Catalog No.
Product Name
Application
Product Information
Citations
- Altretamine is classified as an alkylating antineoplastic agent.This unique structure is believed to damage tumor cells through the production of the weakly alkylating species formaldehyde, a product of CYP450-mediated N-demethylation.
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Bendamustine Hydrochloride is a small molecule bifunctional DNA alkylating agent, combining a nitrogen mustard functionality with a purine-analog structure. The dense DNA-damaging functionality of Bendamustine differentiates it from other compounds used as antiproliferative agents, and these functionalities are thought to promote cell death through a variety of different pathways including apoptosis and mitotic catastrophe.
- Procarbazine Hydrochloride is an alkylating agent, with anticancer activity.
- Cyclophosphamide monohydrate is an alkylating, cytotoxic agent experimentally shown to crosslink DNA, causing strand breakage and inducing mutations.
- Palifosfamide is a synthetic mustard compound with potential antineoplastic activity.
- Uramustine is a chemotherapy drug which belongs to the class of alkylating agents.
- Miriplatin hydrate is a lipophilic platinum complex containing myristates as leaving groups, and can be easily suspended in ethyl esters of iodized fatty acids obtained from poppy seed oil.
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DNA/RNA Alkylator
Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA. - Nimustine hydrochloride is an antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine.
- Lurbinectedin (PM01183) is a new DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively.
- Treosulfan (NSC 39069;Treosulphan) is an alkylating agent with activity in ovarian cancer and other solid tumor types.
- Methylnitronitrosoguanidine (MNNG) is an alkylating agent with toxic and mutagenic effects.
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DNA alkylating agent
(+)-CBI-CDPI2 is an enhanced functional analog of CC-1065. (+)-CBI-CDPI1 is a DNA alkylating agent. (+)-CBI-CDPI2 is an antibody drug conjugates (ADCs) toxin. -
DNA alkylating agent
(+)-CBI-CDPI1 is an enhanced functional analog of CC-1065. (+)-CBI-CDPI1 is a DNA alkylating agent. (+)-CBI-CDPI1 is an antibody drug conjugates (ADCs) toxin. -
DNA alkylating agent
Duocarmycin GA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin GA can be used against multi-drug resistant cell lines. -
DNA alkylator
Duocarmycin TM is an exceptionally potent antitumor antibiotic. Duocarmycin TM is a DNA alkylator. -
DNA alkylator
DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer. -
alkylating agent
Satraplatin is an alkylating agent, with potent antitumor effect. -
DNA alkylator
Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3?? end of AT-rich sequences in the DNA. -
DNA Alkylator
Illudin S is a natural sesquiterpene compound with potent cytotoxic, anti-tumor, and antiviral activities. It exhibits genotoxic effects and disrupts cell cycle progression by blocking the G1-S phase transition in human leukemia cells. Illudin S is of interest in cancer research due to its ability to target rapidly proliferating cells. -
DNA Alkylator
(S)-Seco-Duocarmycin SA is a potent DNA alkylator that binds to DNA, leading to cytotoxic effects in tumor cells. This compound exhibits significant antitumor activity, with an IC50 of 10 pM, and induces a concentration-dependent increase in apoptotic cell death. Additionally, (S)-Seco-Duocarmycin SA is capable of causing substantial cell cycle arrest in the S and G2/M phases. Its mechanism of action makes it a valuable cytotoxic agent for antibody-drug conjugates in cancer research applications. -
DNA Alkylator
Seco-Duocarmycin SA is a potent DNA alkylator that functions as an antitumor antibiotic with an IC50 of 10 pM. It induces a concentration-dependent increase in apoptotic cell death and is known to cause significant cell cycle arrest in the S and G2/M phases. Additionally, Seco-Duocarmycin SA acts as a cytotoxic agent in antibody-drug conjugates (ADCs), making it a valuable tool for cancer research and therapeutic development. -
DNA Alkylator
Illudin M is a cytotoxic fungal sesquiterpene that functions as a DNA alkylator. Derived from the culture medium of Omphalotus illudens mushrooms, Illudin M exhibits significant anti-tumor properties. Its ability to alkylate DNA positions it as a valuable tool for research into cancer therapeutics and mechanisms of DNA damage response. -
DNA Alkylator/Crosslinker Inducer
Anticancer agent 11 functions as a DNA alkylator and crosslinker inducer, exhibiting broad-spectrum anticancer activity. This compound inhibits angiogenesis and promotes the formation of DNA cross-links, leading to disruptions in DNA replication and repair processes. It has potential applications in cancer research, particularly in the study of tumor biology and the development of novel therapeutic strategies. -
DNA Alkylator/Crosslinker Control
4-Ketocyclophosphamide is an inactive metabolite that serves as a control for the alkylating agent Cyclophosphamide, functioning as a DNA alkylator and crosslinker. This compound is utilized in research to investigate the mechanisms of action and toxicity of alkylating agents, aiding in the study of cancer therapies and the development of related pharmaceuticals. Its role in understanding the cellular responses to DNA damage makes it valuable for both preclinical and clinical research applications. -
DNA Alkylator/Crosslinker
Brostallicin is a DNA alkylator and crosslinker known for its potent cytotoxic properties. It effectively induces DNA damage, leading to apoptosis in cancer cells, while exhibiting low myelotoxicity. This compound is primarily utilized in cancer research to explore mechanisms of DNA repair and resistance to therapeutic agents. Its unique profile makes it a valuable tool for advancing studies in oncology and molecular biology. -
DNA Alkylator/Crosslinker Chemical
Canfosfamide hydrochloride functions as a DNA alkylator and crosslinker. Upon activation by the enzyme glutathione S-transferase P1-1 (GSTP1-1), it generates an active anticancer alkylating agent alongside a glutathione derivative. This compound is primarily utilized in cancer research to investigate its therapeutic potential and mechanisms of action in tumor cell lines. -
DNA Alkylator
Methyl methanesulfonate is a potent DNA alkylator known for its ability to transfer methyl groups, leading to the induction of DNA damage. This chemical reagent is commonly employed in research focusing on mutagenesis, DNA repair mechanisms, and the study of cellular responses to genotoxic stress. Its applications extend to investigating the effects of alkylating agents on genetic stability and understanding the underlying processes of carcinogenesis. -
DNA Alkylator/Crosslinker
Phosphoramide mustard cyclohexanamine is a DNA alkylator and crosslinker that exerts its biological effects through the induction of DNA damage. As a biologically active metabolite of cyclophosphamide, it plays a crucial role in anticancer research by disrupting cellular replication processes. This compound is primarily utilized in studies focused on cancer treatment mechanisms and the exploration of targeted therapies. -
DNA Alkylator/Crosslinker
Fotemustine is a DNA alkylator and crosslinker that exhibits potent antitumor activity. By binding to DNA, it induces damage that triggers cellular apoptosis in cancer cells. This compound is primarily utilized in cancer research, particularly for studies focusing on DNA damage response mechanisms and therapeutic efficacy in various malignancies. -
DNA Alkylator/Crosslinker
Duocarmycin analog-1 is a potent DNA alkylator and crosslinker, functioning through the formation of covalent bonds with DNA, leading to cellular damage and apoptosis. It is a valuable tool in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy. This compound is primarily utilized in research involving DNA interactions and cancer treatment modalities. -
DNA Alkylator/Crosslinker Chemical
Palifosfamide tromethamine is a synthetic alkylating agent that targets DNA, exhibiting potent antineoplastic activity. As the stabilized active metabolite of ifosfamide, it irreversibly alkylates and crosslinks DNA at GC base pairs, leading to inhibition of DNA replication and subsequent cell death. Palifosfamide tromethamine offers a reduced toxicity profile compared to its parent compound, making it a valuable tool for cancer research and therapeutic applications. -
DNA Alkylator/Crosslinker
Phosphoramide mustard is a potent DNA alkylator and crosslinker, functioning as a key metabolite of Cyclophosphamide. It exerts significant anticancer activity by inducing DNA damage, thereby interfering with cell proliferation. This compound is widely utilized in cancer research to study DNA repair mechanisms and the effectiveness of alkylating agents in therapeutic applications. -
DNA Alkylator/Crosslinker Inducer
Hepsulfam is a potent DNA alkylator and crosslinker inducer. It demonstrates significant antileukemic activity, with a median IC50 of 0.91 μg/mL across various tumor types. This compound is primarily utilized in cancer research to investigate mechanisms of DNA damage and repair, as well as to evaluate its potential in therapeutic applications against leukemia. -
DNA Alkylator/Crosslinker
Altretamine hydrochloride is an alkylating agent that primarily targets DNA by forming crosslinks. It exhibits significant antitumor activity, making it useful in the treatment of certain cancers, particularly ovarian cancer. This compound is often utilized in research settings to study its effects on tumor cell proliferation and apoptosis. -
DNA Alkylator/Crosslinker
NCI172112 is a bifunctional alkylating agent that acts as a DNA crosslinker. This compound demonstrates significant antitumor activity, particularly against central nervous system (CNS) tumors. It is utilized in research aimed at understanding the mechanisms of DNA damage and repair, as well as developing therapeutic strategies for cancer treatment. -
DNA Alkylator/Crosslinker
Seco-Duocarmycin TM is a potent DNA alkylator and crosslinker derived from the Duocarmycin family, known for its ability to inhibit DNA synthesis. This cytotoxic agent plays a crucial role as the active component in antibody-drug conjugates (ADCs), enabling targeted therapy in cancer research. Its unique mechanism of action is pivotal in understanding and developing novel therapeutic strategies against malignant tumors. -
DNA Alkylator/Crosslinker
DC10SMe is a potent DNA alkylator and crosslinker used primarily in the synthesis of antibody-drug conjugates (ADCs). It demonstrates significant cytotoxicity with IC50 values of 15 pM, 12 pM, and 12 pM against Ramos, Namalwa, and HL60/s cancer cell lines, respectively. This compound serves as a valuable tool in cancer research, particularly in the development of targeted therapies. -
DNA Alkylator/Crosslinker Inducer
Colibactin 742 is a potent DNA alkylator and crosslinker inducer that covalently targets DNA, exhibiting an IC50 of 5.2 μM in human cervical cancer cells (HeLa). This compound forms interstrand crosslinks, thereby activating the Fanconi anemia DNA repair pathway and promoting the formation of γH2AX and FANCD2 foci, which can lead to cell cycle arrest. Colibactin 742 serves as a valuable tool for investigations into colorectal cancer, microbial tumorigenesis, DNA damage repair mechanisms, and the study of mutation signatures, effectively mimicking the genotoxic effects of natural Colibactin while providing enhanced stability. -
DNA Alkylator/Crosslinker Control
Alagebrium bromide is a potent DNA alkylator and crosslinker control that plays a significant role in disrupting glucose cross-links. This compound has been shown to enhance ventricular and arterial compliance, showing promise in improving left ventricular diastolic filling. Alagebrium bromide is utilized in research to investigate its potential therapeutic effects on diastolic heart failure (DHF) and related cardiovascular conditions.
