Fig. 1 · Structure
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2'-O,4'-C-Methyleneadenosine
Adenosine Analog
2'-O,4'-C-Methyleneadenosine is a locked nucleic acid (LNA) and an adenosine analog that exhibits increased stability and binding affinity for complementary RNA sequences. This compound serves as a valuable tool in nucleic acid research, enabling precise modulation of gene expression and investigation of RNA structures. Its application extends to antisense oligonucleotide design and RNA interference studies, making it essential for researchers exploring RNA-related therapies and molecular diagnostics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 206055-70-1 |
| Applications | Adenosine Analog |
| Formula | C11H13N5O4 |
| Molecular Weight | 279.26 |
| Synonyms | LNA-A |
| SMILES | OC[C@]1(CO2)[C@@H](O)[C@@H]2[C@H](N3C(N=CN=C4N)=C4N=C3)O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.