Fig. 1 · Structure
Documents & Downloads
2′-Deoxy-2′-fluoroadenosine
Nucleoside Antimetabolite/Analog
2′-Deoxy-2′-fluoroadenosine is a fluorinated nucleoside analog that functions as an antimetabolite, displaying significant antitumor and antiviral properties. It disrupts DNA replication in cancer and viral cells upon incorporation, hindering their proliferation. This compound is particularly valuable for synthesizing 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. Additionally, 2′-Deoxy-2′-fluoroadenosine can be converted by E. coli purine nucleoside phosphorylase (PNP) into the cytotoxic agent 2-fluoroadenine (FAde), demonstrating promising in vivo efficacy against tumors with E. coli PNP expression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 64183-27-3 |
| Applications | Nucleoside Antimetabolite/Analog |
| Formula | C10H12FN5O3 |
| Molecular Weight | 269.24 |
| SMILES | OC[C@@H]1[C@@H](O)[C@@H](F)[C@H](N2C(N=CN=C3N)=C3N=C2)O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.