma. -
DNA/RNA Synthesis Inhibitor
3-Isomangostin is a potent inhibitor of the MutT homologue 1 (MTH1) with an IC50 value of 52 nM, impacting DNA and RNA synthesis. Derived from the shell of Garcinia mangostana L., it presents a valuable chemical tool for investigating anticancer mechanisms and developing novel therapeutic strategies against cancer. Its ability to inhibit MTH1 highlights its potential for applications in cancer research and drug discovery. -
DNA Polymerase α Inhibitor
NSC639828 is a potent inhibitor of DNA polymerase α, exhibiting an IC50 of 70 μM. This compound demonstrates significant antitumor activity, making it a valuable tool for cancer research. NSC639828 can be utilized to investigate the role of DNA polymerase α in tumorigenesis and to explore potential therapeutic strategies in cancer treatment. -
DNA/RNA Synthesis Chemical
2-O-Methylcytosine is an O-alkylated analogue of cytosine, functioning as a DNA and RNA synthesis chemical. This modified nucleobase plays a critical role in the study of DNA alterations and epigenetic modifications. It is widely utilized in molecular biology research, particularly in the synthesis of modified nucleic acids and the investigation of nucleobase interactions. -
DNA Polymerase Inhibtior
3′-Deoxythymidine, also known as 2′,3′-dideoxythymidine, serves as a potent inhibitor of eukaryotic cellular and viral DNA polymerases. This nucleoside analog demonstrates significant antiviral activity, particularly against retroviruses, making it a valuable tool in the study of viral replication and infection mechanisms. Its application extends to research targeting antiviral therapies and understanding the biochemical pathways of DNA synthesis. -
DNA Polymerase Substrate
7-Deaza-2'-deoxyadenosine is a structural analog of 2'-deoxyadenosine that serves as a substrate for various DNA polymerases. Its unique chemical properties facilitate incorporation into DNA strands, enabling site-specific labeling through a bioorthogonal inverse electron demand Diels-Alder reaction with tetrazine-modified molecules. This reagent has shown to influence DNA curvature and reduce the stability of DNA/RNA double helices, with implications for decreasing antisense activity against SV40 T Antigen. 7-Deaza-2'-deoxyadenosine is particularly useful in the study of cancers related to SV40 T Antigen. -
Adenosine Analog
2'-O,4'-C-Methyleneadenosine is a locked nucleic acid (LNA) and an adenosine analog that exhibits increased stability and binding affinity for complementary RNA sequences. This compound serves as a valuable tool in nucleic acid research, enabling precise modulation of gene expression and investigation of RNA structures. Its application extends to antisense oligonucleotide design and RNA interference studies, making it essential for researchers exploring RNA-related therapies and molecular diagnostics. -
RNA Synthesis Inhibitor
Nitracrine is an RNA synthesis inhibitor that covalently and reversibly binds to DNA, forming covalent adducts in vivo. As a 1-nitroacridine derivative, it exhibits potent hypoxia-selective cytotoxicity in vitro and serves as an effective antitumor agent. Nitracrine demonstrates cytotoxic effects against a wide range of cell types, making it a valuable tool for cancer research and therapeutic investigations. -
DNA Synthesis Substrate
5-Fluoro-2′-deoxy-UTP is a nucleotide analog primarily utilized as a substrate in DNA synthesis. This compound incorporates into DNA strands, allowing researchers to study nucleotide incorporation and the effects of fluorinated nucleotides on replication and genetic stability. It is widely used in molecular biology applications, including the synthesis of modified oligonucleotides and in various labeling techniques for DNA analysis. -
DNA Polymerase Inhibitor
Acyclovir triphosphate sodium is a potent inhibitor of viral DNA polymerase, functioning as a competitive analogue of deoxyguanosine triphosphate (dGTP). This compound also exhibits inhibitory activity against HIV-1 reverse transcriptase, leading to the termination of viral DNA synthesis. Acyclovir triphosphate sodium is valuable for research applications in virology and the study of antiviral mechanisms. -
DNA Polymerase Substrate
2'-Deoxyadenosine-5'-triphosphate (dATP) serves as a critical substrate for DNA polymerase during DNA synthesis and replication. This nucleotide plays a vital role in the formation of DNA molecules by providing the necessary building blocks for polymerization. dATP is essential for various molecular biology applications, including DNA amplification, sequencing, and cloning, making it a valuable reagent for biochemical and genetic research. -
DNA Synthesis Activator
Isorhamnetin 3-gentiobioside is a flavonoid known for its role as a DNA synthesis activator, particularly in MCF-7 human breast cancer cells, exhibiting an EC50 of 3.1 μg/mL. This compound demonstrates significant biological activity, promoting cell proliferation and exhibiting ABTS radical scavenging activity with an IC50 of 33.43 μg/mL. It serves as a valuable reagent for investigating the regulatory mechanisms underlying cancer biology. -
DNA/RNA Synthesis Inhibitor
Methotrexate α-tert-butyl ester is an antimetabolite and antifolate compound that acts as a potent inhibitor of DNA and RNA synthesis. It demonstrates significant anti-tumor activity by effectively reducing tumor growth in HT1080 tumor-bearing mouse models. This compound is also utilized for its immunosuppressive and antineoplastic properties in various research applications. -
RNA Polymerase I Transcription Inhibitor
BMH-22 is a selective inhibitor of RNA polymerase I transcription, functioning independently of p53 pathways. This benzonaphthyridin compound induces reorganization of nucleolar marker proteins, indicative of nucleolar segregation, and destabilizes RPA194 through a proteasome-dependent mechanism. Additionally, BMH-22 effectively inhibits the synthesis of nascent rRNA and the expression of the 45S rRNA precursor. Its potent anticancer properties make it a valuable tool for studying cancer biology and RNA transcription regulation in various tumor models. -
RNA Polymerase Inhibitor
MMV688845 is an RNA polymerase inhibitor targeting nontuberculous mycobacteria (NTM) with demonstrated bactericidal activity against Mycobacterium abscessus. This compound exhibits potential anti-tuberculosis efficacy, making it a valuable tool for research in tackling mycobacterial infections. Its selective mechanism positions MMV688845 as a promising candidate for further exploration in antimicrobial studies and drug development. -
MTH1 Activator
MTH1 activator-1 is a potent activator of MTH1, a critical enzyme involved in the repair of oxidative damage to nucleotide pools. This compound significantly enhances endogenous MTH1 activity, leading to reduced levels of 8-oxo-dG in cellular DNA. MTH1 activator-1 serves as a valuable tool for investigating the cellular and biological implications of enhanced oxidative damage repair, and it may provide insights into strategies for delaying or preventing tumorigenesis. -
NS5B Polymerase/RdRp Inhibitor
Lomibuvir is a selective non-nucleoside inhibitor of the NS5B RNA-dependent RNA polymerase (RdRp) associated with Hepatitis C Virus (HCV). It targets the thumb pocket 2 of the NS5B polymerase with a binding affinity (Kd) of 17 nM and effectively inhibits HCV replication, demonstrated by an EC50 value of 5.2 nM in the 1b/Con1 subgenomic replicon model. Lomibuvir primarily interferes with the elongation phase of RNA synthesis, making it a valuable tool for studying HCV replication mechanisms and developing antiviral therapies. -
RNA Polymerases Inhibitor
3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that serves as an inhibitor of DNA-dependent RNA polymerases I and II. It competitively inhibits the incorporation of UTP into RNA, demonstrating potent biological activity with a Ki value of 2.0 μM. This compound is valuable for research applications involving transcription regulation and the study of RNA synthesis mechanisms. -
DNA Polymerase
Pfu DNA Polymerase is a thermostable DNA polymerase sourced from Pyrococcus furiosus, known for its high fidelity during DNA amplification. This enzyme is essential for polymerase chain reaction (PCR) applications, particularly in generating accurate and reliable DNA products. Its robustness at elevated temperatures makes it ideal for amplifying complex templates and minimizing errors in nucleotide incorporation. -
Nucleoside Analogue
2′-O-(2-Methoxyethyl)guanosine is a nucleoside analogue that features a 2'-O-methoxyethyl modification, serving as a valuable intermediate in the synthesis of nucleic acid therapeutics. This compound is not significantly phosphorylated by cytosolic nucleoside kinases and is not incorporated into cellular DNA or RNA, making it crucial for studies involving nucleoside analogues and their applications in drug design and development. Its unique properties allow for exploration in various biochemical research areas, including antiviral and anticancer drug development. -
DNA Synthesis Inhibitor
Cytarabine triphosphate (Ara-CTP) is a competitive inhibitor of DNA synthesis, serving as an active metabolite of Cytarabine. This compound plays a crucial role in cellular mechanisms by disrupting normal DNA replication processes. Its intracellular levels are valuable for predicting the chemosensitivity of leukemic blasts to Cytarabine, making it a significant biomarker in the treatment of leukemia and related hematological disorders. -
DNA Synthesis Inhibitor
Cytembena is a potent inhibitor of DNA synthesis, primarily targeting replicative DNA processes, purine biosynthesis, and tetrahydrofolate formylase activity. Its biological activity demonstrates significant anti-cancer effects, particularly in the treatment of ovarian and breast cancer, as well as providing pain relief in cases of skeletal metastases. This compound is valuable in research applications focused on cancer therapeutics and the mechanisms of DNA replication and repair. -
MTH1 Degrader
aTAG 4531 is a selective MTH1 degrader that exerts its action through the formation of a ternary complex with MTH1, CRBN E3 ligase, and the degrader itself. It displays a DC50 value of 0.28 nM and a Ki value of 1.8 nM, highlighting its potent degradation capability. This compound is valuable for research focused on MTH1 inhibition and subsequent cellular effects, offering insights into its role in cancer biology and related therapeutic applications. -
DNA Alkylator
Methyl methanesulfonate is a potent DNA alkylator known for its ability to transfer methyl groups, leading to the induction of DNA damage. This chemical reagent is commonly employed in research focusing on mutagenesis, DNA repair mechanisms, and the study of cellular responses to genotoxic stress. Its applications extend to investigating the effects of alkylating agents on genetic stability and understanding the underlying processes of carcinogenesis. -
DNA Alkylator/Crosslinker
Phosphoramide mustard cyclohexanamine is a DNA alkylator and crosslinker that exerts its biological effects through the induction of DNA damage. As a biologically active metabolite of cyclophosphamide, it plays a crucial role in anticancer research by disrupting cellular replication processes. This compound is primarily utilized in studies focused on cancer treatment mechanisms and the exploration of targeted therapies. -
DNA Alkylator/Crosslinker
Fotemustine is a DNA alkylator and crosslinker that exhibits potent antitumor activity. By binding to DNA, it induces damage that triggers cellular apoptosis in cancer cells. This compound is primarily utilized in cancer research, particularly for studies focusing on DNA damage response mechanisms and therapeutic efficacy in various malignancies. -
DNA Alkylator/Crosslinker
Duocarmycin analog-1 is a potent DNA alkylator and crosslinker, functioning through the formation of covalent bonds with DNA, leading to cellular damage and apoptosis. It is a valuable tool in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy. This compound is primarily utilized in research involving DNA interactions and cancer treatment modalities. -
DNA Alkylator/Crosslinker Chemical
Palifosfamide tromethamine is a synthetic alkylating agent that targets DNA, exhibiting potent antineoplastic activity. As the stabilized active metabolite of ifosfamide, it irreversibly alkylates and crosslinks DNA at GC base pairs, leading to inhibition of DNA replication and subsequent cell death. Palifosfamide tromethamine offers a reduced toxicity profile compared to its parent compound, making it a valuable tool for cancer research and therapeutic applications. -
DNA Alkylator/Crosslinker
Phosphoramide mustard is a potent DNA alkylator and crosslinker, functioning as a key metabolite of Cyclophosphamide. It exerts significant anticancer activity by inducing DNA damage, thereby interfering with cell proliferation. This compound is widely utilized in cancer research to study DNA repair mechanisms and the effectiveness of alkylating agents in therapeutic applications. -
DNA Alkylator/Crosslinker Inducer
Hepsulfam is a potent DNA alkylator and crosslinker inducer. It demonstrates significant antileukemic activity, with a median IC50 of 0.91 μg/mL across various tumor types. This compound is primarily utilized in cancer research to investigate mechanisms of DNA damage and repair, as well as to evaluate its potential in therapeutic applications against leukemia. -
DNA Alkylator/Crosslinker
Altretamine hydrochloride is an alkylating agent that primarily targets DNA by forming crosslinks. It exhibits significant antitumor activity, making it useful in the treatment of certain cancers, particularly ovarian cancer. This compound is often utilized in research settings to study its effects on tumor cell proliferation and apoptosis. -
DNA Alkylator/Crosslinker
NCI172112 is a bifunctional alkylating agent that acts as a DNA crosslinker. This compound demonstrates significant antitumor activity, particularly against central nervous system (CNS) tumors. It is utilized in research aimed at understanding the mechanisms of DNA damage and repair, as well as developing therapeutic strategies for cancer treatment. -
DNA Alkylator/Crosslinker
Seco-Duocarmycin TM is a potent DNA alkylator and crosslinker derived from the Duocarmycin family, known for its ability to inhibit DNA synthesis. This cytotoxic agent plays a crucial role as the active component in antibody-drug conjugates (ADCs), enabling targeted therapy in cancer research. Its unique mechanism of action is pivotal in understanding and developing novel therapeutic strategies against malignant tumors. -
DNA Alkylator/Crosslinker
DC10SMe is a potent DNA alkylator and crosslinker used primarily in the synthesis of antibody-drug conjugates (ADCs). It demonstrates significant cytotoxicity with IC50 values of 15 pM, 12 pM, and 12 pM against Ramos, Namalwa, and HL60/s cancer cell lines, respectively. This compound serves as a valuable tool in cancer research, particularly in the development of targeted therapies. -
DNA Alkylator/Crosslinker Inducer
Colibactin 742 is a potent DNA alkylator and crosslinker inducer that covalently targets DNA, exhibiting an IC50 of 5.2 μM in human cervical cancer cells (HeLa). This compound forms interstrand crosslinks, thereby activating the Fanconi anemia DNA repair pathway and promoting the formation of γH2AX and FANCD2 foci, which can lead to cell cycle arrest. Colibactin 742 serves as a valuable tool for investigations into colorectal cancer, microbial tumorigenesis, DNA damage repair mechanisms, and the study of mutation signatures, effectively mimicking the genotoxic effects of natural Colibactin while providing enhanced stability. -
DNA Alkylator/Crosslinker Control
Alagebrium bromide is a potent DNA alkylator and crosslinker control that plays a significant role in disrupting glucose cross-links. This compound has been shown to enhance ventricular and arterial compliance, showing promise in improving left ventricular diastolic filling. Alagebrium bromide is utilized in research to investigate its potential therapeutic effects on diastolic heart failure (DHF) and related cardiovascular conditions. -
SIRT3 Agonist
SKLB-11A is a selective, orally active allosteric agonist of SIRT3 (sirtuin 3), exhibiting a Kd value of 4.7 μM and demonstrating high selectivity for SIRT family members. This compound activates autophagy-related signaling pathways and plays a critical role in preventing mitochondrial dysfunction. SKLB-11A has shown efficacy in improving cardiac function in models of Doxorubicin-induced cardiotoxicity and myocardial ischemia/reperfusion, making it a valuable tool for research in cardiovascular protection and mitochondrial biology. -
Topoisomerase I Inhibitor
Irinotecan-d10 is a deuterated derivative of Irinotecan, a potent inhibitor of topoisomerase I. By binding to the topoisomerase I-DNA complex, it disrupts the religation of DNA strands, thereby inducing DNA damage and apoptosis in rapidly dividing cells. This reagent is useful in cancer research, particularly in studies aimed at understanding the mechanisms of action of topoisomerase inhibitors and their therapeutic potential in oncology. -
Topoisomerase Inhibitor
Amonafide L-malate is a topoisomerase II inhibitor that functions as a DNA intercalator. This compound induces apoptotic signaling by disrupting the interaction between topoisomerase II and DNA, leading to inhibited DNA replication and cell proliferation. Amonafide L-malate is utilized in cancer research to study mechanisms of apoptosis and the effects of topoisomerase inhibition on tumor cells. -
HDAC Inhibitor
HDAC-IN-37 is a potent inhibitor of histone deacetylases (HDACs), demonstrating IC50 values of 0.0551 μM for HDAC1, 1.24 μM for HDAC3, 0.948 μM for HDAC8, and 34.2 μM for HDAC6. This compound effectively increases histone acetylation through a slow-off binding mechanism. Additionally, HDAC-IN-37 disrupts the transition from the G1 phase to the S phase of the cell cycle and promotes early apoptosis in various cell types, making it a valuable tool for research in cancer biology and therapeutic development. -
c-Met/HDAC Inhibitor
c-Met/HDAC-IN-3 is a dual inhibitor targeting c-Met and histone deacetylase 1 (HDAC1), exhibiting IC50 values of 12.50 nM and 26.97 nM, respectively. This compound demonstrates significant biological activity by inducing apoptosis and causing cell cycle arrest at the G2/M phase. c-Met/HDAC-IN-3 serves as a valuable tool for research in cancer biology and therapeutic development, particularly in studies focused on synergistic inhibition of oncogenic pathways. -
PARP-1/2/TNKS1/2 Inhibitor
PARP1/2/TNKS1/2-IN-1 is an inhibitor targeting PARP-1, PARP-2, TNKS1, and TNKS2, with IC50 values of 0.25 nM, 1.2 nM, 13.5 nM, and 4.15 nM, respectively. This compound demonstrates significant antitumor activity and promotes apoptosis, making it a valuable tool for research focused on cancer biology and therapeutic strategies. Its dual inhibitory action can facilitate the exploration of cellular repair mechanisms and enhance the understanding of poly(ADP-ribose) polymerases in cancer treatment. -
HDAC6 Inhibitor
HDAC6-IN-4 is a potent and selective inhibitor of histone deacetylase 6 (HDAC6), exhibiting an IC50 value of 23 nM. This compound promotes apoptosis in cancer cells and demonstrates significant antitumor efficacy while exhibiting minimal toxicity. HDAC6-IN-4 is valuable for research in cancer biology, particularly in studies focused on epigenetic regulation and therapeutic development. -
HDAC Inhibitor
HDAC-IN-31 is a selective and orally active histone deacetylase (HDAC) inhibitor, exhibiting IC50 values of 84.90 nM for HDAC1, 168.0 nM for HDAC2, 442.7 nM for HDAC3, and greater than 10,000 nM for HDAC8. This compound induces apoptosis and triggers G2/M phase cell cycle arrest, demonstrating significant antitumor efficacy. HDAC-IN-31 is applicable in research focused on diffuse large B-cell lymphoma and other cancer studies. -
Topoisomerase/HDAC Inhibitor
Top/HDAC-IN-1 is a dual inhibitor targeting both topoisomerase and histone deacetylases (HDACs), demonstrating IC50 values of 18 nM for HDAC1, 230 nM for HDAC2, 790 nM for HDAC3, 87 nM for HDAC6, and 5250 nM for HDAC8. This compound exhibits significant antitumor activity against HCT116 cells, with an IC50 of 180 nM, effectively inducing apoptosis and promoting G2 cell cycle arrest. Top/HDAC-IN-1 serves as a valuable tool in cancer research, particularly for studies involving epigenetic modulation and cell proliferation. -
Nucleoside Analogue
LCB-2122 is a nucleoside analogue that mimics adenosine and features a C2'-stereogenic all-carbon quaternary center. This compound exhibits protective effects against Doxorubicin-induced apoptosis in cardiomyocytes with an IC50 of 0.5 μM and also mitigates apoptosis induced by Imatinib. LCB-2122 activates AMPK signaling pathways, promoting the phosphorylation of AMPK and its downstream target, acetyl-CoA carboxylase (ACC), while reducing mitochondrial damage linked to Doxorubicin treatment. Its biological activities make LCB-2122 a valuable reagent for investigating mechanisms related to heart failure. -
mTOR/HDAC6 Inhibitor
mTOR/HDAC6-IN-1 is a potent dual inhibitor targeting mTOR and HDAC6, exhibiting IC50 values of 133.7 nM and 56 nM, respectively. This compound is known to induce significant autophagy and apoptosis while suppressing cell migration. It holds potential for research applications in triple-negative breast cancer (TNBC) studies, offering insights into the interplay between these critical pathways in cancer progression. -
HDAC Inhibitor
HDAC-IN-59 is a potent inhibitor of histone deacetylases (HDACs), demonstrating significant biological activity in cancer research. This compound promotes the generation of reactive oxygen species (ROS), leading to DNA damage and the induction of apoptosis via the mitochondria-related pathway. Additionally, HDAC-IN-59 effectively disrupts the cell cycle at the G2/M phase, making it a valuable tool for studying the mechanisms of cell growth regulation and apoptosis in various cancer models.
