Catalog No.
Product Name
Application
Product Information
Citations
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GTP Analogue
5′-Guanylyl methylenediphosphonate sodium is a GTP analogue that acts as a specific, competitive inhibitor of GTP-dependent processes in protein synthesis. By mimicking GTP, it disrupts nucleotide binding, thereby affecting the translation mechanism in cells. This reagent is valuable for researchers investigating protein biosynthesis pathways and studying the regulatory roles of GTP in various cellular functions. -
ATP Analog
3BrB-PP1 is an ATP-competitive analog designed to selectively inhibit protein kinases with mutations in the ATP-binding pocket, particularly targeting the Thr97 mutation within Sty1. This compound offers a unique tool for investigating the effects of ATP-binding site alterations on kinase activity. Its specificity makes it valuable for studying mutant forms of kinases in various biological contexts and cancer research. -
Nucleoside
DMT-2'Fluoro-DG(IB) Amidite is a phosphoramidite nucleoside primarily targeting oligonucleotide synthesis. It facilitates the incorporation of 2'-fluoro modifications, allowing for the preparation of 4'-modified 2'-deoxy-2'-fluorouridine. This reagent is valuable in the study of nucleic acid structure and function, as well as in the development of therapeutic oligonucleotides. -
Adenosine Analog
2,8-Dimethyladenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits significant vasodilatory effects on smooth muscle and has demonstrated potential in inhibiting cancer progression. It serves as a valuable tool for research in cardiovascular studies and cancer biology. -
Purine Nucleoside Analog
2'-Deoxy-2'-fluoro-β-D-arabino-6-azauridine is a purine nucleoside analog that primarily targets DNA synthesis pathways. Exhibiting broad antitumor activity, it is particularly effective against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA replication and the induction of apoptosis, making it a valuable tool for cancer research and therapeutic development in oncology. -
Cytidine Analog
3′-O-Methylcytidine is a cytidine analog that functions as an inhibitor of DNA methyltransferases. This compound exhibits potential anti-metabolic and anti-tumor activities, making it a valuable tool in cancer research. Its ability to modulate gene expression through epigenetic mechanisms positions it as an important reagent for studies focused on DNA methylation and its role in various biological processes. -
Pyrimidine Nucleoside
L-Cytidine is a pyrimidine nucleoside that plays a crucial role as a building block of RNA. It is known to regulate the glial glutamate cycle and influence brain phospholipid metabolism, catecholamine synthesis, and mitochondrial function. This compound is valuable in research applications involving RNA biochemistry, neurobiology, and cellular metabolism. -
Adenosine Derivative
Adenosine 5′-monophosphoramidate sodium is an adenosine derivative that serves as an intermediate in nucleotide synthesis. It significantly influences the accumulation of cyclic AMP, playing a critical role in various cellular signaling pathways. This reagent is valuable for research applications focused on the modulation of adenine nucleotide metabolism and cyclic nucleotide signaling. -
Purine Nucleoside Analog
2’-O-(2-Methoxyethyl) inosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for research in cancer therapeutics and molecular biology. This reagent may facilitate investigations into the roles of purine metabolism and nucleoside signaling pathways in cancer progression. -
Purine Nucleoside Analog
1-O-Acetyl-2-O-benzoyl-3-O-tert-butyldiphenylsilyl-L-threofuranose is a purine nucleoside analog that primarily targets DNA synthesis pathways. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of nucleic acid synthesis and the induction of apoptotic pathways, making it valuable for research in cancer therapeutics and drug development. -
Purine Nucleoside Analog
5-Bromocytidine is a purine nucleoside analog that exhibits broad antitumor activity against indolent lymphoid malignancies. Its anticancer mechanisms primarily involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research and therapeutic exploration. This compound is suitable for studies aimed at understanding nucleoside metabolism and the role of DNA replication in tumorigenesis. -
Nucleoside Antimetabolite/Analog
5'-DMT-3'-TBDMS-Bz-rA is a nucleoside analog designed for use as an antimetabolite. This compound features protective and modification groups that enhance its stability and reactivity. It is suitable for various molecular biology applications, including oligonucleotide synthesis and nucleic acid research, where it can be utilized to study nucleoside function and metabolism. -
Purine Nucleoside Analog
3'-Deoxycytidine is a purine nucleoside analog that primarily influences DNA synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting DNA replication and promoting apoptosis. It is utilized in various research applications aimed at understanding cancer mechanisms and developing therapeutic strategies. -
Purine Nucleoside Analog
Alpha-Adenosine is a purine nucleoside analog that exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is suitable for studies focused on the therapeutic effects of nucleoside analogs in treating various malignancies. -
Adenosine Analog
N-Acetyladenosine is an adenosine analog that primarily functions as a smooth muscle vasodilator. This compound has demonstrated the ability to inhibit cancer progression, making it relevant in cancer research. N-Acetyladenosine is utilized in studies focusing on vascular biology and may serve as a therapeutic candidate in the development of anti-cancer strategies. -
Nucleoside Analog
VP-U-6 is a nucleoside analog primarily utilized in oligonucleotide synthesis. This compound serves as a critical building block for the development of diverse oligonucleotides, enhancing the specificity and stability of nucleic acid interactions. VP-U-6 is instrumental in various applications, including antisense oligonucleotide design, RNA interference studies, and molecular diagnostic techniques. -
Intermediate
5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine is an adenosine derivative primarily used as an intermediate in oligonucleotide synthesis. This compound facilitates the incorporation of adenosine units into nucleic acid sequences, enhancing the efficiency of synthetic procedures. Its stable protective groups make it suitable for various modifications in chemical biology and nucleic acid research. -
Nucleosides
N6-Threonylcarbamoyladenosine is a modified nucleoside targeting tRNA molecules. This compound plays a crucial role in the post-transcriptional modification of tRNA, influencing its stability and function. Research applications include investigating tRNA structure-function relationships and studying the effects of nucleoside modifications on protein synthesis and translation efficiency. -
Antiviral Agents
Ribavirin 5'-monophosphate dilithium is an active metabolite of ribavirin that predominantly inhibits inosine monophosphate (IMP) dehydrogenase. As a broad-spectrum antiviral agent, it is utilized in research to investigate viral replication mechanisms and assess therapeutic strategies against various viral infections. This compound's ability to modulate nucleotide synthesis positions it as a valuable tool in virology studies. -
Nucleoside Analog
2'-O-POM-rA(Bz) is a nucleoside analog that serves as a key monomer for nucleic acid synthesis. It is utilized in the preparation of modified oligonucleotides and plays a crucial role in research applications involving RNA chemistry and therapeutic development. This compound enhances the stability and functionality of nucleic acid constructs, making it valuable in various biochemical studies. -
Purine Nucleoside Analog
2’-O-Methyl-4-thiouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable in research applications aimed at exploring novel cancer therapies and understanding the molecular pathways involved in tumor progression. -
Usherin Synthesis Promotor
Ultevursen (QR-421a) is a single-stranded RNA oligonucleotide that acts as a splice-switching agent, designed to promote the skipping of exon 13 in the USH2A gene, which encodes usherin. This mechanism aims to halt vision loss associated with retinitis pigmentosa caused by mutations within this exon. Ultevursen has potential applications in gene therapy and research focused on treatments for genetic retinal diseases. -
Purine Nucleoside Analog
2',3',5'-Tri-O-acetyl-2-thiouridine is a purine nucleoside analog known for its broad antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. This compound serves as a valuable reagent for researchers studying cancer therapeutics and the molecular pathways involved in nucleoside metabolism. -
Adenosine Analog
2-Chloro-2′-β-C-methyladenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits vasodilatory effects on smooth muscle and demonstrates the potential to inhibit cancer progression. It serves as a valuable tool for research applications focused on vascular biology and cancer therapeutics. -
D-DT Inhibitor
RGB097 is a potent inhibitor of D-dopachrome tautomerase (D-DT), demonstrating an IC50 value of 0.5 µM. This compound exhibits significant biological activity and has potential applications in cancer research, particularly in elucidating the role of D-DT in oncogenesis and tumor progression. -
MIF Inhibitor
MIF-IN-5 is a potent and reversible inhibitor of macrophage migration inhibitory factor (MIF), exhibiting a competitive mechanism of action. With an IC50 of 4.8 μM and a Ki value of 3.3 μM, it effectively disrupts MIF's biological activity. This compound is valuable for research applications involving inflammation, immune response modulation, and potential therapeutic strategies targeting various diseases associated with MIF dysregulation. -
MIF Inhibitor
HTS05585 is a selective inhibitor of macrophage migration inhibitory factor (MIF), demonstrating a Kd value of 0.29 μM via microscale thermophoresis and 0.32±0.01 μM confirmed by isothermal titration calorimetry. This compound effectively inhibits the release of pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β, from LPS-stimulated macrophages. HTS05585 is a valuable tool for studying inflammation-related diseases, particularly in the context of sepsis research. -
MIF tautomerase Inhibitor
TE-11 is a potent MIF tautomerase inhibitor, exhibiting an IC50 value of 5.63 μM. This compound effectively ameliorates CD-like colitis and reduces migration of MIF-induced eosinophils and neutrophils. Additionally, TE-11 prevents M1 polarization and the associated metabolic reprogramming, making it a valuable tool for research in inflammatory and autoimmune disorders. -
Purine Nucleoside Analog
3’-Azido-3’-deoxy-5-iodouridine is a purine nucleoside analog that targets DNA synthesis pathways to exhibit antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are primarily mediated through inhibition of DNA replication and the induction of apoptosis. Additionally, this compound serves as a versatile click chemistry reagent, featuring an azide group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne, DBCO, or BCN-functionalized molecules. This makes it a valuable tool for bioconjugation applications in chemical biology research. -
Adenosine Analog
3,5-Bis-O-(2,4-dichlorobenzyl)adenosine is an adenosine analog that primarily serves as a vasodilator through its action on smooth muscle. This compound has also demonstrated potential in inhibiting cancer progression, making it relevant for various therapeutic research applications. Its structural modifications allow for enhanced biological activity, contributing to studies in drug design and development focused on cardiovascular and oncology therapies. -
Purine Nucleoside Analog
3’-Deoxy-3’-α-C-methyl-5-methyluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, leading to the induction of apoptosis in malignant cells. This compound is valuable for research applications centered on cancer biology and the development of novel therapeutic strategies against lymphoid cancers. -
Guanosine Analog
3'-O-MOE-G(iBu)-2'-phosphoramidite is a guanosine analog that targets Toll-like receptor 7 (TLR7). This compound exhibits immunostimulatory activity, which can lead to the induction of type I interferons in various animal models, thereby generating antiviral effects. Its unique properties make it valuable for research applications focused on immune response and antiviral therapies. -
Purine Nucleoside Analog
3'-Amino-3'-deoxy-5-fluorouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms of action involve the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for researchers studying cancer biology and the therapeutic potential of nucleoside analogs in oncology. -
Thymidine Analog
1-(β-D-Xylofuranosyl)-5-methyluracil is a thymidine analog that functions by incorporating into replicated DNA. This compound exhibits insertional activity, making it useful for labeling cells and investigating DNA synthesis dynamics. It serves as a valuable tool in studies of cell proliferation and nucleic acid metabolism. -
Pyrimidine Nucleoside Analog
4-Amino-6-bromo-5-cyano-1-(beta-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a pyrimidine nucleoside analog that targets nucleic acid metabolism. This compound demonstrates significant biological activity, including the inhibition of DNA and RNA synthesis, as well as antiviral and immunomodulatory effects. Its versatile properties make it a valuable tool for research applications in cancer biology, virology, and immune response studies. -
Nucleoside Metabolite
(24E)-3α,7α-Dihydroxy-5β-cholest-24-enoyl-CoA is a nucleoside metabolite that plays a critical role in cholesterol metabolism. It serves as a substrate for various enzymatic reactions involved in lipid biosynthesis and has potential applications in studying cellular pathways related to lipid synthesis and degradation. This compound is valuable for researchers investigating metabolic disorders and cholesterol-related diseases. -
Purine Nucleoside Analog
2-Chloro-N6-cyclopentyl-2'-deoxy-2'-fluoro-beta-D-arabinoadenosine is a purine nucleoside analog that targets mechanisms involved in DNA synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its pharmacological effects are linked to the induction of apoptosis and inhibition of cellular proliferation, making it a valuable tool for cancer research and therapeutic development. -
Purine Nucleoside Analog
2-Aminomethyl adenosine is a purine nucleoside analog known for its antitumor activity against indolent lymphoid malignancies. This compound exerts its effects primarily through the inhibition of DNA synthesis and the induction of apoptosis. Its applications in cancer research make it a valuable tool for studying the mechanisms of tumor cell proliferation and survival. -
Pyrimidine Nucleoside Analog
4,6-Diamino-1-(2-deoxy-beta-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a pyrimidine nucleoside analog targeting nucleic acid metabolism. This compound demonstrates significant biological activities, including inhibition of DNA and RNA synthesis, antiviral properties, and immunomodulatory effects. It is a valuable research tool for studying molecular mechanisms in cancer biology, virology, and immunology. -
Nucleoside Metabolite
3-Oxo-3-ureidoisobutyrate is a nucleoside metabolite involved in various biochemical pathways. It plays a crucial role in the metabolism of nucleotides, influencing nucleobase synthesis and cellular energy homeostasis. This compound is useful in research applications related to nucleotide metabolism and can aid in understanding the regulatory mechanisms of nucleoside derivatives in cellular processes. -
Purine Nucleoside Analog
5'-Deoxy-5'-N,N-diethylamino thymidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for cancer research and therapeutic studies focused on lymphoid neoplasms. This compound is instrumental in understanding the role of nucleoside analogs in cancer treatment and their potential effects on cell proliferation and viability. -
Purine Nucleoside Analog
3’-Azido-3’-deoxy-5-methyluridine is a purine nucleoside analog primarily effective in inhibiting DNA synthesis, which promotes apoptosis in cancer cells. Its broad antitumor activity is particularly relevant for indolent lymphoid malignancies. Additionally, this compound serves as a click chemistry reagent, featuring an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, facilitating various biochemical applications in research. -
Purine Nucleoside Analog
2’-dG (iBu)-2’-phosphoramidite is a purine nucleoside analog that selectively targets DNA synthesis pathways. It exhibits significant antitumor activity against indolent lymphoid malignancies through mechanisms such as the inhibition of DNA replication and the induction of apoptosis. This reagent is essential for research applications focused on cancer biology and nucleic acid synthesis. -
Purine Nucleoside Analog
8-Methyl-2’-deoxyguanosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research and therapeutic studies. This compound is instrumental in investigating mechanisms of action and developing targeted treatments for various malignancies. -
Thymidine Analog
5-Hydroxymethyl-arauridine is a thymidine analogue that exhibits insertional activity towards replicated DNA. This compound is particularly valuable for labeling cells and monitoring DNA synthesis in various research applications. Its ability to mimic natural nucleotides makes it an effective tool for investigating cellular proliferation and the dynamics of DNA replication. -
Purine Nucleoside Analog
5-Hydroxymethyl-2',3'-O-isopropylidene-2-thiouridine is a purine nucleoside analog that exhibits notable antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms include the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound serves as a valuable research tool for investigating therapeutic strategies in cancer treatment and understanding the molecular pathways involved in tumor progression. -
Guanosine Analog
7-Cyano-7-deaza-2'-deoxy guanosine is a guanosine analog with significant immunostimulatory properties. It has been demonstrated to induce type I interferons in various animal models, thereby exerting antiviral effects. The biological activity of this compound is closely linked to the activation of Toll-like receptor 7 (TLR7), making it a valuable tool for research in immunology and antiviral therapies. -
Adenosine Analog
N6-Benzoyl-7'-O-DMT-morpholino adenine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits notable biological activities, including smooth muscle vasodilation and the potential inhibition of cancer progression. It is commonly utilized in research applications related to cardiovascular studies and cancer therapeutics, contributing valuable insights into adenosine signaling and its effects on physiological processes. -
Purine Nucleoside Analog
5-Difluoromethyluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis. This reagent is valuable for research applications focused on cancer biology and the development of therapeutic strategies targeting tumor cell proliferation. -
Purine Nucleoside Analog
1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4(1H)-pyrimidinone is a purine nucleoside analog known for its potential anticancer activity. It exhibits efficacy against indolent lymphoid malignancies primarily through mechanisms that inhibit DNA synthesis and induce apoptosis. This compound is valuable for research in cancer biology and drug development focused on targeted therapies for lymphoid-related tumors.
