Catalog No.
Product Name
Application
Product Information
Citations
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Queuine Precursor
preQ1 dihydrochloride is a modified guanine-derived nucleobase that serves as a precursor in the biosynthesis of queuine. This compound demonstrates a high-affinity interaction with the aptamer of the preQ1 riboswitch, making it valuable for research in RNA biology and gene regulation. Its unique properties support studies aimed at understanding nucleobase metabolism and the role of queuine in cellular processes. -
Mononucleotide
2'-Deoxyguanosine 5'-monophosphate disodium is a nucleotide analog targeting cellular processes associated with guanine. This mononucleotide serves as a key reactant in studies of self-assembly in solution and the nucleation and growth of G-quadruplex structures. In addition, it plays a role in nucleophilic trapping and reductive alkylation, making it valuable for research on oxidative stress and DNA synthesis. As a precursor to guanosine triphosphate (GTP), it is essential for various biochemical assays and applications in nucleic acid research. -
Purine Nucleoside Analog
4-Thiothymidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for cancer research. This analog is essential for studies focused on the development of targeted therapies and the understanding of cellular responses to nucleoside analogs in oncological contexts. -
Isonuclear Anhydride Derivative
N-Methylisatoic anhydride is an isonuclear anhydride derivative that serves as a highly selective reagent for 2'-OH acylation of RNA. This compound is conjugated with biotin and a disulfide linker, facilitating the capture of RNA from complex biological mixtures containing both RNA and DNA. Its unique properties make it a valuable tool in RNA manipulation and isolation for various research applications. -
Purine Nucleoside Analog
5-Bromouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis. This compound is an important tool for research applications in cancer biology and therapeutic development. -
Nucleoside Analog
Bz-OMe-rA is a nucleoside analog that primarily targets cellular nucleoside metabolism. It exhibits potential biological activity as an inhibitor of nucleoside transporters and may influence RNA synthesis and processing. Bz-OMe-rA is utilized in research to study nucleoside analogs in therapeutic applications, including antiviral and anticancer strategies. -
Purine Nucleoside Analog
2'-Deoxy-2'-fluoro-5-iodouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is relevant in studies focused on cancer therapeutics and the development of novel treatment strategies targeting nucleoside metabolism. -
Cytidine Analog
2’-Fluoro-2’-deoxy-ara-C(Bz)-3’-phosphoramidite is a cytidine analog that inhibits DNA methyltransferases, thereby influencing gene expression and cellular metabolism. This compound demonstrates significant anti-metabolic and anti-tumor activities, making it a valuable tool in cancer research and epigenetic studies. Its unique structure allows for incorporation into nucleic acids, facilitating investigations into gene regulation and therapeutic development. -
Nucleoside Analog
5'(E)-VP-2'-OMe-U phosphoramidite is a nucleoside analog utilized as a monomer in oligonucleotide synthesis. This reagent is instrumental in generating modified nucleic acids, enabling the study of RNA structure and function. Its unique properties make it suitable for applications in biological research, including probe design and therapeutic development. -
Nucleoside Antimetabolite/Analog
2′-Deoxy-2′-fluoroadenosine is a fluorinated nucleoside analog that functions as an antimetabolite, displaying significant antitumor and antiviral properties. It disrupts DNA replication in cancer and viral cells upon incorporation, hindering their proliferation. This compound is particularly valuable for synthesizing 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. Additionally, 2′-Deoxy-2′-fluoroadenosine can be converted by E. coli purine nucleoside phosphorylase (PNP) into the cytotoxic agent 2-fluoroadenine (FAde), demonstrating promising in vivo efficacy against tumors with E. coli PNP expression. -
Purine Nucleoside Analog
5-Methoxyuridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms primarily involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound can be utilized in studies focusing on nucleoside metabolism and the therapeutic potential of nucleoside analogs in oncology. -
Immunosuppressive Agent
6-Thioguanosine is a potent immunosuppressive agent and an active metabolite of Azathioprine. It functions by inhibiting nucleotide synthesis, leading to the suppression of lymphocyte proliferation. This compound is primarily utilized in research applications related to transplantation, autoimmune disorders, and cancer therapy, where modulation of the immune response is critical. -
Thymidine Phosphorylase Inhibitor
KIN59 (5’-O-Tritylinosine) is a potent allosteric inhibitor of thymidine phosphorylase, effectively impacting cellular proliferation. This compound demonstrates the ability to inhibit FGF2-stimulated cell growth and reduces the expression of phosphorylated FGFR1 and Akt in FGF2-stimulated cells. KIN59 showcases significant anti-tumor activity, making it valuable for research in cancer therapeutics and cell signaling pathways. -
Purine Nucleoside Analog
5-(Hydroxymethyl)cytidine is a purine nucleoside analog that serves as a valuable reagent in oligonucleotide synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting DNA synthesis and inducing apoptosis in cancer cells. Its mechanism of action makes it a critical tool for research focused on cancer therapeutics and genetic studies. -
Nucleoside Analog
Bz-dA (N6-Benzoyl-2'-deoxyadenosine) is a nucleoside analog that serves as a versatile building block for the synthesis of oligoribonucleotides. Its structural modifications facilitate the incorporation into RNA sequences, providing insights into RNA biology and function. Bz-dA is valuable for applications in molecular biology, including studies on RNA folding, stability, and interactions. -
Purine Nucleoside Analog
5'-Amino-5'-deoxyadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action includes inhibition of DNA synthesis and induction of apoptosis, making it a valuable tool for cancer research. This compound is suitable for studies focused on understanding the cellular and molecular effects of nucleoside analogs in therapeutic applications. -
Cytidine Analog
N4-Methylcytidine is a cytidine nucleoside analog that functions by inhibiting DNA methyltransferases. This compound exhibits potential anti-metabolic and anti-tumor activities, making it a valuable reagent in cancer research. Its ability to modulate DNA methylation patterns allows for exploration in epigenetic studies and therapeutic applications targeting methyltransferase-related pathways. -
Nucleoside Analog
1,2-Dideoxy-D-ribofuranose is a nucleoside analog that serves as a critical building block for the synthesis of nucleic acids. This compound is instrumental in the development of antiviral and anticancer agents, facilitating research in molecular biology and genetics. Its unique structural properties offer significant potential for the creation of modified nucleotides in various therapeutic applications. -
Anticancer Agent
Tegafur-gimeracil-oteracil potassium is an oral anticancer agent that combines Tegafur, Gimeracil, and Oteracil potassium in a molar ratio of 1:0.4:1. This compound exhibits significant biological activity in inhibiting tumor growth and is predominantly applied in research related to gastric cancer, particularly in studies of peritoneal dissemination. Its unique combination of components enhances its efficacy in targeting cancer cells, making it a valuable tool for oncological research. -
Metabolite
5,6-Dihydro-5-Fluorouracil, a metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil, acts by inhibiting the activity of dihydropyrimidine dehydrogenase (DPD). This compound exhibits cytotoxic effects on HaCaT keratinocytes, with an IC50 value of 13.5 μM. In preclinical studies, intravenous administration of 5,6-Dihydro-5-Fluorouracil in combination with 5-fluorouracil and the DPD inhibitor eniluracil has demonstrated the ability to impede tumor growth in a rat colon cancer model, highlighting its potential in cancer research applications. -
Antisense Oligonucleotide
Viltolarsen is a phosphorodiamidate morpholino antisense oligonucleotide designed to target dystrophin mRNA by binding to exon 53. This mechanism promotes exon skipping, leading to the restoration of the open-reading frame and the production of a truncated dystrophin protein that preserves essential functional elements. Viltolarsen is primarily utilized in research related to Duchenne muscular dystrophy (DMD), making it a valuable tool for advancing therapeutic strategies in this condition. -
Purine Nucleoside Analog
2'-Deoxy-N4-methylcytidine is a purine nucleoside analog that exerts antitumor effects primarily by inhibiting DNA synthesis and inducing apoptosis. This compound has shown promise in targeting indolent lymphoid malignancies, making it a valuable tool in cancer research. Its biological activity in modulating cellular processes supports its potential applications in exploring treatment strategies for various malignancies. -
Cytidine Analog
N4-Benzoyl-2’-O-methylcytidine is a cytidine analog that functions primarily as an inhibitor of DNA methyltransferase. This compound exhibits potential antimetabolite and antitumor activities, making it a valuable tool in cancer research. Its mechanism of action contributes to the modulation of epigenetic regulation, offering insights into therapeutic strategies for various malignancies. Research applications include studying gene expression, DNA methylation patterns, and the biochemical pathways involved in tumorigenesis. -
Purine Nucleoside Analog
2-Thiocytidine is a purine nucleoside analog that demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms are attributed to the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for research in cancer therapeutics. This reagent can be utilized in various studies focused on understanding the molecular mechanisms underlying tumor growth and treatment resistance. -
Purine Nucleoside Analog
2'-O-Methylinosine, a purine nucleoside analog, exhibits significant antitumor activity primarily against indolent lymphoid malignancies. Its mechanism of action includes the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research applications focused on cancer biology and the development of therapeutic strategies targeting nucleoside metabolism. -
Purine Nucleoside Analog
5-Azidomethyl-2'-deoxyuridine (5-AmdU) is a purine nucleoside analog that functions as a radiosensitizer, particularly effective in EMT6 tumor cell lines. This compound serves as a valuable reagent in click chemistry, possessing an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds that possess DBCO or BCN reactive groups, making it a versatile tool for biochemical research and molecular labeling applications. -
Intermediate
N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine functions as an essential intermediate in the synthesis of oligonucleotides. This compound facilitates the production of modified nucleic acids for various research applications, including gene expression studies and the development of therapeutic oligonucleotides. Its protective groups and chemical stability render it suitable for complex synthetic routes in nucleic acid chemistry. -
Uridine Analog
5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine is a modified uridine analog featuring a 5'-O-(4,4'-dimethoxytrityl) protecting group and a 2'-O-methyl modification. This compound is primarily utilized as a precursor for the synthesis of conformationally rigid cyclic uridylic acid derivatives, which are valuable in various biochemical research applications. Its structural modifications enhance the stability and binding properties of oligonucleotides, making it an important tool for studies in nucleic acid chemistry and drug development. -
Purine Nucleoside Analog
4,10-Dioxatri cyclo[5.2.1.02.6]dec-8-ene-3,5-dione is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is useful in studies aimed at understanding and targeting specific cancer pathways. -
Nucleic Acid Analog
5'-ODMT cEt N-Bzm5 C Phosphoramidite is a modified nucleic acid analog that effectively enhances antisense oligonucleotide performance. Through the incorporation of a cEt modification, this reagent promotes the formation of a specific conformation of the furanose ring, which significantly improves hybridization to complementary RNA. Its primary applications include research into gene expression regulation associated with metabolic disorders, cardiovascular diseases, and cancer, as well as the advancement of antisense therapeutic compounds. -
Purine Nucleoside Analog
N1-Methyl-2'-deoxyadenosine is a purine nucleoside analog that serves as a DNA adduct. This compound demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological effects are attributed to mechanisms such as inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research and therapeutic applications. -
Adenosine Analog
8-Bromoadenosine is an adenosine analog known for its vasodilatory effects on smooth muscle and its potential to inhibit cancer progression. This compound can effectively quench the intrinsic fluorescence of human serum albumin through a static quenching mechanism. 8-Bromoadenosine serves as a precursor for synthesizing various adenosine phosphates, such as Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine, making it valuable for biochemical research and therapeutic applications. -
Nucleoside Analogue
2'-O,4'-C-Methylenecytidine is a bicyclic nucleoside analogue known for its fixed N-type conformation. This compound serves as a key building block for the synthesis of oligonucleotides, allowing for the formation of stable duplexes with complementary DNA and RNA strands. Its unique structural properties make it valuable for various applications in nucleic acid research and therapeutic development. -
Cytidine Analog
DMT-2'-OMe-Bz-C is a cytidine analog that primarily inhibits DNA methyltransferases. This compound exhibits significant anti-metabolic and anti-tumor activities, making it valuable in cancer research. It is utilized in studies exploring epigenetic modulation and the role of DNA methylation in gene regulation and tumorigenesis. -
Purine Nucleoside Analog
1,N6-Ethenoadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research applications focused on cancer biology and therapeutic development. -
Nucleoside Antimetabolite/Analog
Isocytosine is a synthetic nucleoside analog and structural isomer of cytosine. This compound serves as a nucleobase in the study of unnatural nucleic acid analogs, particularly when used in combination with Isoguanine. Isocytosine facilitates research into hachimoji RNA systems, contributing to advancements in genetic coding and nucleic acid chemistry. -
Purine Nucleoside Analog
4-Thio-2’-deoxyuridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, which subsequently induces apoptotic pathways in malignant cells. This compound is valuable in cancer research and may serve as a tool for studying DNA synthesis inhibition and apoptosis in oncological studies. -
LNA Analogue
5'-ODMT cEt m5U Phosphoramidite is a locked nucleic acid (LNA) analog that enhances oligonucleotide stability and binding affinity. This reagent demonstrates significant antisense activity, making it suitable for applications in gene regulation and therapeutic research. Its favorable safety profile in murine models further supports its use in various molecular biology studies. -
Intermediate
5'-O-DMT-Bz-rA is an important intermediate in the synthesis of cyclic di-nucleotide compounds. This reagent facilitates various biochemical applications, particularly in the development of nucleic acid-based therapeutics and diagnostic tools. Its utility in research makes it a valuable component in the study of nucleotide signaling pathways. -
Purine Nucleoside
8-Bromoguanosine is a brominated derivative of guanosine that targets purine nucleosides. It has been shown to significantly reduce the conformational heterogeneity of RNA, thereby enhancing its functional capabilities. This compound is useful in various molecular biology applications, particularly in studies focused on RNA stability and function. -
Nucleoside Analog
2'-F-Bz-A (N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine) is a nucleoside analog designed for the synthesis of oligoribonucleotides. Its structural modification enhances thermal stability and can influence hybridization properties. This reagent is valuable in nucleic acid research, particularly in studies involving RNA synthesis and modification. -
Nucleoside Analogue
2',3'-O-Isopropylideneadenosine is a nucleoside analogue that functions as a Golgi-targeting moiety. Exhibiting cyclization at the O (2') and O (3') atoms, it features a furanose ribose group, enabling its incorporation into fluorescent probes. As a key element of the fluorescent probe TPE-Ade, this compound facilitates specific Golgi localization for fluorescence imaging applications. Additionally, 2',3'-O-Isopropylideneadenosine plays a role in the development of aggregation-induced emission (AIE) fluorescent probes, contributing to advancements in biochemical research and imaging technologies. -
Adenosine Analog
2-Iodoadenosine is an adenosine analog known for its vasodilatory properties, primarily acting through smooth muscle relaxation. In addition to promoting vascular function, it exhibits potential in inhibiting cancer progression, making it a valuable tool for various research applications in oncology and cardiovascular studies. Its unique structural modifications enable investigations into adenosine's receptor interactions and biological effects, supporting its use in exploring therapeutic avenues. -
Adenosine Analog
N-Propargyladenosine is an adenosine analogue that primarily acts as a vasodilator by targeting adenosine receptors. This compound exhibits significant biological activity, demonstrating potential in inhibiting cancer progression. Additionally, N-Propargyladenosine functions as a click chemistry reagent, containing an alkyne group that allows it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, making it valuable for various chemical biology applications. -
Purine Nucleotide Analogue
Bredinin aglycone (5-Hydroxy-1H-imidazole-4-carboxamide) is a purine nucleotide analogue that serves as a valuable tool in biochemical research. This compound is utilized to investigate the efficiency of catalytic processes in the synthesis of purine nucleotide analogues, thereby enhancing the understanding of nucleic acid metabolism and associated pathways. Its applications extend to studies in pharmacology and biochemistry, particularly involving nucleotide synthesis and modification. -
Purine Nucleoside Analog
2-Methylthioadenosine is a purine nucleoside analog with significant antitumor activity, primarily targeting indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is used to explore therapeutic strategies for lymphoid malignancies and understand the underlying biochemical pathways involved in tumor development and progression. -
Nucleoside
iBu-rG (N-Isobutyrylguanosine) is a nucleoside compound that serves as a valuable precursor for the synthesis of oligoribonucleotides. It provides enhanced stability and handling properties for RNA research applications. This compound is essential for studies involving RNA processing, transcriptional regulation, and the development of RNA-based therapeutics. -
Purine Nucleoside Analog
2',3'-Dideoxyuridine is a purine nucleoside analog that primarily targets nucleic acid synthesis. It exhibits significant anticancer activity, particularly against indolent lymphoid malignancies, through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. This compound is utilized in research to explore therapeutic strategies for cancer treatment. -
Purine Nucleoside Analog
3'-Deoxyinosine is a purine nucleoside analog that exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound serves as a valuable tool for researchers investigating cancer biology and therapeutic strategies. -
Purine Nucleoside Analog
8-Bromo-2'-deoxyadenosine is a purine nucleoside analog that exerts anticancer effects primarily through the inhibition of DNA synthesis and the induction of apoptosis. This compound has demonstrated broad antitumor activity, particularly against indolent lymphoid malignancies. It serves as a valuable tool for research applications related to cancer biology and therapeutic development.
