Nucleoside Antimetabolite/Analog

Items 1351-1400 of 1704

Page
per page
Set Descending Direction
Catalog No.
Product Name
Application
Product Information
Citations
  1. Purine Nucleoside Analog

    3’,5’-Di-O-benzoyl-2’-deoxy-2’-fluoro-5-methyl-β-D-arabino-uridine is a purine nucleoside analog known for its antitumor activity. This compound targets indolent lymphoid malignancies through mechanisms that include the inhibition of DNA synthesis and the induction of apoptosis. Its unique structural modifications enhance its efficacy in cancer research applications.
  2. Purine Nucleoside Analog

    2'-Deoxy-N6-phenoxyacetyladenosine is a purine nucleoside analog that demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research and therapeutic applications. This reagent is essential for studies focusing on the development of novel anticancer strategies and understanding the molecular pathways involved in tumorigenesis.
  3. Purine Nucleoside Analog

    2’-Deoxy-2’-fluoro-arabino-tubercidine is a purine nucleoside analogue that demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound serves as an important reagent for studying the pharmacological effects of purine analogs in therapeutic applications.
  4. Purine Nucleoside Analog

    3’-Deoxy-3’-fluoro-5-methylcytidine is a purine nucleoside analog that demonstrates significant antitumor activity by targeting indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is suitable for studies investigating therapeutic strategies in oncology and the molecular mechanisms underlying lymphoid malignancies.
  5. Nucleoside Metabolite

    Aldosterone hemiacetal is a nucleoside metabolite that serves as an important biologically active compound contributing to the understanding of steroid hormone signaling. This compound is utilized in research applications focused on aldosterone synthesis and its effects on mineralocorticoid receptors, thereby aiding in studies related to cardiovascular health and renal physiology.
  6. Thymidine Analog

    5-(Azidomethyl) arauridine is a thymidine analogue that exhibits insertional activity into replicated DNA, making it valuable for labeling and tracking DNA synthesis in cellular studies. As a click chemistry reagent, it features an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds possessing DBCO or BCN groups, expanding its utility in bioconjugation applications.
  7. Nucleoside Metabolite

    L-Serine-phosphoethanolamine is a nucleoside metabolite that plays a crucial role in cellular signaling and phospholipid metabolism. It is involved in various biological processes, including the synthesis of phospholipids and neurotransmitters. This compound is valuable for research in cell biology, neurobiology, and metabolic studies, providing insight into the intricate network of cellular functions and signaling pathways.
  8. Purine Nucleoside Analog

    6-(Thiophen-3-yl)purine-beta-D-(3’-deoxy-3’-fluoro)riboside is a purine nucleoside analog that exhibits notable antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable reagent for studying cancer biology and therapeutic interventions. This compound provides a critical tool for researchers investigating the effects of purine analogs in cancer treatment.
  9. Thymidine Analog

    5-Carboxymethylaminomethyluridine is a thymidine analogue that exhibits insertional activity towards replicated DNA. This compound serves as a useful tool for labeling cells and studying DNA synthesis dynamics. Its applications in molecular biology can facilitate research in cellular proliferation and nucleotide metabolism.
  10. Purine Nucleoside Analog

    5-Bromo-2'-O-methyluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action primarily involves the inhibition of DNA synthesis and the induction of apoptosis. This compound is useful in cancer research for exploring therapeutic strategies targeting nucleoside metabolism and cancer cell proliferation.
  11. Guanosine Analog

    8-Hydroxymethyl guanosine is a guanosine analog that acts as an immunostimulant. This compound has been shown to induce type I interferons in various animal models, leading to significant antiviral effects. Its functional activity is primarily mediated through the activation of Toll-like receptor 7 (TLR7), making it a valuable tool for research in immunology and antiviral therapies.
  12. Purine Nucleoside Analog

    3′-Chloro-3′-deoxy-5′-O-(triphenylmethyl)thymidine is a purine nucleoside analog that targets DNA synthesis. It exhibits significant antitumor activity against indolent lymphoid malignancies through mechanisms such as the inhibition of DNA replication and the induction of apoptosis. This compound is useful in cancer research and therapeutic studies focused on lymphoid malignancies.
  13. Nucleoside Metabolite

    (S)-3-Hydroxytetradecanoyl-CoA primarily serves as a nucleoside metabolite involved in lipid metabolism. It plays a critical role in the biosynthesis of fatty acids and the regulation of energy homeostasis. This compound is relevant in studies focused on metabolic pathways and cellular energy regulation, making it a valuable tool for researching lipid-related disorders and metabolic diseases.
  14. Adenosine Analog

    2’-O-Propargyladenosine is an adenosine analog that serves as a versatile click chemistry reagent due to its unique alkyne group. This compound exhibits smooth muscle vasodilatory effects and demonstrates potential for inhibiting cancer progression. Its ability to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) makes it an essential tool for bioconjugation applications in chemical biology research.
  15. Purine Nucleoside Analog

    3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinocytidine is a purine nucleoside analog with significant potential in cancer therapy. It exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for research in oncology and cancer treatment development.
  16. Purine Nucleoside Analog

    N1-Cyclopropylmethylpseudouridine is a purine nucleoside analog that exhibits significant antitumor activity, specifically targeting indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research applications focused on understanding the cellular pathways involved in cancer progression and therapeutic response.
  17. Purine Nucleoside Analog

    9-(2-β-C-Methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine is a purine nucleoside analog known for its broad antitumor activity, particularly against indolent lymphoid malignancies. This compound's anticancer mechanisms primarily involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for research in cancer biology and therapeutic development. Its distinctive structural features allow for exploration in various nucleoside-related studies and therapeutic strategies.
  18. Purine Nucleoside Analog

    N2,2'-O-Dimethylguanosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is suited for investigations into therapeutic strategies and the underlying biology of malignant transformation.
  19. Purine Nucleoside Analog

    Alpha-inosine is a purine nucleoside analog that exhibits significant antitumor activity against indolent lymphoid malignancies. Its therapeutic mechanisms primarily involve the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is useful in research applications focused on cancer biology and the development of novel therapeutic strategies.
  20. 5-FU Precursor

    Bis-Pro-5FU is a 5-Fluorouracil (5-FU) precursor designed to enhance oral bioavailability and improve the safety profile of 5-FU chemotherapy protocols. As an antineoplastic antimetabolite, 5-FU is commonly utilized in cancer research, particularly for colorectal and pancreatic cancer studies. Bis-Pro-5FU serves as a valuable tool for investigating more effective and safer treatment options in oncological research.
  21. Purine Nucleoside Analog

    2'-Deoxy-2'-fluoro-4'-thio-β-D-arabinouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This reagent serves as a valuable tool for researchers investigating novel therapeutic strategies in oncology and elucidating the pathways involved in cancer cell proliferation and survival.
  22. Hypoxanthine Analog

    2′-C-Methyl-6-O-methylinosine is a hypoxanthine analog that functions primarily by targeting metabolic pathways involving purines. This compound exhibits notable anti-inflammatory properties and has potential applications as an endogenous poly(ADP-ribose) polymerase (PARP) inhibitor, contributing to cytoprotection through the inhibition of PARP activity. Additionally, 2′-C-Methyl-6-O-methylinosine may serve as a valuable indicator of hypoxic conditions in various biological studies, facilitating research into cellular metabolism and stress responses.
  23. Purine Nucleoside Analog

    6-Amino-9-[2-deoxy-β-D-ribofuranosyl]-9H-purine functions as a purine nucleoside analog. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms are primarily linked to the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for research in oncology and therapeutic applications targeting cancer cell proliferation.
  24. Nucleoside Metabolite

    N(ω)-Hydroxyarginine is a nucleoside metabolite that serves as an intermediate in the metabolism of arginine. It is involved in various biological processes, including the regulation of nitric oxide synthase and the modulation of immune response. This compound is utilized in research applications focusing on nitric oxide synthesis, cardiovascular studies, and cellular signaling pathways.
  25. Nucleoside Metabolite

    4-Guanidinobutanal is a nucleoside metabolite that acts as an important precursor in various biochemical pathways. This compound is utilized in research focused on nucleotide metabolism and can contribute to investigations into cellular processes such as energy production and signaling. Its role in nucleoside metabolism makes it a valuable reagent for studies in cell biology and biochemistry.
  26. Tryptophan Product

    7,8-Dihydroxykynurenate is a key metabolite in the tryptophan metabolic pathway, acting as an agonist of the NMDA receptor. It has been shown to exhibit neuroprotective effects and can modulate glutamate activity, making it valuable for research in neurobiology and psychiatric disorders. This compound is useful in studying the role of tryptophan derivatives in cellular signaling and excitotoxicity.
  27. Purine Nucleoside Analog

    N1-Benzyl pseudouridine is a purine nucleoside analogue that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. The compound operates primarily through the inhibition of DNA synthesis and the induction of apoptosis. Its biological activity makes it a valuable tool for research in cancer biology and the development of therapeutic strategies targeting nucleotide metabolism and tumor proliferation.
  28. Purine Nucleoside Analog

    3’-Azido-3’-deoxy-beta-L-cytidine is a purine nucleoside analog that exhibits significant antitumor activity against indolent lymphoid malignancies. Its anticancer effects are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis. Additionally, this compound serves as an efficient click chemistry reagent due to its azide functional group, allowing it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It is also compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) for reactions involving DBCO or BCN-modified compounds.
  29. Nucleoside Metabolite

    Glutathioselenol (GS-SeH) is a nucleoside metabolite that acts as a potent antioxidant, facilitating the detoxification of reactive oxygen species. This compound is involved in redox regulation and cellular defense mechanisms, making it relevant for research on oxidative stress, cancer biology, and neuroprotection. Its unique properties allow for exploration in the study of metabolic pathways and potential therapeutic applications in related diseases.
  30. Purine Nucleoside Analog

    3,5-Bis-O-(4-methylbenzoyl)-2-C-methyl-D-ribonic acid gamma-lactone is a purine nucleoside analog that exerts significant antitumor activity, particularly against indolent lymphoid malignancies. Its mode of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound can be utilized effectively in studies aimed at understanding the mechanisms of tumor growth and developing novel therapeutic strategies.
  31. Purine Nucleoside Analog

    5′-Amino-5′-deoxythymidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. This compound functions primarily by inhibiting DNA synthesis and inducing apoptosis, thereby disrupting cancer cell proliferation. It serves as a valuable tool in cancer research and therapeutic applications aimed at understanding and targeting tumorigenic processes.
  32. Nucleoside Metabolite

    11,12,15(S)-THETA, also known as 11,12,15(S)-Trihydroxyicosatrienoic acid, is a nucleoside metabolite that plays a crucial role in cellular signaling pathways. It is involved in the regulation of various biological processes, including inflammation and vascular function. This compound is of interest in research applications focusing on metabolic pathways and the effects of nucleoside metabolites in health and disease.
  33. Purine Nucleoside Analog

    1,2-Di-O-acetyl-3,5-di-O-benzoyl-D-xylofuranose is a purine nucleoside analog that exhibits significant antitumor activity. This compound primarily targets indolent lymphoid malignancies through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. Its potential applications in cancer research include the study of therapeutic strategies aimed at disrupting nucleotide metabolism in tumor cells.
  34. Thymidine Analog

    5-[3-[(2,2,2-Trifluoroacetyl)amino]-1-propyn-1-yl]uridine is a thymidine analog that exhibits insertional activity towards replicated DNA. This compound can effectively label cells, allowing for the tracking of DNA synthesis in various biological contexts. Additionally, it serves as a click chemistry reagent due to its alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its utility in DNA research and labeling makes it a valuable tool for cell biology studies.
  35. Thymidine Analog

    2’,3’,5’-Tri-O-benzoyl-5-hydroxymethyl-2’-β-C-methyluridine is a thymidine analog that exhibits insertional activity towards replicated DNA. This compound can be utilized to label cells, enabling the tracking of DNA synthesis in various biological systems. Its unique structure allows for enhanced applications in molecular biology and cancer research, providing insights into replication processes.
  36. Product of 3,4-Dihydroxyphenylacetate

    5-Formyl-2-hydroxy-2,4-heptadienedioic acid is a product formed through the meta-cleavage of 3,4-dihydroxyphenylacetate. This compound exhibits key biological activities related to phenolic compound metabolism and can be utilized in studies of metabolic pathways and environmental biochemistry. Its unique structure may also serve as a valuable tool for investigating the biochemical roles of phenolic acids in various biological systems.
  37. Nucleoside Metabolite

    Episterone is a nucleoside metabolite that exhibits properties of a steroid hormone. It plays a significant role in various biological processes, including the modulation of gene expression and cellular metabolism. Episterone is utilized in research applications focused on steroidogenesis, hormonal regulation, and related biochemical pathways. Its unique profile makes it a valuable tool for investigating the effects of steroid metabolites in both in vitro and in vivo models.
  38. Purine Nucleoside Analog

    3’-Azido-3’-deoxy-5-methyl-beta-L-uridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. Additionally, this compound serves as a versatile click chemistry reagent, featuring an azide group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules, such as those with DBCO or BCN moieties.
  39. Purine Nucleoside Analog

    N6-Bz-5'-O-DMTr-2'-O-hexadecanyl adenosine is a purine nucleoside analog that exhibits significant antitumor activity. This compound primarily targets indolent lymphoid malignancies, functioning through mechanisms such as inhibition of DNA synthesis and induction of apoptosis. It serves as a valuable tool for research applications focused on cancer biology and therapeutic development.
  40. Purine Nucleoside Analog

    Methyl 3'-O-benzyl xyloriboside is a purine nucleoside analog with significant biological activity in inhibiting DNA synthesis and inducing apoptosis. This compound demonstrates broad antitumor effects, particularly in the treatment of indolent lymphoid malignancies. Its mechanisms make it a valuable tool for cancer research and therapeutic investigations.
  41. Purine Nucleoside Analog

    5-Me-3’-dU-2’-phosphoramidite is a purine nucleoside analog designed to inhibit DNA synthesis, contributing to its antitumor activity. This compound demonstrates effectiveness in targeting indolent lymphoid malignancies, mediating cellular apoptosis and disrupting cellular proliferation. Its applications extend to cancer research, particularly in exploring therapeutic strategies against hematological malignancies.
  42. Purine Nucleoside Analog

    7-(3-Deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action includes the inhibition of DNA synthesis and the induction of apoptosis in cancerous cells. This compound is valuable for research applications focused on cancer biology and therapeutic development for lymphoid cancers.
  43. Fatty Acid

    9,10-Epoxy-13-hydroxy-11-octadecenoic acid is a fatty acid known for its role in lipid metabolism. This compound exhibits bioactive properties and is involved in various biochemical pathways, making it suitable for research in cellular signaling and metabolic regulation. It serves as a valuable tool for investigating the physiological effects of fatty acids and their derivatives in diverse biological systems.
  44. Cytidine Analog

    4'-C-Methyl-5-methylcytidine is a cytidine nucleoside analog specifically designed to inhibit DNA methyltransferases. This compound exhibits potential anti-metabolic and anti-tumor activities, making it a valuable tool in cancer research and epigenetic studies. Researchers may utilize this reagent to investigate the role of DNA methylation in gene regulation and the development of therapeutic strategies targeting aberrant methylation patterns.
  45. Purine Nucleoside Analog

    6-Methylpurine-β-D-(3-azido-3-deoxy)riboside is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms include the inhibition of DNA synthesis and the induction of apoptosis. Additionally, this compound serves as a versatile click chemistry reagent, featuring an azide group capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds.
  46. Purine Nucleoside Analog

    1-(5-O-Methoxytrityl-2-deoxy-β-D-xylofuranosyl)uracil is a purine nucleoside analog that demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis in cancer cells, making it a valuable tool for cancer research. This compound can be used in studies focused on elucidating mechanisms of tumorigenesis and therapeutic resistance in various malignancies.
  47. Purine Nucleoside Analog

    2′-O-Hexadecyl-adenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a vital tool in cancer research. This compound is suitable for studies focusing on nucleoside metabolism and therapeutic interventions in hematological cancers.
  48. Guanine Adduct

    AFB1-FapyGua is a prominent guanine adduct formed from the alkylation of nucleic acids by aflatoxin B1 (AFB1). This compound has been shown to exert significant mutagenic effects, making it crucial for studying DNA damage and repair mechanisms. AFB1-FapyGua serves as an important tool in cancer research, particularly in understanding the cellular response to genotoxic stress and the mutational processes involved in tumorigenesis.
  49. Purine Nucleoside Analog

    2'-Deoxy-8-(phenylmethoxy)guanosine is a purine nucleoside analog that exhibits notable antitumor activity, particularly against indolent lymphoid malignancies. Its biological mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable reagent for cancer research. This compound is significant for studies aimed at exploring therapeutic strategies in oncology and understanding the underlying pharmacological effects of nucleoside analogs.
  50. Purine Nucleoside Analog

    Isocytidine is a purine nucleoside analog that targets nucleic acid synthesis. This compound exhibits notable antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research and therapeutic applications.

Items 1351-1400 of 1704

Page
per page
Set Descending Direction