Catalog No.
Product Name
Application
Product Information
Citations
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Purine Nucleoside Analog
6-Chloro-2-iodo-9-(2’,3’,5’-tri-O-acetyl-β-D-ribofuranosyl)purine is a purine nucleoside analog that exerts significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, contributing to its potential as an effective therapeutic agent in cancer research. This compound can be utilized in studies investigating the molecular pathways of cancer progression and treatment efficacy. -
Thymidine Analog
2’-O-Acetyl-5’-O-benzoyl-3’-O-methyl-5-methyl uridine is a thymidine analog that targets DNA synthesis through insertional activity into replicated DNA. This compound can be effectively utilized for cellular labeling and the monitoring of DNA synthesis dynamics in various research applications. Its unique structural modifications enhance its utility in nucleic acid studies, making it a valuable tool for molecular biology and genetic research. -
Purine Nucleoside Analog
1,3'-Dimethylguanosine is a purine nucleoside analog that exhibits significant anticancer properties. This compound primarily targets indolent lymphoid malignancies through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. It serves as a valuable tool in cancer research and therapeutic development, contributing to the understanding of purine metabolism and its implications in tumorigenesis. -
Purine Nucleoside Analog
3,4-Dihydro-3-oxo-4-β-D-ribofuranosyl-2-pyrazinecarboxamide functions as a purine nucleoside analog. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological effects are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research and therapeutic development. -
Purine Nucleoside Analog
5’-Deoxy-5’-iodo-2’-O-(2-methoxyethyl)uridine is a purine nucleoside analog known for its antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis. This compound is useful in cancer research for investigating cellular responses to nucleoside analog treatment and exploring therapeutic strategies in hematological malignancies. -
Purine Nucleoside Analog
2'-Deoxy-2'-fluoroarabino inosine is a purine nucleoside analog that exhibits potent antitumor activity through its ability to inhibit DNA synthesis and induce apoptosis. This compound is particularly relevant in the investigation of indolent lymphoid malignancies. Its mechanism of action makes it a valuable tool in cancer research and therapeutic development. -
Pyrimidine Nucleoside Analog
4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine is a pyrimidine nucleoside analog known for its ability to inhibit both DNA and RNA synthesis. This compound exhibits significant biological activity, making it a valuable tool in anticancer research, antiviral studies, and immunomodulation investigations. Its diverse applications in biochemical assays contribute to the understanding of nucleic acid metabolism and therapeutic development. -
Adenosine Analog
2-(4-Methylbenzyl)thioadenosine is an adenosine analog that primarily targets adenosine receptors. It is recognized for its vasodilatory effects on smooth muscle and demonstrates potential in inhibiting cancer progression. This compound serves as a valuable tool in researching adenosine receptor signaling, cardiovascular function, and cancer biology. -
Modified Adenosine Nucleotide
Adenosine 5′-O-(1-thiotriphosphate) is a modified adenosine nucleotide featuring a thiol substitution at the α-phosphate position. This compound serves as a potent analog of ATP, effectively participating in various biochemical assays and enzymatic reactions. It is widely utilized in studies exploring signal transduction pathways, nucleotide-binding proteins, and cellular energy metabolism. -
Cytidine Analog
2'-Deoxy-5'-O-DMT-N4-Fmoc-5-methylcytidine is a cytidine analog that targets DNA methyltransferases. By inhibiting these enzymes, this compound demonstrates potential anti-metabolic and anti-tumor activities, making it a valuable tool for epigenetic research. Its unique chemical structure allows for specific modifications in nucleoside studies and provides insight into cellular processes related to DNA methylation. -
Purine Nucleoside Analog
N1-Methyl-arabinoadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly in indolent lymphoid malignancies. Its primary biological mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound serves as a valuable tool for researchers investigating targeted therapies and mechanisms of action in cancer treatment. -
Purine Nucleoside Analog
4'-Methylguanosine is a purine nucleoside analogue that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable in research applications focused on understanding and targeting malignant lymphoproliferative disorders. -
Purine Nucleoside Analog
N4-Benzoyl-3’-deoxycytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. This compound functions by inhibiting DNA synthesis and inducing apoptosis, making it a valuable tool in cancer research. Its biological properties offer potential for exploring therapeutic strategies in oncology and studying mechanisms of cell cycle regulation. -
Purine Nucleoside Analog
2′-Deoxy-8-(methylthio)adenosine is a purine nucleoside analog known for its broad antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is utilized in various studies aimed at understanding the mechanisms of tumor growth and potential therapeutic interventions. -
Purine Nucleoside Analog
5-O-(tert-Butyldiphenylsilyl)-2,3-isopropylidene-D-ribonolactone is a purine nucleoside analog known for its antitumor properties. This compound exhibits significant biological activity by inhibiting DNA synthesis and inducing apoptosis, making it a valuable tool in the research of indolent lymphoid malignancies. Its application in cancer research enhances understanding of cellular mechanisms and therapeutic strategies. -
Purine Nucleoside Analog
8-Chloro-2'-beta-C-methyl inosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for cancer research. This reagent is utilized in studies focused on exploring novel therapeutic strategies for malignancies involving purine metabolism. -
Purine Nucleoside Analog
2’-Deoxy-2’-fluoro-N1-methyl inosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is suited for studies exploring the biochemical pathways of purine metabolism and the therapeutic potential of nucleoside analogs in oncology. -
Thymidine Analog
3'-O-(2-Methoxyethyl)-5-methyluridine functions as a thymidine analog, exhibiting incorporation into replicated DNA. This compound is utilized to label cells, providing insights into DNA synthesis and cellular proliferation. Its unique structure allows for potential applications in studies of nucleic acid metabolism and the exploration of DNA-related processes in various biological contexts. -
GCN2-targeting Agent
RAPT-37-Me is a selective GCN2 inhibitor that demonstrates potent activity with an IC50 of 0.002 μM for GCN2, alongside higher IC50 values of more than 10 μM for PERK, 4.40 μM for HRl, and 1.31 μM for PKR. This compound is valuable for research applications focused on the integrated stress response and its implications in various diseases, offering insights into GCN2-mediated signaling pathways. It is particularly relevant for studies investigating therapeutic interventions that modulate cellular stress responses. -
MNK1/MNK2 Inhibitor
HD202A is a selective dual inhibitor of MNK1 and MNK2, exhibiting IC50 values of 6.09 nM and 8.06 nM, respectively. This compound effectively inhibits the MNK-eIF4E signaling pathway, leading to downregulation of perilipin 2 and SCD1, while upregulating adipose triglyceride lipase and PPARγ coactivator 1α. HD202A enhances mitochondrial fatty acid oxidation, redox homeostasis, and demonstrates significant effects on metabolic health, including suppression of body weight gain, reduction in hepatic lipid accumulation, and improvement in glucose tolerance and insulin sensitivity. These properties make HD202A a valuable tool for researching metabolic dysfunction-associated steatotic liver disease. -
ISR Activator
ISR Activator 3 (Compound cc81) is a potent activator of the integrated stress response (ISR), targeting RIG-I with a dissociation constant of approximately 0.55 μM. This compound enhances the interferon response in the presence of viral mimicry signals while not inducing lipid droplet clearance. ISR Activator 3 is suitable for research related to neurodegenerative diseases and immune stress mechanisms, providing valuable insights into cellular stress pathways and their implications in various biological contexts. -
Nucleoside Metabolite
(R)-b-Aminoisobutyric acid is a nucleoside metabolite that serves as an effective amino donor. It plays a significant role in various biochemical pathways, making it valuable for studies on amino acid metabolism and nucleoside synthesis. This compound can be used in research applications focused on metabolic disorders and the regulation of nucleoside levels within cells. -
Nucleoside Metabolite
3,4-Dihydroxyphenylpyruvic acid is a nucleoside metabolite that plays a crucial role in the biosynthesis of catecholamines. This compound exhibits antioxidant properties and is involved in the regulation of cellular stress responses. Its applications in research include studying metabolic disorders and neurodegenerative diseases, as well as investigating its potential therapeutic effects in various biological contexts. -
Ribonucleoside Analog
4-Thiouridine is a ribonucleoside analog that serves as a valuable tool in RNA analysis and mRNA labeling. It effectively inhibits rRNA synthesis, leading to a nucleolar stress response, which can be utilized to study cellular stress mechanisms and RNA processing pathways. This compound is essential for researchers investigating RNA dynamics and the regulation of gene expression. -
Oligonucleotide Enhancer
UNC10217938A is a 3-deazapteridine analog that functions as an oligonucleotide enhancer. It effectively modulates intracellular trafficking and promotes the release of oligonucleotides from endosomes, leading to enhanced biological activity. This compound is particularly useful in research applications involving the optimization of antisense and siRNA oligonucleotide efficacy. -
Adenine Nucleoside Analogue
N-6-Methyl-2-deoxyadenosine (m6dA) is an adenine nucleoside analogue that targets nuclear processes and DNA replication machinery. It functions as a multifaceted epigenetic regulator, influencing transcription, DNA damage response, cell cycle progression, transposon silencing, and nucleosome organization in both prokaryotic and eukaryotic systems. Additionally, m6dA plays a crucial role in mitochondrial epigenetic inheritance and is implicated in fear extinction memory in murine models. Dysregulated levels of N-6-Methyl-2-deoxyadenosine have been associated with various cancers, making it a valuable reagent for research into glioblastoma, triple-negative breast cancer, and conditioned fear responses. -
Queuine Precursor
preQ1 dihydrochloride is a modified guanine-derived nucleobase that serves as a precursor in the biosynthesis of queuine. This compound demonstrates a high-affinity interaction with the aptamer of the preQ1 riboswitch, making it valuable for research in RNA biology and gene regulation. Its unique properties support studies aimed at understanding nucleobase metabolism and the role of queuine in cellular processes. -
Mononucleotide
2'-Deoxyguanosine 5'-monophosphate disodium is a nucleotide analog targeting cellular processes associated with guanine. This mononucleotide serves as a key reactant in studies of self-assembly in solution and the nucleation and growth of G-quadruplex structures. In addition, it plays a role in nucleophilic trapping and reductive alkylation, making it valuable for research on oxidative stress and DNA synthesis. As a precursor to guanosine triphosphate (GTP), it is essential for various biochemical assays and applications in nucleic acid research. -
Purine Nucleoside Analog
4-Thiothymidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for cancer research. This analog is essential for studies focused on the development of targeted therapies and the understanding of cellular responses to nucleoside analogs in oncological contexts. -
Isonuclear Anhydride Derivative
N-Methylisatoic anhydride is an isonuclear anhydride derivative that serves as a highly selective reagent for 2'-OH acylation of RNA. This compound is conjugated with biotin and a disulfide linker, facilitating the capture of RNA from complex biological mixtures containing both RNA and DNA. Its unique properties make it a valuable tool in RNA manipulation and isolation for various research applications. -
Purine Nucleoside Analog
5-Bromouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis. This compound is an important tool for research applications in cancer biology and therapeutic development. -
Nucleoside Analog
Bz-OMe-rA is a nucleoside analog that primarily targets cellular nucleoside metabolism. It exhibits potential biological activity as an inhibitor of nucleoside transporters and may influence RNA synthesis and processing. Bz-OMe-rA is utilized in research to study nucleoside analogs in therapeutic applications, including antiviral and anticancer strategies. -
Purine Nucleoside Analog
2'-Deoxy-2'-fluoro-5-iodouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is relevant in studies focused on cancer therapeutics and the development of novel treatment strategies targeting nucleoside metabolism. -
Cytidine Analog
2’-Fluoro-2’-deoxy-ara-C(Bz)-3’-phosphoramidite is a cytidine analog that inhibits DNA methyltransferases, thereby influencing gene expression and cellular metabolism. This compound demonstrates significant anti-metabolic and anti-tumor activities, making it a valuable tool in cancer research and epigenetic studies. Its unique structure allows for incorporation into nucleic acids, facilitating investigations into gene regulation and therapeutic development. -
Nucleoside Analog
5'(E)-VP-2'-OMe-U phosphoramidite is a nucleoside analog utilized as a monomer in oligonucleotide synthesis. This reagent is instrumental in generating modified nucleic acids, enabling the study of RNA structure and function. Its unique properties make it suitable for applications in biological research, including probe design and therapeutic development. -
Nucleoside Antimetabolite/Analog
2′-Deoxy-2′-fluoroadenosine is a fluorinated nucleoside analog that functions as an antimetabolite, displaying significant antitumor and antiviral properties. It disrupts DNA replication in cancer and viral cells upon incorporation, hindering their proliferation. This compound is particularly valuable for synthesizing 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. Additionally, 2′-Deoxy-2′-fluoroadenosine can be converted by E. coli purine nucleoside phosphorylase (PNP) into the cytotoxic agent 2-fluoroadenine (FAde), demonstrating promising in vivo efficacy against tumors with E. coli PNP expression. -
Purine Nucleoside Analog
5-Methoxyuridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms primarily involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound can be utilized in studies focusing on nucleoside metabolism and the therapeutic potential of nucleoside analogs in oncology. -
Immunosuppressive Agent
6-Thioguanosine is a potent immunosuppressive agent and an active metabolite of Azathioprine. It functions by inhibiting nucleotide synthesis, leading to the suppression of lymphocyte proliferation. This compound is primarily utilized in research applications related to transplantation, autoimmune disorders, and cancer therapy, where modulation of the immune response is critical. -
Thymidine Phosphorylase Inhibitor
KIN59 (5’-O-Tritylinosine) is a potent allosteric inhibitor of thymidine phosphorylase, effectively impacting cellular proliferation. This compound demonstrates the ability to inhibit FGF2-stimulated cell growth and reduces the expression of phosphorylated FGFR1 and Akt in FGF2-stimulated cells. KIN59 showcases significant anti-tumor activity, making it valuable for research in cancer therapeutics and cell signaling pathways. -
Purine Nucleoside Analog
5-(Hydroxymethyl)cytidine is a purine nucleoside analog that serves as a valuable reagent in oligonucleotide synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting DNA synthesis and inducing apoptosis in cancer cells. Its mechanism of action makes it a critical tool for research focused on cancer therapeutics and genetic studies. -
Nucleoside Analog
Bz-dA (N6-Benzoyl-2'-deoxyadenosine) is a nucleoside analog that serves as a versatile building block for the synthesis of oligoribonucleotides. Its structural modifications facilitate the incorporation into RNA sequences, providing insights into RNA biology and function. Bz-dA is valuable for applications in molecular biology, including studies on RNA folding, stability, and interactions. -
Purine Nucleoside Analog
5'-Amino-5'-deoxyadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action includes inhibition of DNA synthesis and induction of apoptosis, making it a valuable tool for cancer research. This compound is suitable for studies focused on understanding the cellular and molecular effects of nucleoside analogs in therapeutic applications. -
Cytidine Analog
N4-Methylcytidine is a cytidine nucleoside analog that functions by inhibiting DNA methyltransferases. This compound exhibits potential anti-metabolic and anti-tumor activities, making it a valuable reagent in cancer research. Its ability to modulate DNA methylation patterns allows for exploration in epigenetic studies and therapeutic applications targeting methyltransferase-related pathways. -
Nucleoside Analog
1,2-Dideoxy-D-ribofuranose is a nucleoside analog that serves as a critical building block for the synthesis of nucleic acids. This compound is instrumental in the development of antiviral and anticancer agents, facilitating research in molecular biology and genetics. Its unique structural properties offer significant potential for the creation of modified nucleotides in various therapeutic applications. -
Anticancer Agent
Tegafur-gimeracil-oteracil potassium is an oral anticancer agent that combines Tegafur, Gimeracil, and Oteracil potassium in a molar ratio of 1:0.4:1. This compound exhibits significant biological activity in inhibiting tumor growth and is predominantly applied in research related to gastric cancer, particularly in studies of peritoneal dissemination. Its unique combination of components enhances its efficacy in targeting cancer cells, making it a valuable tool for oncological research. -
Metabolite
5,6-Dihydro-5-Fluorouracil, a metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil, acts by inhibiting the activity of dihydropyrimidine dehydrogenase (DPD). This compound exhibits cytotoxic effects on HaCaT keratinocytes, with an IC50 value of 13.5 μM. In preclinical studies, intravenous administration of 5,6-Dihydro-5-Fluorouracil in combination with 5-fluorouracil and the DPD inhibitor eniluracil has demonstrated the ability to impede tumor growth in a rat colon cancer model, highlighting its potential in cancer research applications. -
Antisense Oligonucleotide
Viltolarsen is a phosphorodiamidate morpholino antisense oligonucleotide designed to target dystrophin mRNA by binding to exon 53. This mechanism promotes exon skipping, leading to the restoration of the open-reading frame and the production of a truncated dystrophin protein that preserves essential functional elements. Viltolarsen is primarily utilized in research related to Duchenne muscular dystrophy (DMD), making it a valuable tool for advancing therapeutic strategies in this condition. -
Purine Nucleoside Analog
2'-Deoxy-N4-methylcytidine is a purine nucleoside analog that exerts antitumor effects primarily by inhibiting DNA synthesis and inducing apoptosis. This compound has shown promise in targeting indolent lymphoid malignancies, making it a valuable tool in cancer research. Its biological activity in modulating cellular processes supports its potential applications in exploring treatment strategies for various malignancies. -
Cytidine Analog
N4-Benzoyl-2’-O-methylcytidine is a cytidine analog that functions primarily as an inhibitor of DNA methyltransferase. This compound exhibits potential antimetabolite and antitumor activities, making it a valuable tool in cancer research. Its mechanism of action contributes to the modulation of epigenetic regulation, offering insights into therapeutic strategies for various malignancies. Research applications include studying gene expression, DNA methylation patterns, and the biochemical pathways involved in tumorigenesis. -
Purine Nucleoside Analog
2-Thiocytidine is a purine nucleoside analog that demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms are attributed to the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for research in cancer therapeutics. This reagent can be utilized in various studies focused on understanding the molecular mechanisms underlying tumor growth and treatment resistance.
