Catalog No.
Product Name
Application
Product Information
Citations
-
Adenosine Analog
2-Aminoadenosine is an adenosine analog and a modified adenine base that enhances the stability of RNA duplexes. By forming three hydrogen bonds with uracil, 2-Aminoadenosine increases the melting temperature of hybrid strands, making it a valuable tool for stabilizing uracil-containing RNA structures. This compound is widely utilized in biochemical research, particularly in studies involving RNA structure and function, template-directed nucleotide condensation reactions, and nucleic acid hybridization. -
Modified Uridine
2',3'-O-Isopropylideneuridine is a modified uridine that serves as a valuable tool in virology research. It exhibits antiviral activity, particularly against cytomegalovirus and varicella-zoster virus. This compound is primarily utilized to investigate the mechanisms of viral replication and to develop therapeutic strategies targeting viral infections. -
Purine Nucleoside Analog
3’-Azido-3’-deoxyuridine is a purine nucleoside analog that exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. Additionally, this compound acts as a click chemistry reagent, featuring an azide functional group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules. This versatility makes it valuable for various applications in chemical biology and medicinal chemistry. -
Guanosine Analog
3’-O-(2-Methoxyethyl)guanosine is a guanosine analog that primarily targets Toll-like receptor 7 (TLR7). This compound exhibits immunostimulatory activity and has been shown to induce type I interferons, leading to antiviral effects in various animal models. Its unique biological activity makes it a valuable reagent for research applications related to innate immunity and antiviral response. -
Adenosine Analog
2-Methyladenosine is an adenosine analog that primarily functions as a smooth muscle vasodilator. This compound exhibits significant biological activity, including the potential to inhibit cancer progression. Its applications in research include studies focused on vasodilation, cancer biology, and the broader field of nucleotide signaling pathways. -
Adenosine Analog
3′-O-Methyladenosine is an adenosine analogue that primarily targets adenosine receptors. This compound exhibits significant biological activity as a smooth muscle vasodilator and has also demonstrated potential in inhibiting cancer progression. Its applications extend to various research fields, including cardiovascular studies and oncology, making it a valuable tool for investigating adenosine-related pathways and therapeutic targets. -
Purine Nucleoside Analog
Nebularine is a purine nucleoside analog that exerts its effects primarily through the inhibition of DNA synthesis. This compound demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the induction of apoptosis and disruption of cellular replication, making it a valuable tool for cancer research and therapeutic applications. -
Purine Nucleoside Analog
2'-Deoxy-N1-methylguanosine is a purine nucleoside analog that primarily interferes with DNA synthesis. This compound exhibits significant antitumor activity, particularly in indolent lymphoid malignancies, through mechanisms such as apoptosis induction. Its properties make it a valuable tool for research in cancer biology and therapeutic development. -
Derivative Of Guanosine
3′-Deoxyguanosine is a derivative of guanosine that primarily targets human purine nucleoside phosphorylase. This compound interacts through hydrogen bonding with key residues, including Glu201 and Asn243, and exhibits moderate displacement activity for [3H]-guanosine in rat meninges. 3′-Deoxyguanosine is valuable for research focused on the mechanisms of guanosine receptors and the pathways of purine metabolism. -
Purine Nucleoside Analog
3'-Deoxy-3'-fluoroadenosine is a purine nucleoside analogue that targets DNA synthesis in cells. This compound exhibits broad antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting cellular proliferation and inducing apoptosis. Its role in cancer research makes it a valuable tool for studying mechanisms of tumorigenesis and therapeutic response. -
Intermediate
2,2'-Anhydrouridine is a nucleoside analog that serves as a crucial intermediate in the synthesis of various nucleoside-related compounds. Its unique structural properties facilitate the development of novel therapeutic agents in research applications, particularly in the fields of biochemistry and molecular biology. Researchers utilize 2,2'-Anhydrouridine to enhance understanding of nucleoside metabolism and to explore potential drug development pathways. -
Purine Nucleoside Analog
5-Iodo-cytidine is a purine nucleoside analog that exhibits notable antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is essential for studies focused on understanding cancer biology and developing novel therapeutic strategies. -
Purine Nucleoside Analog
5-Hydroxyuridine (OHUrd) is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research applications aimed at exploring therapeutic strategies in cancer treatment and understanding the molecular mechanisms underlying tumor growth and proliferation. -
Purine Nucleoside Analog
6-O-Methyldeoxyguanosine is a purine nucleoside analog that functions as a DNA adduct. This compound demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for research in cancer biology and therapeutic development. -
Purine Nucleoside Analog
N-Acetyl-2′-deoxycytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, leading to subsequent induction of apoptosis in cancer cells. This compound is valuable for research applications focused on cancer biology and therapeutic development in oncology. -
Purine Nucleoside Analog
2'-Chloro-2'-deoxyadenosine is a purine nucleoside analog that exerts significant antitumor activity, particularly against indolent lymphoid malignancies. This compound mainly functions by inhibiting DNA synthesis and inducing apoptosis in cancer cells, making it a valuable tool for cancer research and therapeutic studies. It is commonly utilized in investigations focused on the mechanisms of tumor growth and the development of novel treatment strategies. -
LNA Analogue
5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer utilized for the synthesis of locked nucleic acid (LNA) analog oligonucleotides. This compound enhances hybridization affinity and mismatch discrimination with RNA due to its 2',4'-constrained ethyl modification, which locks the furanose ring in an N-type conformation. Its properties significantly improve resistance to exonuclease digestion and facilitate the formation of stable RNA hybrids that can mediate RNase H-dependent mRNA degradation or inhibit translation. Applications include the development of antisense oligonucleotides for gene expression regulation, gene function research, and the synthesis of oligonucleotides for therapeutic interventions. -
Thymidine Analog
5-Methoxycarbonylmethyl-2'-O-methyluridine is a thymidine analog primarily targeting DNA synthesis. This compound exhibits insertional activity towards replicated DNA, making it an effective tool for cellular labeling and tracking of DNA synthesis. Its unique properties facilitate its application in various molecular biology research contexts, particularly in studies related to nucleic acid metabolism and cell proliferation. -
Purine Nucleoside Analog
5-Methyl-2-thiouridine is a purine nucleoside analogue known for its significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research applications focusing on cancer biology and the development of therapeutic strategies targeting nucleic acid metabolism. -
Nucleic Acid Analog
5'-ODMT cEt G Phosphoramidite is a potent nucleic acid analog that serves as a key reagent for the synthesis of modified oligonucleotides. This compound exhibits effective antisense activity, making it valuable for research applications in gene regulation and therapeutic development. Its structural properties allow for enhanced stability and specificity in nucleic acid interactions. -
Oligonucleotide
DMT-2'-F-iBu-G is a chemically modified oligonucleotide that features a 2'-deoxy-2'-fluoro modification. This structure enhances nuclease resistance while maintaining strong binding affinity to RNA targets. It is valuable for applications in molecular biology research, including RNA interference and antisense oligonucleotide studies. -
Adenosine
Bz-rA (N6-Benzoyladenosine) targets adenosine and serves as a nucleoside derivative featuring an N6 protecting group. This compound is primarily utilized as a synthetic intermediate in photocatalytic oxidative cyclization reactions, facilitating the synthesis of oligoribonucleotides. Bz-rA is effective in constructing heterocyclic skeletons through photochemical conversions and offers protection to the ribose moiety, thereby regulating the cyclization pathway in research applications. -
Nucleoside Analog
N4-Benzoyl-2'-fluoro-2'-deoxycytidine is a nucleoside analog that serves as a building block for nucleic acid synthesis. It exhibits important structural modifications that enhance its utility in the development of nucleotide-based therapeutics and molecular probes. This compound is valuable for research in areas such as antiviral drug design and studies on DNA/RNA interactions. -
Purine Nucleoside Analog
1,3,5-Tri-O-benzoyl-a-D-ribofuranose serves as a purine nucleoside analog, exhibiting significant antitumor activity particularly against indolent lymphoid malignancies. Its primary mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research and therapeutic applications. This compound is crucial for studies aimed at understanding the molecular pathways involved in lymphoid malignancies and developing targeted treatments. -
Purine Nucleoside Analog
2′-Deoxy-N-methylguanosine is a purine nucleoside analog primarily targeting DNA synthesis pathways. This compound exhibits significant antitumor activity, particularly in the context of indolent lymphoid malignancies. Its anticancer mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research and therapeutic applications. -
Pyrimidinone
1-Methylcytosine is a pyrimidinone that functions as a nucleobase in hachimoji DNA, pairing specifically with isoguanine. This compound exhibits weak antiproliferative activity against cervical cancer cells, making it a valuable tool for cancer research. Its unique properties facilitate studies in nucleic acid chemistry and the exploration of alternative genetic systems in oncological applications. -
Bicyclic Nucleosid
2’-O,4’-C-Methyleneuridine is a bicyclic nucleoside that serves as a structural analog of natural ribonucleosides. It exhibits significant antiviral activity by inhibiting viral RNA polymerases, making it a valuable tool in virology research. This compound has applications in studying nucleotide metabolism and the development of antiviral therapies. -
Purine Nucleoside Analog
6-Methylmercaptopurine riboside is a purine nucleoside analog that exhibits significant antitumor activity, primarily effective against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research into therapeutic strategies targeting various malignancies. -
Purine Nucleoside Analog
2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone is a purine nucleoside analog known for its potential antitumor activity. This compound exhibits biological effects such as inhibition of DNA synthesis and induction of apoptosis, making it relevant for research into the treatment of indolent lymphoid malignancies. It can be synthesized from D-ribose through Fischer glycosylation with methanol, providing a useful tool in anticancer studies aimed at understanding and combating lymphoid malignancies. -
Purine Nucleoside Analog
L-Threonolactone, a purine nucleoside analog, exhibits significant antitumor activity, particularly effective against indolent lymphoid malignancies. Its biological activity is attributed to mechanisms such as inhibition of DNA synthesis and the induction of apoptosis. This compound serves as a valuable tool in cancer research, allowing for the exploration of therapeutic strategies targeting nucleoside metabolism and cancer cell proliferation. -
Purine Nucleoside
8-Hydroxyadenosine is a modified purine nucleoside that serves as a marker for oxidative stress in nucleic acids. It plays a crucial role in cellular processes and is involved in the regulation of various biological activities, including gene expression and DNA repair mechanisms. This compound is commonly utilized in research studies focused on oxidative damage, cellular response to stress, and the examination of RNA modifications. -
Active Compound
Orotic acid zinc acts as an active compound involved in the biosynthesis of pyrimidine nucleotides and RNA. It is released as a product from mitochondrial dihydroorotate dehydrogenase (DHODH) and subsequently converted to UMP by UMP synthase in the cytoplasm. This compound is utilized as a biomarker in newborn screening for urea cycle disorders and has been shown to induce hepatic steatosis and hepatomegaly in rodent models, making it relevant for studies in metabolic and liver disorders. -
Purine Nucleoside Analog
2'-Deoxy-N3-methylcytidine hydriodide is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are primarily mediated through the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound serves as a valuable research tool for investigating therapeutic strategies in oncology. -
Purine Nucleoside Analog
1-(a-D-ribofuranosyl)uracil is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for research in cancer biology and therapeutic development. This reagent is suited for studies focusing on nucleic acid metabolism and the molecular pathways involved in tumor growth and progression. -
Purine Nucleoside Analog
Dideoxycytidinene, a purine nucleoside analog, primarily targets DNA synthesis processes. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for research in cancer therapeutics. -
Purine Nucleoside Analog
2'-Deoxy-2'-fluoro-β-D-arabinocytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound holds promise for studies aimed at understanding and developing therapies for various hematological cancers. -
Purine Nucleoside Analog
6-Chloroguanineriboside is a purine nucleoside analog that serves as a substrate for various nucleoside kinases. It demonstrates low affinity for guanosine binding sites, with a Ki value of 253.1 μM in rat brain tissues. This compound can be utilized in research related to nucleoside metabolism and the pharmacological effects of purine analogs in neurological studies. -
Isomer
(2S,3R,5S)-7-Deaza-2'-deoxy-7-iodoadenosine is an isomeric variant of 7-Deaza-2'-deoxy-7-iodoadenosine, serving primarily as a control in biochemical experiments. This modified oligonucleotide includes 7-Deazaadenine and is utilized in research applications focused on nucleic acid interactions and modifications. Its unique structure allows for the exploration of various biological processes involving adenine analogs. -
Nucleoside Analog
3'-NH2-ddA (3'-Amino-2',3'-dideoxyadenosine) is a nucleoside analog that serves as an important building block for the synthesis of nucleic acids. Its structural features facilitate incorporation into DNA and RNA, making it valuable for studies involving genetic manipulation and molecular biology applications. This reagent is essential for developing advanced nucleic acid-based technologies such as antisense oligonucleotides and gene editing strategies. -
Deoxyribonucleoside
DMT-dI (5'-O-DMT-dI) is a modified deoxyribonucleoside featuring a hypoxanthine base. It serves as a precursor for synthesizing convertible nucleoside derivatives, which are valuable for generating modified oligonucleotides that can effectively target specific genes involved in gene editing applications. DMT-dI is particularly useful for researching conditions and disorders influenced by adenosine metabolism. -
Cytidine Analogue
N-Benzoylcytidine is a cytidine analogue that acts as a substrate for uracil-cytidine kinases (UCK1 and UCK2). It is integral to the synthesis of 2-OH protective groups for solid-phase RNA synthesis and is utilized in the production of synthetic oligonucleotides. This compound has applications in UV induction and targeted gene silencing in zebrafish embryos, making it a valuable tool in molecular biology research. -
Purine Nucleoside Analog
2’-Azido-2’-deoxycytidine is a purine nucleoside analogue that exhibits significant anticancer properties by inhibiting DNA synthesis and inducing apoptosis, particularly in indolent lymphoid malignancies. This compound serves as a versatile click chemistry reagent, containing an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne, DBCO, or BCN-containing molecules. Additionally, 2’-Azido-2’-deoxycytidine requires dual phosphorylation to function as an inhibitor of ribonucleotide reductase, positioning it as a valuable tool in cancer research and therapeutic development. -
Purine Nucleoside Analog
6-Methylpurine riboside is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable reagent for cancer research. This compound is utilized in investigations focused on therapeutic strategies targeting nucleoside metabolism and cell proliferation. -
Purine Nucleoside Analog
3'-Azido-3'-deoxyadenosine is a purine nucleoside analog that exhibits potent antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects stem from mechanisms such as inhibition of DNA synthesis and induction of apoptosis. In addition to its biological applications, 3'-Azido-3'-deoxyadenosine functions as a click chemistry reagent, featuring an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) with alkyne-containing molecules. This versatility makes it a valuable tool in chemical biology and medicinal chemistry research. -
Purine Nucleoside Analog
3′-Deoxy-3′-fluorouridine is a purine nucleoside analog that exhibits significant antitumor activity. This compound primarily acts by inhibiting DNA synthesis and inducing apoptosis in neoplastic cells. Its application in research includes studying therapeutic strategies against indolent lymphoid malignancies, making it a valuable tool for cancer research and drug development. -
Nucleoside Analog
(3R,5S)-5-O-DMT-3-pyrrolidinol is a nucleoside analog featuring a dimethoxytrityl (DMT) protecting group and a 3-pyrrolidinol framework. This compound plays a crucial role in the synthesis of nucleic acids, facilitating the development of oligonucleotides and other nucleic acid-based materials for research applications. Its unique structural properties make it a valuable reagent in chemical biology and molecular genetics studies. -
Adenosine Analog
2’,3’,5’-Tri-O-acetyl adenosine is an adenosine analog that primarily targets adenosine receptors, serving as a potent smooth muscle vasodilator. This compound has been shown to exert inhibitory effects on cancer progression, making it a valuable tool in oncology research. It is useful for studying adenosine signaling pathways and their implications in various biological processes. -
Thymidine Analog
5-Hydroxymethyl uridine is a thymidine analog that exhibits insertional activity towards replicated DNA. This compound is utilized in various research applications, including cell labeling and the monitoring of DNA synthesis. Its capacity to mimic natural thymidine makes it a valuable tool for studying DNA replication dynamics and cellular processes. -
Purine Nucleoside Analog
5-Methyl-2′-O-methylcytidine is a purine nucleoside analog that exerts significant antitumor activity against indolent lymphoid malignancies. Its primary mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research applications focused on cancer biology and the development of therapeutic strategies targeting nucleoside metabolism. -
Purine Nucleoside Analog
Spongosine, also known as 2-Methoxyadenosine, acts as a purine nucleoside analog. It exhibits significant antitumor activity, particularly in targeting indolent lymphoid malignancies. The compound's anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable reagent for cancer research applications.
