Fig. 1 · Structure
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N-6-Methyl-2-deoxyadenosine
Adenine Nucleoside Analogue
N-6-Methyl-2-deoxyadenosine (m6dA) is an adenine nucleoside analogue that targets nuclear processes and DNA replication machinery. It functions as a multifaceted epigenetic regulator, influencing transcription, DNA damage response, cell cycle progression, transposon silencing, and nucleosome organization in both prokaryotic and eukaryotic systems. Additionally, m6dA plays a crucial role in mitochondrial epigenetic inheritance and is implicated in fear extinction memory in murine models. Dysregulated levels of N-6-Methyl-2-deoxyadenosine have been associated with various cancers, making it a valuable reagent for research into glioblastoma, triple-negative breast cancer, and conditioned fear responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2002-35-9 |
| Applications | Adenine Nucleoside Analogue |
| Formula | C11H15N5O3 |
| Molecular Weight | 265.27 |
| Synonyms | m6dA |
| SMILES | OC[C@@H]1[C@@H](O)C[C@H](N2C(N=CN=C3NC)=C3N=C2)O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.